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Original Articles

Methamphetamine Administration Produces Immunomodulation in Mice

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Pages 2133-2145 | Published online: 06 Feb 2008

Keep up to date with the latest research on this topic with citation updates for this article.

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Seung Jun Kwack, Kyung Sik Yoon, Seong Kwang Lim, Hyo-min Gwak, Ji Yun Kim, Yoon Mi Um, Jung Dae Lee, Ji Hyeon Hyeon, Yeon Joo Kim, Hyung Sik Kim & Byung-Mu Lee. (2014) A One-Generation Reproductive Toxicity Study of 3,4-Methylenedioxy-N-Methamphetamine (MDMA, Ecstasy), an Amphetamine Derivative, in C57BL/6 Mice. Journal of Toxicology and Environmental Health, Part A 77:22-24, pages 1431-1442.
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Raul Gonzalez & Mariana Cherner. (2008) Co-factors in HIV neurobehavioural disturbances: Substance abuse, hepatitis C and aging. International Review of Psychiatry 20:1, pages 49-60.
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Articles from other publishers (50)

Khalid Elhadi, Atul P. Daiwile & Jean Lud Cadet. (2023) Modeling methamphetamine use disorder and relapse in animals: Short- and long-term epigenetic, transcriptional., and biochemical consequences in the rat brain. Neuroscience & Biobehavioral Reviews 155, pages 105440.
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Rasmon Kalayasiri, Kanokwan Dadwat, Supaksorn Thika, Sunee Sirivichayakul & Michael Maes. (2023) Methamphetamine (MA) use and MA-induced psychosis are associated with increasing aberrations in the compensatory immunoregulatory system, interleukin-1α, and CCL5 levels. Translational Psychiatry 13:1.
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Adithya Gopinath, Tabish Riaz, Emily Miller, Leah Phan, Aidan Smith, Ohee Syed, Stephen Franks, Luis R. Martinez & Habibeh Khoshbouei. (2023) Methamphetamine induces a low dopamine transporter expressing state without altering the total number of peripheral immune cells. Basic & Clinical Pharmacology & Toxicology 133:5, pages 496-507.
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Emily J. Miller & Habibeh Khoshbouei. 2023.
V.V. Yekhalov, O.V. Kravets, I.A. Romanyuta & V.A. Sedinkin. (2022) Особливості невідкладної стоматологічної допомоги та анестезії в осіб з метамфетаміновою залежністю (літературний огляд). EMERGENCY MEDICINE 18:3, pages 6-13.
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Douglas R. Miller, Mengfei Bu, Adithya Gopinath, Luis R. Martinez & Habibeh Khoshbouei. (2021) Methamphetamine Dysregulation of the Central Nervous System and Peripheral Immunity. Journal of Pharmacology and Experimental Therapeutics 379:3, pages 372-385.
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Adriana C. Hernandez-Santini, Anum N. Mitha, Daniela Chow, Mohamed F. Hamed, Azad L. Gucwa, Valerie Vaval & Luis R. Martinez. (2021) Methamphetamine facilitates pulmonary and splenic tissue injury and reduces T cell infiltration in C57BL/6 mice after antigenic challenge. Scientific Reports 11:1.
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Anum N. Mitha, Daniela Chow, Valerie Vaval, Paulina Guerrero, Dormarie E. Rivera-Rodriguez & Luis R. Martinez. (2021) Methamphetamine Compromises the Adaptive B Cell-Mediated Immunity to Antigenic Challenge in C57BL/6 Mice. Frontiers in Toxicology 3.
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Xue Yang, Hui Zhao, Xuebing Liu, Qin Xie, Xiaoliang Zhou, Qijian Deng & Gang Wang. (2020) The Relationship Between Serum Cytokine Levels and the Degree of Psychosis and Cognitive Impairment in Patients With Methamphetamine-Associated Psychosis in Chinese Patients. Frontiers in Psychiatry 11.
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Mohsen Yazdanian, Bahram Armoon, Alireza Noroozi, Rasool Mohammadi, Amir-Hosein Bayat, Elahe Ahounbar, Peter Higgs, Hormoz Sanaei Nasab, Azadeh Bayani & Morteza Hemmat. (2020) Dental caries and periodontal disease among people who use drugs: a systematic review and meta-analysis. BMC Oral Health 20:1.
