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Clinical Toxicology Volume 55, 2017 - Issue 6
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Clinical Research

A preliminary study in the alterations of mitochondrial respiration in patients with carbon monoxide poisoning measured in blood cells

David H. JangDivision of Medical Toxicology and Critical Care Medicine, Department of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Correspondence[email protected]
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Matthew KellyDivision of Undersea and Hyperbaric Medicine, Department of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; View further author information
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Kevin HardyDivision of Undersea and Hyperbaric Medicine, Department of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; View further author information
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David S. LambertDivision of Undersea and Hyperbaric Medicine, Department of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; View further author information
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Frances S. ShoferDepartment of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; View further author information
&
David M. EckmannDepartment of Anesthesiology and Critical Care, Institute for Medicine and Engineering, Cardiovascular Institute, Philadelphia, PA, USA; ;Department of Bioengineering, Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA, USAView further author information
Pages 579-584 | Received 15 Dec 2016, Accepted 25 Jan 2017, Published online: 16 Feb 2017

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David H. Jang, Sarah Piel, John C. Greenwood, Matthew Kelly, Vanessa M. Mazandi, Abhay Ranganathan, Yuxi Lin, Jonathan Starr, Thomas Hallowell, Frances S. Shofer, Wesley B. Baker, Alec Lafontant, Kristen Andersen, Johannes K. Ehinger & Todd J. Kilbaugh. (2021) Alterations in cerebral and cardiac mitochondrial function in a porcine model of acute carbon monoxide poisoning. Clinical Toxicology 59:9, pages 801-809.
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Alexander Reisinger, Jasmin Rabensteiner & Gerald Hackl. (2020) Diagnosis of acute intoxications in critically ill patients: focus on biomarkers – part 2: markers for specific intoxications. Biomarkers 25:2, pages 112-125.
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Articles from other publishers (19)

