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Clinical Toxicology Volume 46, 2008 - Issue 7
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Practice Guideline

Valproic acid poisoning: An evidence-based consensus guideline for out-of-hospital management

Anthony S. Manoguerra American Association of Poison Control Centers, Washington, District of Columbia, USA
, Pharm.D.,
Andrew R. Erdman American Association of Poison Control Centers, Washington, District of Columbia, USA
, M.D.,
Alan D. Woolf American Association of Poison Control Centers, Washington, District of Columbia, USA
, M.P.H. , M.D.,
Peter A. Chyka American Association of Poison Control Centers, Washington, District of Columbia, USA
, Pharm.D.,
E. Martin Caravati American Association of Poison Control Centers, Washington, District of Columbia, USA
, M.P.H. , M.D.,
Elizabeth J. Scharman American Association of Poison Control Centers, Washington, District of Columbia, USA
, Pharm.D.,
Lisa L. Booze American Association of Poison Control Centers, Washington, District of Columbia, USA
, Pharm.D.,
Gwenn Christianson American Association of Poison Control Centers, Washington, District of Columbia, USA
, M.S.N.,
Lewis S. Nelson American Association of Poison Control Centers, Washington, District of Columbia, USA
, M.D.,
Daniel J. Cobaugh American Association of Poison Control Centers, Washington, District of Columbia, USA
, M.P.H. , Pharm.D. &
William G. Troutman American Association of Poison Control Centers, Washington, District of Columbia, USA
, Pharm.D. show all
Pages 661-676 | Received 22 Dec 2006, Accepted 01 May 2008, Published online: 20 Jan 2009

