502
Views
58
CrossRef citations to date
0
Altmetric
Research Article

Polyphenols of virgin coconut oil prevent pro-oxidant mediated cell death

ORCID Icon, ORCID Icon & ORCID Icon
Pages 442-450 | Received 14 Feb 2017, Accepted 13 Apr 2017, Published online: 26 Apr 2017

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (10)

Soorya Parathodi Illam, Sruthi Panniyan Kandiyil, Arunaksharan Narayanankutty, Soumya Valappan Veetil, Thekkekara Devassy Babu, Rao M. Uppu & Achuthan C. Raghavamenon. (2022) Virgin coconut oil complements with its polyphenol components mitigate sodium fluoride toxicity in vitro and in vivo. Drug and Chemical Toxicology 45:6, pages 2528-2534.
Read now
Deepika N. P, Mohammed Shameer Kondengadan, Sherouk Hussein Sweilam, Md. Habibur Rahman, K.M Muhasina, Puja Ghosh, Divya Bhargavi, Divya Jyothi Palati, Fathi Maiz & B. Duraiswamy. (2022) Neuroprotective role of coconut oil for the prevention and treatment of Parkinson’s disease: potential mechanisms of action. Biotechnology and Genetic Engineering Reviews 0:0, pages 1-33.
Read now
Joice Tom Job, Rajakrishnan Rajagopal, Ahmed Alfarhan & Arunaksharan Narayanankutty. (2022) Borassus flabellifer Linn haustorium methanol extract mitigates fluoride-induced apoptosis by enhancing Nrf2/Haeme oxygenase 1 –dependent glutathione metabolism in intestinal epithelial cells. Drug and Chemical Toxicology 45:5, pages 2269-2275.
Read now
Yu-Qing Zeng, Jin-Tao He, Bo-Yong Hu, Wen Li, Jing Deng, Qin-Lu Lin & Yong Fang. (2022) Virgin coconut oil: A comprehensive review of antioxidant activity and mechanisms contributed by phenolic compounds. Critical Reviews in Food Science and Nutrition 0:0, pages 1-24.
Read now
Dhilna Malayil, Nivedya Cheerakuzhi House, Drisya Puthenparambil, Joice Tom Job & Arunaksharan Narayanankutty. (2022) Borassus flabellifer haustorium extract prevents pro-oxidant mediated cell death and LPS-induced inflammation. Drug and Chemical Toxicology 45:4, pages 1716-1722.
Read now
Arunaksharan Narayanankutty, Soorya Parathodi Illam, Varsha Rao, Sabah Shehabudheen & Achuthan C. Raghavamenon. (2022) Hot-processed virgin coconut oil abrogates cisplatin-induced nephrotoxicity by restoring redox balance in rats compared to fermentation-processed virgin coconut oil. Drug and Chemical Toxicology 45:3, pages 1373-1382.
Read now
Nur Syafiqah Rahim, Siong Meng Lim, Vasudevan Mani, Nurul Aqmar Mohamad Nor Hazalin, Abu Bakar Abdul Majeed & Kalavathy Ramasamy. (2021) Virgin Coconut Oil-Induced Neuroprotection in Lipopolysaccharide-Challenged Rats is Mediated, in Part, Through Cholinergic, Anti-Oxidative and Anti-Inflammatory Pathways. Journal of Dietary Supplements 18:6, pages 655-681.
Read now
Ademola C. Famurewa, Chioma S. Ugwu-Ejezie, Eghosa E. Iyare, Abiola M. Folawiyo, Ekenechukwu K. Maduagwuna & Fidelis E. Ejezie. (2021) Hepatoprotective effect of polyphenols isolated from virgin coconut oil against sub-chronic cadmium hepatotoxicity in rats is associated with improvement in antioxidant defense system. Drug and Chemical Toxicology 44:4, pages 418-426.
