3,662
Views
81
CrossRef citations to date
0
Altmetric
Basic Research Paper

The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells

, , , , , , & show all
Pages 1636-1651 | Received 07 Oct 2014, Accepted 05 Jun 2015, Published online: 18 Sep 2015

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Kai Kaarniranta, Janusz Blasiak, Paloma Liton, Michael Boulton, Daniel J. Klionsky & Debasish Sinha. (2023) Autophagy in age-related macular degeneration. Autophagy 19:2, pages 388-400.
Read now
Chong Wang, Zhao Tang, Ze Zhang, Tiantian Liu, Jingwei Zhang, Houbao Huang & Yawei Li. (2022) MiR-7-5p suppresses invasion via downregulation of the autophagy-related gene ATG7 and increases chemoresistance to cisplatin in BCa. Bioengineered 13:3, pages 7328-7339.
Read now
Zhongyu Ren, Jing Liang, Peng Zhang, Jianjiao Chen & Jian Wen. (2019) Inhibition of human glioblastoma cell invasion involves PION@E6 mediated autophagy process. Cancer Management and Research 11, pages 2643-2652.
Read now
Wei Zhang, Yingxue Ma, Yue Zhang, Jing Yang, Guanghui He & Song Chen. (2019) Photo-Oxidative Blue-Light Stimulation in Retinal Pigment Epithelium Cells Promotes Exosome Secretion and Increases the Activity of the NLRP3 Inflammasome. Current Eye Research 44:1, pages 67-75.
Read now
Jennifer Mildenberger, Ida Johansson, Ismail Sergin, Eli Kjøbli, Jan Kristian Damås, Babak Razani, Trude Helen Flo & Geir Bjørkøy. (2017) N-3 PUFAs induce inflammatory tolerance by formation of KEAP1-containing SQSTM1/p62-bodies and activation of NFE2L2. Autophagy 13:10, pages 1664-1678.
Read now
Ahruem Baek, Soojin Yoon, Jean Kim, Yu Mi Baek, Hanna Park, Daehan Lim, Hyewon Chung & Dong-Eun Kim. (2017) Autophagy and KRT8/keratin 8 protect degeneration of retinal pigment epithelium under oxidative stress. Autophagy 13:2, pages 248-263.
Read now

Articles from other publishers (75)

Almar Neiteler, Anwar A. Palakkan, Kevin M. Gallagher & James A. Ross. (2023) Oxidative stress and docosahexaenoic acid injury lead to increased necroptosis and ferroptosis in retinal pigment epithelium. Scientific Reports 13:1.
Crossref
Sujoy Bhattacharya, Jinggang Yin, Weihong Huo & Edward Chaum. (2023) Loss of Prom1 impairs autophagy and promotes epithelial‐mesenchymal transition in mouse retinal pigment epithelial cells. Journal of Cellular Physiology 238:10, pages 2373-2389.
Crossref
Zhibo Si, Yajuan Zheng & Jing Zhao. (2023) The Role of Retinal Pigment Epithelial Cells in Age-Related Macular Degeneration: Phagocytosis and Autophagy. Biomolecules 13:6, pages 901.
Crossref
Faezeh Tolue Ghasaban, Amirhosein Maharati, Iman Akhlaghipour & Meysam Moghbeli. (2023) MicroRNAs as the critical regulators of autophagy-mediated cisplatin response in tumor cells. Cancer Cell International 23:1.
Crossref
Jiqu Xu, Ben Ni, Congcong Ma, Shuang Rong, Hui Gao, Li Zhang, Xia Xiang, Qingde Huang, Qianchun Deng & Fenghong Huang. (2023) Docosahexaenoic acid enhances hippocampal insulin sensitivity to promote cognitive function of aged rats on a high-fat diet. Journal of Advanced Research 45, pages 31-42.
Crossref
Kevin Y. Wu, Merve Kulbay, Dana Toameh, An Qi Xu, Ananda Kalevar & Simon D. Tran. (2023) Retinitis Pigmentosa: Novel Therapeutic Targets and Drug Development. Pharmaceutics 15:2, pages 685.