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Anilendu Pramanik, Sudeshna Das & Gulshan Lal Khanna. (2020) Differential effects of performance-enhancing drugs ‘Methamphetamine’ and ‘hCG’ on ex-vivo cultured primary blood mononuclear cells of male athletes. Pharmacological Reports 72:4, pages 1047-1057.
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Arthur A. Vandenbark, Roberto Meza-Romero, Gil Benedek & Halina Offner. (2019) A novel neurotherapeutic for multiple sclerosis, ischemic injury, methamphetamine addiction, and traumatic brain injury. Journal of Neuroinflammation 16:1.
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Tao Ye, Dongliang Sun, Guangying Dong, Guangjie Xu, Ligang Wang, Jinjin Du, Pengcheng Ren & Shibin Yu. (2018) The effect of methamphetamine abuse on dental caries and periodontal diseases in an Eastern China city. BMC Oral Health 18:1.
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Shin-Chang Kuo, Yi-Wei Yeh, Chun-Yen Chen, Chang-Chih Huang, Pei-Shen Ho, Chih-Sung Liang, Chun-Long Lin, Ta-Chuan Yeh, Chang-Chih Tsou, Bao-Zhu Yang, Ru-Band Lu & San-Yuan Huang. (2018) Differential effect of the DRD3 genotype on inflammatory cytokine responses during abstinence in amphetamine-dependent women. Psychoneuroendocrinology 97, pages 37-46.
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A Workman & G Rajesh. (2017) Methamphetamine abuse: The link between Immunosuppression, Fournier’s gangrene and Candida. Open Journal of Trauma 1:3, pages 069-071.
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Monica D. Prakash, Kathy Tangalakis, Juliana Antonipillai, Lily Stojanovska, Kulmira Nurgali & Vasso Apostolopoulos. (2017) Methamphetamine: Effects on the brain, gut and immune system. Pharmacological Research 120, pages 60-67.
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Ana Sanchez & Marcus Kaul. (2017) Neuronal Stress and Injury Caused by HIV-1, cART and Drug Abuse: Converging Contributions to HAND. Brain Sciences 7:12, pages 25.
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Li Xue, Yan Geng, Ming Li, Yao-Feng Jin, Hui-Xun Ren, Xia Li, Feng Wu, Biao Wang, Wei-Ying Cheng, Teng Chen & Yan-Jiong Chen. (2016) The effects of D3R on TLR4 signaling involved in the regulation of METH-mediated mast cells activation. International Immunopharmacology 36, pages 187-198.
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Niklas Rommel, Nils H. Rohleder, Stefan Wagenpfeil, Roland Härtel-Petri, Frederic Jacob, Klaus-Dietrich Wolff & Marco R. Kesting. (2015) The impact of the new scene drug “crystal meth” on oral health: a case–control study. Clinical Oral Investigations 20:3, pages 469-475.
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Xiao-Li Wu, Xiang Li, Ye Li, Ling-Pin Kong, Jiao-Long Fang, Xiao-Shuang Zhou, Mei Li, Jin-Jing Jia & Jie Bai. (2016) The overexpression of Thioredoxin-1 suppressing inflammation induced by methamphetamine in spleen. Drug and Alcohol Dependence 159, pages 66-71.
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Mircea Radu Mihu, Jessica Roman-Sosa, Avanish K. Varshney, Eliseo A. Eugenin, Bhavikkumar P. Shah, Hiu Ham Lee, Long N. Nguyen, Allan J. Guimaraes, Bettina C. Fries, Joshua D. Nosanchuk & Luis R. Martinez. (2015) Methamphetamine Alters the Antimicrobial Efficacy of Phagocytic Cells during Methicillin-Resistant Staphylococcus aureus Skin Infection. mBio 6:6.
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Kathleen Borgmann & Anuja Ghorpade. (2015) HIV-1, methamphetamine and astrocytes at neuroinflammatory Crossroads. Frontiers in Microbiology 6.