Read now
Arunaksharan Narayanankutty, Anusree Nair, Soorya Parathodi Illam, Aman Upaganlawar & Achuthan C. Raghavamenon. (2021) Curcumin Enriched VCO Protects against 7,12-Dimethyl Benz[a] Anthracene-Induced Skin Papilloma in Mice. Nutrition and Cancer 73:5, pages 809-816.
Read now
Abdul Rohman, Irnawati, Yuny Erwanto, Endang Lukitaningsih, Muhamad Rafi, Nurrulhidayah A. Fadzilah, Anjar Windarsih, Ainin Sulaiman & Zalina Zakaria. (2021) Virgin Coconut Oil: Extraction, Physicochemical Properties, Biological Activities and Its Authentication Analysis. Food Reviews International 37:1, pages 46-66.
Read now

Articles from other publishers (48)

Aan Priyanto, Yadi Mulyadi Rohman, Dian Ahmad Hapidin, Dhewa Edikresnha & Khairurrijal Khairurrijal. (2023) Rotary Forcespun Polyvinylpyrrolidone Fibers Matrix Loaded with Virgin Coconut Oil: Physicochemical Characterization, In Vitro Antioxidant Assessment, and Release Profile. Food and Bioprocess Technology.
Crossref
Usana Chatturong, Iyapa Palang, Kittiwoot To‐on, Watcharakorn Deetud, Suriya Chaiwong, Natthiya Sakulsak, Phattarapon Sonthi, Rachanee Chanasong, Ekarin Chulikorn, Winranath Kanprakobkit, Sakchai Wittaya‐areekul, Filip Kielar & Krongkarn Chootip. (2023) Reduction of lauric acid content in virgin coconut oil improved plasma lipid profile in high‐fat diet‐induced hypercholesterolemic mice. Journal of Food Science 88:10, pages 4305-4315.
Crossref
Amit, Shivani Kumari & Rahul Jamwal. (2023) Use of FTIR spectroscopy integrated with multivariate chemometrics as a swift, and non-destructive technique to detect various adulterants in virgin coconut oil: A comprehensive review. Food Chemistry Advances 2, pages 100203.
Crossref
Gamal S. Abd El-Aziz, Hani A. Alturkistani, Rasha A. Alshali, Mervat M. Halawani, Raid M. Hamdy, Waheeb S. Aggad, Nezar J. Kamal & Emad A. Hindi. (2023) The potential protectivity of honey and olive oil in methotrexate induced renal damage in rats. Toxicon, pages 107268.
Crossref
Riri Rimbun Anggih Chaidir, Lili Suharli, Kusdianawati Kusdianawati & Izzul Islam. (2023) Pemanfaatan potensi lokal Desa Mokong Sumbawa NTB melalui pelatihan pembuatan Virgin Coconut Oil (VCO). KACANEGARA Jurnal Pengabdian pada Masyarakat 6:3.
Crossref
Zeynep Tasdan, Gülçin Alp Avci & Emre Avci. (2023) Evaluation of effects on hepatocellular carcinoma cell line of Cocos nucifera : In vitro study . Acta Marisiensis - Seria Medica 69:1, pages 45-49.
Crossref
Andina Setyawati, Moh Syafar Sangkala, Silvia Malasari, Nuurhidayat Jafar, Elly L Sjattar, Syahrul Syahrul & Haerani Rasyid. (2023) Virgin Coconut Oil: A Dietary Intervention for Dyslipidaemia in Patients with Diabetes Mellitus. Nutrients 15:3, pages 564.
