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Cell Cycle Volume 14, 2015 - Issue 7
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BCR-ABL inactivates cytosolic PTEN through Casein Kinase II mediated tail phosphorylation

Alessandro MorottiDepartment of Clinical and Biological Sciences; San Luigi Hospital; Orbassano - Turin University; Turin, ItalyCorrespondence[email protected]
,
Cristina PanuzzoDepartment of Clinical and Biological Sciences; San Luigi Hospital; Orbassano - Turin University; Turin, Italy
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Sabrina CrivellaroDepartment of Clinical and Biological Sciences; San Luigi Hospital; Orbassano - Turin University; Turin, Italy
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Giovanna CarràDepartment of Clinical and Biological Sciences; San Luigi Hospital; Orbassano - Turin University; Turin, Italy
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Carmen FavaDepartment of Clinical and Biological Sciences; San Luigi Hospital; Orbassano - Turin University; Turin, Italy
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Angelo GuerrasioDepartment of Clinical and Biological Sciences; San Luigi Hospital; Orbassano - Turin University; Turin, Italy
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Pier Paolo PandolfiCancer Research Institute; Beth Israel Deaconess Cancer Center; Department of Medicine and Pathology; Beth Israel Deaconess Medical Center; Harvard Medical School; Boston, MAUSA
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Giuseppe SaglioDepartment of Clinical and Biological Sciences; San Luigi Hospital; Orbassano - Turin University; Turin, Italy
 show all
Pages 973-979 | Received 24 Sep 2014, Accepted 07 Jan 2015, Published online: 01 Apr 2015

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Giovanna Carrà, Antonio Cartellà, Beatrice Maffeo & Alessandro Morotti. (2019) Strategies For Targeting Chronic Myeloid Leukaemia Stem Cells. Blood and Lymphatic Cancer: Targets and Therapy 9, pages 45-52.
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Articles from other publishers (23)

