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Expert Opinion on Drug Delivery Volume 15, 2018 - Issue 5
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Original Research

Low density, good flowability cyclodextrin-raffinose binary carrier for dry powder inhaler: anti-hygroscopicity and aerosolization performance enhancement

Ziyu ZhaoSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, P.R. ChinaView further author information
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Zhengwei HuangSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, P.R. ChinaView further author information
,
Xuejuan ZhangSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, P.R. China;Institute for Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, P.R. ChinaView further author information
,
Ying HuangSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, P.R. ChinaCorrespondence[email protected] [email protected]
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,
Yingtong CuiSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, P.R. ChinaView further author information
,
Cheng MaSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, P.R. ChinaView further author information
,
Guanlin WangSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, P.R. ChinaView further author information
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Tim FreemanFreeman Technology Ltd., Tewkesbury, UKView further author information
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Xiang-yun LuFreeman Technology Ltd., Tewkesbury, UKView further author information
,
Xin PanSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, P.R. ChinaView further author information
&
Chuanbin WuSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, P.R. ChinaCorrespondence[email protected] [email protected]
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Pages 443-457 | Received 21 Dec 2017, Accepted 07 Mar 2018, Published online: 13 Mar 2018

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Mostafa Rostamnezhad, Hossein Jafari, Farzad Moradikhah, Sara Bahrainian, Homa Faghihi, Reza Khalvati, Reza Bafkary & Alireza Vatanara. (2022) Spray freeze-drying for inhalation application: process and formulation variables. Pharmaceutical Development and Technology 27:3, pages 251-267.
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Shahriar Milani, Homa Faghihi, Abdolhosein Roulholamini Najafabadi, Mohsen Amini, Hamed Montazeri & Alireza Vatanara. (2020) Hydroxypropyl beta cyclodextrin: a water-replacement agent or a surfactant upon spray freeze-drying of IgG with enhanced stability and aerosolization. Drug Development and Industrial Pharmacy 46:3, pages 403-411.
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Articles from other publishers (26)