Crossref
Ana Paula da Costa Soares, Eliane Carvalho Minighin, Natália Cristina de Faria, Guilherme Fonseca Graciano, Tamires Cássia de Melo Souza, Lucilene Rezende Anastácio, Mariana Wanessa Santana de Souza, Cristina de Almeida Hott, Luiza Andrade Tomaz, Luciana M. Carabetti Gontijo, Ronália Leite Alvarenga, Sttefany Viana Gomes, Carolina Sheng Whei Miaw Botelho, Bárbara Chaves Santos, Alessandra Lovato, Vinícius Tadeu da Veiga Correia, Danielle Fátima D’ Angelis, Josilene Lopes de Oliveira, Ana Clara Costa Dias, Sarah Morais Senna Prates, Yassana Marvila Girondoli, Annayara Celestina Ferreira Fernandes, Renata Luana de Pádua Gandra, Anna Cláudia de Freitas e Loyola, Adriane Moreira Machado, Nayara Benedito Martins da Silva, Priscila Vaz de Melo Ribeiro, Luísa Martins Trindade, Isabel David de Matos & Kellen Pereira Bragança. 2023. ALIMENTOS COM PROPRIEDADES FUNCIONAIS E DE SAÚDE: EVIDÊNCIAS E PRETENSOS EFEITOS. ALIMENTOS COM PROPRIEDADES FUNCIONAIS E DE SAÚDE: EVIDÊNCIAS E PRETENSOS EFEITOS.
Arunaksharan Narayanankutty, Joice Tom Job, Aswathi Moothakoottil Kuttithodi, Anju Sasidharan, P.B. Benil, Varsha Ramesh, Mohamed Farouk Elsadek, Humaira Rizwana & Maha M. Essam El-Din. (2023) Proximate composition, antioxidant, anti-inflammatory and anti-diabetic properties of the haustorium from Coconut (Cocos nucifera L.) and Palmyra palm (Borassus flabellifer L.). Journal of King Saud University - Science 35:1, pages 102404.
Crossref
Rodel Jonathan Santos VitorIIII, Ryota Tochinai, Shin-Ichi Sekizawa & Masayoshi Kuwahara. (2022) Favorable Effects of Virgin Coconut Oil on Neuronal Damage and Mortality after a Stroke Incidence in the Stroke-Prone Spontaneously Hypertensive Rat. Life 12:11, pages 1857.
Crossref
Kho Swen Jack, Mohd Razip Bin Asaruddin & Showkat Ahmad Bhawani. (2022) Pharmacophore study, molecular docking and molecular dynamic simulation of virgin coconut oil derivatives as anti-inflammatory agent against COX-2. Chemical and Biological Technologies in Agriculture 9:1.
Crossref
Shimaa K. Ali, Sara M. Mahmoud, Samar S. El-Masry, Dalal Hussien M. Alkhalifah, Wael N. Hozzein & Moustafa A. Aboel-Ainin. (2022) Phytochemical screening and characterization of the antioxidant, anti-proliferative and antibacterial effects of different extracts of Opuntia ficus-indica peel. Journal of King Saud University - Science 34:7, pages 102216.
Crossref
Bruna Guedes de Melo, Sibele Santos Fernandes, Alejandra Domínguez Razo, Ulil Us Medina & Maira Rubi Segura Campos. (2022) Chia seeds as functional ingredient of healthy muffins. Journal of Food Measurement and Characterization 16:5, pages 4251-4261.
Crossref
Aan Priyanto, Dian Ahmad Hapidin & Khairurrijal Khairurrijal. (2022) Potential Loading of Virgin Coconut Oil into Centrifugally‐Spun Nanofibers for Biomedical Applications. ChemBioEng Reviews 9:4, pages 393-408.
Crossref
Shilpa S. Shetty, P. G. Roopashree, S. V. Ramesh, Ajeet Singh, M. Arivalagan, M. R. Manikantan, Ullal Harshini Devi, K. P. Sharmila, K. B. Hebbar & N. Suchetha Kumari. (2022) Virgin Coconut Oil (VCO) Ameliorates High Fat Diet (HFD)-Induced Obesity, Dyslipidemia and Bestows Cardiovascular Protection in Rats. Proceedings of the National Academy of Sciences, India Section B: Biological Sciences 92:2, pages 249-259.
Crossref
Poorni Sandupama, Dilusha Munasinghe & Madhura Jayasinghe. (2022) Coconut oil as a therapeutic treatment for alzheimer's disease: a review. Journal of Future Foods 2:1, pages 41-52.