Crossref
Hui-li Zheng, Meng-ting Li, Tong Zhou, Ying-yi Wang, Er-Xin Shang, Yong-qing Hua, Jin-ao Duan & Yue Zhu. (2023) Protective effects of Lycium barbarum L. berry extracts against oxidative stress-induced damage of the retina of aging mouse and ARPE-19 cells . Food & Function 14:1, pages 399-412.
Crossref
Marcella N. Dátilo, Guilherme P. Formigari, José B.Lopes de Faria & Jacqueline M.Lopes de Faria. (2023) AMP kinase activation by Omega-3 polyunsaturated fatty acid protects the retina against ischemic insult: An in vitro and in vivo study. Experimental Eye Research 226, pages 109345.
Crossref
Jessica Maiuolo, Rosa Maria Bulotta, Francesca Oppedisano, Francesca Bosco, Federica Scarano, Saverio Nucera, Lorenza Guarnieri, Stefano Ruga, Roberta Macri, Rosamaria Caminiti, Vincenzo Musolino, Micaela Gliozzi, Cristina Carresi, Antonio Cardamone, Annarita Coppoletta, Martina Nicita, Adriano Carnevali, Vincenzo Scorcia & Vincenzo Mollace. (2022) Potential Properties of Natural Nutraceuticals and Antioxidants in Age-Related Eye Disorders. Life 13:1, pages 77.
Crossref
Renxu Chang, Xudong Sun, Hongdou Jia, Qiushi Xu, Zhihao Dong, Yan Tang, Shengbin Luo, Qianming Jiang, Juan J. Loor & Chuang Xu. (2022) Inhibiting nuclear factor erythroid 2 related factor 2-mediated autophagy in bovine mammary epithelial cells induces oxidative stress in response to exogenous fatty acids. Journal of Animal Science and Biotechnology 13:1.
Crossref
M. Ardourel, I. Ranchon-Cole, A. Pâris, C. Felgerolle, N. Acar, F. Lesne, S. Briault & O. Perche. (2022) FMR protein: Evidence of an emerging role in retinal aging?. Experimental Eye Research 225, pages 109282.
Crossref
Francesco Giorgianni & Sarka Beranova-Giorgianni. (2022) Oxidized low-density lipoprotein causes ribosome reduction and inhibition of protein synthesis in retinal pigment epithelial cells. Biochemistry and Biophysics Reports 32, pages 101345.
Crossref
Kai Shan, Ninghan Feng, Doudou Zhu, Hongyan Qu, Guoling Fu, Jiaqi Li, Jing Cui, Heyan Chen, Rong Wang, Yumin Qi & Yong Q. Chen. (2022) Free docosahexaenoic acid promotes ferroptotic cell death via lipoxygenase dependent and independent pathways in cancer cells. European Journal of Nutrition 61:8, pages 4059-4075.
Crossref
Feng Lin, Minyue Xie, Xiaonan Sheng, Lingxi Guo, Jinchao Jia & Yimin Wang. (2022) Research trends in the field of retinitis pigmentosa from 2002 to 2021: a 20 years bibliometric analysis. International Ophthalmology 43:6, pages 1825-1833.
Crossref
Tessa C. Gillespie, Esther S. Kim, Tristan Grogan, Irena Tsui, Alison Chu & Kara L. Calkins. (2022) Decreased Levels of Erythrocyte Membrane Arachidonic and Docosahexaenoic Acids Are Associated With Retinopathy of Prematurity. Investigative Opthalmology & Visual Science 63:12, pages 23.
Crossref
Bo Yang, Ping-Tao Tseng, Xiang Hu, Bing-Yan Zeng, Jane Pei-Chen Chang, Yang Liu, Wei-Jie Chu, Shuang-Shuang Zhang, Zhi-Liang Zhou, Chih-Sheng Chu, Cheng-Ho Chang, Yu-Kang Tu, Yi-Cheng Wu, Brendon Stubbs, Andre F. Carvalho, Pao-Yen Lin, Yutaka J. Matsuoka, Mein-Woei Suen & Kuan-Pin Su. (2022) Comparative efficacy of omega-3 polyunsaturated fatty acids on major cardiovascular events: A network meta-analysis of randomized controlled trials. Progress in Lipid Research 88, pages 101196.
