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Original

Connexin43 Mimetic Peptides Reduce Swelling, Astrogliosis, and Neuronal Cell Death after Spinal Cord Injury

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Pages 27-42 | Received 29 Oct 2007, Accepted 07 Nov 2007, Published online: 11 Jul 2009

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Anne Caufriez, Denise Böck, Charlotte Martin, Steven Ballet & Mathieu Vinken. (2020) Peptide-based targeting of connexins and pannexins for therapeutic purposes. Expert Opinion on Drug Discovery 15:10, pages 1213-1222.
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Joost Willebrords, Sara Crespo Yanguas, Michaël Maes, Elke Decrock, Nan Wang, Luc Leybaert, Brenda R. Kwak, Colin R. Green, Bruno Cogliati & Mathieu Vinken. (2016) Connexins and their channels in inflammation. Critical Reviews in Biochemistry and Molecular Biology 51:6, pages 413-439.
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Crossref
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Crossref
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Crossref
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Crossref
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Beverley J. Glass, Rebecca G. Hu, Anthony R. J. Phillips & David L. Becker. (2015) The action of mimetic peptides on connexins protects fibroblasts from the negative effects of ischemia reperfusion. Biology Open 4:11, pages 1473-1480.
Crossref
J.O. Davidson, C.R. Green, L. Bennet & A.J. Gunn. (2014) Battle of the hemichannels – Connexins and Pannexins in ischemic brain injury. International Journal of Developmental Neuroscience 45:1, pages 66-74.
Crossref
Joanne O. Davidson, Guido Wassink, Lotte G. van den Heuij, Laura Bennet & Alistair J. Gunn. (2015) Therapeutic Hypothermia for Neonatal Hypoxic–Ischemic Encephalopathy – Where to from Here?. Frontiers in Neurology 6.
Crossref
Rainer Schulz, Philipp Maximilian Görge, Anikó Görbe, Péter Ferdinandy, Paul D. Lampe & Luc Leybaert. (2015) Connexin 43 is an emerging therapeutic target in ischemia/reperfusion injury, cardioprotection and neuroprotection. Pharmacology & Therapeutics 153, pages 90-106.
Crossref
Ying-Shan Chen, Colin R. Green, Helen V. Danesh-Meyer & Ilva D. Rupenthal. (2015) Neuroprotection in the treatment of glaucoma – A focus on connexin43 gap junction channel blockers. European Journal of Pharmaceutics and Biopharmaceutics 95, pages 182-193.
Crossref
Elke Decrock, Marijke De Bock, Nan Wang, Geert Bultynck, Christian Giaume, Christian C. Naus, Colin R. Green & Luc Leybaert. (2015) Connexin and pannexin signaling pathways, an architectural blueprint for CNS physiology and pathology?. Cellular and Molecular Life Sciences 72:15, pages 2823-2851.
Crossref
Mauricio A. Retamal, Edison P. Reyes, Isaac E. García, Bernardo Pinto, Agustín D. Martínez & Carlos González. (2015) Diseases associated with leaky hemichannels. Frontiers in Cellular Neuroscience 9.
Crossref
A Tittarelli, I Guerrero, F Tempio, M A Gleisner, I Avalos, S Sabanegh, C Ortíz, L Michea, M N López, A Mendoza-Naranjo & F Salazar-Onfray. (2015) Overexpression of connexin 43 reduces melanoma proliferative and metastatic capacity. British Journal of Cancer 113:2, pages 259-267.
Crossref
Maximiliano Rovegno, Paola A. Soto, Pablo J. Sáez, Christian C. Naus, Juan C. Sáez & Rommy von Bernhardi. (2015) Connexin43 hemichannels mediate secondary cellular damage spread from the trauma zone to distal zones in astrocyte monolayers. Glia 63:7, pages 1185-1199.