Crossref
K.V. Sumitha, John E. Thoppil, Sabah Shihabudeen, Najat A. Bukhari, Fatimah S. Al-Khattaf & Ashraf Atef Hatamleh. (2022) Methanol extracts of different species of Ocimum alleviate the peroxide radical-mediated cell injury and redox imbalance in human colon epithelial cells. Physiological and Molecular Plant Pathology 117, pages 101759.
Crossref
Arunaksharan Narayanankutty, Krishnaprasad Kunnath, Ademola C. Famurewa, Varsha Ramesh, Rajakrishnan Rajagopal & Ahmed Alfarhan. (2022) Variations in the composition, cytoprotective and anti-inflammatory effects of natural polyphenols of edible oils extracted from fresh and dried coconut testa. Physiological and Molecular Plant Pathology 117, pages 101742.
Crossref
Hak-Jae Kim, Arunaksharan Narayanankutty, Anju Sasidharan, Joice Tom Job, Young Ock Kim, Sae Won Na, Rajakrishnan Rajagopal, Ahmed Alfarhan & Bander Al-Munqedhi. (2022) Methanolic extract of coconut (Cocos nucifera L.) haustorium mitigates pro-oxidant-mediated apoptotic cell death via Nrf-2 pathway and lipopolysaccharide-induced cytokine release in cells. Journal of King Saud University - Science 34:1, pages 101715.
Crossref
Joice Tom Job, Rajakrishnan Rajagopal, Ahmed Alfarhan, Varsha Ramesh & Arunaksharan Narayanankutty. (2021) Toxic effects of fluoride in intestinal epithelial cells and the mitigating effect of methanol extract of coconut haustorium by enhancing de novo glutathione biosynthesis. Environmental Research 200, pages 111717.
Crossref
S.V. Ramesh, Veda Krishnan, Shelly Praveen & K.B. Hebbar. (2021) Dietary prospects of coconut oil for the prevention and treatment of Alzheimer's disease (AD): A review of recent evidences. Trends in Food Science & Technology 112, pages 201-211.
Crossref
Soorya Parathodi Illam, Arunaksharan Narayanankutty, Sruthi Panniyan Kandiyil & Achuthan Chathrattil Raghavamenon. (2021) Variations in natural polyphenols determine the anti‐inflammatory potential of virgin coconut oils. Journal of Food Science 86:5, pages 1620-1628.
Crossref
Afka Deen, Rizliya Visvanathan, Dhanushki Wickramarachchi, Nazrim Marikkar, Sirinivas Nammi, Barana C Jayawardana & Ruvini Liyanage. (2020) Chemical composition and health benefits of coconut oil: an overview. Journal of the Science of Food and Agriculture 101:6, pages 2182-2193.
Crossref
Janine Mett & Uli Müller. (2021) The medium-chain fatty acid decanoic acid reduces oxidative stress levels in neuroblastoma cells. Scientific Reports 11:1.
Crossref
Nameer Khairullah Mohammed, Ziad Tariq Samir, Mohammed Ahmed Jassim & Sami Khudhur Saeed. (2021) Effect of different extraction methods on physicochemical properties, antioxidant activity, of virgin coconut oil. Materials Today: Proceedings 42, pages 2000-2005.
Crossref
Ming Chang, Pinzhen Zhao, Tao Zhang, Yong Wang, Xin Guo, Ruijie Liu, Qingzhe Jin & Xingguo Wang. (2020) Characteristic volatiles fingerprints and profiles determination in different grades of coconut oil by HS‐GC‐IMS and HS‐SPME‐GC‐MS. International Journal of Food Science & Technology 55:12, pages 3670-3679.
Crossref
Heba M.A. Khalil, Heba H. Salama, Asmaa K. Al-Mokaddem, Samira H. Aljuaydi & Amr E. Edris. (2020) Edible dairy formula fortified with coconut oil for neuroprotection against aluminium chloride-induced Alzheimer's disease in rats. Journal of Functional Foods 75, pages 104296.
