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Clinical Toxicology Volume 46, 2008 - Issue 1
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Research Article

Treatment of experimental verapamil poisoning with levosimendan utilizing a rodent model of drug toxicity

Andis Graudins Clinical and Experimental Toxicology Unit and Department of Emergency Medicine, Prince of Wales Hospital, Randwick, Australia; Prince of Wales Clinical School, Faculty of Medicine, University of New South Wales, Kensington, Australia; The School of Medical Sciences, Faculty of Medicine, University of New South Wales, Kensington, Australia
, FACMT , MBBS (Hons) Ph.D. , FACEM,
Javad Najafi Clinical and Experimental Toxicology Unit and Department of Emergency Medicine, Prince of Wales Hospital, Randwick, Australia
, MBBS &
Michael Perry M. Rur-sc The School of Medical Sciences, Faculty of Medicine, University of New South Wales, Kensington, Australia
, Ph.D.
Pages 50-56 | Received 27 Jun 2006, Accepted 02 Mar 2007, Published online: 01 Mar 2010

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Ola E. Nafea & Heba A. Hassan. (2019) Comparative effectiveness of methylene blue versus intravenous lipid emulsion in a rodent model of amlodipine toxicity. Clinical Toxicology 57:9, pages 784-789.
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M. St-Onge, P.-A. Dubé, S. Gosselin, C. Guimont, J. Godwin, P. M. Archambault, J.-M. Chauny, A. J. Frenette, M. Darveau, N. Le sage, J. Poitras, J. Provencher, D. N. Juurlink & R. Blais. (2014) Treatment for calcium channel blocker poisoning: A systematic review. Clinical Toxicology 52:9, pages 926-944.
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Yasmean Kalam & Andis Graudins. (2012) The effects of fructose-1,6-diphosphate on haemodynamic parameters and survival in a rodent model of propranolol and verapamil poisoning. Clinical Toxicology 50:7, pages 546-554.
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Articles from other publishers (17)

Carsten Lott, Anatolij Truhlář, Anette Alfonzo, Alessandro Barelli, Violeta González-Salvado, Jochen Hinkelbein, Jerry P. Nolan, Peter Paal, Gavin D. Perkins, Karl-Christian Thies, Joyce Yeung, David A. Zideman & Jasmeet Soar. (2021) Kreislaufstillstand unter besonderen UmständenCardiac arrest under special circumstances. Notfall + Rettungsmedizin 24:4, pages 447-523.
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Carsten Lott, Anatolij Truhlář, Annette Alfonzo, Alessandro Barelli, Violeta González-Salvado, Jochen Hinkelbein, Jerry P. Nolan, Peter Paal, Gavin D. Perkins, Karl-Christian Thies, Joyce Yeung, David A. Zideman, Jasmeet Soar, Gamal Eldin Abbas Khalifa, Efrén Álvarez, Roberta Barelli, Joost J.L.M. Bierens, Bernd Boettiger, Guttorm Brattebø, Douglas Browne, Hermann Brugger, Tomasz Darocha, Charles D. Deakin, Joel Dunning, Silvija Hunyadi-Anticevic, Rudolph W. Koster, David J. Lockey, Mathieu Pasquier & Jan Schmitz. (2021) European Resuscitation Council Guidelines 2021: Cardiac arrest in special circumstances. Resuscitation 161, pages 152-219.
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Fiqry Fadhlillah & Shashank Patil. (2018) Pharmacological and mechanical management of calcium channel blocker toxicity. BMJ Case Reports, pages bcr-2018-225324.
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Maude St-OngeKurt Anseeuw, Frank Lee CantrellIan C. GilchristPhilippe HantsonBenoit BaileyValéry LavergneSophie GosselinWilliam KernsMartin LalibertéEric J. LavonasDavid N. JuurlinkJohn MuscedereChen-Chang Yang, Tasnim SinuffMichael RiederBruno Mégarbane. (2017) Experts Consensus Recommendations for the Management of Calcium Channel Blocker Poisoning in Adults. Critical Care Medicine 45:3, pages e306-e315.
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Florian Eyer. 2017. Critical Care Toxicology. Critical Care Toxicology 295 323 .
Florian Eyer. 2016. Critical Care Toxicology. Critical Care Toxicology 1 30 .
Florian Eyer. 2016. Critical Care Toxicology. Critical Care Toxicology 1 30 .
Sule Ozbilgin, Mucahit Ozbilgin, Beyza Kucukoztas, Gonca Kamaci, Tarkan Unek, Bülent Serhan Yurtlu, Mehmet Ensari Güneli, Volkan Hanci & Ali Gunerli. (2013) Evaluation of the Effectiveness of Sugammadex for Verapamil Intoxication. Basic & Clinical Pharmacology & Toxicology 113:4, pages 280-285.
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Y Kalam & A Graudins. (2012) Levosimendan infusion improves cardiac output but not blood pressure in a rodent model of severe metoprolol toxicity. Human & Experimental Toxicology 31:9, pages 955-963.
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Yasmean Kalam & Andis Graudins. (2012) Levosimendan Does Not Improve Cardiac Output or Blood Pressure in a Rodent Model of Propranolol Toxicity When Administered Using Various Dosing Regimens. International Journal of Toxicology 31:2, pages 166-174.
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Andis Graudins & Kathy Ka Ling Wong. (2010) Comparative Hemodynamic Effects of Levosimendan Alone and in Conjunction with 4-Aminopyridine or Calcium Chloride in a Rodent Model of Severe Verapamil Poisoning. Journal of Medical Toxicology 6:2, pages 85-93.
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Mirjam Osthoff, Christine Bernsmeier, Stephan C. Marsch & Patrick R. Hunziker. (2010) Levosimendan as Treatment Option in Severe Verapamil Intoxication: A Case Report and Review of the Literature. Case Reports in Medicine 2010, pages 1-3.
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Juha Aittomäki, Sasu Liuhanen, Marko Sallisalmi, Markku T. Salmenperä, James E. Heavner & Per H. Rosenberg. (2010) The Effect of Levosimendan on Bupivacaine-Induced Severe Myocardial Depression in Anesthetized Pigs. Regional Anesthesia and Pain Medicine 35:1, pages 34-40.
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Tero Varpula, Janne Rapola, Marko Sallisalmi & Jouni Kurola. (2009) Levosimendan for Calcium Channel Blocker Poisoning in Humans. Anesthesia & Analgesia 109:3, pages 992-993.
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Tamara R. Espinoza, Allan R. Mottram & Sean M. Bryant. (2009) Levosimendan for Calcium Channel Blocker Poisoning in Humans. Anesthesia & Analgesia 109:3, pages 992.
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Andis Graudins. (2009) Letter regarding levosimendan in a rat model of severe verapamil poisoning. Journal of Medical Toxicology 5:3, pages 175-175.
Crossref
Markku Salmenperä & Heidi Eriksson. (2009) Levosimendan in perioperative and critical care patients. Current Opinion in Anaesthesiology 22:4, pages 496-501.
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