Citations (34)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (4)
Volker Strauss, Maria Cecilia Rey Moreno, Jeanette Vogt, Martina Dammann, Steffen Schneider, Sibylle Gröters & Bennard van Ravenzwaay. (2017) Acetylcholinesterase measurement in various brain regions and muscles of juvenile, adolescent, and adult rats. Toxicology Mechanisms and Methods 27:9, pages 666-676.
Read now
Read now
Jiri Kassa, Jana Zdarova Karasova & Vendula Sepsova. (2013) A comparison of the reactivating efficacy of a novel bispyridinium oxime K203 with currently available oximes in VX agent-poisoned rats. Journal of Enzyme Inhibition and Medicinal Chemistry 28:4, pages 753-757.
Read now
Read now
Tsung-Ming Shih, John A. Guarisco, Todd M. Myers, Robert K. Kan & John H. McDonough. (2011) The oxime pro-2-PAM provides minimal protection against the CNS effects of the nerve agents sarin, cyclosarin, and VX in guinea pigs. Toxicology Mechanisms and Methods 21:1, pages 53-62.
Read now
Read now
John C. O’Donnell, Cindy Acon-Chen, John H. McDonough & Tsung-Ming Shih. (2010) Comparison of extracellular striatal acetylcholine and brain seizure activity following acute exposure to the nerve agents cyclosarin and tabun in freely moving guinea pigs. Toxicology Mechanisms and Methods 20:9, pages 600-608.
Read now
Read now
Articles from other publishers (30)
Gabriel Amitai, Alexander Plotnikov, Shira Chapman, Shlomi Lazar, Rellie Gez, Dan Loewenthal, Khriesto A. Shurrush, Galit Cohen, Leonardo J. Solmesky, Haim Barr & Alan J. Russell. (2021) Non-quaternary oximes detoxify nerve agents and reactivate nerve agent-inhibited human butyrylcholinesterase. Communications Biology 4:1.
Crossref
Crossref
Thomas R. Hayes, Chih-Kai Chao, Joseph E. Blecha, Tony L. Huynh, Kurt R. Zinn, Charles M. Thompson, John M. Gerdes & Henry F. VanBrocklin. (2020) Biological Distribution and Metabolic Profiles of Carbon-11 and Fluorine-18 Tracers of VX- and Sarin-Analogs in Sprague–Dawley Rats. Chemical Research in Toxicology 34:1, pages 63-69.
Crossref
Crossref
Jeffrey A. Koenig, Cindy Acon Chen & Tsung-Ming Shih. (2020) Development of a Larval Zebrafish Model for Acute Organophosphorus Nerve Agent and Pesticide Exposure and Therapeutic Evaluation. Toxics 8:4, pages 106.
Crossref
Crossref
Thomas R. Hayes, Joseph E. Blecha, Chih‐Kai Chao, Tony L. Huynh, Henry F. VanBrocklin, Kurt R. Zinn, Palmer W. Taylor, John M. Gerdes & Charles M. Thompson. (2020)
Positron emission tomography evaluation of oxime countermeasures in live rats using the tracer
O
‐(2‐[
18
F]fluoroethyl)‐
O
‐(
p‐
nitrophenyl)methylphosphonate [
18
F]‐VXS
. Annals of the New York Academy of Sciences 1479:1, pages 180-195.
Crossref
Crossref
James B. Machamer, James P. Apland, Brittany M. Winner, Sarah E. Wolfe, Kathleen T. Pagarigan, Kevin M. Bounader, Shane A. Kasten, Michael Adler & Patrick M. McNutt. (2020) Functional basis for dose-dependent antagonism of rat and rabbit neuromuscular transmission by the bis-pyridinium oxime MMB4. Archives of Toxicology 94:11, pages 3877-3891.
Crossref
Crossref
Liana M. Matson, Robyn B. Lee-Stubbs, C. Lin. Cadieux, Jeffrey A. Koenig, Cherish E. Ardinger, Jessica Chandler, Erik A. Johnson, Heidi M. Hoard-Fruchey, Tsung-Ming A. Shih, Doug M. Cerasoli & John H. McDonough. (2018) Assessment of mouse strain differences in baseline esterase activities and toxic response to sarin. Toxicology 410, pages 10-15.
Crossref
Crossref
Fernanda D'Avila da Silva, Pablo Andrei Nogara, Marcos Martins Braga, Bruna Candia Piccoli & João Batista Teixeira Rocha. (2018) Molecular docking analysis of acetylcholinesterase corroborates the protective effect of pralidoxime against chlorpyrifos-induced behavioral and neurochemical impairments in Nauphoeta cinerea. Computational Toxicology 8, pages 25-33.