Ayse Ertay, Rob M. Ewing & Yihua Wang. (2023) Synthetic lethal approaches to target cancers with loss of PTEN function. Genes & Diseases 10:6, pages 2511-2527.
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Rongguiyi Zhang, Jiyuan Ai, Jiakun Wang, Chi sun, Hongcheng Lu, Aoxiao He, Min Li, Yuting Liao, Jun Lei, Fan Zhou, Linquan Wu & Wenjun Liao. (2022) NCAPG promotes the proliferation of hepatocellular carcinoma through the CKII-dependent regulation of PTEN. Journal of Translational Medicine 20:1.
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Daniel Diaz-Gil, Chrystalle Katte Carreon, Natalia Silva-Gomez, Alan E. Benheim, Sitaram M. Emani, Pedro J. del Nido, Gerald R. Marx & Ingeborg Friehs. (2022) Case report: Active clinical manifestation of endocardial fibroelastosis in adolescence in a patient with mitral and aortic obstruction–histologic presence of endothelial-to-mesenchymal transformation. Frontiers in Cardiovascular Medicine 9.
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María Paula Dizanzo, Marina Bugnon Valdano, Om Basukala, Lawrence Banks & Daniela Gardiol. (2022) Novel effect of the high risk-HPV E7 CKII phospho-acceptor site on polarity protein expression. BMC Cancer 22:1.
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Mahmoud Hallal, Sophie Braga-Lagache, Jovana Jankovic, Cedric Simillion, Rémy Bruggmann, Anne-Christine Uldry, Ramanjaneyulu Allam, Manfred Heller & Nicolas Bonadies. (2021) Inference of kinase-signaling networks in human myeloid cell line models by Phosphoproteomics using kinase activity enrichment analysis (KAEA). BMC Cancer 21:1.
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Christian Boni & Claudio Sorio. (2021) Current Views on the Interplay between Tyrosine Kinases and Phosphatases in Chronic Myeloid Leukemia. Cancers 13:10, pages 2311.
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Guoliang Li, Thanigaivelan Kanagasabai, Wenfu Lu, Mike R. Zou, Shang-Min Zhang, Sherly I. Celada, Michael G. Izban, Qi Liu, Tao Lu, Billy R. Ballard, Xinchun Zhou, Samuel E. Adunyah, Robert J. Matusik, Qin Yan & Zhenbang Chen. (2020) KDM5B Is Essential for the Hyperactivation of PI3K/AKT Signaling in Prostate Tumorigenesis. Cancer Research 80:21, pages 4633-4643.
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Giacomo Andreani, Giovanna Carrà, Marcello Francesco Lingua, Beatrice Maffeo, Mara Brancaccio, Riccardo Taulli & Alessandro Morotti. (2020) Tumor Suppressors in Chronic Lymphocytic Leukemia: From Lost Partners to Active Targets. Cancers 12:3, pages 629.
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Christian Borgo & Maria Ruzzene. (2019) Role of protein kinase CK2 in antitumor drug resistance. Journal of Experimental & Clinical Cancer Research 38:1.
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Xiaolin Yin, Minran Zhou, Yue Fu, Lin Yang, Man Xu, Ting Sun, Xiaoming Wang, Tao Huang & Chunyan Chen. (2019) Histone demethylase RBP2 mediates the blast crisis of chronic myeloid leukemia through an RBP2/PTEN/BCR-ABL cascade. Cellular Signalling 63, pages 109360.
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Tian Liu, Yiwei Wang, Yubing Wang & Andrew M. Chan. (2019) Multifaceted Regulation of PTEN Subcellular Distributions and Biological Functions. Cancers 11:9, pages 1247.
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Chunjuan Zhao, Tao Tao, Longyan Yang, Qiong Qin, Ying Wang, Hua Liu, Ran Song, Xiaomei Yang, Qiqi Wang, Siyu Gu, Ying Xiong, Dong Zhao, Songlin Wang, Duiping Feng, Wen G. Jiang, Jun Zhang & Junqi He. (2019) Loss of PDZK1 expression activates PI3K/AKT signaling via PTEN phosphorylation in gastric cancer. Cancer Letters 453, pages 107-121.
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Raquel Alves, Ana Cristina Gonçalves, Joana Jorge, Joana Alves, António Alves da Silva, Paulo Freitas-Tavares, José M. Nascimento Costa, António M. Almeida & Ana B. Sarmento-Ribeiro. (2019) Everolimus in combination with Imatinib overcomes resistance in Chronic myeloid leukaemia. Medical Oncology 36:3.
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Robert W. Figliozzi, Feng Chen & S. Victor Hsia. (2017) New insights on thyroid hormone mediated regulation of herpesvirus infections. Cell & Bioscience 7:1.
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Prerna Malaney, Vladimir N. Uversky & Vrushank Davé. (2017) PTEN proteoforms in biology and disease. Cellular and Molecular Life Sciences 74:15, pages 2783-2794.
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Tianyou Yan, Yamei Leng, Xi Yang, Yuping Gong, Huaqin Sun, Ke Wang, Wenming Xu, Yuhuan Zheng, Duolan Naren & Rui Shi. (2017) High-expressing cystic fibrosis transmembrane conductance regulator interacts with histone deacetylase 2 to promote the development of Ph+ leukemia through the HDAC2-mediated PTEN pathway. Leukemia Research 57, pages 9-19.
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Alessandro Morotti, Sabrina Crivellaro, Cristina Panuzzo, Giovanna Carrà, Angelo Guerrasio & Giuseppe Saglio. (2017) IκB-α: At the crossroad between oncogenic and tumor-suppressive signals. Oncology Letters 13:2, pages 531-534.
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Sabrina Crivellaro, Giovanna Carrà, Cristina Panuzzo, Riccardo Taulli, Angelo Guerrasio, Giuseppe Saglio & Alessandro Morotti. (2016) The non-genomic loss of function of tumor suppressors: an essential role in the pathogenesis of chronic myeloid leukemia chronic phase. BMC Cancer 16:1.
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Valentina Salizzato, Christian Borgo, Luca Cesaro, Lorenzo A. Pinna & Arianna Donella-Deana. (2016) Inhibition of protein kinase CK2 by CX-5011 counteracts imatinib-resistance preventing rpS6 phosphorylation in chronic myeloid leukaemia cells: new combined therapeutic strategies. Oncotarget 7:14, pages 18204-18218.
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Alessandro Morotti, Cristina Panuzzo, Sabrina Crivellaro, Giovanna Carrà, Davide Torti, Angelo Guerrasio & Giuseppe Saglio. (2015) The Role of PTEN in Myeloid Malignancies. Hematology Reports 7:4, pages 6027.
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Sabrina Crivellaro, Cristina Panuzzo, Giovanna Carrà, Alessandro Volpengo, Francesca Crasto, Enrico Gottardi, Ubaldo Familiari, Mauro Papotti, Davide Torti, Rocco Piazza, Sara Redaelli, Riccardo Taulli, Angelo Guerrasio, Giuseppe Saglio & Alessandro Morotti. (2015) Non genomic loss of function of tumor suppressors in CML: BCR-ABL promotes IκBα mediated p53 nuclear exclusion. Oncotarget 6:28, pages 25217-25225.
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Ronit Vogt Sionov, Spiros A. Vlahopoulos & Zvi Granot. (2015) Regulation of Bim in Health and Disease. Oncotarget 6:27, pages 23058-23134.
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Alessandro Morotti, Giovanna Carrà, Cristina Panuzzo, Sabrina Crivellaro, Riccardo Taulli, Angelo Guerrasio & Giuseppe Saglio. (2015) Protein Kinase CK2: A Targetable BCR-ABL Partner in Philadelphia Positive Leukemias. Advances in Hematology 2015, pages 1-6.
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