Crossref
Ali Koskela, Federico Manai, Filippo Basagni, Mikko Liukkonen, Michela Rosini, Stefano Govoni, Massimo Dal Monte, Adrian Smedowski, Kai Kaarniranta & Marialaura Amadio. (2022) Nature-Inspired Hybrids (NIH) Improve Proteostasis by Activating Nrf2-Mediated Protective Pathways in Retinal Pigment Epithelial Cells. Antioxidants 11:7, pages 1385.
Crossref
Hans O. Kalkman. (2022) Potential Suicide Prophylactic Activity by the Fish Oil Metabolite, 4-Hydroxyhexenal. International Journal of Molecular Sciences 23:13, pages 6953.
Crossref
Wanqin Liu, Shanshan Liu, Ping Li & Kai Yao. (2022) Retinitis Pigmentosa: Progress in Molecular Pathology and Biotherapeutical Strategies. International Journal of Molecular Sciences 23:9, pages 4883.
Crossref
Yasuaki Tatsumi, Ayako Kato, Naoko Niimi, Hideji Yako, Tatsuhito Himeno, Masaki Kondo, Shin Tsunekawa, Yoshiro Kato, Hideki Kamiya, Jiro Nakamura, Koji Higai, Kazunori Sango & Koichi Kato. (2022) Docosahexaenoic Acid Suppresses Oxidative Stress-Induced Autophagy and Cell Death via the AMPK-Dependent Signaling Pathway in Immortalized Fischer Rat Schwann Cells 1. International Journal of Molecular Sciences 23:8, pages 4405.
Crossref
Hua Fan & Jian-Tao Song. (2022) Potential mechanisms of macular degeneration protection by fatty fish consumption. Current Opinion in Pharmacology 63, pages 102186.
Crossref
Andrea Elmore, William S. Harris, Lina Mu, William E. Brady, Kathleen M. Hovey, Julie A. Mares, Mark A. Espeland, Mary N. Haan & Amy E. Millen. (2022) Red blood cell fatty acids and age-related macular degeneration in postmenopausal women. European Journal of Nutrition 61:3, pages 1585-1594.
Crossref
Xi Chen, Yujie Zhu, Xiaoqing Shi, Jing Zuo, Tianming Hu, Hao Wu, Ying Xia, Wei Shi & Wei Wei. (2022) Ming-Mu-Di-Huang-Pill Activates SQSTM1 via AMPK-Mediated Autophagic KEAP1 Degradation and Protects RPE Cells from Oxidative Damage. Oxidative Medicine and Cellular Longevity 2022, pages 1-21.
Crossref
Xian Qin, Kun Zhang, Juhui Qiu, Nan Wang, Kai Qu, Yuliang Cui, Junli Huang, Li Luo, Yuan Zhong, Tian Tian, Wei Wu, Yi Wang & Guixue Wang. (2022) Uptake of oxidative stress-mediated extracellular vesicles by vascular endothelial cells under low magnitude shear stress. Bioactive Materials 9, pages 397-410.
Crossref
Arun Upadhyay. (2021) Natural compounds in the regulation of proteostatic pathways: An invincible artillery against stress, ageing, and diseases. Acta Pharmaceutica Sinica B 11:10, pages 2995-3014.
Crossref
Chia-Han Tsai, Chong-Kuei Lii, Tsu-Shing Wang, Kai-Li Liu, Haw-Wen Chen, Chin-Shiu Huang & Chien-Chun Li. (2021) Docosahexaenoic acid promotes the formation of autophagosomes in MCF-7 breast cancer cells through oxidative stress-induced growth inhibitor 1 mediated activation of AMPK/mTOR pathway. Food and Chemical Toxicology 154, pages 112318.
Crossref
María Constanza Potilinski, Pablo S. Tate, Valeria E. Lorenc & Juan E. Gallo. (2021) New insights into oxidative stress and immune mechanisms involved in age-related macular degeneration tackled by novel therapies. Neuropharmacology 188, pages 108513.
Crossref
José A. Fernández-Albarral, Esther de Julián-López, Carmen Soler-Domínguez, Rosa de Hoz, Inés López-Cuenca, Elena Salobrar-García, José M. Ramírez, María D. Pinazo-Durán, Juan J. Salazar & Ana I. Ramírez. (2021) The Role of Autophagy in Eye Diseases. Life 11:3, pages 189.
