278
Views
29
CrossRef citations to date
0
Altmetric
Research Article

Decreased Ubiquinone Availability and Impaired Mitochondrial Cytochrome Oxidase Activity Associated With Statin Treatment

, , , &
Pages 44-50 | Received 22 May 2008, Accepted 25 Jun 2008, Published online: 16 Dec 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Ta-Liang Chen, Chao-Shun Lin, Jui-An Lin, Chun-Chieh Yeh, Li-Chin Sung, Yi-Cheng Chang, Chun-Chuan Shih & Chien-Chang Liao. (2020) Evaluating Risk of Incident Diabetes Between Patients Who Used Lovastatin and Red Yeast Rice Prescriptions (LipoCol Forte): A Retrospective Cohort Study Based on a Real-World Database. Diabetes, Metabolic Syndrome and Obesity 13, pages 89-98.
Read now
Susana Barros, Ana M. Coimbra, Nélson Alves, Marlene Pinheiro, José Benito Quintana, Miguel M. Santos & Teresa Neuparth. (2020) Chronic exposure to environmentally relevant levels of simvastatin disrupts zebrafish brain gene signaling involved in energy metabolism. Journal of Toxicology and Environmental Health, Part A 83:3, pages 113-125.
Read now

Articles from other publishers (27)

Martin Lund, Robert Heaton, Iain P. Hargreaves, Niels Gregersen & Rikke K.J. Olsen. (2023) Odd- and even-numbered medium-chained fatty acids protect against glutathione depletion in very long-chain acyl-CoA dehydrogenase deficiency. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1868:2, pages 159248.
Crossref
Rebecca L. Jensen, Robyn T. Kiy, Faten F. Bin Dayel & Amy E. Chadwick. 2023. Mitochondrial Intoxication. Mitochondrial Intoxication 77 100 .
Radosław Motkowski, Mateusz Maciejczyk, Marta Hryniewicka, Joanna Karpińska & Bożena Mikołuć. (2020) Effect of Statin Therapy on the Plasma Concentrations of Retinol, Alpha-Tocopherol and Coenzyme Q10 in Children with Familial Hypercholesterolemia. Cardiovascular Drugs and Therapy 36:1, pages 75-84.
Crossref
Martin Lund, Kathrine G. Andersen, Robert Heaton, Iain P. Hargreaves, Niels Gregersen & Rikke K.J. Olsen. (2021) Bezafibrate activation of PPAR drives disturbances in mitochondrial redox bioenergetics and decreases the viability of cells from patients with VLCAD deficiency. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1867:6, pages 166100.
Crossref
Hamid Mollazadeh, Erfan Tavana, Giovanni Fanni, Simona Bo, Maciej Banach, Matteo Pirro, Stephan von Haehling, Tannaz Jamialahmadi & Amirhossein Sahebkar. (2021) Effects of statins on mitochondrial pathways. Journal of Cachexia, Sarcopenia and Muscle 12:2, pages 237-251.
Crossref
Vlad Florian Avram, Anca Mihaela Bîna, Alexandra Sima, Oana Maria Aburel, Adrian Sturza, Ovidiu Burlacu, Romulus Zorin Timar, Danina Mirela Muntean, Eskil Elmér & Octavian Marius Crețu. (2021) Improvement of Platelet Respiration by Cell–Permeable Succinate in Diabetic Patients Treated with Statins. Life 11:4, pages 288.
Crossref
Vlad F. Avram, Imen Chamkha, Eleonor Åsander-Frostner, Johannes K. Ehinger, Romulus Z. Timar, Magnus J. Hansson, Danina M. Muntean & Eskil Elmér. (2021) Cell-Permeable Succinate Rescues Mitochondrial Respiration in Cellular Models of Statin Toxicity. International Journal of Molecular Sciences 22:1, pages 424.
Crossref
Jamal Bouitbir, Gerda M. Sanvee, Miljenko V. Panajatovic, François Singh & Stephan Krähenbühl. (2020) Mechanisms of statin-associated skeletal muscle-associated symptoms. Pharmacological Research 154, pages 104201.
Crossref
Jonathan R. Murrow. 2020. Diabetes. Diabetes 333 341 .
