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The World Journal of Biological Psychiatry Volume 10, 2009 - Issue 3
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Original Investigations

Inappropriate crying and laughing in Parkinson disease and movement disorders

Mustafa S. Siddiqui Department of Neurology, Wake Forest University School of Medicine, Winston-Salem, NC, USA; Departments of Neurology
,
Hubert H. Fernandez Departments of Neurology
,
Cynthia W. Garvan Division of Biostatistics, College of Medicine, University of Florida, Gainesville, FL, USA
,
Lindsey Kirsch-Darrow Clinical and Health Psychology
,
Dawn Bowers Clinical and Health Psychology
,
Ramon L. Rodriguez Departments of Neurology
,
Charles E. Jacobson IV Departments of Neurology
,
Christian Rosado Departments of Neurology
,
Swetha Vaidyanathan Departments of Neurology
,
Kelly D. Foote Department of Neurosurgery, Movement Disorders Center, McKnight Brain Institute, University of Florida, Gainesville, FL, USA
&
Michael S. Okun Departments of Neurology; Department of Neurosurgery, Movement Disorders Center, McKnight Brain Institute, University of Florida, Gainesville, FL, USACorrespondence[email protected]
, MD show all
Pages 234-240 | Received 12 Jun 2007, Published online: 13 Aug 2009

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Sophie Fitzgerald, Fergus Gracey, Emma Trigg & Niall Broomfield. (2023) Predictors and correlates of emotionalism across acquired and progressive neurological conditions: A systematic review. Neuropsychological Rehabilitation 33:5, pages 945-987.
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Peter Bede & Eoin Finegan. (2018) Revisiting the pathoanatomy of pseudobulbar affect: mechanisms beyond corticobulbar dysfunction. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 19:1-2, pages 4-6.
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Rachel Schwartz & Marc D. Pell. (2017) When emotion and expression diverge: The social costs of Parkinson’s disease. Journal of Clinical and Experimental Neuropsychology 39:3, pages 211-230.
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Kerri A Schoedel, Sarah A Morrow & Edward M Sellers. (2014) Evaluating the safety and efficacy of dextromethorphan/quinidine in the treatment of pseudobulbar affect. Neuropsychiatric Disease and Treatment 10, pages 1161-1174.
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Gary L. Pattee, James P. Wymer, Catherine Lomen-Hoerth, Stanley H. Appel, Andrea E. Formella & Laura E. Pope. (2014) An open-label multicenter study to assess the safety of dextromethorphan/quinidine in patients with pseudobulbar affect associated with a range of underlying neurological conditions. Current Medical Research and Opinion 30:11, pages 2255-2265.
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Rebecca R King & Jeffrey P Reiss. (2013) The epidemiology and pathophysiology of pseudobulbar affect and its association with neurodegeneration. Degenerative Neurological and Neuromuscular Disease 3, pages 23-31.
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Ariel Miller, Hillel Pratt & Randolph B Schiffer. (2011) Pseudobulbar affect: the spectrum of clinical presentations, etiologies and treatments. Expert Review of Neurotherapeutics 11:7, pages 1077-1088.
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Articles from other publishers (26)