Crossref
T Tang, QJ Xia & MR Xi. (2021) Dihydroartemisinin and its anticancer activity against endometrial carcinoma and cervical cancer: involvement of apoptosis, autophagy and transferrin receptor. Singapore Medical Journal 62:2, pages 96-103.
Crossref
Tantai Zhao, Xiaojian Guo & Yun Sun. (2021) Iron Accumulation and Lipid Peroxidation in the Aging Retina: Implication of Ferroptosis in Age-Related Macular Degeneration. Aging and disease 12:2, pages 529.
Crossref
Espérance Moine, Manel Boukhallat, David Cia, Nathalie Jacquemot, Laurent Guillou, Thierry Durand, Joseph Vercauteren, Philippe Brabet & Céline Crauste. (2021) New lipophenols prevent carbonyl and oxidative stresses involved in macular degeneration. Free Radical Biology and Medicine 162, pages 367-382.
Crossref
Gyeoung Jin Kang, Eun Ji Kim & Chang Hoon Lee. (2020) Therapeutic Effects of Specialized Pro-Resolving Lipids Mediators on Cardiac Fibrosis via NRF2 Activation. Antioxidants 9:12, pages 1259.
Crossref
Manuel L. Montero, Jo‐Wen Liu, José Orozco, Carlos A. Casiano & Marino De Leon. (2020) Docosahexaenoic acid protection against palmitic acid‐induced lipotoxicity in NGF‐differentiated PC12 cells involves enhancement of autophagy and inhibition of apoptosis and necroptosis. Journal of Neurochemistry 155:5, pages 559-576.
Crossref
Kai Kaarniranta, Hannu Uusitalo, Janusz Blasiak, Szabolcs Felszeghy, Ram Kannan, Anu Kauppinen, Antero Salminen, Debasish Sinha & Deborah Ferrington. (2020) Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration. Progress in Retinal and Eye Research 79, pages 100858.
Crossref
Paolo Abrescia, Lucia Treppiccione, Mauro Rossi & Paolo Bergamo. (2020) Modulatory role of dietary polyunsaturated fatty acids in Nrf2-mediated redox homeostasis. Progress in Lipid Research 80, pages 101066.
Crossref
Zi-Yuan Zhang, Xiao-Li Bao, Yun-Yi Cong, Bin Fan & Guang-Yu Li. (2020) Autophagy in Age-Related Macular Degeneration: A Regulatory Mechanism of Oxidative Stress. Oxidative Medicine and Cellular Longevity 2020, pages 1-13.
Crossref
Bo Yang, Yan Zhou, Mengjiao Wu, Xueshan Li, Kangsen Mai & Qinghui Ai. (2020) ω-6 Polyunsaturated fatty acids (linoleic acid) activate both autophagy and antioxidation in a synergistic feedback loop via TOR-dependent and TOR-independent signaling pathways. Cell Death & Disease 11:7.
Crossref
Younghyun Lim, Seyoung Kim, Sehoon Kim, Dong-In Kim, Kyung Won Kang, So-Hee Hong, Sang-Myeong Lee, Hye Ran Koh & Young-Jin Seo. (2020) n-3 Polyunsaturated Fatty Acids Impede the TCR Mobility and the TCR–pMHC Interaction of Anti-Viral CD8+ T Cells. Viruses 12:6, pages 639.
Crossref
Jarmo Laihia & Kai Kaarniranta. (2020) Trehalose for Ocular Surface Health. Biomolecules 10:5, pages 809.
Crossref
Yuanzhong Zhang, Yan Yang, Haitao Yu, Min Li, Li Hang & Xinrong Xu. (2020) Apigenin Protects Mouse Retina against Oxidative Damage by Regulating the Nrf2 Pathway and Autophagy. Oxidative Medicine and Cellular Longevity 2020, pages 1-14.
Crossref
Yasukazu Takanezawa, Ryosuke Nakamura, Tomoya Kusaka, Yuka Ohshiro, Shimpei Uraguchi & Masako Kiyono. (2020) Significant contribution of autophagy in mitigating cytotoxicity of gadolinium ions. Biochemical and Biophysical Research Communications 526:1, pages 206-212.