Crossref
Ryan S. Tonkin, Yilin Mao, Simon J. O’Carroll, Louise F. B. Nicholson, Colin R. Green, Catherine A. Gorrie & Gila Moalem-Taylor. (2015) Gap junction proteins and their role in spinal cord injury. Frontiers in Molecular Neuroscience 7.
Crossref
Young Hoon JeonDong Ho Youn. (2015) Spinal Gap Junction Channels in Neuropathic Pain. The Korean Journal of Pain 28:4, pages 231.
Crossref
Marijke De Bock, Nan Wang, Elke Decrock, Geert Bultynck & Luc Leybaert. (2015) Intracellular Cleavage of the Cx43 C-Terminal Domain by Matrix-Metalloproteases: A Novel Contributor to Inflammation?. Mediators of Inflammation 2015, pages 1-18.
Crossref
Karina Goncharenko, Eftekhar EftekharpourAlexander A. Velumian, Peter L. Carlen & Michael G. Fehlings. (2014) Changes in gap junction expression and function following ischemic injury of spinal cord white matter. Journal of Neurophysiology 112:9, pages 2067-2075.
Crossref
Verónica Abudara, John Bechberger, Moises Freitas-Andrade, Marijke De Bock, Nan Wang, Geert Bultynck, Christian C. Naus, Luc Leybaert & Christian Giaume. (2014) The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes. Frontiers in Cellular Neuroscience 8.
Crossref
Marijke De Bock, Elke Decrock, Nan Wang, Mélissa Bol, Mathieu Vinken, Geert Bultynck & Luc Leybaert. (2014) The dual face of connexin-based astroglial Ca2+ communication: A key player in brain physiology and a prime target in pathology. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1843:10, pages 2211-2232.
Crossref
Ning Shen, Li-Qiu Mo, Fen Hu, Pei-Xi Chen, Rui-Xian Guo & Jian-Qiang Feng. (2014) A Novel Role of Spinal Astrocytic Connexin 43: Mediating Morphine Antinociceptive Tolerance by Activation of NMDA Receptors and Inhibition of Glutamate Transporter-1 in Rats. CNS Neuroscience & Therapeutics 20:8, pages 728-736.
Crossref
Tianci Chu, Hengxing Zhou, Fuyuan Li, Tianyi Wang, Lu Lu & Shiqing Feng. (2014) Astrocyte transplantation for spinal cord injury: Current status and perspective. Brain Research Bulletin 107, pages 18-30.
Crossref
Joanne O. Davidson, Paul P. Drury, Colin R. Green, Louise F. Nicholson, Laura Bennet & Alistair J. Gunn. (2014) Connexin Hemichannel Blockade Is Neuroprotective after Asphyxia in Preterm Fetal Sheep. PLoS ONE 9:5, pages e96558.
Crossref
Juan C. Sáez & Luc Leybaert. (2014) Hunting for connexin hemichannels. FEBS Letters 588:8, pages 1205-1211.
Crossref
Jie Zhang, Simon J. O'Carroll, Kimiora Henare, Lai-Ming Ching, Susan Ormonde, Louise F.B. Nicholson, Helen V. Danesh-Meyer & Colin R. Green. (2014) Connexin hemichannel induced vascular leak suggests a new paradigm for cancer therapy. FEBS Letters 588:8, pages 1365-1371.
Crossref
Xuehua Liu, Yi Zhou, Zhiwei Wang, Jing Yang, Chunjin Gao & Qingjun Su. (2014) Effect of VEGF and CX43 on the promotion of neurological recovery by hyperbaric oxygen treatment in spinal cord–injured rats. The Spine Journal 14:1, pages 119-127.
Crossref
Alexander Velumian & Marina Samoilova. 2014. White Matter Injury in Stroke and CNS Disease. White Matter Injury in Stroke and CNS Disease 3 38 .
Nan Wang, Marijke De Bock, Elke Decrock, M?lissa Bol, Ashish Gadicherla, Geert Bultynck & Luc Leybaert. (2013) Connexin targeting peptides as inhibitors of voltage- and intracellular Ca2+-triggered Cx43 hemichannel opening. Neuropharmacology 75, pages 506-516.
