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Case Report

QT Prolongation and delayed atrioventricular conduction caused by acute ingestion of trazodone

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Pages 71-73 | Received 04 Oct 2006, Accepted 12 Feb 2007, Published online: 20 Jan 2009

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Nicholas Husak, James Brewer Leonard, Hyunuk Seung & Wendy Klein-Schwartz. (2022) Single-substance trazodone exposures reported to US poison centers from 2000 to 2019. Clinical Toxicology 60:9, pages 1032-1038.
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Sharan L. Campleman, Jeffery Brent, Anthony F. Pizon, Joshua Shulman, Paul Wax & Alex F. Manini. (2020) Drug-specific risk of severe QT prolongation following acute drug overdose. Clinical Toxicology 58:12, pages 1326-1334.
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Bhesh Raj Karki, Paritosh Prasai, Asim Ruhela & Yub Raj Sedhai. (2020) Trazodone overdose–induced Prinzmetal’s angina pectoris. Baylor University Medical Center Proceedings 33:1, pages 75-76.
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Maria Paneta & William Stephen Waring. (2019) Literature review of the evidence regarding intravenous lipid administration in drug-induced cardiotoxicity. Expert Review of Clinical Pharmacology 12:7, pages 591-602.
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Tharwat El Zahran, Brent W. Morgan, Stephanie Hon, Lloyd Herrington & Robert J. Geller. (2019) Unintentional trazodone overdoses in children ≤6 years of age: data from poison center over a period of 16 years. Clinical Toxicology 57:1, pages 56-59.
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W Stephen Waring. (2012) Clinical use of antidepressant therapy and associated cardiovascular risk. Drug, Healthcare and Patient Safety 4, pages 93-101.
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Letizia Bossini, Ilaria Casolaro, Despoina Koukouna, Federica Cecchini & Andrea Fagiolini. (2012) Off-label uses of trazodone: a review. Expert Opinion on Pharmacotherapy 13:12, pages 1707-1717.
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W Stephen Waring. (2012) Intravenous lipid administration for drug-induced toxicity: a critical review of the existing data. Expert Review of Clinical Pharmacology 5:4, pages 437-444.
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Articles from other publishers (31)