Crossref
Ho Hang Leung, Jean-Marie Galano, Céline Crauste, Thierry Durand & Jetty Chung-Yung Lee. (2020) Combination of Lutein and Zeaxanthin, and DHA Regulated Polyunsaturated Fatty Acid Oxidation in H2O2-Stressed Retinal Cells. Neurochemical Research 45:5, pages 1007-1019.
Crossref
Milan Obradovic, Magbubah Essack, Sonja Zafirovic, Emina Sudar‐Milovanovic, Vladan P. Bajic, Christophe Van Neste, Andreja Trpkovic, Julijana Stanimirovic, Vladimir B. Bajic & Esma R. Isenovic. (2019) Redox control of vascular biology. BioFactors 46:2, pages 246-262.
Crossref
Hyttinen, Kannan, Felszeghy, Niittykoski, Salminen & Kaarniranta. (2019) The Regulation of NFE2L2 (NRF2) Signalling and Epithelial-to-Mesenchymal Transition in Age-Related Macular Degeneration Pathology. International Journal of Molecular Sciences 20:22, pages 5800.
Crossref
Rosell, Giera, Brabet, Shchepinov, Guichardant, Durand, Vercauteren, Galano & Crauste. (2019) Bis-allylic Deuterated DHA Alleviates Oxidative Stress in Retinal Epithelial Cells. Antioxidants 8:10, pages 447.
Crossref
Mostafa Kiamehr, Alexa Klettner, Elisabeth Richert, Ali Koskela, Arto Koistinen, Heli Skottman, Kai Kaarniranta, Katriina Aalto-Setälä & Kati Juuti-Uusitalo. (2019) Compromised Barrier Function in Human Induced Pluripotent Stem-Cell-Derived Retinal Pigment Epithelial Cells from Type 2 Diabetic Patients. International Journal of Molecular Sciences 20:15, pages 3773.
Crossref
Shoubi Wang, Xiaoran Wang, Yaqi Cheng, Weijie Ouyang, Xuan Sang, Jiahui Liu, Yaru Su, Ying Liu, Chaoyang Li, Liu Yang, Lin Jin & Zhichong Wang. (2019) Autophagy Dysfunction, Cellular Senescence, and Abnormal Immune-Inflammatory Responses in AMD: From Mechanisms to Therapeutic Potential. Oxidative Medicine and Cellular Longevity 2019, pages 1-13.
Crossref
Yasukazu Takanezawa, Ryosuke Nakamura, Miho Hamaguchi, Kanae Yamamoto, Yuka Sone, Shimpei Uraguchi & Masako Kiyono. (2019) Docosahexaenoic acid enhances methylmercury-induced endoplasmic reticulum stress and cell death and eicosapentaenoic acid potentially attenuates these effects in mouse embryonic fibroblasts. Toxicology Letters 306, pages 35-42.
Crossref
Eveliina Korhonen, Niina Piippo, Maria Hytti, Juha M.T. Hyttinen, Kai Kaarniranta & Anu Kauppinen. (2019) SQSTM1/p62 regulates the production of IL-8 and MCP-1 in IL-1β-stimulated human retinal pigment epithelial cells. Cytokine 116, pages 70-77.
Crossref
Kai Kaarniranta, Ali Koskela, Szabolcs Felszeghy, Niko Kivinen, Antero Salminen & Anu Kauppinen. (2019) Fatty acids and oxidized lipoproteins contribute to autophagy and innate immunity responses upon the degeneration of retinal pigment epithelium and development of age-related macular degeneration. Biochimie 159, pages 49-54.
Crossref
Kaiping Deng, Caifang Ren, Guomin Zhang, Yanli Zhang, Peihua You, Feng Wang & Yixuan Fan. (2019) Polyphenol Compounds Attenuate High‐Dose PUFA‐Induced Oxidative Damage in Adipocytes. European Journal of Lipid Science and Technology 121:4.
