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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 38, 2023 - Issue 1
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Research Paper

Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors

Moataz A. Shaldama Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, EgyptORCID Iconhttps://orcid.org/0000-0002-0420-4364View further author information
ORCID Icon,
Hadia Almahlib Department of Chemistry, University of Cambridge, Cambridge, UKView further author information
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Andrea Angelic Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Sesto Fiorentino, ItalyORCID Iconhttps://orcid.org/0000-0002-1470-7192View further author information
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Rehab Mustafa Badid Department of Medical Physiology, College of Medicine, King Khalid University, Abha, Saudi ArabiaView further author information
,
Eman F. Khaleeld Department of Medical Physiology, College of Medicine, King Khalid University, Abha, Saudi ArabiaView further author information
,
Abdelrahman I. Zain-Alabdeene Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta, EgyptORCID Iconhttps://orcid.org/0000-0001-9213-7191View further author information
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Zainab M. Elsayedf Scientific Research and Innovation Support Unit, Faculty of Pharmacy, Kafrelsheikh Uinversity, Kafrelsheikh, EgyptView further author information
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Eslam B. Elkaeedg Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh, Saudi Arabia;h Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, EgyptView further author information
,
Rofaida Salema Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, EgyptView further author information
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Claudiu T. Supuranc Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Sesto Fiorentino, ItalyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-4262-0323View further author information
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Wagdy M. Eldehnaa Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt;i School of Biotechnology, Badr University in Cairo, Badr City, EgyptCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-6996-4017View further author information
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Haytham O. Tawfike Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta, EgyptCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-6455-5716View further author information
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Article: 2203389 | Received 10 Mar 2023, Accepted 10 Apr 2023, Published online: 25 Apr 2023

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Claudiu T Supuran. (2023) Targeting carbonic anhydrases for the management of hypoxic metastatic tumors. Expert Opinion on Therapeutic Patents 33:11, pages 701-720.
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Mohammed A. Assiri, Tarik E. Ali, Maha N. Alqahtani, Ali. A. Shati, Mohammed. Y. Alfaifi & Serag. E. I. Elbehairi. (2023) Synthesis, cytotoxic evaluation, apoptosis, cell cycle, and molecular docking studies of some new 5-(arylidene/heteroarylidene)-2-(morpholinoimino)-3-phenylthiazolidin-4-ones. Synthetic Communications 53:15, pages 1240-1261.
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Dhakshinamurthy Divya, Venkatesan Srinivasan, Arunachalam Prabakaran, Chandramohan Uma Maheswari, Thamilselvan Rajamani & Sambantham Muthu. Computational, Reactivity, Fukui Function, Molecular Docking, and Spectroscopic Studies of a Novel (E)-1-Benzyl-3-(2-(Pyrindin-2-yl)Hydrazono)Indolin-2-One. Polycyclic Aromatic Compounds 0:0, pages 1-21.
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Articles from other publishers (9)

Gourav Kumar, Parveen Kumar, Akta Soni, Venu Sharma & Meena Nemiwal. (2024) Efficient synthesis and molecular docking analysis of quinazoline and azole hybrid derivatives as promising agents for anti-cancer and anti-tuberculosis activities. Journal of Molecular Structure 1310, pages 138289.
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Moataz A. Shaldam, Maha-Hamadien Abdulla, Andrea Angeli, Salma M. Hefny, Eman M. El-labbad, Abdullah Bin Obeed, Noura S. Alhassan, Claudiu T. Supuran, Wagdy M. Eldehna & Haytham O. Tawfik. (2024) Novel sulfonamide-tethered Schiff bases as anti-proliferative agents with VEGFR-2 inhibitory activity: Synthesis, biological assessment, and molecular dynamic simulations. Journal of Molecular Structure 1309, pages 138148.
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Md. Saddam Hossain, Md. Anisur Rahman, Prithbey Raj Dey, Md. Parvez Khandocar, Md. Yeakub Ali, Mahajabin Snigdha, Henrique Douglas Melo Coutinho & Muhammad Torequl Islam. (2024) Natural Isatin Derivatives Against Black Fungus: In Silico Studies. Current Microbiology 81:5.
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Salma M. Hefny, Tarek F. El-Moselhy, Nabaweya El-Din, Simone Giovannuzzi, Thamer Bin Traiki, Mansoor-Ali Vaali-Mohammed, Ahmed M. El-Dessouki, Koki Yamaguchi, Masaharu Sugiura, Moataz A. Shaldam, Claudiu T. Supuran, Maha-Hamadien Abdulla, Wagdy M. Eldehna & Haytham O. Tawfik. (2024) Discovery and Mechanistic Studies of Dual-Target Hits for Carbonic Anhydrase IX and VEGFR-2 as Potential Agents for Solid Tumors: X-ray, In Vitro , In Vivo , and In Silico Investigations of Coumarin-Based Thiazoles . Journal of Medicinal Chemistry.
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Alia Mushtaq, Peng Wu & Muhammad Moazzam Naseer. (2024) Recent drug design strategies and identification of key heterocyclic scaffolds for promising anticancer targets. Pharmacology & Therapeutics 254, pages 108579.
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Haytham O. Tawfik, Mohamed M. Saleh, Andrea Ammara, Eman F. Khaleel, Rehab Badi, Yomna T. T. Khater, Rabab A. Rasheed, Ahmed A. Attia, Salma M. Hefny, Eslam B. Elkaeed, Alessio Nocentini, Claudiu T. Supuran, Wagdy M. Eldehna & Moataz A. Shaldam. (2024) Discovery of Novel Pyridazine-Tethered Sulfonamides as Carbonic Anhydrase II Inhibitors for the Management of Glaucoma. Journal of Medicinal Chemistry 67:2, pages 1611-1623.
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Samir Bondock, Tallah Albarqi, Moaz M. Abdou & Nada M. Mohamed. (2023) Computational insights into novel benzenesulfonamide-1,3,4-thiadiazole hybrids as a possible VEGFR-2 inhibitor: design, synthesis and anticancer evaluation with molecular dynamics studies. New Journal of Chemistry 47:44, pages 20602-20618.
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Zainab Kifah Abbas, Noor H. Naser & Rana Neama Atiya. (2023) IN SILICO STUDY OF NOVEL SULFONAMIDE DERIVATIVES BEARING A 1, 2, 4-TRIAZOLE MOIETY ACT AS CARBONIC ANHYDRASE INHIBITORS WITH PROMISING ANTI-CANCER ACTIVITY. Polski Merkuriusz Lekarski 51:5, pages 527-532.
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Ankush KumarBhupinder KumarRohit Bhatia. (2023) Design, Synthesis, Molecular Docking, and Biological Evaluation of Isatin-Based Fused Heterocycles As Epidermal Growth Factor Receptor Inhibitors. ASSAY and Drug Development Technologies 21:5, pages 222-233.
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