Fardin Nabizadeh, Mahsa Nikfarjam, Mobin Azami, Hossein Sharifkazemi & Fatemeh Sodeifian. (2022) Pseudobulbar affect in neurodegenerative diseases: A systematic review and meta-analysis. Journal of Clinical Neuroscience 100, pages 100-107.
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Ophir Keret. 2022. Encyclopedia of Behavioral Neuroscience, 2nd edition. Encyclopedia of Behavioral Neuroscience, 2nd edition 115 130 .
Hendrik Lintel, Timothy Corpuz, Saif-ur-Rahman Paracha & George T. Grossberg. (2021) Mood Disorders and Anxiety in Parkinson’s Disease: Current Concepts. Journal of Geriatric Psychiatry and Neurology 34:4, pages 280-288.
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LingYu Zhang, Bei Cao, Qian-Qian Wei, RuWei Ou, Bi Zhao, Jing Yang, Ying Wu & HuiFang Shang. (2021) Pathological laughter and crying in multiple system atrophy with different subtypes: Frequency and related factors. Journal of Affective Disorders 283, pages 60-65.
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Dinesh Saini, Adreesh Mukherjee, Arijit Roy & Atanu Biswas. (2020) A Comparative Study of the Behavioral Profile of the Behavioral Variant of Frontotemporal Dementia and Parkinson’s Disease Dementia. Dementia and Geriatric Cognitive Disorders Extra 10:3, pages 182-194.
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Natalia Ospina-García, Marisa Escobar-Barrios, Mayela Rodríguez-Violante, Juan Benitez-Valenzuela & Amin Cervantes-Arriaga. (2020) Neuropsychiatric profile of patients with craniocervical dystonia: A case-control study. Clinical Neurology and Neurosurgery 193, pages 105794.
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Vishnupriya Veeraraghavan, Krishnan Srinivasan & JohnDinesh Alexander. (2020) A rare co occurrence of Cervical Dystonia and Pathological Laughter in an elderly female. Journal of Geriatric Mental Health 7:2, pages 113.
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Michael Fralick, Chana A. Sacks & Aaron S. Kesselheim. (2019) Assessment of Use of Combined Dextromethorphan and Quinidine in Patients With Dementia or Parkinson Disease After US Food and Drug Administration Approval for Pseudobulbar Affect. JAMA Internal Medicine 179:2, pages 224.
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Mathew Hakimi & Carine W. Maurer. (2019) Pseudobulbar Affect in Parkinsonian Disorders: A Review. Journal of Movement Disorders 12:1, pages 14-21.
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Linda Nguyen & Rae R. Matsumoto. 2019. Psychopharmacology of Neurologic Disease. Psychopharmacology of Neurologic Disease 243 251 .
Marc E. Wolf, Mahmoud Abdallat, Christian Blahak & Joachim K. Krauss. (2017) Pathological crying induced by deep brain stimulation of the subthalamic nucleus in Parkinson’s disease. Journal of Clinical Neuroscience 45, pages 159-161.
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Anna De Rosa, Sabina Pappatà, Silvio Peluso, Francesco Saccà, Maria Lieto, Alessandro Filla & Giuseppe De Michele. (2016) Pathological laughter as onset symptom in atypical parkinsonisms. Journal of Neurology 264:1, pages 182-184.
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Kevin Foley, R. Tamara Konetzka, Anthony Bunin & Charles Yonan. (2016) Prevalence of pseudobulbar affect symptoms and clinical correlates in nursing home residents. International Journal of Geriatric Psychiatry 31:7, pages 694-701.
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P. K. Chattha, P. E. Greene & Ritesh A. Ramdhani. (2015) Pseudobulbar laughter as a levodopa off phenomenon exacerbated by subthalamic deep brain stimulation. Journal of Clinical Movement Disorders 2:1.
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Erik P. Pioro. (2014) Review of Dextromethorphan 20 mg/Quinidine 10 mg (NUEDEXTA®) for Pseudobulbar Affect. Neurology and Therapy 3:1, pages 15-28.
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Sarah C. Janicki, Stephanie Cosentino & Elan D. Louis. (2013) The cognitive side of essential tremor: what are the therapeutic implications?. Therapeutic Advances in Neurological Disorders 6:6, pages 353-368.
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Edward C. Lauterbach, Jeffrey L. Cummings & Preetha Sharone Kuppuswamy. (2013) Toward a more precise, clinically—informed pathophysiology of pathological laughing and crying. Neuroscience & Biobehavioral Reviews 37:8, pages 1893-1916.
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Pornjira Pariwatcharakul, Chris Clough, Paul Shotbolt, Robert Morris, Natasha Hulse, Angela Costello, Michael Samuel & Keyoumars Ashkan. (2013) Pathological crying after subthalamic nucleus stimulation. Movement Disorders 28:10, pages 1348-1349.
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Benjamin Rix Brooks, David Crumpacker, Jonathan Fellus, Daniel Kantor & Randall E. Kaye. (2013) PRISM: A Novel Research Tool to Assess the Prevalence of Pseudobulbar Affect Symptoms across Neurological Conditions. PLoS ONE 8:8, pages e72232.
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Oscar Bernal-Pacheco, Genko Oyama, Kelly D. Foote, Yunfeng E. Dai, Samuel S. Wu, Charles E. JacobsonIVIV, Natlada Limotai, Pamela R. Zeilman, Janet Romrell, Nelson Hwynn, Ramon L. Rodriguez, Irene A. Malaty & Michael S. Okun. (2013) Taking a Better History for Behavioral Issues Pre- and Post-Deep Brain Stimulation: Issues Missed by Standardized Scales. Neuromodulation: Technology at the Neural Interface 16:1, pages 35-40.
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Jennifer Colamonico, Andrea Formella & Walter Bradley. (2012) Pseudobulbar Affect: Burden of Illness in the USA. Advances in Therapy 29:9, pages 775-798.
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Laura E. Pope, Kerri A. Schoedel, Cynthia Bartlett & Edward M. Sellers. (2012) A Study of Potential Pharmacokinetic and Pharmacodynamic Interactions between Dextromethorphan/Quinidine and Memantine in Healthy Volunteers. Clinical Drug Investigation 32:8, pages e1-e15.
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Laura E. Pope, Kerri A. Schoedel, Cynthia Bartlett & Edward M. Sellers. (2012) A Study of Potential Pharmacokinetic and Pharmacodynamic Interactions between Dextromethorphan/Quinidine and Memantine in Healthy Volunteers. Clinical Drug Investigation 32:8, pages e1-e15.
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Kerri A. Schoedel, Laura E. Pope & Edward M. Sellers. (2012) Randomized Open-Label Drug-Drug Interaction Trial of Dextromethorphan/Quinidine and Paroxetine in Healthy Volunteers. Clinical Drug Investigation 32:3, pages 157-169.
Crossref
Susan S. Work, Jennifer A. Colamonico, Walter G. Bradley & Randall E. Kaye. (2011) Pseudobulbar affect: an under-recognized and under-treated neurological disorder. Advances in Therapy 28:7, pages 586-601.
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Félix Bermejo-Pareja. (2011) Essential tremor—a neurodegenerative disorder associated with cognitive defects?. Nature Reviews Neurology 7:5, pages 273-282.
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