Nazareth Eliana Ceschan, Verónica Bucalá & M. Verónica Ramírez-Rigo. (2024) Levofloxacin dry powder inhaler for high dose delivery. Powder Technology 432, pages 119168.
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Mostafa Rostamnezhad, Katayoon MireskandariMohammad Reza RouiniSamira AnsariMajid DarabiAlireza Vatanara. (2023) Screening of Cyclodextrins in the Processing of Buserelin Dry Powders for Inhalation Prepared by Spray Freeze-Drying. Advanced Pharmaceutical Bulletin 13:4, pages 772-783.
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Yue Zhou, Jiayuan Huang, Guanlin Wang, Zizhao Zhai, Maizbha Uddin Ahmed, Xiao Xia, Cenfeng Liu, Yuzhen Jin, Xin Pan, Ying Huang, Chuanbin Wu & Xuejuan Zhang. (2023) Polymyxin B sulfate inhalable microparticles with high-lectin-affinity sugar carriers for efficient treatment of biofilm-associated pulmonary infections. Science Bulletin.
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Dlivan Fattah Aziz, Mostafa Rostamnezhad, Kimia Azad, Yehia Ismail Khalil & Alireza Vatanara. (2023) Screening of sugars and cyclodextrins as carriers in montelukast dry powder inhalers processed by spray freeze drying. Advanced Powder Technology 34:10, pages 104152.
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Shixue Bao, Yi Zou, Caleb Kesse Firempong, Yingshu Feng, Yang Yu, Ying Wang, Huiying Dai, Weiwei Mo, Changshan Sun & Hongfei Liu. (2023) Preparation and evaluation of sustained release pirfenidone-loaded microsphere dry powder inhalation for treatment of idiopathic pulmonary fibrosis. European Journal of Pharmaceutical Sciences 188, pages 106509.
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Piyush Pradeep Mehta & Vividha Dhapte-Pawar. 2023. Pulmonary Drug Delivery Systems: Material and Technological Advances. Pulmonary Drug Delivery Systems: Material and Technological Advances 247 279 .
Jiayi Li, Sibo Ma, Ying Sun, Ruxiao Song, Baoli Cai, Hao Li, Ying Chen, Xin Zhang, Jian Guan & Shirui Mao. (2022) Predicting in vitro lung deposition behavior of combined dry powder inhaler via rheological properties. European Journal of Pharmaceutics and Biopharmaceutics 181, pages 195-206.
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Riya Mahar, Arpita Chakraborty & Nidhi Nainwal. (2022) The influence of carrier type, physical characteristics, and blending techniques on the performance of dry powder inhalers. Journal of Drug Delivery Science and Technology 76, pages 103759.
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Xuejuan Zhang, Yue Zhou, Guanlin Wang, Ziyu Zhao, Zhongxiang Jiang, Yingtong Cui, Xiao Yue, Zhengwei Huang, Ying Huang, Xin Pan & Chuanbin Wu. (2022) Co-spray-dried poly-L-lysine with L-leucine as dry powder inhalations for the treatment of pulmonary infection: Moisture-resistance and desirable aerosolization performance. International Journal of Pharmaceutics 624, pages 122011.
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Ziyu Zhao, Guanlin Wang, Zhengwei Huang, Ying Huang, Hangping Chen, Xin Pan & Xuejuan Zhang. (2022) Dry Powder Inhalers Based on Chitosan-Mannitol Binary Carriers: Effect of the Powder Properties on the Aerosolization Performance. AAPS PharmSciTech 23:5.
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Anna Lechanteur, Erwan Plougonven, Luisa Orozco, Geoffroy Lumay, Nicolas Vandewalle, Angélique Léonard & Brigitte Evrard. (2022) Engineered-inhaled particles: Influence of carbohydrates excipients nature on powder properties and behavior. International Journal of Pharmaceutics 613, pages 121319.
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Yingtong Cui, Ying Huang, Xuejuan Zhang, Xiangyun Lu, Jun Xue, Guanlin Wang, Ping Hu, Xiao Yue, Ziyu Zhao, Xin Pan & Chuanbin Wu. (2022) A real-time and modular approach for quick detection and mechanism exploration of DPIs with different carrier particle sizes. Acta Pharmaceutica Sinica B 12:1, pages 437-450.
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Xiuhua Wang, Wei Wan, Jing Lu, Guilan Quan, Xin Pan & Peiqing Liu. (2021) Effects of L-leucine on the properties of spray-dried swellable microparticles with wrinkled surfaces for inhalation therapy of pulmonary fibrosis. International Journal of Pharmaceutics 610, pages 121223.
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Ashutosh Sharma, Dikshitkumar Khamar, Sean Cullen, Ambrose Hayden & Helen Hughes. (2021) Innovative Drying Technologies for Biopharmaceuticals. International Journal of Pharmaceutics 609, pages 121115.
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Heejun Park, Eun-Sol Ha & Min-Soo Kim. (2021) Surface modification strategies for high-dose dry powder inhalers. Journal of Pharmaceutical Investigation 51:6, pages 635-668.
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Shadi Yaqoubi, Hak-Kim Chan, Ali Nokhodchi, Siavoush Dastmalchi, Ali Akbar Alizadeh, Mohammad Barzegar-Jalali, Khosro Adibkia & Hamed Hamishehkar. (2021) A quantitative approach to predicting lung deposition profiles of pharmaceutical powder aerosols. International Journal of Pharmaceutics 602, pages 120568.
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Amanpreet Kaur, Dnyaneshwar P. Kale & Arvind K. Bansal. (2021) Surface characterization of pharmaceutical solids. TrAC Trends in Analytical Chemistry 138, pages 116228.
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Minyi Guan, Xuan Zeng, Rui Shi, Yuying Zheng, Weiyang Fan & Weiwei Su. (2021) Aerosolization Performance, Antitussive Effect and Local Toxicity of Naringenin-Hydroxypropyl-β-Cyclodextrin Inhalation Solution for Pulmonary Delivery. AAPS PharmSciTech 22:1.
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Chune Zhu, Jianting Chen, Shihui Yu, Chailu Que, Lynne S. Taylor, Wen Tan, Chuanbin Wu & Qi Tony Zhou. (2020) Inhalable Nanocomposite Microparticles with Enhanced Dissolution and Superior Aerosol Performance. Molecular Pharmaceutics 17:9, pages 3270-3280.
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Xuejuan Zhang, Yingtong Cui, Ruifeng Liang, Guanlin Wang, Xiao Yue, Ziyu Zhao, Zhengwei Huang, Ying Huang, Jianfang Geng, Xin Pan & Chuanbin Wu. (2020) Novel approach for real-time monitoring of carrier-based DPIs delivery process via pulmonary route based on modular modified Sympatec HELOS. Acta Pharmaceutica Sinica B 10:7, pages 1331-1346.
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Xuejuan Zhang, Xiao Yue, Yingtong Cui, Ziyu Zhao, Ying Huang, Shihao Cai, Guanlin Wang, Wenhao Wang, Smyth Hugh, Xin Pan, Chuanbin Wu & Wen Tan. (2020) A Systematic Safety Evaluation of Nanoporous Mannitol Material as a Dry-Powder Inhalation Carrier System. Journal of Pharmaceutical Sciences 109:5, pages 1692-1702.
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Anna Lechanteur & Brigitte Evrard. (2020) Influence of Composition and Spray-Drying Process Parameters on Carrier-Free DPI Properties and Behaviors in the Lung: A review. Pharmaceutics 12:1, pages 55.
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Chan Zhou, Zhengwei Huang, Ying Huang, Bei Wang, Peipei Yang, Yanliang Fan, Ailin Hou, Beibei Yang, Ziyu Zhao, Guilan Quan, Xin Pan & Chuanbin Wu. (2019) In situ gelation of rhEGF-containing liquid crystalline precursor with good cargo stability and system mechanical properties: a novel delivery system for chronic wounds treatment . Biomaterials Science 7:3, pages 995-1010.
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Chunxia Liu, Ling Lin, Zhengwei Huang, Qiaoli Wu, Junhuang Jiang, Li Lv, Xiaoxia Yu, Guilan Quan, Guocheng Li & Chuanbin Wu. (2019) Novel Inhalable Ciprofloxacin Dry Powders for Bronchiectasis Therapy: Mannitol–Silk Fibroin Binary Microparticles with High-Payload and Improved Aerosolized Properties. AAPS PharmSciTech 20:2.
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Yingtong Cui, Xuejuan Zhang, Wen Wang, Zhengwei Huang, Ziyu Zhao, Guanlin Wang, Shihao Cai, Hui Jing, Ying Huang, Xin Pan & Chuanbin Wu. (2018) Moisture-Resistant Co-Spray-Dried Netilmicin with l-Leucine as Dry Powder Inhalation for the Treatment of Respiratory Infections. Pharmaceutics 10:4, pages 252.
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Ying Huang, Zhengwei Huang, Xuejuan Zhang, Ziyu Zhao, Xuan Zhang, Kexin Wang, Cheng Ma, Chune Zhu, Xin Pan & Chuanbin Wu. (2018) Chitosan-based binary dry powder inhaler carrier with nanometer roughness for improving in vitro and in vivo aerosolization performance. Drug Delivery and Translational Research 8:5, pages 1274-1288.
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