448
Views
59
CrossRef citations to date
0
Altmetric
Article

Silver nanoparticles induce neurotoxicity in a human embryonic stem cell-derived neuron and astrocyte network

, , , , &
Pages 104-116 | Received 13 Jun 2017, Accepted 05 Jan 2018, Published online: 15 Jan 2018

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Daniela F Báez, Eduardo Gallardo-Toledo, María Paz Oyarzún, Eyleen Araya & Marcelo J Kogan. (2021) The Influence of Size and Chemical Composition of Silver and Gold Nanoparticles on in vivo Toxicity with Potential Applications to Central Nervous System Diseases. International Journal of Nanomedicine 16, pages 2187-2201.
Read now
Nathalie Leynen, Frank G.A.J Van Belleghem, Annelies Wouters, Hannelore Bove, Jan-Pieter Ploem, Elsy Thijssen, Sabine A.S. Langie, Robert Carleer, Marcel Ameloot, Tom Artois & Karen Smeets. (2019) In vivo Toxicity Assessment of Silver Nanoparticles in Homeostatic versus Regenerating Planarians. Nanotoxicology 13:4, pages 476-491.
Read now

Articles from other publishers (57)

Anissa Zergui. (2023) Metallic nanoparticles in food: An overview on consumers’ health effects. Food and Humanity 1, pages 51-56.
Crossref
Kaimei Wang, Shiqi Wang, Jingju Yin, Qiankun Yang, Yi Yu & Lin Chen. (2023) Long-term application of silver nanoparticles in dental restoration materials: potential toxic injury to the CNS. Journal of Materials Science: Materials in Medicine 34:11.
Crossref
Jia Liu, Zhendong Huang, Suhan Yin, Xinru Zhou, Yanping Jiang & Longquan Shao. (2023) The lysosome-mitochondrion crosstalk engaged in silver nanoparticles-disturbed mitochondrial homeostasis. Science of The Total Environment 889, pages 164078.
Crossref
Yavuz Yavuz, Gamze Yesilay, Bilge Guvenc Tuna, Akif Maharramov, Mustafa Culha, Cihan Suleyman Erdogan, Gunseli Ayse Garip & Bayram Yilmaz. (2022) Investigation of effects of transferrin-conjugated gold nanoparticles on hippocampal neuronal activity and anxiety behavior in mice. Molecular and Cellular Biochemistry 478:8, pages 1813-1824.
Crossref
Anshul Sharma, Sanjay, Varun Jaiswal, Miey Park & Hae-Jeung Lee. (2023) Biogenic silver NPs alleviate LPS-induced neuroinflammation in a human fetal brain-derived cell line: Molecular switch to the M2 phenotype, modulation of TLR4/MyD88 and Nrf2/HO-1 signaling pathways, and molecular docking analysis. Biomaterials Advances 148, pages 213363.
Crossref
Maciej Noga, Justyna Milan, Adrian Frydrych & Kamil Jurowski. (2023) Toxicological Aspects, Safety Assessment, and Green Toxicology of Silver Nanoparticles (AgNPs)—Critical Review: State of the Art. International Journal of Molecular Sciences 24:6, pages 5133.
Crossref
Muskan Goel, Anurag Sharma & Bechan Sharma. (2023) Recent Advances in Biogenic Silver Nanoparticles for Their Biomedical Applications. Sustainable Chemistry 4:1, pages 61-94.
Crossref
Venkateshwaran Krishnaswami, Balakrishnan Natarajan, Saravanakumar Arthanari, Jeseeta Suresh & Nirmal Aranvindaraj. (2023) Insights on Bioactive Peptide-loaded Nanoformulations. Current Biotechnology 12:1, pages 3-13.
Crossref
Ece Guler, Elif Beyzanur Polat & Muhammet Emin Cam. 2023. Biomaterials for Neural Tissue Engineering. Biomaterials for Neural Tissue Engineering 221 268 .