Crossref
Jegan Iyyathurai, Catheleyne D'hondt, Nan Wang, Marijke De Bock, Bernard Himpens, Mauricio A. Retamal, Jimmy Stehberg, Luc Leybaert & Geert Bultynck. (2013) Peptides and peptide-derived molecules targeting the intracellular domains of Cx43: Gap junctions versus hemichannels. Neuropharmacology 75, pages 491-505.
Crossref
Carthur K. Wan, Simon J. O'Carroll, Sue-Ling Kim, Colin R. Green & Louise F. B. Nicholson. (2013) Spatiotemporal changes in Cx30 and Cx43 expression during neuronal differentiation of P19 EC and NT2/D1 cells. Cell Biology International Reports 20:2, pages 13-23.
Crossref
Owen D. Jones, Sarah R. Hulme & Wickliffe C. Abraham. (2013) Purinergic receptor- and gap junction-mediated intercellular signalling as a mechanism of heterosynaptic metaplasticity. Neurobiology of Learning and Memory 105, pages 31-39.
Crossref
J.O. Davidson, C.R. Green, L.F.B. Nicholson, L. Bennet & A.J. Gunn. (2013) Connexin hemichannel blockade is neuroprotective after, but not during, global cerebral ischemia in near-term fetal sheep. Experimental Neurology 248, pages 301-308.
Crossref
Keith Moore, Zachary J. Bryant, Gautam Ghatnekar, Udai P. Singh, Robert G. Gourdie & Jay D. Potts. (2013) A synthetic connexin 43 mimetic peptide augments corneal wound healing. Experimental Eye Research 115, pages 178-188.
Crossref
Ying-Shan Chen, Istvan Toth, Helen V. Danesh-Meyer, Colin R. Green & Ilva D. Rupenthal. (2013) Cytotoxicity and Vitreous Stability of Chemically Modified Connexin43 Mimetic Peptides for the Treatment of Optic Neuropathy. Journal of Pharmaceutical Sciences 102:7, pages 2322-2331.
Crossref
Véronique Phé, Delphine Behr-Roussel, Stéphanie Oger-Roussel, Morgan Rouprêt, Emmanuel Chartier-Kastler, Thierry Lebret, Gilles Karsenty, Eva Compérat, Philippe Camparo & François Giuliano. (2013) Involvement of Connexins 43 and 45 in Functional Mechanism of Human Detrusor Overactivity in Neurogenic Bladder. Urology 81:5, pages 1108.e1-1108.e6.
Crossref
Ernesto Oviedo-Orta, Brenda Kwak & William EvansDavid Becker, Jeremy Cook, Peter Cormie, Colin Green, Ariadna Mendoza-Naranjo, Anthony Phillips, Antonio Serrano & Christopher Thrasivoulou. 2013. Connexin Cell Communication Channels. Connexin Cell Communication Channels 307 332 .
Ernesto Oviedo-Orta, Brenda Kwak & William EvansJie Zhang, Simon O’Carroll, Helen Danesh-Meyer, Henri Van der Heyde, David Becker, Louise Nicholson & Colin Green. 2013. Connexin Cell Communication Channels. Connexin Cell Communication Channels 273 306 .
Ernesto Oviedo-Orta, Brenda Kwak & William EvansChristian Giaume, Nicolas Froger, rés Orellana, Mauricio Retamal & Juan Sáez. 2013. Connexin Cell Communication Channels. Connexin Cell Communication Channels 219 232 .
Simon J. O’Carroll, Catherine A. Gorrie, Sailakshmi Velamoor, Colin R. Green & Louise F.B. Nicholson. (2013) Connexin43 mimetic peptide is neuroprotective and improves function following spinal cord injury. Neuroscience Research 75:3, pages 256-267.