Eduardo J. Benjamin, O. Lynne Nelson, Ryan Baumwart & Jillian Haines. (2023) Adverse effects of trazodone in dogs on primary hemostasis and electrocardiogram: A single‐blinded placebo‐controlled crossover study. Journal of Veterinary Internal Medicine 37:6, pages 2131-2136.
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Gaurav Mohan, Ashika Ajitkumar, Poorva Bhide, Jayashree Ravilla & Violet Kramer. (2023) Trazodone Overdose Manifesting as Hypotension and QT Prolongation. Cureus.
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西方 亮太郎吉川 慧西沢 良平海田 賢彦松田 剛明山口 芳裕. (2022) トラゾドン塩酸塩の過量内服により致死性不整脈を呈した1例(Trazodone overdose–induced life–threatening arrhythmia: a case report). Nihon Kyukyu Igakukai Zasshi: Journal of Japanese Association for Acute Medicine 33:12, pages 1022-1027.
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David M. Taylor, Thomas R. E. Barnes & Allan H. Young. 2021. The Maudsley Prescribing Guidelines in Psychiatry. The Maudsley Prescribing Guidelines in Psychiatry 875 895 .
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Wayne A. Ray, Cecilia P. Chung, Katherine T. Murray, Beth A. Malow, James R. Daugherty & C. Michael Stein. (2021) Mortality and concurrent use of opioids and hypnotics in older patients: A retrospective cohort study. PLOS Medicine 18:7, pages e1003709.
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Alexandria Arnold, Ashley Davis, Tina Wismer & Justine A. Lee. (2020) Suspected hepatotoxicity secondary to trazodone therapy in a dog. Journal of Veterinary Emergency and Critical Care 31:1, pages 112-116.
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Roger Taylor, Joshua Burg & Jeff Mullen. (2020) A Case of Trazodone Overdose Successfully Rescued With Lipid Emulsion Therapy. Cureus.
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Alexandra Warnant, Ludovic Gerard, Vincent Haufroid & Philippe Hantson. (2020) Coma Reversal After Intravenous Lipid Emulsion Therapy in a Trazodone-Poisoned Patient. Clinical Neuropharmacology 43:1, pages 31-33.
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Luis David Camacho, Jack Stearns & Richard Amini. (2019) Management of Trazodone Overdose with Severe Hypotension. Case Reports in Emergency Medicine 2019, pages 1-3.
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O Atli, V Kilic, M Baysal, G Kilic, G Gormus, S Ucarcan, B Korkut & S Ilgin. (2018) Assessment of trazodone-induced cardiotoxicity after repeated doses in rats. Human & Experimental Toxicology 38:1, pages 45-55.
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Xiao-yan Yi, Shi-fen Ni, Mohammad Rasoul Ghadami, Hua-qing Meng, Ming-yan Chen, Li Kuang, Yu-qing Zhang, Li Zhang & Xin-yu Zhou. (2018) Trazodone for the treatment of insomnia: a meta-analysis of randomized placebo-controlled trials. Sleep Medicine 45, pages 25-32.
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S V Ivanov, B A Volel, E A Syrkina, E S Ternovaya, D V Troshina, M V Grubova, I A Tolkacheva, A N Rozhkov & A N Simonov. (2017) A retrospective historical study evaluating the safe use of current antidepressants in cardiology practice. Terapevticheskii arkhiv 89:12, pages 34-42.
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Miriam Saiz-Rodríguez, Carmen Belmonte, Nieves Derqui-Fernández, Teresa Cabaleiro, Manuel Román, Dolores Ochoa, María Talegón, María C Ovejero-Benito & Francisco Abad-Santos. (2017) Pharmacogenetics of trazodone in healthy volunteers: association with pharmacokinetics, pharmacodynamics and safety. Pharmacogenomics 18:16, pages 1491-1502.
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Kai G. Kahl, Mechthild Westhoff-Bleck & Tillmann H.C. Krüger. (2017) Effects of psychopharmacological treatment with antidepressants on the vascular system. Vascular Pharmacology 96-98, pages 11-18.
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Andrew H. Dawson. 2017. Critical Care Toxicology. Critical Care Toxicology 1027 1039 .
Sa'ed H. Zyoud, W. Stephen Waring, Samah W. Al-Jabi, Waleed M. Sweileh, Belal Rahhal & Rahmat Awang. (2016) Intravenous Lipid Emulsion as an Antidote for the Treatment of Acute Poisoning: A Bibliometric Analysis of Human and Animal Studies. Basic & Clinical Pharmacology & Toxicology 119:5, pages 512-519.
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S Lee, H-A Lee, SJ Kim & K-S Kim. (2015) Cellular mechanisms for trazodone-induced cardiotoxicity. Human & Experimental Toxicology 35:5, pages 501-510.
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Scott R. Beach, Christopher M. Celano, Jeff C. Huffman & Theodore A. Stern. 2016. Handbook of Psychocardiology. Handbook of Psychocardiology 1043 1059 .
Andrew H. Dawson. 2016. Critical Care Toxicology. Critical Care Toxicology 1 13 .
Iain M. McIntyre, Phyllis Mallett & Robert Stabley. (2015) Postmortem distribution of trazodone concentrations. Forensic Science International 251, pages 195-201.
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Naoya Miura, Takeshi Saito, Takayuki Taira, Rimako Umebachi & Sadaki Inokuchi. (2015) Risk factors for QT prolongation associated with acute psychotropic drug overdose. The American Journal of Emergency Medicine 33:2, pages 142-149.
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Cynthia M. Cooper & Jason M. Baron. (2015) Case 4-2015. New England Journal of Medicine 372:5, pages 465-473.
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Scott R. Beach, Christopher M. Celano, Jeff C. Huffman & Theodore A. Stern. 2015. Handbook of Psychocardiology. Handbook of Psychocardiology 1 17 .
Bo Sung KimSu Young KimSeung Hee HanHe Kyung ParkDong Hyun LeeJong Sung Park. (2013) Delayed-Onset Complete Atrioventricular Block in a Patient with Murine Typhus Myocarditis. Korean Journal of Medicine 84:5, pages 723.
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Tien-Chun Li, Hsiu-Wen Chiu, Kai-Jen Ho & Dong-Sheng Tzeng. (2011) Bradycardia following a single low dose of trazodone. Asian Journal of Psychiatry 4:1, pages 77-79.
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J. Michael Bostwick. (2010) A Generalist's Guide to Treating Patients With Depression With an Emphasis on Using Side Effects to Tailor Antidepressant Therapy. Mayo Clinic Proceedings 85:6, pages 538-550.
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David Taylor, Carol Paton & Shitij Kapur. 2009. The Maudsley Prescribing Guidelines, Tenth Edition. The Maudsley Prescribing Guidelines, Tenth Edition 464 516 .
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Francina Fonseca, Julio Marti-Almor, Antoni Pastor, Mercè Cladellas, Magí Farré, Rafael de la Torre & Marta Torrens. (2009) Prevalence of long QTc interval in methadone maintenance patients. Drug and Alcohol Dependence 99:1-3, pages 327-332.
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