Crossref
Crossref
Mark C. Moffett, John H. McDonough, Joseph D. McMonagle & Todd M. Myers. (2018) Behavioral, Pharmacokinetic, and Cardiovascular Evaluation of Candidate Oximes in African Green Monkeys. International Journal of Toxicology 37:5, pages 352-363.
Crossref
Crossref
Gabriel Amitai, Rellie Gez, Lily Raveh, Nira Bar-Ner, Ettie Grauer & Shira Chapman. (2016) Novel bifunctional hybrid small molecule scavengers for mitigating nerve agents toxicity. Chemico-Biological Interactions 259, pages 187-204.
Crossref
Crossref
C. Linn Cadieux, Haoyu Wang, Yuchen Zhang, Jeffrey A. Koenig, Tsung-Ming Shih, John McDonough, John Koh & Douglas Cerasoli. (2016) Probing the activity of a non-oxime reactivator for acetylcholinesterase inhibited by organophosphorus nerve agents. Chemico-Biological Interactions 259, pages 133-141.
Crossref
Crossref
Jeffrey A. Koenig, Thuy L. Dao, Robert K. Kan & Tsung-Ming Shih. (2016) Zebrafish as a model for acetylcholinesterase-inhibiting organophosphorus agent exposure and oxime reactivation. Annals of the New York Academy of Sciences 1374:1, pages 68-77.
Crossref
Crossref
Ming-Yuan Xu, Pan Wang, Ying-Jian Sun, Hui-Ping Wang, Yu-Jie Liang, Li Zhu & Yi-Jun Wu. (2015) Redox status in liver of rats following subchronic exposure to the combination of low dose dichlorvos and deltamethrin. Pesticide Biochemistry and Physiology 124, pages 60-65.
Crossref
Crossref
Thomas H. Snider, Christina M. Wilhelm, Michael C. Babin, Gennady E. Platoff Jr. & David T. Yeung. (2015) Assessing the therapeutic efficacy of oxime therapies against percutaneous organophosphorus pesticide and nerve agent challenges in the Hartley guinea pig. The Journal of Toxicological Sciences 40:6, pages 759-775.
Crossref
Crossref
Christina M. Wilhelm, Thomas H. Snider, Michael C. Babin, David A. Jett, Gennady E. PlatoffJr.Jr. & David T. Yeung. (2014) A comprehensive evaluation of the efficacy of leading oxime therapies in guinea pigs exposed to organophosphorus chemical warfare agents or pesticides. Toxicology and Applied Pharmacology 281:3, pages 254-265.
Crossref
Crossref
Franz Worek, Thomas Seeger, Moshe Goldsmith, Yacov Ashani, Haim Leader, Joel S. Sussman, Dan Tawfik, Horst Thiermann & Timo Wille. (2014) Efficacy of the rePON1 mutant IIG1 to prevent cyclosarin toxicity in vivo and to detoxify structurally different nerve agents in vitro. Archives of Toxicology 88:6, pages 1257-1266.
Crossref
Crossref
Franz Worek, Thomas Seeger, Michael Zengerle, Stefan Kubik, Horst Thiermann & Timo Wille. (2014) Effectiveness of a substituted β-cyclodextrin to prevent cyclosarin toxicity in vivo. Toxicology Letters 226:2, pages 222-227.
Crossref
Crossref
Jill A. Harvilchuck, S. Peter Hong, Jamie S. Richey, Merrill R. Osheroff & Jerry D. Johnson. (2013) In Vivo Acetylcholinesterase Reactivation in Male Guinea Pigs and Rhesus Macaques Following Cyclosarin Exposure and Treatment With 1,1′-Methylenebis{4-[(hydroxyimino)methyl] pyridinium} Dimethanesulfonate. International Journal of Toxicology 32:4_suppl, pages 99S-107S.
Crossref
Crossref
Jill A. Harvilchuck, S. Peter Hong, Jamie S. Richey, Merrill R. Osheroff & Jerry D. Johnson. (2013) Efficacy and Pharmacokinetic/Pharmacodynamic Study of 1,1′-Methylenebis{4-[(hydroxyimino)methyl] pyridinium} Dimethanesulfonate in Guinea Pigs and Rhesus Macaques Exposed to Cyclosarin. International Journal of Toxicology 32:4_suppl, pages 108S-117S.
