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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 38, 2023 - Issue 1
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Research Paper

Development of new TAK-285 derivatives as potent EGFR/HER2 inhibitors possessing antiproliferative effects against 22RV1 and PC3 prostate carcinoma cell lines

Seohyun Sona College of Pharmacy, BK21 FOUR Team and Integrated Research Institute for Drug Development, Dongguk University-Seoul, Goyang, Republic of KoreaView further author information
,
Ahmed Elkamhawya College of Pharmacy, BK21 FOUR Team and Integrated Research Institute for Drug Development, Dongguk University-Seoul, Goyang, Republic of Korea;b Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, EgyptView further author information
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Anam Rana Gulc Department of Chemistry, Research Institute of Chem-Bio Diagnostic Technology, Chung-Ang University, Seoul, Republic of KoreaView further author information
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Ahmed A. Al‐Karmalawyd Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, Giza, EgyptORCID Iconhttps://orcid.org/0000-0002-8173-6073View further author information
ORCID Icon,
Radwan Alnajjare Department of Chemistry, Faculty of Science, University of Benghazi, Benghazi, Libya;f Faculty of Pharmacy, Libyan International Medical University, Benghazi, Libya;g Department of Chemistry, University of Cape Town, Rondebosch, South AfricaView further author information
,
Ahmed Abdeenh Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University, Toukh, EgyptView further author information
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Samah F. Ibrahimi Department of Clinical Sciences, College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh, Saudi ArabiaView further author information
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Saud O. Alshammarij Department of Plant Chemistry and Natural Products, Faculty of Pharmacy, Northern Border University, Arar, Saudi ArabiaView further author information
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Qamar A. Alshammarik Department of Pharmacology and Toxicology, Faculty of Pharmacy, Northern Border University, Arar, Saudi ArabiaView further author information
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Won Jun Choia College of Pharmacy, BK21 FOUR Team and Integrated Research Institute for Drug Development, Dongguk University-Seoul, Goyang, Republic of KoreaView further author information
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Tae Jung Parkc Department of Chemistry, Research Institute of Chem-Bio Diagnostic Technology, Chung-Ang University, Seoul, Republic of KoreaCorrespondence[email protected]
View further author information
&
Kyeong Leea College of Pharmacy, BK21 FOUR Team and Integrated Research Institute for Drug Development, Dongguk University-Seoul, Goyang, Republic of KoreaCorrespondence[email protected]
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Article: 2202358 | Received 06 Feb 2023, Accepted 07 Apr 2023, Published online: 25 Apr 2023

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Ahmed A Gaber, Marwa Sharaky, Ayman Abo Elmaaty, Mohamed M Hammouda, Ahmed AE Mourad, Samy Y Elkhawaga, Mahmoud Mohamed Mokhtar, Amr S Abouzied, Mai AE Mourad & Ahmed A Al-Karmalawy. (2023) Design and Synthesis of Novel Pyrazolopyrimidine Candidates As Promising EGFR-T790M Inhibitors and Apoptosis Inducers. Future Medicinal Chemistry 15:19, pages 1773-1790.
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Articles from other publishers (1)

Eslam M. Abbass, Ahmed A. Al-Karmalawy, Marwa Sharaky, Muhammad Khattab, Abdullah Yahya Abdullah Alzahrani & Aya I. Hassaballah. (2024) Rational design and eco-friendly one-pot multicomponent synthesis of novel ethylidenehydrazineylthiazol-4(5H)-ones as potential apoptotic inducers targeting wild and mutant EGFR-TK in triple negative breast cancer. Bioorganic Chemistry 142, pages 106936.
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