Jitendra Kumar Suthar, Anuradha Vaidya & Selvan Ravindran. (2022) Toxic implications of silver nanoparticles on the central nervous system: A systematic literature review. Journal of Applied Toxicology 43:1, pages 4-21.
Crossref
Mai Tareq, Yasser A. Khadrawy, Monira M. Rageh & Haitham S. Mohammed. (2022) Dose-dependent biological toxicity of green synthesized silver nanoparticles in rat’s brain. Scientific Reports 12:1.
Crossref
Zequn Zhang, Chen Meng, Kun Hou, Zhigong Wang, Yan Huang & Xiaoying Lü. (2022) The cytological and electrophysiological effects of silver nanoparticles on neuron-like PC12 cells. PLOS ONE 17:12, pages e0277942.
Crossref
Lora-Sophie Gerber, Harm J. Heusinkveld, Celine Langendoen, Burkhard Stahlmecke, Roel PF Schins & Remco HS Westerink. (2022) Acute, sub-chronic and chronic exposures to TiO2 and Ag nanoparticles differentially affects neuronal function in vitro. NeuroToxicology 93, pages 311-323.
Crossref
Tingting Ku, Zhihua Ren, Renjun Yang, Qian S. Liu, Nan Sang, Francesco Faiola, Qunfang Zhou & Guibin Jiang. (2022) Abnormal neural differentiation in response to graphene quantum dots through histone modification interference. Environment International 170, pages 107572.
Crossref
Yan Huang, Lulu Guo, Chulin Cao, Rui Ma, Yuting Huang, Kai Zhong, Hong Gao, Yina Huang & Qian Bu. (2022) Silver nanoparticles exposure induces developmental neurotoxicity in hiPSC-derived cerebral organoids. Science of The Total Environment 845, pages 157047.
Crossref
Murali Kumarasamy, Ngoc Tran, Javier Patarroyo, Sushmita Mishra, Marco Monopoli, Emilia Madarasz & Victor Puntes. (2022) “The Effects of Silver Nanoparticle Shape on Protein Adsorption and Neural Stem Cell Viability”. ChemistrySelect 7:39.
Crossref
Xuedi Zhai, Shan Shan, Jianmei Wan, Hailin Tian, Jianshu Wang & Lili Xin. (2022) Silver Nanoparticles Induce a Size-dependent Neurotoxicity to SH-SY5Y Neuroblastoma Cells via Ferritinophagy-mediated Oxidative Stress. Neurotoxicity Research 40:5, pages 1369-1379.
Crossref
Mengting Xu, Xinyue Liu, Qianqian Wang, Yunping Zhu & Chenxi Jia. (2022) Phosphoproteomic analysis reveals the effects of sleep deprivation on the hippocampus in mice. Molecular Omics 18:7, pages 677-685.
Crossref
Jia-You Gong, Matthew G. Holt, Peter H. M. Hoet & Manosij Ghosh. (2022) Neurotoxicity of four frequently used nanoparticles: a systematic review to reveal the missing data. Archives of Toxicology 96:5, pages 1141-1212.
Crossref
Kai Liu, Lesan Yan, Ruotao Li, Zhiming Song, Jianxun Ding, Bin Liu & Xuesi Chen. (2022) 3D Printed Personalized Nerve Guide Conduits for Precision Repair of Peripheral Nerve Defects. Advanced Science 9:12, pages 2103875.
Crossref
Yiling Hong. 2022. Neurotoxicity - New Advances. Neurotoxicity - New Advances.
Bowen Hu, Zhanwen Cheng & Shengxian Liang. (2022) Advantages and prospects of stem cells in nanotoxicology. Chemosphere 291, pages 132861.
Crossref
Katarzyna Dziendzikowska, Jacek Wilczak, Wojciech Grodzicki, Joanna Gromadzka-Ostrowska, Małgorzata Węsierska & Marcin Kruszewski. (2022) Coating-Dependent Neurotoxicity of Silver Nanoparticles—An In Vivo Study on Hippocampal Oxidative Stress and Neurosteroids. International Journal of Molecular Sciences 23:3, pages 1365.
Crossref