Crossref
Jingjing Cai, He Zhang, Yun-feng Zhang, Zhonglou Zhou & Shengzhou Wu. (2019) MicroRNA-29 enhances autophagy and cleanses exogenous mutant αB-crystallin in retinal pigment epithelial cells. Experimental Cell Research 374:1, pages 231-248.
Crossref
Szabolcs Felszeghy, Johanna Viiri, Jussi J. Paterno, Juha M.T. Hyttinen, Ali Koskela, Mei Chen, Henri Leinonen, Heikki Tanila, Niko Kivinen, Arto Koistinen, Elisa Toropainen, Marialaura Amadio, Adrian Smedowski, Mika Reinisalo, Mateusz Winiarczyk, Jerzy Mackiewicz, Maija Mutikainen, Anna-Kaisa Ruotsalainen, Mikko Kettunen, Kimmo Jokivarsi, Debasish Sinha, Kati Kinnunen, Goran Petrovski, Janusz Blasiak, Geir Bjørkøy, Ari Koskelainen, Heli Skottman, Arto Urtti, Antero Salminen, Ram Kannan, Deborah A. Ferrington, Heping Xu, Anna-Liisa Levonen, Pasi Tavi, Anu Kauppinen & Kai Kaarniranta. (2019) Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration. Redox Biology 20, pages 1-12.
Crossref
Espérance Moine, Philippe Brabet, Laurent Guillou, Thierry Durand, Joseph Vercauteren & Céline Crauste. (2018) New Lipophenol Antioxidants Reduce Oxidative Damage in Retina Pigment Epithelial Cells. Antioxidants 7:12, pages 197.
Crossref
Marcella Neves Dátilo, Marcella Ramos Sant’Ana, Guilherme Pedron Formigari, Patrícia Brito Rodrigues, Leandro Pereira de Moura, Adelino Sanchez Ramos da Silva, Eduardo Rochete Ropelle, José Rodrigo Pauli & Dennys Esper Cintra. (2018) Omega-3 from Flaxseed Oil Protects Obese Mice Against Diabetic Retinopathy Through GPR120 Receptor. Scientific Reports 8:1.
Crossref
Ryoji Yanai, Shang Chen, Sho-Hei Uchi, Tomoaki Nanri, Kip M. Connor & Kazuhiro Kimura. (2018) Attenuation of choroidal neovascularization by dietary intake of ω-3 long-chain polyunsaturated fatty acids and lutein in mice. PLOS ONE 13:4, pages e0196037.
Crossref
Niko Kivinen. (2018) The role of autophagy in age‐related macular degeneration. Acta Ophthalmologica 96:A110, pages 1-50.
Crossref
Yan Yin, Eric Li, George Sun, Hong Q. Yan, Lesley M. Foley, Liwia A. Andrzejczuk, Insiya Y. Attarwala, T. Kevin Hitchens, Kirill Kiselyov, C. Edward Dixon & Dandan Sun. (2017) Effects of DHA on Hippocampal Autophagy and Lysosome Function After Traumatic Brain Injury. Molecular Neurobiology 55:3, pages 2454-2470.
Crossref
Qin M. Chen & Anthony J. Maltagliati. (2018) Nrf2 at the heart of oxidative stress and cardiac protection. Physiological Genomics 50:2, pages 77-97.
Crossref
Kai Kaarniranta, Heping Xu & Anu Kauppinen. (2018) Mechanistical retinal drug targets and challenges. Advanced Drug Delivery Reviews 126, pages 177-184.
Crossref
Jing Wu, Xiaoyun Chen, Xialin Liu, Shan Huang, Chang He, Baoxin Chen & Yizhi Liu. (2017) Autophagy regulates TGF-β2-induced epithelial-mesenchymal transition in human retinal pigment epithelium cells. Molecular Medicine Reports.
Crossref
Li Yao, Jian Wang, Bin‐Yao Tian, Tian‐Hua Xu & Zi‐Tong Sheng. (2017) Retracted : Activation of the Nrf2‐ARE Signaling Pathway Prevents Hyperphosphatemia‐Induced Vascular Calcification by Inducing Autophagy in Renal Vascular Smooth Muscle Cells . Journal of Cellular Biochemistry 118:12, pages 4708-4715.
