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Clinical Research

Is naloxone the best antidote to reverse tramadol-induced neuro-respiratory toxicity in overdose? An experimental investigation in the rat

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Pages 737-743 | Received 23 Aug 2017, Accepted 30 Oct 2017, Published online: 17 Nov 2017

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Weniko Caré, Alexane Tangre, Laurène Dufayet, Béranger Lekens, Hervé Laborde-Casterot, Jérôme Langrand, Bruno Mégarbane & Dominique Vodovar. (2022) Exposure to immediate-release tramadol in children 6 years and under – a nationwide French poison control center study. Clinical Toxicology 60:6, pages 750-758.
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Mohsen Doostmohammadi & Hamid-Reza Rahimi. (2020) ADME and toxicity considerations for tramadol: from basic research to clinical implications. Expert Opinion on Drug Metabolism & Toxicology 16:7, pages 627-640.
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Samaneh Nakhaee, Jeffrey Brent, Christopher Hoyte, Khadijeh Farrokhfall, Farshad M Shirazi, Masoumeh Askari & Omid Mehrpour. (2020) The effect of tramadol on blood glucose concentrations: a systematic review. Expert Review of Clinical Pharmacology 13:5, pages 531-543.
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Bruno Mégarbane, Ahmed S. Gouda & Nagla A. El-Nabarawy. (2019) Understanding the risk of seizure in tramadol overdose: still a long way to go. Clinical Toxicology 57:12, pages 1161-1162.
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Samaneh Nakhaee, Alireza Amirabadizadeh, Jeffrey Brent, Ebrahim Miri-Moghaddam, Mohsen Foadoddini, Khadijeh Farrokhfall, Mehran Hosseini, Mohammad Abdollahi & Omid Mehrpour. (2019) Tramadol and the occurrence of seizures: a systematic review and meta-analysis. Critical Reviews in Toxicology 49:8, pages 710-723.
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Brian Patrick Murray, Joseph E. Carpenter, Camille A. Dunkley, Tim P. Moran, Musa Alfaifi, Waleed S. Alsukaiti & Ziad Kazzi. (2019) Seizures in tramadol overdoses reported in the ToxIC registry: predisposing factors and the role of naloxone. Clinical Toxicology 57:8, pages 692-696.
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Articles from other publishers (12)

Shaimaa A. ElShebiney, Rania Elgohary, Sayed H. Kenawy, Gehan T. El-Bassyouni & Esmat M. A. Hamzawy. (2023) Zinc oxide calcium silicate composite attenuates acute tramadol toxicity in mice. BMC Pharmacology and Toxicology 24:1.
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Ehsan Sakhaee, Ali Amirahmadi, Morteza Mahdiani, Maziar Shojaei, Hossein Hassanian‐Moghaddam, Roman Bauer, Nasim Zamani, Hossein Pakdaman & Kourosh Gharagozli. (2022) Developing a novel prediction model in opioid overdose using machine learning; a pilot analytical study. Health Science Reports 5:5.
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Lance Ruhter, Matthew Juhascik, Jennifer Watson, Kaylin Sweeney & Raminta Daniulaityte. (2022) Tramadol in seized drugs containing non-pharmaceutical fentanyl: Crime lab data from Ohio, USA. Emerging Trends in Drugs, Addictions, and Health 2, pages 100042.
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Robert Garnier & Bruno Mégarbane. 2022. History of Modern Clinical Toxicology. History of Modern Clinical Toxicology 431 439 .
Samaneh Nakhaee, Khadijeh Farrokhfall, Ebrahim Miri-Moghaddam, Mohsen Foadoddini, Masoumeh Askari & Omid Mehrpour. (2021) The effects of quercetin on seizure, inflammation parameters and oxidative stress in acute on chronic tramadol intoxication. BMC Pharmacology and Toxicology 22:1.
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Samaneh Nakhaee, Khadijeh Farrokhfall, Ebrahim Miri-Moghaddam, Masoumeh Askari, Alireza Amirabadizadeh, Mohsen Foadoddini & Omid Mehrpour. (2021) Effects of naloxone and diazepam on blood glucose levels in tramadol overdose using generalized estimating equation (GEE) model; (an experimental study). BMC Endocrine Disorders 21:1.
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Sabrine Bilel, Micaela Tirri, Raffaella Arfè, Chiara Sturaro, Anna Fantinati, Virginia Cristofori, Tatiana Bernardi, Federica Boccuto, Marco Cavallo, Alessandro Cavalli, Fabio De-Giorgio, Girolamo Calò & Matteo Marti. (2021) In Vitro and In Vivo Pharmaco-Toxicological Characterization of 1-Cyclohexyl-x-methoxybenzene Derivatives in Mice: Comparison with Tramadol and PCP. International Journal of Molecular Sciences 22:14, pages 7659.
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Samaneh Nakhaee, Christopher Hoyte, Richard C. Dart, Masoumeh Askari, Roland J. Lamarine & Omid Mehrpour. (2021) A review on tramadol toxicity: mechanism of action, clinical presentation, and treatment. Forensic Toxicology 39:2, pages 293-310.
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Richard J. Bodnar. (2020) Endogenous Opiates and Behavior: 2018. Peptides 132, pages 170348.
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D. Vodovar, J. Langrand, N. Tournier & B. Mégarbane. (2019) La crise des overdoses américaines : une menace pour la France ?. La Revue de Médecine Interne 40:6, pages 389-394.
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D. Vodovar, C. Lagard, L. Chevillard, J. Callebert, H. Liang, P. Risède, N. Tournier & B. Mégarbane. (2019) Modulation allostérique négative des récepteurs GABA-A à l’origine des convulsions induites par le tramadol ? Une étude par tomographie par émission de positons et 11C-flumazenil chez le rat. Toxicologie Analytique et Clinique 31:2, pages S53.
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Dominique Vodovar & Bruno Mégarbane. (2019) Seizures induced by tramadol overdose: what is the respective contribution of tramadol and each of its metabolites?. Drug Metabolism and Personalized Therapy 34:1.
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