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Research Paper

TRIM21 is a novel regulator of Par-4 in colon and pancreatic cancer cells

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Pages 16-25 | Received 18 Jul 2016, Accepted 16 Oct 2016, Published online: 27 Dec 2016

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Wenbin Zhou, Yayuan Zhang, Caineng Zhong, Jintao Hu, Hong Hu, Dongxian Zhou & MeiQun Cao. (2018) Decreased expression of TRIM21 indicates unfavorable outcome and promotes cell growth in breast cancer. Cancer Management and Research 10, pages 3687-3696.
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Articles from other publishers (41)

Junjie Gu, Jingyi Chen, Shuaixi Xiang, Xikun Zhou & Jing Li. (2023) Intricate confrontation: Research progress and application potential of TRIM family proteins in tumor immune escape. Journal of Advanced Research 54, pages 147-179.
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Chueh-Hsuan Hsu & Yung-Luen Yu. (2023) The interconnected roles of TRIM21/Ro52 in systemic lupus erythematosus, primary Sjögren’s syndrome, cancers, and cancer metabolism. Cancer Cell International 23:1.
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Jiani Yang, Yuanyu Liao, Bojun Wang, Luying Cui, Xuefan Yu, Feng Wu, Yanqiao Zhang, Ruiqi Liu & Yuanfei Yao. (2023) EDARADD promotes colon cancer progression by suppressing E3 ligase Trim21-mediated ubiquitination and degradation of Snail. Cancer Letters 577, pages 216427.
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Chengdong Huo, Yanmei Gu, Daijun Wang, Xiaoxia Zhang, Futian Tang, Bin Zhao, Tao Liu, Wenting He & Yumin Li. (2023) STAT1 suppresses the transcriptional activity of TRIM21 in gastric cancer. Journal of Cancer Research and Clinical Oncology 149:17, pages 15335-15348.
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Hualin Sun, Mengli Wu, Zhonghui Zhang, Yiwang Wang, Jifei Yang, Zhijie Liu, Guiquan Guan, Jianxun Luo, Hong Yin & Qingli Niu. (2023) OAS1 suppresses African swine fever virus replication by recruiting TRIM21 to degrade viral major capsid protein. Journal of Virology 97:10.
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Jun Gong, Yuhui Liu, Wenjia Wang, Ruizhi He, Qilong Xia, Lin Chen, Chunle Zhao, Yang Gao, Yongkang Shi, Yu Bai, Yangwei Liao, Qi Zhang, Feng Zhu, Min Wang, Xu Li & Renyi Qin. (2023) TRIM21‐Promoted FSP1 Plasma Membrane Translocation Confers Ferroptosis Resistance in Human Cancers. Advanced Science 10:29.
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Chunlan Xu, Kunao Yang, Zuodong Xuan, Jinxin Li, Yankuo Liu, Yue Zhao, Zeyuan Zheng, Yang Bai, Zhiyuan Shi, Chen Shao, Lei Zhang & Huimin Sun. (2023) BCKDK regulates breast cancer cell adhesion and tumor metastasis by inhibiting TRIM21 ubiquitinate talin1. Cell Death & Disease 14:7.
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Feng Hu, Yan Liu, Feiyang Wang, Xinyi Fu, Xiangjun Liu, Zhenhong Zou & Bin Zhou. (2023) Prognostic and clinicopathological significance of TRIM21 in various cancers: A meta and bioinformatic analysis. Medicine 102:23, pages e34012.
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Yijie Wang, Xiong Liu, Weixiao Huang, Junjie Liang & Yan Chen. (2022) The intricate interplay between HIFs, ROS, and the ubiquitin system in the tumor hypoxic microenvironment. Pharmacology & Therapeutics 240, pages 108303.