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Li Zhu, Jie Zhu, Yufeng Liu, Yanjiong Chen, Yanlin Li, Sisi Chen, Tao Li, Yonghui Dang & Teng Chen. (2015) Chronic methamphetamine regulates the expression of MicroRNAs and putative target genes in the nucleus accumbens of mice. Journal of Neuroscience Research 93:10, pages 1600-1610.
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Marta Massanella, Sara Gianella, Rachel Schrier, Jennifer M. Dan, Josué Pérez-Santiago, Michelli F. Oliveira, Douglas D. Richman, Susan J. Little, Constance A. Benson, Eric S. Daar, Michael P. Dube, Richard H. Haubrich, Davey M. Smith & Sheldon R. Morris. (2015) Methamphetamine Use in HIV-infected Individuals Affects T-cell Function and Viral Outcome during Suppressive Antiretroviral Therapy. Scientific Reports 5:1.
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Uma Sriram, Bijayesh Haldar, Jonathan M. Cenna, Larisa Gofman & Raghava Potula. (2015) Methamphetamine mediates immune dysregulation in a murine model of chronic viral infection. Frontiers in Microbiology 6.
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Li Xue, Xia Li, Hui-Xun Ren, Feng Wu, Ming Li, Biao Wang, Fang-Yuan Chen, Wei-Ying Cheng, Ju-Ping Li, Yan-Jiong Chen & Teng Chen. (2015) The dopamine D3 receptor regulates the effects of methamphetamine on LPS-induced cytokine production in murine mast cells. Immunobiology 220:6, pages 744-752.
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Sergio A. Salamanca, Edra E. Sorrentino, Joshua D. Nosanchuk & Luis R. Martinez. (2015) Impact of methamphetamine on infection and immunity. Frontiers in Neuroscience 8.
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Luke A. Downey & Jennifer M. Loftis. (2014) Altered energy production, lowered antioxidant potential, and inflammatory processes mediate CNS damage associated with abuse of the psychostimulants MDMA and methamphetamine. European Journal of Pharmacology 727, pages 125-129.
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Jennifer M. Loftis & Aaron Janowsky. 2014. Neuroimmune Signaling in Drug Actions and Addictions. Neuroimmune Signaling in Drug Actions and Addictions 165 197 .
Ping CenLi YeQi-Jian SuXu WangJie-Liang LiXin-Qin LinHao LiangWen-Zhe Ho. (2013) Methamphetamine Inhibits Toll-Like Receptor 9-Mediated Anti-HIV Activity in Macrophages. AIDS Research and Human Retroviruses 29:8, pages 1129-1137.
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Michael Heninger & Kim A. Collins. (2013) Acute Bacterial Meningitis with Coincident Methamphetamine Use: A Case Report and Review of the Literature. Journal of Forensic Sciences 58:4, pages 1088-1091.
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Jennifer M. Loftis, Clare J. Wilhelm, Arthur A. Vandenbark & Marilyn Huckans. (2013) Partial MHC/Neuroantigen Peptide Constructs: A Potential Neuroimmune-Based Treatment for Methamphetamine Addiction. PLoS ONE 8:2, pages e56306.
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Robert Harms, Brenda Morsey, Craig W. Boyer, Howard S. Fox & Nora Sarvetnick. (2012) Methamphetamine Administration Targets Multiple Immune Subsets and Induces Phenotypic Alterations Suggestive of Immunosuppression. PLoS ONE 7:12, pages e49897.
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Jennifer M. Loftis, Dongseok Choi, William Hoffman & Marilyn S. Huckans. (2010) Methamphetamine Causes Persistent Immune Dysregulation: A Cross-Species, Translational Report. Neurotoxicity Research 20:1, pages 59-68.
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JENNIFER M. LOFTIS & MARILYN HUCKANS. (2011) COGNITIVE ENHANCEMENT IN COMBINATION WITH ‘BRAIN REPAIR’ MAY BE OPTIMAL FOR THE TREATMENT OF STIMULANT ADDICTION. Addiction 106:5, pages 1021-1022.
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Xu Wang & Wen-Zhe Ho. (2011) Drugs of abuse and HIV infection/replication: Implications for mother–fetus transmission. Life Sciences 88:21-22, pages 972-979.