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Ahmad Salimi, Nasrin Alyan, Nasim Akbari, Zhaleh Jamali & Jalal Pourahmad. (2022) Selenium and L-carnitine protects from valproic acid-Induced oxidative stress and mitochondrial damages in rat cortical neurons. Drug and Chemical Toxicology 45:3, pages 1150-1157.
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Shaikha Al Jawder, Eiman AlJishi, Shaikhah Al-Otaibi & Mohammed S Al-Shahrani. (2018) All guns blazing: management and survival of massive valproic acid overdose - case report and literature review. Open Access Emergency Medicine 10, pages 31-36.
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Verena Schrettl, Norbert Felgenhauer, Christian Rabe, Malkanthi Fernando & Florian Eyer. (2017) L-Arginine in the treatment of valproate overdose – five clinical cases. Clinical Toxicology 55:4, pages 260-266.
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Jigar Patel, Ivan Berezowski, Maryann Mazer-Amirshahi, Sarah E. Frasure, Quincy K. Tran & Ali Pourmand. (2022) Valproic Acid Overdose: Case Report and Literature Review. The Journal of Emergency Medicine 63:5, pages 651-655.
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Soodabeh Kheirkhah & Kiumars Bahmani. (2020) A rare case of fenpyroximate poisoning with presenting anticholinesterase poisoning signs. Clinical Case Reports 8:12, pages 2406-2408.
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Amberly R. Johnson, Casey R. Tak, Kathleen Anderson, Bradley Dahl, Cathie Smith & Barbara I. Crouch. (2020) Poison-related visits in a pediatric emergency department: A retrospective analysis of patients who bypass poison control centers. The American Journal of Emergency Medicine 38:8, pages 1554-1559.
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Silvia Ferranti, Elisabetta Grande, Carla Gaggiano & Salvatore Grosso. (2018) Antiepileptic drugs: Role in paediatric poisoning. Journal of Paediatrics and Child Health 54:5, pages 475-479.
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Simone E. Dekker, Vahagn C. Nikolian, Martin Sillesen, Ted Bambakidis, Patrick Schober & Hasan B. Alam. (2017) Different resuscitation strategies and novel pharmacologic treatment with valproic acid in traumatic brain injury. Journal of Neuroscience Research 96:4, pages 711-719.
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Maxime Doré, Adriana E. San Juan, Anne Julie Frenette & David Williamson. (2017) Clinical Importance of Monitoring Unbound Valproic Acid Concentration in Patients with Hypoalbuminemia. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 37:8, pages 900-907.
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Tom MunyerJames Leonard & Bruce Anderson. 2017. PharmacotherapyFirst: A Multimedia Learning Resource. PharmacotherapyFirst: A Multimedia Learning Resource.
Toby Litovitz, Blaine E. Benson & Susan Smolinske. (2016) webPOISONCONTROL: can poison control be automated?. The American Journal of Emergency Medicine 34:8, pages 1614-1619.
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. 2016. Meyler's Side Effects of Drugs. Meyler's Side Effects of Drugs 303 337 .
Zahra Tolou-Ghamari & Abbas Ali Palizban. (2015) Review of Sodium Valproate Clinical and Biochemical Properties. Zahedan Journal of Research in Medical Sciences 17:8.
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MEIYING JI, EUN JEOUNG LEE, KI BAE KIM, YANGMI KIM, ROHYUN SUNG, SANG-JEON LEE, DON SOO KIM & SEON MEE PARK. (2015) HDAC inhibitors induce epithelial-mesenchymal transition in colon carcinoma cells. Oncology Reports 33:5, pages 2299-2308.
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Joseph Villarreal, Christopher A. Kahn, James V. Dunford, Ekta Patel & Richard F. Clark. (2015) A retrospective review of the prehospital use of activated charcoal. The American Journal of Emergency Medicine 33:1, pages 56-59.
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D. G. Cunningham Owens. 2014. A Guide to the Extrapyramidal Side-Effects of Antipsychotic Drugs. A Guide to the Extrapyramidal Side-Effects of Antipsychotic Drugs 13 34 .
D. G. Cunningham Owens. 2014. A Guide to the Extrapyramidal Side-Effects of Antipsychotic Drugs. A Guide to the Extrapyramidal Side-Effects of Antipsychotic Drugs 1 34 .
S. Chateauvieux, F. Morceau & M. Diederich. 2014. Encyclopedia of Toxicology. Encyclopedia of Toxicology 905 908 .
Janice E. Sullivan & Mark J. McDonald. 2014. Pediatric Critical Care Medicine. Pediatric Critical Care Medicine 695 727 .
Nasim Zamani & Omid Mehrpour. (2013) Outpatient treatment of the poisoned patients in Iran; may it be a feasible plan?. DARU Journal of Pharmaceutical Sciences 21:1.
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M. Maignan & V. Danel. (2013) Prise en charge préhospitalière des intoxications aiguës gravesSevere poisoning management in the prehospital setting. Annales françaises de médecine d'urgence 3:2, pages 95-102.
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Jeannie M. Padowski & Gary M. Pollack. (2012) Influence of Enterohepatic Recycling on the Time Course of Brain-to-Blood Partitioning of Valproic Acid in Rats. Drug Metabolism and Disposition 40:9, pages 1846-1853.
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O. Brissaud, J. Naud & F. Villega. (2011) Intoxications médicamenteuses de l'enfant. EMC - Médecine d 'urgence 6:1, pages 1-18.
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Gaetano Zaccara & Luciana Tramacere. 2011. A worldwide yearly survey of new data in adverse drug reactions. A worldwide yearly survey of new data in adverse drug reactions 125 204 .
Melissa Carran. (2009) Anticonvulsant overdose: Can we shorten the coma?*. Critical Care Medicine 37:12, pages 3187-3188.
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Sang Cheon ChoiJung Hwan AhnYoon Seok JungYoung Gi Min. (2009) A Case of Valproic Acid Overdose Treated with Continuous Veno-Venous Hemodiafiltration - A Case Report -. The Korean Journal of Critical Care Medicine 24:2, pages 99.
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Horst Berzewski. 2009. Der psychiatrische Notfall. Der psychiatrische Notfall 187 257 .

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