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Pushuai Wen, Huade Wang, Yi Li, Xinyao Sui, Zhijuan Hou, Xiaoyan Guo, Wanying Xue, Dahua Liu, Yu Wang & Jing Gao. (2022) MICALL2 as a substrate of ubiquitinase TRIM21 regulates tumorigenesis of colorectal cancer. Cell Communication and Signaling 20:1.
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Qingxiang Lin, Shichen Shen, Zhicheng Qian, Sailee S. Rasam, Andrea Serratore, William J. Jusko, Eugene S. Kandel, Jun Qu & Robert M. Straubinger. (2022) Comparative Proteomic Analysis Identifies Key Metabolic Regulators of Gemcitabine Resistance in Pancreatic Cancer. Molecular & Cellular Proteomics 21:10, pages 100409.
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Xintian Chen, Menghan Cao, Pengfei Wang, Sufang Chu, Minle Li, Pingfu Hou, Junnian Zheng, Zhongwei Li & Jin Bai. (2022) The emerging roles of TRIM21 in coordinating cancer metabolism, immunity and cancer treatment. Frontiers in Immunology 13.
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Jianxiong Li, Bin Li, Yujie Bu, Hailin Zhang, Jia Guo, Jianping Hu & Yanfang Zhang. (2022) Sertad1 Induces Neurological Injury after Ischemic Stroke via the CDK4/p-Rb Pathway. Molecules and Cells 45:4, pages 216-230.
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Mei Ping, Shumin Wang, Yarong Guo & Junmei Jia. (2022) TRIM21 improves apatinib treatment in gastric cancer through suppressing EZH1 stability. Biochemical and Biophysical Research Communications 586, pages 177-184.
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Nikhil Hebbar & Vivek M. Rangnekar. 2022. Tumor Suppressor Par-4. Tumor Suppressor Par-4 151 183 .
Saptadwipa Ganguly, Ravshan Burikhanov, Shirley Qiu & Vivek M. Rangnekar. 2022. Tumor Suppressor Par-4. Tumor Suppressor Par-4 1 59 .
Anne Offermann, Duan Kang, Christian Watermann, Anika Weingart, Marie C Hupe, Alireza Saraji, Janine Stegmann-Frehse, Rosemarie Kruper, Roland Schüle, Klaus Pantel, Helge Taubert, Stefan Duensing, Zoran Culig, Achim Aigner, Wolfram Klapper, Danny Jonigk, Mark Philipp Kühnel, Axel S Merseburger, Jutta Kirfel, Verena Sailer & Sven Perner. (2021) Analysis of tripartite motif (TRIM) family gene expression in prostate cancer bone metastases. Carcinogenesis 42:12, pages 1475-1484.
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Dimitrios P. Bogdanos, Athanasios Gkoutzourelas, Vasilios Papadopoulos, Christos Liaskos, Eleni Patrikiou, Christina Tsigalou, Athanasios Saratziotis, John Hajiioannou, Thomas Scheper, Wolfgang Meyer, Lazaros I. Sakkas & Christos Papandreou. (2021) Anti-Ro52 antibody is highly prevalent and a marker of better prognosis in patients with ovarian cancer. Clinica Chimica Acta 521, pages 199-205.
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Hongwei Luo, Yingchun Zhang, Nan Hu, Yancheng He & Chengcheng He. (2021) Systematic Construction and Validation of an RNA-Binding Protein-Associated Prognostic Model for Acute Myeloid Leukemia. Frontiers in Genetics 12.
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Kai Hou, Jianliang Shen, Junrong Yan, Chuannan Zhai, Jingxia Zhang, Ji-An Pan, Ye Zhang, Yaping Jiang, Yongbo Wang, Richard Z. Lin, Hongliang Cong, Shenglan Gao & Wei-Xing Zong. (2021) Loss of TRIM21 alleviates cardiotoxicity by suppressing ferroptosis induced by the chemotherapeutic agent doxorubicin. eBioMedicine 69, pages 103456.