Constantine D. Mavroudis, Alistair Lewis, John C. Greenwood, Matthew Kelly, Tiffany S. Ko, Rodrigo M. Forti, Samuel S. Shin, Frances S. Shofer, Johannes K. Ehinger, Wesley B. Baker, Todd J. Kilbaugh & David H. Jang. (2023) Investigation of Cerebral Mitochondrial Injury in a Porcine Survivor Model of Carbon Monoxide Poisoning. Journal of Medical Toxicology.
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Tanvir Hossain & David M. Eckmann. (2023) Hyperoxic exposure alters intracellular bioenergetics distribution in human pulmonary cells. Life Sciences 328, pages 121880.
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Carolyn Fox, Michael L. Ekaney, Michael Runyon, Hieu M. Nguyen, Philip J. Turk, Iain H. McKillop & Christine M. Murphy. (2023) Assessing Platelet Mitochondrial Dysfunction in a Murine Model of Acute Acetaminophen Toxicity. Journal of Medical Toxicology.
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Alistair Lewis, Rodrigo M. Forti, Oladunni Alomaja, Clementina Mesaros, Sarah Piel, John C. Greenwood, Fatima M. Talebi, Constantine D. Mavroudis, Matthew Kelly, Shih-Han Kao, Frances S. Shofer, Johannes K. Ehinger, Todd J. Kilbaugh, Wesley B. Baker & David H. Jang. (2022) Preliminary Research: Application of Non-Invasive Measure of Cytochrome c Oxidase Redox States and Mitochondrial Function in a Porcine Model of Carbon Monoxide Poisoning. Journal of Medical Toxicology 18:3, pages 214-222.
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Songjiao Li, Ke Yang, Jiayu Zeng, Yuqing Xia, Dan Cheng & Longwei He. (2022) A NIR-emissive probe with a remarkable Stokes shift for CO-releasing molecule-3 detection in cells and in vivo . The Analyst 147:6, pages 1169-1174.
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Jonathan Rutchik & Marcia H. Ratner. 2022. Occupational Neurotoxicology. Occupational Neurotoxicology 257 282 .
David H. Jang, Sarah Piel, John C. Greenwood, Johannes K. Ehinger & Todd J. Kilbaugh. (2021) Emerging cellular-based therapies in carbon monoxide poisoning. American Journal of Physiology-Cell Physiology 321:2, pages C269-C275.
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Adam Green, Tanvir Hossain & David M. Eckmann. (2021) Hyperbaric oxygen alters intracellular bioenergetics distribution in human dermal fibroblasts. Life Sciences 278, pages 119616.
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Shawn Owiredu, Abhay Ranganathan, David M. Eckmann, Frances S. Shofer, Kevin Hardy, David S. Lambert, Matthew Kelly & David H. Jang. (2020) Ex vivo use of cell-permeable succinate prodrug attenuates mitochondrial dysfunction in blood cells obtained from carbon monoxide-poisoned individuals. American Journal of Physiology-Cell Physiology 319:1, pages C129-C135.
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Abhay Ranganathan, Shawn Owiredu, David H. Jang & David M. Eckmann. (2020) Prophylaxis of mitochondrial dysfunction caused by cellular decompression from hyperbaric exposure. Mitochondrion 52, pages 8-19.
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Shawn Owiredu, Abhay Ranganathan, John C. Greenwood, Sarah Piel, Joanna I. Janowska, David M. Eckmann, Matthew Kelly, Johannes K. Ehinger, Todd J. Kilbaugh & David H. Jang. (2020) In vitro comparison of hydroxocobalamin (B12a) and the mitochondrial directed therapy by a succinate prodrug in a cellular model of cyanide poisoning. Toxicology Reports 7, pages 1263-1271.
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Yongjuan Li, Juanjuan Dang, Qiujun Liang & Lichen Yin. (2019) Thermal-Responsive Carbon Monoxide (CO) Delivery Expedites Metabolic Exhaustion of Cancer Cells toward Reversal of Chemotherapy Resistance. ACS Central Science 5:6, pages 1044-1058.
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David H. Jang, John C. Greenwood, Shawn Owiredu, Abhay Ranganathan & David M. Eckmann. (2019) Mitochondrial networking in human blood cells with application in acute care illnesses. Mitochondrion 44, pages 27-34.
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David H. Jang, Utsha G. Khatri, Brenna P. Shortal, Matthew Kelly, Kevin Hardy, David S. Lambert & David M. Eckmann. (2018) Alterations in mitochondrial respiration and reactive oxygen species in patients poisoned with carbon monoxide treated with hyperbaric oxygen. Intensive Care Medicine Experimental 6:1.
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David H. Jang, Shawn Owiredu, Abhay Ranganathan & David M. Eckmann. (2018) Acute decompression following simulated dive conditions alters mitochondrial respiration and motility. American Journal of Physiology-Cell Physiology 315:5, pages C699-C705.
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Song-Jiao Li, Dong-Ye Zhou, Yong-Fei Li, Bin Yang, Juan Ou-Yang, Jia Jie, Juan Liu & Chun-Yan Li. (2018) Mitochondria-targeted near-infrared fluorescent probe for the detection of carbon monoxide in vivo. Talanta 188, pages 691-700.
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David H. Jang, Utsha G. Khatri, Anita Mudan, Jennifer S. Love, Shawn Owiredu & David M. Eckmann. (2018) Translational Application of Measuring Mitochondrial Functions in Blood Cells Obtained from Patients with Acute Poisoning. Journal of Medical Toxicology 14:2, pages 144-151.
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Ntambwe Malangu. 2017. Poisoning - From Specific Toxic Agents to Novel Rapid and Simplified Techniques for Analysis. Poisoning - From Specific Toxic Agents to Novel Rapid and Simplified Techniques for Analysis.
David H. Jang, Sarah C. Seeger, Martha E. Grady, Frances S. Shofer & David M. Eckmann. (2017) Mitochondrial dynamics and respiration within cells with increased open pore cytoskeletal meshes. Biology Open 6:12, pages 1831-1839.
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