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Original Articles

31-Day Study of Cobalt(II) Chloride Ingestion in Humans: Pharmacokinetics and Clinical Effects

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Pages 1210-1224 | Published online: 27 Nov 2013

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Michael Kovochich, Brent L. Finley, Rachel Novick, Andrew D. Monnot, Ellen Donovan, Kenneth M. Unice, Ernest S. Fung, David Fung & Dennis J. Paustenbach. (2018) Understanding outcomes and toxicological aspects of second generation metal-on-metal hip implants: a state-of-the-art review. Critical Reviews in Toxicology 48:10, pages 839-887.
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Brent Finley, Paul K. Scott, Meghan E. Glynn, Dennis Paustenbach, Ellen Donovan & Kerry A. Thuett. (2017) Chromium speciation in the blood of metal-on-metal hip implant patients. Toxicological & Environmental Chemistry 99:1, pages 48-64.
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Brent D. Kerger, Russell Gerads, Hakan Gurleyuk, Ania Urban & Dennis J. Paustenbach. (2015) Total cobalt determination in human blood and synovial fluid using inductively coupled plasma-mass spectrometry: method validation and evaluation of performance variables affecting metal hip implant patient samples. Toxicological & Environmental Chemistry 97:9, pages 1145-1163.
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Brooke E. Tvermoes, Dennis J. Paustenbach, Brent D. Kerger, Brent L. Finley & Kenneth M. Unice. (2015) Review of cobalt toxicokinetics following oral dosing: Implications for health risk assessments and metal-on-metal hip implant patients. Critical Reviews in Toxicology 45:5, pages 367-387.
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Sung Ha Ryu, Ji Won Kim, Yong Soon Kim, Seung-Ho Lee, Yong-Baik Cho, Hyo Keun Lee, Yoon Gyoon Kim, Woo-Sik Jeong & Kyu-Bong Kim. (2014) Negligible Pharmacokinetic Interaction of Red Ginseng and Antihypertensive Agent Amlodipine in Sprague-Dawley Rats. Journal of Toxicology and Environmental Health, Part A 77:22-24, pages 1372-1383.
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Ghee Hwan Kim, Mi Jeong Kang, Keumhan Noh, Do Gyeong Oh, Wonku Kang, Hye Gwang Jeong, Kwang Youl Lee, Hangun Kim, Hyung Sik Kim & Tae Cheon Jeong. (2014) Nephrotoxic Potential and Toxicokinetics of Melamine Combined with Cyanuric Acid in Rats. Journal of Toxicology and Environmental Health, Part A 77:22-24, pages 1346-1358.
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Articles from other publishers (25)