Crossref
Ahmed M. Shehata, Omar A. Ahmed-Farid, Hanan A. Rizk, Sara M. Saber, Fawzy M. Lashin & Lamberto Re. (2020) Neurochemical, neurobehavioral and histochemical effects of therapeutic dose of l-dopa on striatal neurons in rats: Protective effect of virgin coconut oil. Biomedicine & Pharmacotherapy 130, pages 110473.
Crossref
Pratishtha Chatterjee, Malika Fernando, Binosha Fernando, Cintia B. Dias, Tejal Shah, Renuka Silva, Shehan Williams, Steve Pedrini, Heidi Hillebrandt, Kathryn Goozee, Edward Barin, Hamid R. Sohrabi, Manohar Garg, Stephen Cunnane & Ralph N. Martins. (2020) Potential of coconut oil and medium chain triglycerides in the prevention and treatment of Alzheimer’s disease. Mechanisms of Ageing and Development 186, pages 111209.
Crossref
Ademola C. Famurewa, Ekenechukwu K. Maduagwuna, Abiola M. Folawiyo, Elizabeth E. Besong, Albert N. Eteudo, Opeyemi A. Famurewa & Fidelis E. Ejezie. (2019) Antioxidant, anti‐inflammatory, and antiapoptotic effects of virgin coconut oil against antibiotic drug gentamicin‐induced nephrotoxicity via the suppression of oxidative stress and modulation of iNOS/NF‐ĸB/caspase‐3 signaling pathway in Wistar rats. Journal of Food Biochemistry 44:1.
Crossref
Siong Meng Lim, Nur Syafiqah Rahim & Kalavathy Ramasamy. 2020. Oxidative Stress and Dietary Antioxidants in Neurological Diseases. Oxidative Stress and Dietary Antioxidants in Neurological Diseases 231 247 .
Mamta Thakur, Kirty Pant & Vikas Nanda. 2020. Antioxidants in Vegetables and Nuts - Properties and Health Benefits. Antioxidants in Vegetables and Nuts - Properties and Health Benefits 357 384 .
Fatemeh Mirzaei, Mozafar Khazaei, Alireza Komaki, Iraj Amiri & Cyrus Jalili. (2019) The Effects of Virgin Coconut Oil on Prevention of Alzheimer’s Disease. Jundishapur Journal of Natural Pharmaceutical Products 14:4.
Crossref
Pan Gao, Ruijie Liu, Qingzhe Jin & Xingguo Wang. (2019) Comparison of solvents for extraction of walnut oils: Lipid yield, lipid compositions, minor-component content, and antioxidant capacity. LWT 110, pages 346-352.
Crossref
DL Sheela, A Narayanankutty, PA Nazeem, AC Raghavamenon & SR Muthangaparambil. (2019) Lauric acid induce cell death in colon cancer cells mediated by the epidermal growth factor receptor downregulation: An in silico and in vitro study. Human & Experimental Toxicology 38:7, pages 753-761.
Crossref
Vinayak Narayanankutty, Arunaksharan Narayanankutty & Anusree Nair. (2019) Heat Shock Proteins (HSPs): A Novel Target for Cancer Metastasis Prevention. Current Drug Targets 20:7, pages 727-737.
Crossref
Soorya Parathodi Illam, Ashif Hussain, Anu Elizabeth, Arunaksharan Narayanankutty & Achuthan C. Raghavamenon. (2019) Natural combination of phenolic glycosides from fruits resists pro-oxidant insults to colon cells and enhances intrinsic antioxidant status in mice. Toxicology Reports 6, pages 703-711.
Crossref
Ali Osman. 2019. Fruit Oils: Chemistry and Functionality. Fruit Oils: Chemistry and Functionality 209 221 .
Arunaksharan Narayanankutty, Anu Anil, Soorya Parathodi Illam, Sruthi Panniyan Kandiyil & Achuthan C. Raghavamenon. (2018) Non-polar lipid carbonyls of thermally oxidized coconut oil induce hepatotoxicity mediated by redox imbalance. Prostaglandins, Leukotrienes and Essential Fatty Acids 138, pages 45-51.
