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Select Reports from Platform Session “Immunotoxicity,” Society of Toxicology 45th Annual Meeting, March 5–9, 2006, San Diego, California

Environmental Contaminant Trichloroethylene Promotes Autoimmune Disease and Inhibits T-cell Apoptosis in MRL+/+ Mice

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Pages 263-267 | Received 12 Jul 2006, Accepted 20 Sep 2006, Published online: 09 Oct 2008

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Josue D. Ordaz, Nur P. Damayanti & Joseph M. K. Irudayaraj. (2017) Toxicological effects of trichloroethylene exposure on immune disorders. Immunopharmacology and Immunotoxicology 39:6, pages 305-317.
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Stephen J. Genuis & Edmond Kyrillos. (2017) The chemical disruption of human metabolism. Toxicology Mechanisms and Methods 27:7, pages 477-500.
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Xiuzhen Fan, Gangduo Wang, Robert D. English & M. Firoze Khan. (2014) Proteomic identification of carbonylated proteins in the kidney of trichloroethene-exposed MRL+/+ mice. Toxicology Mechanisms and Methods 24:1, pages 21-30.
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. (2009) Letters to the Editor. Journal of Environmental Science and Health, Part A 44:1, pages 116-122.
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Articles from other publishers (21)

Tamie Nakajima, Hailan Wang, Yuan Yuan, Yuki Ito, Hisao Naito, Yoshiyuki Kawamoto, Kozue Takeda, Kiyoshi Sakai, Na Zhao, Hongling Li, Xinxiang Qiu, Lihua Xia, Jiabin Chen, Qifeng Wu, Laiyu Li, Hanlin Huang, Yukie Yanagiba, Hiroshi Yatsuya & Michihiro Kamijima. (2022) Increased serum anti-CYP2E1 IgG autoantibody levels may be involved in the pathogenesis of occupational trichloroethylene hypersensitivity syndrome: a case–control study. Archives of Toxicology 96:10, pages 2785-2797.
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Sangeeta Khare, Kuppan Gokulan, Katherine Williams, Shasha Bai, Kathleen M. Gilbert & Sarah J. Blossom. (2019) Irreversible effects of trichloroethylene on the gut microbial community and gut-associated immune responses in autoimmune-prone mice. Journal of Applied Toxicology 39:2, pages 209-220.
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Kathleen M. Gilbert, Sarah J. Blossom, Brad Reisfeld, Stephen W. Erickson, Kanan Vyas, Mary Maher, Brannon Broadfoot, Kirk West, Shasha Bai, Craig A. Cooney & Sudeepa Bhattacharyya. (2017) Trichloroethylene-induced alterations in DNA methylation were enriched in polycomb protein binding sites in effector/memory CD4+ T cells. Environmental Epigenetics 3:3.
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Kathleen M. Gilbert, Shasha Bai, Dustyn Barnette & Sarah J. Blossom. (2017) Exposure Cessation During Adulthood Did Not Prevent Immunotoxicity Caused by Developmental Exposure to Low-Level Trichloroethylene in Drinking Water. Toxicological Sciences 157:2, pages 429-437.
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Kathleen M. Gilbert, Sarah J. Blossom, Stephen W. Erickson, Brannon Broadfoot, Kirk West, Shasha Bai, Jingyun Li & Craig A. Cooney. (2016) Chronic exposure to trichloroethylene increases DNA methylation of the Ifng promoter in CD4+ T cells. Toxicology Letters 260, pages 1-7.
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Kathleen M Gilbert, Sarah J Blossom, Stephen W Erickson, Brad Reisfeld, Todd J Zurlinden, Brannon Broadfoot, Kirk West, Shasha Bai & Craig A Cooney. (2016) Chronic exposure to water pollutant trichloroethylene increased epigenetic drift in CD4 + T cells . Epigenomics 8:5, pages 633-649.
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Yao Pan, Xuetao Wei & Weidong Hao. (2015) Trichloroethylene and Its Oxidative Metabolites Enhance the Activated State and Th1 Cytokine Gene Expression in Jurkat Cells. International Journal of Environmental Research and Public Health 12:9, pages 10575-10586.
