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Review

Manufacturing DTaP-based combination vaccines: industrial challenges around essential public health tools

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Pages 1575-1582 | Received 19 Apr 2016, Accepted 21 Jun 2016, Published online: 06 Jul 2016

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Florence Boisnard, Christine Manson, Laurence Serradell & Denis Macina. (2023) DTaP-IPV-HB-Hib vaccine (Hexaxim): an update 10 years after first licensure. Expert Review of Vaccines 22:1, pages 1196-1213.
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Emmanuel J. Vidor & John F. Modlin. 2023. Plotkin's Vaccines. Plotkin's Vaccines 890 913.e14 .
Jiyan Ma, Zhuo Li, Yinuo Sun, Zuokun Liu, Yuan Dang & Yangmu Huang. (2022) Improving Innovation and Access to Combination Vaccines for Childhood Immunization in China. International Journal of Environmental Research and Public Health 19:23, pages 15557.
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Maria Auxiliadora Miranda-García, Marcus Hoffelner, Hagen Stoll, Dörte Ruhaltinger, Klaus Cichutek, Anette Siedler & Isabelle Bekeredjian-Ding. (2022) A 5-year look-back at the notification and management of vaccine supply shortages in Germany. Eurosurveillance 27:17.
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Xiaoyu Wang, Na Gao, Jiana Wen, Jingyan Li, Yan Ma, Mingbo Sun, Jiangli Liang & Li Shi. (2021) Immunogenicity of a Candidate DTacP-sIPV Combined Vaccine and Its Protection Efficacy against Pertussis in a Rhesus Macaque Model. Vaccines 10:1, pages 47.
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Stephen Jarrett, Sonia Pagliusi, Rachel Park, Taufik Wilmansyah, Suresh Jadhav, Patricia Correa Santana, K.R. Krishnamurthy & Lingjiang Yang. (2021) The importance of vaccine stockpiling to respond to epidemics and remediate global supply shortages affecting immunization: strategic challenges and risks identified by manufacturers. Vaccine: X 9, pages 100119.
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Jiří Jaromír Klemeš, Peng Jiang, Yee Van Fan, Awais Bokhari & Xue-Chao Wang. (2021) COVID-19 pandemics Stage II – Energy and environmental impacts of vaccination. Renewable and Sustainable Energy Reviews 150, pages 111400.
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Emily A. Voigt, Jasmine Fuerte-Stone, Brian Granger, Jacob Archer & Neal Van Hoeven. (2021) Live-attenuated RNA hybrid vaccine technology provides single-dose protection against Chikungunya virus. Molecular Therapy 29:9, pages 2782-2793.
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Raquel Cid & Jorge Bolívar. (2021) Platforms for Production of Protein-Based Vaccines: From Classical to Next-Generation Strategies. Biomolecules 11:8, pages 1072.
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Suthira Taychakhoonavudh. 2020. Global Pharmaceutical Policy. Global Pharmaceutical Policy 309 330 .
E. Chiappini, C. Petrolini, C. Caffarelli, M. Calvani, F. Cardinale, M. Duse, A. Licari, S. Manti, A. Martelli, D. Minasi, M. Miraglia Del Giudice, GB. Pajno, C. Pietrasanta, L. Pugni, MA. Tosca, F. Mosca & GL. Marseglia. (2019) Hexavalent vaccines in preterm infants: an update by Italian Society of Pediatric Allergy and Immunology jointly with the Italian Society of Neonatology. Italian Journal of Pediatrics 45:1.
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Yahiya Y. Syed. (2019) DTaP-IPV-HepB-Hib Vaccine (Hexyon®): An Updated Review of its Use in Primary and Booster Vaccination. Pediatric Drugs 21:5, pages 397-408.
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Kevin Markey, Catpagavalli Asokanathan & Ian Feavers. (2019) Assays for Determining Pertussis Toxin Activity in Acellular Pertussis Vaccines. Toxins 11:7, pages 417.
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Zoltán Kis, Maria Papathanasiou, Raul Calvo‐Serrano, Cleo Kontoravdi & Nilay Shah. (2019) A model‐based quantification of the impact of new manufacturing technologies on developing country vaccine supply chain performance: A Kenyan case study. Journal of Advanced Manufacturing and Processing 1:3.
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Laxmikant Kadam, Krunal Patel, Manish Gautam, Shrikant Thorat, Prathamesh Kale, Arvind Kumar Ghule, Akansha Gairola, Harish Rao, Yojana Shinde, Umesh Shaligram & Sunil Gairola. (2019) Development and validation of magnetic bead pentaplex immunoassay for simultaneous quantification of murine serum IgG antibodies to acellular pertussis, diphtheria and tetanus antigens used in combination vaccines. Methods 158, pages 33-43.
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V. A. Shevtsov, Yu. V. Olefir, V. A. Merkulov, V. P. Bondarev, I. N. Indikova, E. E. Evreinova, A. V. Rukavishnikov, L. M. Khantimirova & D. V. Gorenkov. (2019) Post-approval Variations to Dossiers for Vaccines: Analysis of Regulatory and Methodological Approaches Used in the Russian Federation and Abroad. The Bulletin of the Scientific Centre for Expert Evaluation of Medicinal Products 9:1, pages 41-48.
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Federico Martinón-Torres, Javier Diez-Domingo, Emmanuel Feroldi, Emilia Jordanov, Siham B’Chir & Xavier Da Costa. (2019) Evaluation of a Hexavalent-Pentavalent-Hexavalent Infant Primary Vaccination Series Followed by a Pentavalent Booster Vaccine in Healthy Infants and Toddlers. Pediatric Infectious Disease Journal 38:3, pages 317-322.
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Zoltán Kis, Robin Shattock, Nilay Shah & Cleo Kontoravdi. (2018) Emerging Technologies for Low‐Cost, Rapid Vaccine Manufacture. Biotechnology Journal, pages 1800376.
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B. Soubeyrand. (2018) De la fabrication d’un vaccin à sa mise à disposition en pharmacie. Revue des Maladies Respiratoires 35:10, pages 1005-1019.
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Claudia Mueller, Ulrike Altenburger & Silke Mohl. (2018) Challenges for the pharmaceutical technical development of protein coformulations. Journal of Pharmacy and Pharmacology 70:5, pages 666-674.
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Rebecca Sheets. 2018. Fundamentals of Biologicals Regulation. Fundamentals of Biologicals Regulation 119 128 .
Stanley Plotkin, James M. Robinson, Gerard Cunningham, Robyn Iqbal & Shannon Larsen. (2017) The complexity and cost of vaccine manufacturing – An overview. Vaccine 35:33, pages 4064-4071.
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