Robert Heaton, Kate Duberley & Iain P. Hargreaves. 2020. Clinical and Preclinical Models for Maximizing Healthspan. Clinical and Preclinical Models for Maximizing Healthspan 277 287 .
Jochen H. M. Prehn & Irene Llorente-Folch. 2018. Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants. Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants 133 167 .
Eric K. Herbert, Saul R. Herbert & Karl E. Herbert. 2018. Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants. Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants 111 131 .
Viruna Neergheen, Alex Dyson, Luke Wainwright & Iain P. Hargreaves. 2018. Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants. Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants 457 473 .
Neal Sondheimer, Stacy Hewson, Jessie M. Cameron, Gino R. Somers, Jane Dunning Broadbent, Marcello Ziosi, Catarina Maria Quinzii & Ali B. Naini. (2017) Novel recessive mutations in COQ4 cause severe infantile cardiomyopathy and encephalopathy associated with CoQ 10 deficiency. Molecular Genetics and Metabolism Reports 12, pages 23-27.
Crossref
Radha Ramachandran & Anthony Wierzbicki. (2017) Statins, Muscle Disease and Mitochondria. Journal of Clinical Medicine 6:8, pages 75.
Crossref
Jason T. Tan & Arden R. Barry. (2017) Coenzyme Q10 supplementation in the management of statin-associated myalgia. American Journal of Health-System Pharmacy 74:11, pages 786-793.
Crossref
Magnus Asping, Nis Stride, Ditte Søgaard, Tine Lovsø Dohlmann, Jørn W. Helge, Flemming Dela & Steen Larsen. (2017) The effects of 2 weeks of statin treatment on mitochondrial respiratory capacity in middle-aged males: the LIFESTAT study. European Journal of Clinical Pharmacology 73:6, pages 679-687.
Crossref
Iain P. Hargreaves, Mesfer Al Shahrani, Luke Wainwright & Simon J. R. Heales. (2016) Drug-Induced Mitochondrial Toxicity. Drug Safety 39:7, pages 661-674.
Crossref
. 2016. Meyler's Side Effects of Drugs. Meyler's Side Effects of Drugs 237 240 .
Nitin V. Kolhe, Andrew W. Muirhead, Sally R. Wilkes, Richard J. Fluck & Maarten W. Taal. (2015) National trends in acute kidney injury requiring dialysis in England between 1998 and 2013. Kidney International 88:5, pages 1161-1169.
Crossref
Jonathan R. Murrow. 2014. Diabetes: Oxidative Stress and Dietary Antioxidants. Diabetes: Oxidative Stress and Dietary Antioxidants 183 190 .
Brian R. Berridge, John F. Van Vleet & Eugene Herman. 2013. Haschek and Rousseaux's Handbook of Toxicologic Pathology. Haschek and Rousseaux's Handbook of Toxicologic Pathology 1567 1665 .
Jerzy BełtowskiAnna Jamroz-Wiśniewska. (2012) Modulation of H 2 S Metabolism by Statins: A New Aspect of Cardiovascular Pharmacology . Antioxidants & Redox Signaling 17:1, pages 81-94.
Crossref
Monica J. Hubal, Kimberly A. Reich, Andrea De Biase, Cherie Bilbie, Priscilla M. Clarkson, Eric P. Hoffman & Paul D. Thompson. (2011) Transcriptional deficits in oxidative phosphorylation with statin myopathy. Muscle & Nerve 44:3, pages 393-401.
Crossref
David A. Brealey, Mervyn Singer & Marius Terblanche. (2011) Potential metabolic consequences of statins in sepsis*. Critical Care Medicine 39:6, pages 1514-1520.
Crossref
Hans J. Avis, Ian P. Hargreaves, Jos P.N. Ruiter, John M. Land, Ronald J. Wanders & Frits A. Wijburg. (2011) Rosuvastatin Lowers Coenzyme Q10 Levels, but not Mitochondrial Adenosine Triphosphate Synthesis, in Children with Familial Hypercholesterolemia. The Journal of Pediatrics 158:3, pages 458-462.
Crossref
. (2013) Statin myopathy and nutrition. Arbor Clinical Nutrition Updates 329, pages 1-5.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.