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Clinical Toxicology Volume 54, 2016 - Issue 10
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Review

Evidence-based recommendations on the use of intravenous lipid emulsion therapy in poisoning*

Sophie GosselinDepartment of Emergency Medicine, McGill University Health Centre, Montréal, Québec, Canada; ;Centre Antipoison du Québec, Montréal, Québec, Canada; ;Province of Alberta Drug Information Services, Calgary, Alberta, Canada; Correspondence[email protected]
,
Lotte C. G. HoegbergDanish Poisons Information Centre, Anaesthesiology, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark;
,
Robert. S. HoffmanDivision of Medical Toxicology, Ronald O. Perelman Department of Emergency Medicine, New York University School of Medicine, New York, NY, USA;
,
Andis GraudinsMonash Clinical Toxicology Service, Program of Emergency Medicine, Monash Health and School of Clinical Sciences at Monash Health, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia;
,
Christine M. StorkUpstate NY Poison Center, Syracuse, NY, USA; ;Department of Emergency Medicine, Upstate Medical University, Syracuse, New York, USA;
,
Simon H. L. ThomasNational Poisons Information Service (Newcastle) and Medical Toxicology Centre, Institute of Cellular Medicine, Newcastle University, Newcastle, UK;
,
Samuel J. StellpflugDepartment of Emergency Medicine, Regions Hospital, Saint Paul, MN, USA;
,
Bryan D. HayesDepartment of Pharmacy, University of Maryland Medical Center, Baltimore, MD, USA; ;Department of Emergency Medicine, University of Maryland School of Medicine, Baltimore, MD, USA;
,
Michael LevineDepartment of Emergency Medicine, Section of Medical Toxicology, University of Southern California, Los Angeles, CA, USA;
,
Martin MorrisSchulich Library of Science and Engineering, McGill University, Montréal, Québec, Canada;
,
Andrea Nesbitt-MillerSchulich Library of Science and Engineering, McGill University, Montréal, Québec, Canada;
,
Alexis F. TurgeonDivision of Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, and CHU de Québec, Université Laval Research Center, Population Health and Optimal Health Practices Unit, Université Laval, Québec City, Québec, Canada;
,
Benoit BaileyDivision of Emergency Medicine, Department of Pediatrics, CHU Sainte-Justine, Montréal, Québec, Canada; ;Centre Antipoison du Québec, Quebec, Canada;
,
Diane P. CalelloMedical Toxicology, Department of Emergency Medicine, Morristown Medical Center, Emergency Medical Associates, Morristown, NJ, USA;
,
Ryan ChuangDepartment of Emergency Medicine, Division of Clinical Pharmacology and Toxicology, University of Calgary, Poison and Drug Information Service, Calgary, Alberta, Canada;
,
Theodore C. BaniaSt Luke's Roosevelt Hospital, New York, NY, USA;
,
Bruno MégarbaneDepartment of Medical and Toxicological Intensive Care, Lariboisière Hospital, Paris-Diderot University, INSERM UMRS1144, Paris, France;
,
Ashish BhallaDepartment of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India;
&
Valéry LavergneDepartment of Medical Biology, Sacré-Coeur Hospital, University of Montréal, Montréal, Québec, Canada
 show all
Pages 899-923 | Received 11 May 2016, Accepted 13 Jul 2016, Published online: 08 Sep 2016

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Michael E. Mullins. (2023) Lipid emulsion in the poisoned patient – a few answers, but more questions remain. Clinical Toxicology 61:8, pages 565-566.
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Michael Simpson, Andrew Troger, Chris Feng, James D. Whitledge, Michael Monuteaux & Michele M. Burns. (2023) Clinical and electrocardiographic factors associated with adverse cardiovascular events in bupropion exposures. Clinical Toxicology 61:7, pages 529-535.
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Michael Simpson, Linda Johnson & Charlotte Goldfine. (2023) Sodium bicarbonate treatment for QRS widening in bupropion overdoses. Clinical Toxicology 61:6, pages 436-444.
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Kotaro Hori, Tadashi Matsuura, Shogo Tsujikawa, Hideki Hino, Miyuki Kuno, Yutaka Oda, Kiyonobu Nishikawa & Takashi Mori. (2022) Lipid emulsion facilitates reversal from volatile anesthetics in a rodent model. Clinical Toxicology 60:6, pages 716-724.
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Joseph Clemons, Arvinder Jandu, Brandon Stein & Michael Chary. (2022) Efficacy of lipid emulsion therapy in treating cardiotoxicity from diphenhydramine ingestion: a review and analysis of case reports. Clinical Toxicology 60:5, pages 550-558.
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Anselm Wong, Robert S. Hoffman, Steven J. Walsh, Darren M. Roberts, Sophie Gosselin, Timothy E. Bunchman, Sofia Kebede, Valery Lavergne & Marc Ghannoum. (2021) Extracorporeal treatment for calcium channel blocker poisoning: systematic review and recommendations from the EXTRIP workgroup. Clinical Toxicology 59:5, pages 361-375.
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Kanako Noda, Shinji Akioka, Hiroshi Kubo & Hajime Hosoi. (2021) Detoxification with intravenous lipid emulsion for fatal hydroxychloroquine poisoning. Modern Rheumatology 31:3, pages 772-774.
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Robert S. Hoffman, Sophie Gosselin, Eric Villeneuve, Bryan D. Hayes, Lotte C. G. Hoegberg & Susan C. Smolinske. (2020) Comment on Antidotal use of lipid emulsion – the pendulum swings. Clinical Toxicology 58:12, pages 1355-1356.
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Michael E. Mullins & Donna L. Seger. (2020) Antidotal use of lipid emulsion – the pendulum swings. Clinical Toxicology 58:12, pages 1281-1283.
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Susan Smolinske, Robert S. Hoffman, Eric Villeneuve, Lotte C. G. Hoegberg & Sophie Gosselin. (2019) Utilization of lipid emulsion therapy in fatal overdose cases: an observational study. Clinical Toxicology 57:3, pages 197-202.
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Jonathan H. Sin, Andrew Tom, Alexander Toyoda, Nathalie Roy & Bryan D. Hayes. (2018) High-dose intravenous lipid emulsion affecting successful initiation of continuous venovenous hemofiltration and extracorporeal membrane oxygenation. Clinical Toxicology 56:2, pages 149-150.
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Rhadika Souza, Joshua Jauregui & Matthew Valento. (2018) Mixed propranolol and tizanidine overdose treated with intravenous lipid emulsion. Toxicology Communications 2:1, pages 71-74.
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Lotte C. G. Hoegberg, Robert S. Hoffman, Bryan D. Hayes, Valéry Lavergne & Sophie Gosselin. (2017) Letter in response to “Lipid emulsion improves survival in animal models of local anesthetic toxicity: a meta-analysis”. Clinical Toxicology 55:9, pages 1019-1019.
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Daniel J. Corwin, Alexis Topjian, Brenda L. Banwell & Kevin Osterhoudt. (2017) Adverse events associated with a large dose of intravenous lipid emulsion for suspected local anesthetic toxicity. Clinical Toxicology 55:6, pages 603-607.
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Michael E. Mullins. (2016) Advancing the science of antidotal use of lipid emulsion. Clinical Toxicology 54:10, pages 897-898.
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