Crossref
Marcos Roberto de Oliveira, Seyed Fazel Nabavi, Seyed Mohammad Nabavi & Fernanda Rafaela Jardim. (2017) Omega-3 polyunsaturated fatty acids and mitochondria, back to the future. Trends in Food Science & Technology 67, pages 76-92.
Crossref
Sayantan Datta, Marisol Cano, Katayoon Ebrahimi, Lei Wang & James T. Handa. (2017) The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD. Progress in Retinal and Eye Research 60, pages 201-218.
Crossref
Juha M.T. Hyttinen, Janusz Błasiak, Minna Niittykoski, Kati Kinnunen, Anu Kauppinen, Antero Salminen & Kai Kaarniranta. (2017) DNA damage response and autophagy in the degeneration of retinal pigment epithelial cells—Implications for age-related macular degeneration (AMD). Ageing Research Reviews 36, pages 64-77.
Crossref
Kai Kaarniranta, Paulina Tokarz, Ali Koskela, Jussi Paterno & Janusz Blasiak. (2016) Autophagy regulates death of retinal pigment epithelium cells in age-related macular degeneration. Cell Biology and Toxicology 33:2, pages 113-128.
Crossref
Nady Golestaneh, Yi Chu, Yang-Yu Xiao, Gianna L Stoleru & Alexander C Theos. (2017) Dysfunctional autophagy in RPE, a contributing factor in age-related macular degeneration. Cell Death & Disease 8:1, pages e2537-e2537.
Crossref
Satoshi Yoshida. (2017) Structural Significance of Docosahexaenoic Acid. Journal of Lipid Nutrition 26:1, pages 9-25.
Crossref
Dorota Rogińska, Miłosz P. Kawa, Ewa Pius-Sadowska, Renata Lejkowska, Karolina Łuczkowska, Barbara Wiszniewska, Kai Kaarniranta, Jussi J. Paterno, Christian A. Schmidt, Bogusław Machaliński & Anna Machalińska. (2017) Depletion of the Third Complement Component Ameliorates Age-Dependent Oxidative Stress and Positively Modulates Autophagic Activity in Aged Retinas in a Mouse Model. Oxidative Medicine and Cellular Longevity 2017, pages 1-17.
Crossref
Janusz Blasiak, Malgorzata Piechota, Elzbieta Pawlowska, Magdalena Szatkowska, Ewa Sikora & Kai Kaarniranta. (2017) Cellular Senescence in Age-Related Macular Degeneration: Can Autophagy and DNA Damage Response Play a Role?. Oxidative Medicine and Cellular Longevity 2017, pages 1-15.
Crossref
José Carlos Rivera, Rabah Dabouz, Baraa Noueihed, Samy Omri, Houda Tahiri & Sylvain Chemtob. (2017) Ischemic Retinopathies: Oxidative Stress and Inflammation. Oxidative Medicine and Cellular Longevity 2017, pages 1-16.
Crossref
Markus Karlsson & Tino Kurz. (2016) Attenuation of iron-binding proteins in ARPE-19 cells reduces their resistance to oxidative stress. Acta Ophthalmologica 94:6, pages 556-564.
Crossref
Niko Kivinen, Szabolcs Felszeghy, Aino I. Kinnunen, Niko Setälä, Mari Aikio, Kati Kinnunen, Reijo Sironen, Taina Pihlajaniemi, Anu Kauppinen & Kai Kaarniranta. (2016) Absence of collagen XVIII in mice causes age-related insufficiency in retinal pigment epithelium proteostasis. Biogerontology 17:4, pages 749-761.
Crossref
Bin Wei, Qiaoying Huang, Shunrong Huang, Wei Mai & Xiaogang Zhong. (2016) Trichosanthin-induced autophagy in gastric cancer cell MKN-45 is dependent on reactive oxygen species (ROS) and NF-κB/p53 pathway. Journal of Pharmacological Sciences 131:2, pages 77-83.
Crossref
Ali Koskela, Mika Reinisalo, Goran Petrovski, Debasish Sinha, Céline Olmiere, Reijo Karjalainen & Kai Kaarniranta. (2016) Nutraceutical with Resveratrol and Omega-3 Fatty Acids Induces Autophagy in ARPE-19 Cells. Nutrients 8:5, pages 284.
Crossref