Crossref
Ademola C. Famurewa, Abumchukwu J. Ejezie, Chioma S. Ugwu-Ejezie, Ebele J. Ikekpeazu & Fidelis E. Ejezie. (2018) Antioxidant and anti-inflammatory mechanisms of polyphenols isolated from virgin coconut oil attenuate cadmium-induced oxidative stress-mediated nephrotoxicity and inflammation in rats. Journal of Applied Biomedicine 16:4, pages 281-288.
Crossref
Eun-Jung Lee, Hyeongjoo Oh, Beom Goo Kang, Min-Kyung Kang, Dong Yeon Kim, Yun-Ho Kim, Jeong Yeol Lee, Joung Gun Ji, Soon Sung Lim & Young-Hee Kang. (2018) Lipid-Lowering Effects of Medium-Chain Triglyceride-Enriched Coconut Oil in Combination with Licorice Extracts in Experimental Hyperlipidemic Mice. Journal of Agricultural and Food Chemistry 66:40, pages 10447-10457.
Crossref
Kevin C Maki, Wendy Hasse, Mary R Dicklin, Marjorie Bell, Mary A Buggia, Martha E Cassens & Fulya Eren. (2018) Corn Oil Lowers Plasma Cholesterol Compared with Coconut Oil in Adults with Above-Desirable Levels of Cholesterol in a Randomized Crossover Trial. The Journal of Nutrition 148:10, pages 1556-1563.
Crossref
Arunaksharan Narayanankutty, Soorya Parathodi Illam & Achuthan C. Raghavamenon. (2018) Health impacts of different edible oils prepared from coconut (Cocos nucifera): A comprehensive review. Trends in Food Science & Technology 80, pages 1-7.
Crossref
Ademola C. Famurewa, Abiola M. Folawiyo, Elizabeth B. Enohnyaket, Sharon O. Azubuike-Osu, Innocent Abi, Sunday G. Obaje & Opeyemi A. Famurewa. (2018) Beneficial role of virgin coconut oil supplementation against acute methotrexate chemotherapy-induced oxidative toxicity and inflammation in rats. Integrative Medicine Research 7:3, pages 257-263.
Crossref
Arunaksharan Narayanankutty, Devika Mukundan Palliyil, Kezia Kuruvilla & Achuthan C Raghavamenon. (2018) Virgin coconut oil reverses hepatic steatosis by restoring redox homeostasis and lipid metabolism in male Wistar rats. Journal of the Science of Food and Agriculture 98:5, pages 1757-1764.
Crossref
Xin Zhao, Jia-Le Song, Ruokun Yi, Guijie Li, Peng Sun, Kun-Young Park & Huayi Suo. (2018) Comparison of Antioxidative Effects of Insect Tea and Its Raw Tea (Kuding Tea) Polyphenols in Kunming Mice. Molecules 23:1, pages 204.
Crossref
Devi Lekshmi Sheela, Puthiyaveetil Abdulla Nazeem, Arunaksharan Narayanankutty, R. Muthangaparambil Shylaja, Sangeetha P. Davis, Priyanga James, Ravisankar Valsalan, Thekkekara Devassy Babu & Achuthan C. Raghavamenon. (2017) Coconut phytocompounds inhibits polyol pathway enzymes: Implication in prevention of microvascular diabetic complications. Prostaglandins, Leukotrienes and Essential Fatty Acids 127, pages 20-24.
Crossref
Ademola C. Famurewa, Patrick M. Aja, Ekenechukwu K. Maduagwuna, Chima A. Ekeleme-Egedigwe, Odomero G. Ufebe & Sharon O. Azubuike-Osu. (2017) Antioxidant and anti-inflammatory effects of virgin coconut oil supplementation abrogate acute chemotherapy oxidative nephrotoxicity induced by anticancer drug methotrexate in rats. Biomedicine & Pharmacotherapy 96, pages 905-911.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.