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Kathleen M. Gilbert, William Woodruff & Sarah J. Blossom. (2014) Differential Immunotoxicity Induced by Two Different Windows of Developmental Trichloroethylene Exposure. Autoimmune Diseases 2014, pages 1-12.
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M. Firoze Khan & Gangduo Wang. 2014. Trichloroethylene: Toxicity and Health Risks. Trichloroethylene: Toxicity and Health Risks 53 71 .
Kathleen M. Gilbert. 2014. Trichloroethylene: Toxicity and Health Risks. Trichloroethylene: Toxicity and Health Risks 15 35 .
Carolina Barragán-Martínez, Cesar A. Speck-Hernández, Gladis Montoya-Ortiz, Rubén D. Mantilla, Juan-Manuel Anaya & Adriana Rojas-Villarraga. (2012) Organic Solvents as Risk Factor for Autoimmune Diseases: A Systematic Review and Meta-Analysis. PLoS ONE 7:12, pages e51506.
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Sarah J. Blossom, Stepan Melnyk, Craig A. Cooney, Kathleen M. Gilbert & S. Jill James. (2012) Postnatal exposure to trichloroethylene alters glutathione redox homeostasis, methylation potential, and neurotrophin expression in the mouse hippocampus. NeuroToxicology 33:6, pages 1518-1527.
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Kathleen M. Gilbert, Ashley R. Nelson, Craig A. Cooney, Brad Reisfeld & Sarah J. Blossom. (2012) Epigenetic Alterations May Regulate Temporary Reversal of CD4+ T Cell Activation Caused by Trichloroethylene Exposure. Toxicological Sciences 127:1, pages 169-178.
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Gangduo Wang, Jianling Wang, Xiuzhen Fan, G.A.S. Ansari & M. Firoze Khan. (2012) Protein adducts of malondialdehyde and 4-hydroxynonenal contribute to trichloroethene-mediated autoimmunity via activating Th17 cells: Dose– and time–response studies in female MRL+/+ mice. Toxicology 292:2-3, pages 113-122.
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Ryo Kobayashi, Tsuyoshi Nakanishi & Hisamitsu Nagase. (2012) Trichloroethylene enhances TCR-CD3-induced proliferation of CD8<sup>+</sup> rather than CD4<sup>+</sup> T cells. The Journal of Toxicological Sciences 37:2, pages 381-387.
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Charles W. Schmidt. (2011) Questions Persist: Environmental Factors in Autoimmune Disease. Environmental Health Perspectives 119:6.
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K. M. Gilbert, B. Rowley, H. Gomez-Acevedo & S. J. Blossom. (2010) Coexposure to Mercury Increases Immunotoxicity of Trichloroethylene. Toxicological Sciences 119:2, pages 281-292.
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Stephen J. Genuis. (2010) Sensitivity-related illness: The escalating pandemic of allergy, food intolerance and chemical sensitivity. Science of The Total Environment 408:24, pages 6047-6061.
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K. Michael Pollard, Per Hultman & Dwight H. Kono. (2010) Toxicology of Autoimmune Diseases. Chemical Research in Toxicology 23:3, pages 455-466.
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Glinda Cooper, Kathleen Gilbert, Eric Greidinger, Judith James, Jean Pfau, Leslie Reinlib, Bruce Richardson & Noel Rose. (2009) Recent advances and opportunities in research on lupus: environmental influences and mechanisms of disease. Ciência & Saúde Coletiva 14:5, pages 1865-1876.
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Glinda S. Cooper, Kathleen M. Gilbert, Eric L. Greidinger, Judith A. James, Jean C. Pfau, Leslie Reinlib, Bruce C. Richardson & Noel R. Rose. (2008) Recent Advances and Opportunities in Research on Lupus: Environmental Influences and Mechanisms of Disease. Environmental Health Perspectives 116:6, pages 695-702.
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