Crossref
Crossref
S. Peter Hong, Seth T. Gibbs, Dean J. Kobs, Merrill R. Osheroff, Jerry D. Johnson & Brian L. Burback. (2013) Pharmacokinetics of MMB4 DMS in Rats, Rabbits, and Dogs Following a Single IV Administration. International Journal of Toxicology 32:4_suppl, pages 30S-37S.
Crossref
Crossref
Brian M. Roche, Tom M. Vinci, Michael A. Hawk, Craig R. Hassler, David T. Pressburger, Merrill R. Osheroff, Glenn D. Ritchie & Brian L. Burback. (2013) MMB4 DMS. International Journal of Toxicology 32:4_suppl, pages 49S-58S.
Crossref
Crossref
S. Peter Hong, Seth T. Gibbs, Dean J. Kobs, Michael A. Hawk, Claire R. Croutch, Merrill R. Osheroff, Jerry D. Johnson & Brian L. Burback. (2013) Comparative Toxicokinetics of MMB4 DMS in Rats, Rabbits, Dogs, and Monkeys Following Single and Repeated Intramuscular Administration. International Journal of Toxicology 32:4_suppl, pages 38S-48S.
Crossref
Crossref
Teresa R. Sterner, Christopher D. Ruark, Tammie R. Covington, Kyung O. Yu & Jeffery M. Gearhart. (2013) A physiologically based pharmacokinetic model for the oxime TMB-4: simulation of rodent and human data. Archives of Toxicology 87:4, pages 661-680.
Crossref
Crossref
Franz Worek, Anne Bierwisch, Timo Wille, Marianne Koller & Horst Thiermann. (2012) Kinetic interactions of a homologous series of bispyridinium monooximes (HGG oximes) with native and phosphonylated human acetylcholinesterase. Toxicology Letters 212:1, pages 29-32.
Crossref
Crossref
Alessandra Antunes dos Santos, Danúbia Bonfanti dos Santos, Renata Pietsch Ribeiro, Dirleise Colle, Kaite Cristiane Peres, Júlia Hermes, Anderson Machado Barbosa, Alcir Luiz Dafré, Andreza Fabro de Bem, Kamil Kuca & Marcelo Farina. (2011) Effects of K074 and pralidoxime on antioxidant and acetylcholinesterase response in malathion-poisoned mice. NeuroToxicology 32:6, pages 888-895.
Crossref
Crossref
Farhat A. Khan, Amy J. Campbell, Benjamin Hoyt, Christine Herdman, Therese Ku, Sonia Thangavelu & Richard K. Gordon. (2011) Oxidative mechanisms for the biotransformation of 1-methyl-1,6-dihydropyridine-2-carbaldoxime to pralidoxime chloride. Life Sciences 89:25-26, pages 911-917.
Crossref
Crossref
Paul M. Lundy, Murray G. Hamilton, Thomas W. Sawyer & John Mikler. (2011) Comparative protective effects of HI-6 and MMB-4 against organophosphorous nerve agent poisoning. Toxicology 285:3, pages 90-96.
Crossref
Crossref
Jiří Bajgar, Jiří Kassa, Miroslav Pohanka, Jana Žďárová Karasová, Ladislav Novotný, Josef Fusek & Václav Bláha. (2011) Inhibition of blood and tissue cholinesterases by soman in guinea pigs in vivo. Journal of Applied Biomedicine 9:1, pages 35-41.
Crossref
Crossref
Zdeněk Fišar, Jana Hroudová, Jan Korábečný, Kamil Musílek & Kamil Kuča. (2011) In vitro effects of acetylcholinesterase reactivators on monoamine oxidase activity. Toxicology Letters 201:2, pages 176-180.
Crossref
Crossref
Franz Worek, Timo Wille, Nadine Aurbek, Peter Eyer & Horst Thiermann. (2010) Reactivation of organophosphate-inhibited human, Cynomolgus monkey, swine and guinea pig acetylcholinesterase by MMB-4: A modified kinetic approach. Toxicology and Applied Pharmacology 249:3, pages 231-237.
Crossref
Crossref
Jacob W. Skovira, John C. O’Donnell, Irwin Koplovitz, Robert K. Kan, John H. McDonough & Tsung-Ming Shih. (2010) Reactivation of brain acetylcholinesterase by monoisonitrosoacetone increases the therapeutic efficacy against nerve agents in guinea pigs. Chemico-Biological Interactions 187:1-3, pages 318-324.
Crossref
Crossref