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Huaping Gong, Long Chen & Ruipeng Dong. (2021) Effects and Mechanisms of Tripartite Motif Containing 14 Downregulation on Proliferation, Migration, and Invasion of Cancerous Pancreatic PANC-1 Cells. Journal of Biomaterials and Tissue Engineering 11:3, pages 402-406.
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Munther Alomari. (2021) TRIM21 – A potential novel therapeutic target in cancer. Pharmacological Research 165, pages 105443.
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Flaviana Marzano, Mariano Francesco Caratozzolo, Graziano Pesole, Elisabetta Sbisà & Apollonia Tullo. (2021) TRIM Proteins in Colorectal Cancer: TRIM8 as a Promising Therapeutic Target in Chemo Resistance. Biomedicines 9:3, pages 241.
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Anees Rahman Cheratta, Faisal Thayyullathil, Siraj Pallichankandy, Karthikeyan Subburayan, Ameer Alakkal & Sehamuddin Galadari. (2021) Prostate apoptosis response-4 and tumor suppression: it’s not just about apoptosis anymore. Cell Death & Disease 12:1.
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Huan-Tian Zhang, Qingzhong Zeng, Baomeng Wu, Junlei Lu, Kui-Leung Tong, Jiebin Lin, Qiu-Yu Liu, Lipei Xu, Jie Yang, Xiaohui Liu, Wanting Liu, Yun-Fang Zhang, Qionghua Lian, Langxia Liu & Xuejuan Gao. (2021) TRIM21-regulated Annexin A2 plasma membrane trafficking facilitates osteosarcoma cell differentiation through the TFEB-mediated autophagy. Cell Death & Disease 12:1.
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L. Yang, T. Zhang, C. Zhang, C. Xiao, X. Bai & G. Wang. (2020) Upregulated E3 ligase tripartite motif‐containing protein 21 in psoriatic epidermis ubiquitylates nuclear factor‐κB p65 subunit and promotes inflammation in keratinocytes*. British Journal of Dermatology 184:1, pages 111-122.
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Fang Wang, Ye Zhang, Jianliang Shen, Bin Yang, Weiwei Dai, Junrong Yan, Sara Maimouni, Heineken Q. Daguplo, Sara Coppola, Yingtang Gao, Yijun Wang, Zhi Du, Kesong Peng, Hui Liu, Qin Zhang, Fei Tang, Peng Wang, Shenglan Gao, Yongbo Wang, Wen-Xing Ding, Grace Guo, Fengmei Wang & Wei-Xing Zong. (2021) The Ubiquitin E3 Ligase TRIM21 Promotes Hepatocarcinogenesis by Suppressing the p62-Keap1-Nrf2 Antioxidant Pathway. Cellular and Molecular Gastroenterology and Hepatology 11:5, pages 1369-1385.
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Rosalyn B. Irby, Christina Leah B. Kline & Arun K. Sharma. 2021. Tumor Suppressor Par-4. Tumor Suppressor Par-4 59 68 .
Md. Hafiz Uddin, Asfar S. Azmi & Ramzi M. Mohammad. 2021. Tumor Suppressor Par-4. Tumor Suppressor Par-4 161 170 .
Ethel Juliet Blessie, Wasco Wruck, Benaiah Annertey Abbey, Audrey Ncube, Nina Graffmann, Vincent Amarh, Patrick Kobina Arthur & James Adjaye. (2020) Transcriptomic analysis of marine endophytic fungi extract identifies highly enriched anti-fungal fractions targeting cancer pathways in HepG2 cell lines. BMC Genomics 21:1.
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Hai Zhang, Fei Zhou, Yingying Wang, Huikang Xie, Shilan Luo, Lu Meng, Bin Su, Ying Ye, Kailiang Wu, Yaping Xu & Xiaomei Gong. (2020) Eliminating Radiation Resistance of Non-Small Cell Lung Cancer by Dihydroartemisinin Through Abrogating Immunity Escaping and Promoting Radiation Sensitivity by Inhibiting PD-L1 Expression. Frontiers in Oncology 10.
