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Journal of Immunotoxicology Volume 5, 2008 - Issue 2
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Research Article

The Opioid Antagonist Naltrexone Improves Murine Inflammatory Bowel Disease

Gail L. Matters Departments of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
,
John F. Harms Department of Medicine, Pennsylvania State University College of Medicine, Hershey, Pennsylvania
,
Christopher McGovern Department of Medicine, Pennsylvania State University College of Medicine, Hershey, Pennsylvania
,
Leo Fitzpatrick Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
,
Anuj Parikh Department of Medicine, Pennsylvania State University College of Medicine, Hershey, Pennsylvania
,
Nicholas Nilo Department of Medicine, Pennsylvania State University College of Medicine, Hershey, Pennsylvania
&
Jill P. Smith Department of Medicine, Pennsylvania State University College of Medicine, Hershey, Pennsylvania
 show all
Pages 179-187 | Received 12 Dec 2007, Accepted 21 Feb 2008, Published online: 09 Oct 2008

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Jordan S. Mar, Nabeetha A. Nagalingam, Yuanlin Song, Michio Onizawa, Jae Woo Lee & Susan V Lynch. (2014) Amelioration of DSS-induced murine colitis by VSL#3 supplementation is primarily associated with changes in ileal microbiota composition.. Gut Microbes 5:4, pages 494-503.
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Articles from other publishers (18)

Rajeendra L. Pemathilaka & Nicole N. Hashemi. (2023) Placenta-on-a-chip: Response of neural cells to pharmaceutical agents transported across the placental barrier. Innovation and Emerging Technologies 10.
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Emma Paulides, Mitchell R K L Lie & Christien Janneke van der Woude. (2022) Low-dose naltrexone for the induction of remission in patients with mild to moderate Crohn’s disease: protocol for the randomised, double-blinded, placebo-controlled, multicentre LDN Crohn study. BMJ Open 12:4, pages e058358.
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Naser-Aldin Lashgari, Nazanin Momeni Roudsari, Nadia Zandi, Benyamin Pazoki, Atiyeh Rezaei, Mehrnoosh Hashemi, Saeideh Momtaz, Roja Rahimi, Maryam Shayan, Ahmad Reza Dehpour & Amir Hossein Abdolghaffari. (2021) Current overview of opioids in progression of inflammatory bowel disease; pharmacological and clinical considerations. Molecular Biology Reports 48:1, pages 855-874.
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Neili Xu, Yuejiao Wang, Shuai Zhao, Ting Jiao, Hongxia Xue, Fengping Shan & Ning Zhang. (2020) Naltrexone (NTX) relieves inflammation in the collagen-induced- arthritis (CIA) rat models through regulating TLR4/NFκB signaling pathway. International Immunopharmacology 79, pages 106056.
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Diana Trofimovitch & Steven J. Baumrucker. (2019) Pharmacology Update: Low-Dose Naltrexone as a Possible Nonopioid Modality for Some Chronic, Nonmalignant Pain Syndromes. American Journal of Hospice and Palliative Medicine® 36:10, pages 907-912.
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Ewing Duque-Díaz, Olga Alvarez-Ojeda & Rafael Coveñas. 2019. Opioid Hormones. Opioid Hormones 147 193 .
Mitchell R. K. L. Lie, Janine van der Giessen, Gwenny M. Fuhler, Alison de Lima, Maikel P. Peppelenbosch, Cokkie van der Ent & C. Janneke van der Woude. (2018) Low dose Naltrexone for induction of remission in inflammatory bowel disease patients. Journal of Translational Medicine 16:1.
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Karlo Toljan & Bruce Vrooman. (2018) Low-Dose Naltrexone (LDN)—Review of Therapeutic Utilization. Medical Sciences 6:4, pages 82.
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Patricia J. McLaughlin & Ian S. Zagon. (2015) Duration of opioid receptor blockade determines biotherapeutic response. Biochemical Pharmacology 97:3, pages 236-246.
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L. Anselmi, J. Huynh, C. Duraffourd, I. Jaramillo, G. Vegezzi, F. Saccani, E. Boschetti, N. C. Brecha, R. De Giorgio & C. Sternini. (2015) Activation of μ opioid receptors modulates inflammation in acute experimental colitis . Neurogastroenterology & Motility 27:4, pages 509-523.
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Leonard B. Weinstock. (2014) Naltrexone Therapy for Crohn’s Disease and Ulcerative Colitis. Journal of Clinical Gastroenterology 48:8, pages 742.
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Marta Sobczak, Maciej Sałaga, Martin A. Storr & Jakub Fichna. (2013) Physiology, signaling, and pharmacology of opioid receptors and their ligands in the gastrointestinal tract: current concepts and future perspectives. Journal of Gastroenterology 49:1, pages 24-45.
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Jill P. Smith, Douglas Field, Sandra I. Bingaman, Robert Evans & David T. Mauger. (2013) Safety and Tolerability of Low-dose Naltrexone Therapy in Children With Moderate to Severe Crohn’s Disease. Journal of Clinical Gastroenterology 47:4, pages 339-345.
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Kori L. Brewer, Michelle M. Troendle, Laura Pekman & William J. Meggs. (2013) Naltrexone prevents delayed encephalopathy in rats poisoned with the sarin analogue diisopropylflurophosphate. The American Journal of Emergency Medicine 31:4, pages 676-679.
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Catia Sternini, Celine Duraffourd & Laura Anselmi. 2013. Handbook of Biologically Active Peptides. Handbook of Biologically Active Peptides 1283 1288 .
Jason R. Goldsmith, Joshua M. Uronis & Christian Jobin. (2011) Mu Opioid Signaling Protects Against Acute Murine Intestinal Injury in a Manner Involving Stat3 Signaling. The American Journal of Pathology 179:2, pages 673-683.
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Jill P. Smith, Sandra I. Bingaman, Francesca Ruggiero, David T. Mauger, Aparna Mukherjee, Christopher O. McGovern & Ian S. Zagon. (2011) Therapy with the Opioid Antagonist Naltrexone Promotes Mucosal Healing in Active Crohn’s Disease: A Randomized Placebo-Controlled Trial. Digestive Diseases and Sciences 56:7, pages 2088-2097.
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Richard J. Bodnar. (2009) Endogenous opiates and behavior: 2008. Peptides 30:12, pages 2432-2479.
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