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Raghava Potula, Brian J. Hawkins, Jonathan M. Cenna, Shongshan Fan, Holly Dykstra, Servio H. Ramirez, Brenda Morsey, Michael R. Brodie & Yuri Persidsky. (2010) Methamphetamine Causes Mitrochondrial Oxidative Damage in Human T Lymphocytes Leading to Functional Impairment. The Journal of Immunology 185:5, pages 2867-2876.
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Noreen T Boyle & Thomas J Connor. (2010) Methylenedioxymethamphetamine (‘Ecstasy’)-induced immunosuppression: a cause for concern?. British Journal of Pharmacology 161:1, pages 17-32.
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Gabriel Sarah, Clifford Martin, Myles Stone, Carol Schneiderman & Stephen A. Klotz. 2010. Addictive Disorders in Medical Populations. Addictive Disorders in Medical Populations 239 249 .
Maria Cecilia Garibaldi Marcondes, Claudia Flynn, Debbie D. Watry, Michelle Zandonatti & Howard S. Fox. (2010) Methamphetamine Increases Brain Viral Load and Activates Natural Killer Cells in Simian Immunodeficiency Virus-Infected Monkeys. The American Journal of Pathology 177:1, pages 355-361.
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Osamu Kitamura, Toshiaki Takeichi, Elaine Lu Wang, Itsuo Tokunaga, Akiko Ishigami & Shin-ichi Kubo. (2010) Microglial and astrocytic changes in the striatum of methamphetamine abusers. Legal Medicine 12:2, pages 57-62.
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J.B. Buchanan, N.L. Sparkman & R.W. Johnson. (2010) Methamphetamine sensitization attenuates the febrile and neuroinflammatory response to a subsequent peripheral immune stimulus. Brain, Behavior, and Immunity 24:3, pages 502-511.
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Jennifer B. Treweek, Tobin J. DickersonKim D. Janda. (2009) Drugs of Abuse That Mediate Advanced Glycation End Product Formation: A Chemical Link to Disease Pathology. Accounts of Chemical Research 42:5, pages 659-669.
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Raul Gonzalez, Phillip J. Quartana & Eileen M. Martin. 2009. HIV and the Brain. HIV and the Brain 213 232 .
Shiaw-Pyng Wey, Hsin-Ying Wu, Fang-Chia Chang & Tong-Rong Jan. (2008) Methamphetamine and diazepam suppress antigen-specific cytokine expression and antibody production in ovalbumin-sensitized BALB/c mice. Toxicology Letters 181:3, pages 157-162.
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Raghava Potula & Yuri Persidsky. (2008) Adding Fuel to the Fire: Methamphetamine Enhances HIV Infection. The American Journal of Pathology 172:6, pages 1467-1470.
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Zsolt Tallóczy, Jose Martinez, Danielle Joset, Yonaton Ray, Attila Gácser, Sima Toussi, Noboru Mizushima, Josh Nosanchuk, Harris Goldstein, John Loike, David Sulzer & Laura Santambrogio. (2008) Methamphetamine Inhibits Antigen Processing, Presentation, and Phagocytosis. PLoS Pathogens 4:2, pages e28.
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Masayoshi SAITO, Masaru TERADA, Tetsuya KAWATA, Hisao ITO, Naoyuki SHIGEMATSU, Pudcharaporn KROMKHUN, Makoto YOKOSUKA & Toru R. SAITO. (2008) Effects of Single or Repeated Administrations of Methamphetamine on Immune Response in Mice. Experimental Animals 57:1, pages 35-43.
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Jennifer TreweekSunmee Wee, George F. Koob, Tobin J. Dickerson & Kim D. Janda. (2007) Self-vaccination by methamphetamine glycation products chemically links chronic drug abuse and cardiovascular disease. Proceedings of the National Academy of Sciences 104:28, pages 11580-11584.
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Kurt F. Hauser, Nazira El-Hage, Anne Stiene-Martin, William F. Maragos, Avindra Nath, Yuri Persidsky, David J. Volsky & Pamela E. Knapp. (2007) HIV-1 neuropathogenesis: glial mechanisms revealed through substance abuse. Journal of Neurochemistry 100:3, pages 567-586.
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