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Abhishek Guha, Sharanya Nag & Partho Sarothi Ray. (2020) Negative feedback regulation by HuR controls TRIM21 expression and function in response to UV radiation. Scientific Reports 10:1.
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Fei Fei, Kai Liu, Chunyuan Li, Jiaxing Du, Zhen Wei, Bo Li, Yuwei Li, Yi Zhang & Shiwu Zhang. (2020) Molecular Mechanisms by Which S100A4 Regulates the Migration and Invasion of PGCCs With Their Daughter Cells in Human Colorectal Cancer. Frontiers in Oncology 10.
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Yu-Hang Li, Kui-Leung Tong, Jun-Lei Lu, Jie-Bin Lin, Zhen-Yan Li, Yuan Sang, Abdelmoumin Ghodbane, Xue-Juan Gao, Man-Seng Tam, Chang-Deng Hu, Huan-Tian Zhang & Zhen-Gang Zha. (2020) PRMT5-TRIM21 interaction regulates the senescence of osteosarcoma cells by targeting the TXNIP/p21 axis. Aging 12:3, pages 2507-2529.
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Jiarong Zhou, Linshi Zhang, Huilin Zheng, Wenhao Ge, Yu Huang, Yingcai Yan, Xiaohu Zhou, Wei Zhu, Yang Kong, Yuan Ding & Weilin Wang. (2019) Identification of chemoresistance‐related mRNAs based on gemcitabine‐resistant pancreatic cancer cell lines. Cancer Medicine 9:3, pages 1115-1130.
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Gallardo-Vara, Ruiz-Llorente, Casado-Vela, Ruiz-Rodríguez, López-Andrés, Pattnaik, Quintanilla & Bernabeu. (2019) Endoglin Protein Interactome Profiling Identifies TRIM21 and Galectin-3 as New Binding Partners. Cells 8:9, pages 1082.
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Heran Wang, Yujuan Zhou, Linda Oyang, Yaqian Han, Longzheng Xia, Jingguan Lin, Yanyan Tang, Min Su, Shiming Tan, Yutong Tian, Xiaoyan Chen, Xia Luo, Jiaxin Liang, Shan Rao, Ying Wang, Wei Xiong, Zhaoyang Zeng, Hui Wang, Guiyuan Li & Qianjin Liao. (2019) LPLUNC1 stabilises PHB1 by counteracting TRIM21-mediated ubiquitination to inhibit NF-κB activity in nasopharyngeal carcinoma. Oncogene 38:25, pages 5062-5075.
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Valletti, Marzano, Pesole, Sbisà & Tullo. (2019) Targeting Chemoresistant Tumors: Could TRIM Proteins-p53 Axis Be a Possible Answer?. International Journal of Molecular Sciences 20:7, pages 1776.
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Renata Virgínia Cavalcanti Santos, Wanessa Layssa Batista de Sena, Flaviana Alves dos Santos, Antônio Felix da Silva Filho, Marina Galdino da Rocha Pitta, Maira Galdino da Rocha Pitta, Moacyr Barreto de Melo Rego & Michelly Cristiny Pereira. (2019) Potential Therapeutic Agents Against Par-4 Target for Cancer Treatment: Where Are We Going?. Current Drug Targets 20:6, pages 635-654.
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Zhen Wei, Jinglue Song, Guanghui Wang, Ximao Cui, Jun Zheng, Yunlan Tang, Xinyuan Chen, Jixi Li, Long Cui, Chen-Ying Liu & Wei Yu. (2018) Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis. Nature Communications 9:1.
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Binbin Xue, Huiyi Li, Mengmeng Guo, Jingjing Wang, Yan Xu, Xuan Zou, Rilin Deng, Guangdi Li & Haizhen Zhu. (2018) TRIM21 Promotes Innate Immune Response to RNA Viral Infection through Lys27-Linked Polyubiquitination of MAVS. Journal of Virology 92:14.
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