Monika Moravcová, Marcel Hrubša, Zuzana Lomozová, Maria Carmen Catapano, Roberta Argento, Eduard Jirkovský, Radim Kučera, Laura Mercolini & Přemysl Mladěnka. (2023) A Complex Methodological Approach for the Screening of Efficient and Safe Cobalt Chelators. Medicinal Chemistry 19:5, pages 495-507.
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Pascal-André Vendittoli, Angela Styhler & Ilona Świątkowska. 2023. Biomarkers of Hip Implant Function. Biomarkers of Hip Implant Function 107 135 .
Harry Hothi, Reshid Berber, Shiraz A. Sabah & Alister J. Hart. 2023. Biomarkers of Hip Implant Function. Biomarkers of Hip Implant Function 251 272 .
JUMPEI TETSUKA, TAKEHISA MATSUKAWA, KAZUHITO YOKOYAMA, SYUDO YAMASAKI, SHUNTARO ANDO, ATSUSHI NISHIDA, MARIKO HIRAIWA-HASEGAWAKIYOTO KASAI. (2022) Effects of Trace Elements on Anthropometric Characteristics of Children: Cobalt and Childhood Body Mass Index. Juntendo Medical Journal 68:3, pages 251-260.
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Andrew D. Monnot, Michael Kovochich, Suren B. Bandara, Jared T. Wilsey, Whitney V. Christian, Gary Eichenbaum, Laura E.L. Perkins, Philippe Hasgall, Maneesh Taneja, Kevin Connor, Jorge Sague, Behrooz Nasseri-Aghbosh, Stephen Marcello, Mark Vreeke, Laurence B. Katz, Edward E. Reverdy, Herbert Thelen & Kenneth Unice. (2021) A hazard evaluation of the reproductive/developmental toxicity of cobalt in medical devices. Regulatory Toxicology and Pharmacology 123, pages 104932.
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Romain Carcy, Marc Cougnon, Mallorie Poet, Manon Durandy, Antoine Sicard, Laurent Counillon, Nicolas Blondeau, Thierry Hauet, Michel Tauc & Didier F. Pisani. (2021) Targeting oxidative stress, a crucial challenge in renal transplantation outcome. Free Radical Biology and Medicine 169, pages 258-270.
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Dan Fang, Tingting Xu, Leyi Fang, Huan Chen, Yangyang Huang, Huanyu Zhang, Zhuoyue Miao, Chun Mao, Bo Chi & Hong Xu. (2021) A blood compatible, high-efficient sensor for detection of Cr(VI) in whole blood. Sensors and Actuators B: Chemical 329, pages 129219.
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E.Ph. Galay, R.V. Dorogin & A.Z. Temerdashev. (2021) Quantification of cobalt and nickel in urine using inductively coupled plasma atomic emission spectroscopy. Heliyon 7:1, pages e06046.
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Jianping Tang, Chunyan Zheng, Fuli Zheng, Yuqing Li, Yuan-liang Wang, Michael Aschner, Zhenkun Guo, Guangxia Yu, Siying Wu & Huangyuan Li. (2020) Global N6-methyladenosine profiling of cobalt-exposed cortex and human neuroblastoma H4 cells presents epitranscriptomics alterations in neurodegenerative disease-associated genes. Environmental Pollution 266, pages 115326.
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Kenneth M. Unice, Michael Kovochich & Andrew D. Monnot. (2020) Cobalt-containing dust exposures: Prediction of whole blood and tissue concentrations using a biokinetic model. Science of The Total Environment 723, pages 137968.
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Sohan A. Parbat, Bharat A. Bhanvase & Shirish H. Sonawane. (2020) Investigation on liquid emulsion membrane (LEM) prepared with hydrodynamic cavitation process for cobalt (II) extraction from wastewater. Separation and Purification Technology 237, pages 116385.
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Mina Suh, Stan Casteel, Margaret Dunsmore, Caroline Ring, Ann Verwiel & Deborah M. Proctor. (2019) Bioaccessibility and relative oral bioavailability of cobalt and nickel in residential soil and dust affected by metal grinding operations. Science of The Total Environment 660, pages 677-689.
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Torben Hoffmeister, Dirk Schwenke, Nadine Wachsmuth, Oliver Krug, Mario Thevis, William C. Byrnes & Walter F.J. Schmidt. (2019) Erythropoietic effects of low-dose cobalt application. Drug Testing and Analysis 11:2, pages 200-207.
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Brent D. Kerger, Russell Gerads, Hakan Gurleyuk & Joyce A. Tsuji. 2018. Beyond the Implant: Retrieval Analysis Methods for Implant Surveillance. Beyond the Implant: Retrieval Analysis Methods for Implant Surveillance 229 244 .
Michael J. Glade & Michael M. Meguid. (2018) A glance at…antioxidant and antiinflammatory properties of dietary cobalt. Nutrition 46, pages 62-66.
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Laura Leyssens, Bart Vinck, Catherine Van Der Straeten, Floris Wuyts & Leen Maes. (2017) Cobalt toxicity in humans—A review of the potential sources and systemic health effects. Toxicology 387, pages 43-56.
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F Facchin, S Catalani, E Bianconi, D De Pasquale, S Stea, A Toni, S Canaider & A Beraudi. (2016) Albumin as marker for susceptibility to metal ions in metal-on-metal hip prosthesis patients. Human & Experimental Toxicology 36:4, pages 319-327.
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Devika Poddalgoda, Kristin Macey, Innocent Jayawardene & Kannan Krishnan. (2016) Derivation of biomonitoring equivalent for inorganic tin for interpreting population-level urinary biomonitoring data. Regulatory Toxicology and Pharmacology 81, pages 430-436.
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Brooke E. Tvermoes, Kenneth M. Unice, Bethany Winans, Michael Kovochich, Whitney V. Christian, Ellen Donovan, Ernest S. Fung, Brent L. Finley, Ian Kimber & Dennis J. Paustenbach. (2016) A preliminary evaluation of immune stimulation following exposure to metal particles and ions using the mouse popliteal lymph node assay. Toxicology and Applied Pharmacology 308, pages 77-90.
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ALINA BERAUDI, EVA BIANCONI, SIMONA CATALANI, SILVIA CANAIDER, DALILA DE PASQUALE, PIETRO APOSTOLI, BARBARA BORDINI, SUSANNA STEA, ALDO TONI & FEDERICA FACCHIN. (2016) In vivo response of heme-oxygenase-1 to metal ions released from metal-on-metal hip prostheses. Molecular Medicine Reports 14:1, pages 474-480.
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DJ Snodin. (2015) Regulatory risk assessments. Human & Experimental Toxicology 34:12, pages 1258-1271.
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Amy K. Madl, Michael Kovochich, Monty Liong, Brent L. Finley, Dennis J. Paustenbach & Günter Oberdörster. (2015) Toxicology of wear particles of cobalt-chromium alloy metal-on-metal hip implants Part II: Importance of physicochemical properties and dose in animal and in vitro studies as a basis for risk assessment. Nanomedicine: Nanotechnology, Biology and Medicine 11:5, pages 1285-1298.
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G. Forte, M. Deiana, S. Pasella, A. Baralla, P. Occhineri, I. Mura, R. Madeddu, E. Muresu, S. Sotgia, A. Zinellu, C. Carru, B. Bocca & L. Deiana. (2014) Metals in plasma of nonagenarians and centenarians living in a key area of longevity. Experimental Gerontology 60, pages 197-206.
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Kenneth M. Unice, Brent D. Kerger, Dennis J. Paustenbach, Brent L. Finley & Brooke E. Tvermoes. (2014) Refined biokinetic model for humans exposed to cobalt dietary supplements and other sources of systemic cobalt exposure. Chemico-Biological Interactions 216, pages 53-74.
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Brooke E Tvermoes, Kenneth M Unice, Dennis J Paustenbach, Brent L Finley, Joanne M Otani & David A Galbraith. (2014) Effects and blood concentrations of cobalt after ingestion of 1 mg/d by human volunteers for 90 d. The American Journal of Clinical Nutrition 99:3, pages 632-646.
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