Crossref
Nan Wang, Marijke De Bock, Elke Decrock, Mélissa Bol, Ashish Gadicherla, Mathieu Vinken, Vera Rogiers, Feliksas F. Bukauskas, Geert Bultynck & Luc Leybaert. (2013) Paracrine signaling through plasma membrane hemichannels. Biochimica et Biophysica Acta (BBA) - Biomembranes 1828:1, pages 35-50.
Crossref
Michael G. Kozoriz & Christian C. Naus. 2013. Gap Junctions in the Brain. Gap Junctions in the Brain 231 246 .
Logan J. Voss & James W. Sleigh. 2013. Gap Junctions in the Brain. Gap Junctions in the Brain 217 229 .
Charles K. Abrams & Jennifer Orthmann-Murphy. 2013. Gap Junctions in the Brain. Gap Junctions in the Brain 165 187 .
Simon J. O’Carroll, David L. Becker, Joanne O. Davidson, Alistair J. Gunn, Louise F. B. Nicholson & Colin R. Green. 2013. Wound Regeneration and Repair. Wound Regeneration and Repair 519 546 .
Dustin J. Hines & Philip G. Haydon. 2013. Adenosine. Adenosine 157 177 .
Maria Luisa Cotrina & Maiken Nedergaard. (2012) Brain connexins in demyelinating diseases: Therapeutic potential of glial targets. Brain Research 1487, pages 61-68.
Crossref
Nan Wang, Marijke De Bock, Gudrun Antoons, Ashish K. Gadicherla, Mélissa Bol, Elke Decrock, William Howard Evans, Karin R. Sipido, Feliksas F. Bukauskas & Luc Leybaert. (2012) Connexin mimetic peptides inhibit Cx43 hemichannel opening triggered by voltage and intracellular Ca2+ elevation. Basic Research in Cardiology 107:6.
Crossref
Michael J. Chen, Benjamin Kress, Xiaoning Han, Katherine Moll, Weiguo Peng, Ru-Rong Ji & Maiken Nedergaard. (2012) Astrocytic CX43 hemichannels and gap junctions play a crucial role in development of chronic neuropathic pain following spinal cord injury. Glia 60:11, pages 1660-1670.
Crossref
Charles K. Abrams & Steven S. Scherer. (2012) Gap junctions in inherited human disorders of the central nervous system. Biochimica et Biophysica Acta (BBA) - Biomembranes 1818:8, pages 2030-2047.
Crossref
W. Howard Evans, Geert Bultynck & Luc Leybaert. (2012) Manipulating Connexin Communication Channels: Use of Peptidomimetics and the Translational Outputs. The Journal of Membrane Biology 245:8, pages 437-449.
Crossref
Gabriela García, Gabriela Libisch, Omar Trujillo‐Cenóz, Carlos Robello & Raúl E. Russo. (2012) Modulation of gene expression during early stages of reconnection of the turtle spinal cord. Journal of Neurochemistry 121:6, pages 996-1006.
Crossref
Joanne O. Davidson, Colin R. Green, Louise F. B. Nicholson, Laura Bennet & Alistair J. Gunn. (2012) Deleterious Effects of High Dose Connexin 43 Mimetic Peptide Infusion After Cerebral Ischaemia in Near-Term Fetal Sheep. International Journal of Molecular Sciences 13:5, pages 6303-6319.
Crossref
Shamim B. Shaikh, Benedict Uy, Amali Perera & Louise F.B. Nicholson. (2012) AGEs–RAGE mediated up-regulation of connexin43 in activated human microglial CHME-5 cells. Neurochemistry International 60:6, pages 640-651.
Crossref
Nathan M. Kerr, Cameron S. Johnson, Jie Zhang, Elizabeth K. Eady, Colin R. Green & Helen V. Danesh-Meyer. (2012) High pressure-induced retinal ischaemia reperfusion causes upregulation of gap junction protein connexin43 prior to retinal ganglion cell loss. Experimental Neurology 234:1, pages 144-152.
