Spiro heterocycles bearing piperidine moiety as potential scaffold for antileishmanial activity: synthesis, biological evaluation, and in silico studies

Mounir A. A. Mohameda Chemistry Department, Faculty of Science, Sohag University, Sohag, EgyptCorrespondence[email protected]

Asmaa M. Kadrya Chemistry Department, Faculty of Science, Sohag University, Sohag, Egypt

Salma A. Bekhitb High Institute of Public Health, Alexandria University, Alexandria, Egypt

Mohammed A. S. Abourehabc Department of Pharmaceutics, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia

Kikuko Amagased Laboratory of Pharmacology & Pharmacotherapeutics, College of Pharmaceutical Sciences, Ritsumeikan University, Kusatsu, Japan

Tamer M. Ibrahime Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafr El-Sheikh, EgyptCorrespondence[email protected]

Ahmed M. M. El-Saghiera Chemistry Department, Faculty of Science, Sohag University, Sohag, Egypt

Adnan A. Bekhitf Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt;g Cancer Nanotechnology Research Laboratory (CNRL), Faculty of Pharmacy, Alexandria University, Alexandria, Egypt;h Allied Health Department, College of Health and Sport Sciences, University of Bahrain, Sakhir, Kingdom of BahrainCorrespondence[email protected]

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Joanna Panecka-Hofman & Ina Poehner. (2023) Structure and dynamics of pteridine reductase 1: the key phenomena relevant to enzyme function and drug design. European Biophysics Journal 52:6-7, pages 521-532.
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Nawal Kishore Sahu, Ritu Sharma, Kshirsagar Prasad Suhas, Jyoti Joshi, Kunal Prakash, Richa Sharma, Ramendra Pratap, Xiwen Hu, Sukhbir Kaur, Mukesh Jain, Carmine Coluccini, Paolo Coghi & Sandeep Chaudhary. (2023) Natural-Product-Inspired Microwave-Assisted Synthesis of Novel Spirooxindoles as Antileishmanial Agents: Synthesis, Stereochemical Assignment, Bioevaluation, SAR, and Molecular Docking Studies. Molecules 28:12, pages 4817.
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Spiro heterocycles bearing piperidine moiety as potential scaffold for antileishmanial activity: synthesis, biological evaluation, and in silico studies

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Spiro heterocycles bearing piperidine moiety as potential scaffold for antileishmanial activity: synthesis, biological evaluation, and in silico studies

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