Crossref
Helen V. Danesh-Meyer, Nathan M. Kerr, Jie Zhang, Elizabeth K. Eady, Simon J. O'Carroll, Louise F.B. Nicholson, Cameron S. Johnson & Colin R. Green. (2012) Connexin43 mimetic peptide reduces vascular leak and retinal ganglion cell death following retinal ischaemia. Brain 135:2, pages 506-520.
Crossref
Ann Wu, Colin R. Green, Ilva D. Rupenthal & Gila Moalem‐Taylor. (2011) Role of gap junctions in chronic pain. Journal of Neuroscience Research 90:2, pages 337-345.
Crossref
Joanne O. Davidson, Colin R. Green, Louise F. B. Nicholson, Simon J. O'Carroll, Mhoyra Fraser, Laura Bennet & Alistair Jan Gunn. (2012) Connexin hemichannel blockade improves outcomes in a model of fetal ischemia. Annals of Neurology 71:1, pages 121-132.
Crossref
Elke Decrock, Mathieu Vinken, Mélissa Bol, Katharina D’Herde, Vera Rogiers, Peter Vandenabeele, Dmitri V. Krysko, Geert Bultynck & Luc Leybaert. (2011) Calcium and connexin-based intercellular communication, a deadly catch?. Cell Calcium 50:3, pages 310-321.
Crossref
Stephen J. A. Davies, Chung-Hsuan Shih, Mark Noble, Margot Mayer-Proschel, Jeannette E. Davies & Christoph Proschel. (2011) Transplantation of Specific Human Astrocytes Promotes Functional Recovery after Spinal Cord Injury. PLoS ONE 6:3, pages e17328.
Crossref
Nathan M. Kerr, Cameron S. Johnson, Colin R. Green & Helen V. Danesh-Meyer. (2011) Gap junction protein connexin43 (GJA1) in the human glaucomatous optic nerve head and retina. Journal of Clinical Neuroscience 18:1, pages 102-108.
Crossref
Jinny J. Yoon, Colin R. Green, Simon J. O’Carroll & Louise F.B. Nicholson. (2010) Dose-dependent protective effect of connexin43 mimetic peptide against neurodegeneration in an ex vivo model of epileptiform lesion. Epilepsy Research 92:2-3, pages 153-162.
Crossref
Shenton S.L. Chew, Cameron S. Johnson, Colin R. Green & Helen V. Danesh-Meyer. (2010) Role of connexin43 in central nervous system injury. Experimental Neurology 225:2, pages 250-261.
Crossref
Jie Zhang, Simon J. O’Carroll, Ann Wu, Louise F.B. Nicholson & Colin R. Green. (2010) A model for ex vivo spinal cord segment culture—A tool for analysis of injury repair strategies. Journal of Neuroscience Methods 192:1, pages 49-57.
Crossref
Christian Giaume, Annette Koulakoff, Lisa Roux, David Holcman & Nathalie Rouach. (2010) Astroglial networks: a step further in neuroglial and gliovascular interactions. Nature Reviews Neuroscience 11:2, pages 87-99.
Crossref
E Decrock, M Vinken, E De Vuyst, D V Krysko, K D'Herde, T Vanhaecke, P Vandenabeele, V Rogiers & L Leybaert. (2009) Connexin-related signaling in cell death: to live or let die?. Cell Death & Differentiation 16:4, pages 524-536.
Crossref
Jessica K. Alexander & Phillip G. Popovich. 2009. Neurotherapy: Progress in Restorative Neuroscience and Neurology. Neurotherapy: Progress in Restorative Neuroscience and Neurology 125 137 .
Colin R. Green & Louise F.B. Nicholson. (2013) Interrupting the inflammatory cycle in chronic diseases—Do gap junctions provide the answer?. Cell Biology International 32:12, pages 1578-1583.
Crossref

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