Anna Alexandrovna AntsiferovaMarina Yurievna KopaevaVyacheslav Nikolaevich KochkinPavel Konstantinovich Kashkarov. (2021) Effects of long-term oral administration of silver nanoparticles on the cognitive functions of mammals. Toxicological Review 29:6, pages 33-38.
Crossref
Razvan Vlad Opris, Vlad Toma, Alina Mihaela Baciu, Remus Moldovan, Bogdan Dume, Alexandra Berghian-Sevastre, Bianca Moldovan, Simona Clichici, Luminita David, Gabriela Adriana Filip & Adrian Florea. (2021) Neurobehavioral and Ultrastructural Changes Induced by Phytosynthesized Silver-Nanoparticle Toxicity in an In Vivo Rat Model. Nanomaterials 12:1, pages 58.
Crossref
Hao Li, Qingshun Q. Li & Yiling Hong. (2021) Global gene expression signatures in response to citrate-coated silver nanoparticles exposure. Toxicology 461, pages 152898.
Crossref
Mengting Shang, Xiaoru Chang, Shuyan Niu, Jiangyan Li, Wenli Zhang, Tianshu Wu, Ting Zhang, Meng Tang & Yuying Xue. (2021) The key role of autophagy in silver nanoparticle-induced BV2 cells inflammation and polarization. Food and Chemical Toxicology 154, pages 112324.
Crossref
Zhiling Guo, Peng Zhang, Swaroop Chakraborty, Andrew J Chetwynd, Fazel Abdolahpur MonikhChristopher StarkHanene Ali-Boucetta, Sandra Wilson, Iseult Lynch & Eugenia Valsami-Jones. (2021) Biotransformation modulates the penetration of metallic nanomaterials across an artificial blood–brain barrier model. Proceedings of the National Academy of Sciences 118:28.
Crossref
Zhiwen Yan, Yun Qian & Cunyi Fan. (2021) Biomimicry in 3D printing design: implications for peripheral nerve regeneration. Regenerative Medicine 16:7, pages 683-701.
Crossref
Jie Zhang, Sijin Liu, Jinxiang Han, Zhe Wang & Shuping Zhang. (2021) On the developmental toxicity of silver nanoparticles. Materials & Design 203, pages 109611.
Crossref
Danni Dai, Longwen He, Yuming Chen & Chao Zhang. (2021) Astrocyte responses to nanomaterials: Functional changes, pathological changes and potential applications. Acta Biomaterialia 122, pages 66-81.
Crossref
Paweł Kowalczyk, Mateusz Szymczak, Magdalena Maciejewska, Łukasz Laskowski, Magdalena Laskowska, Ryszard Ostaszewski, Grzegorz Skiba & Ida Franiak-Pietryga. (2021) All That Glitters Is Not Silver—A New Look at Microbiological and Medical Applications of Silver Nanoparticles. International Journal of Molecular Sciences 22:2, pages 854.
Crossref
Xiaoru Chang, Xiujuan Wang, Jiangyan Li, Mengting Shang, Shuyan Niu, Wenli Zhang, Yunjing Li, Zuoyi Sun, Junying Gan, Wenhua Li, Meng Tang & Yuying Xue. (2021) Silver nanoparticles induced cytotoxicity in HT22 cells through autophagy and apoptosis via PI3K/AKT/mTOR signaling pathway. Ecotoxicology and Environmental Safety 208, pages 111696.
Crossref
Arya Uthaman, Hiran Mayookh Lal & Sabu Thomas. 2021. Polymer Nanocomposites Based on Silver Nanoparticles. Polymer Nanocomposites Based on Silver Nanoparticles 1 24 .
Atousa Janzadeh, Michael R. Hamblin, Narges Janzadeh, Hossein Arzani, MahsaTashakori-Miyanroudi, Mahmoud Yousefifard & Fatemeh Ramezani. 2021. Reviews of Environmental Contamination and Toxicology Volume 257. Reviews of Environmental Contamination and Toxicology Volume 257 93 119 .
Ying Jiang, Housheng Gong, Shaohua Jiang, Chaowen She & Yi Cao. (2020) Multi-walled carbon nanotubes decrease neuronal NO synthase in 3D brain organoids. Science of The Total Environment 748, pages 141384.
Crossref
Zahid Hussain, Hnin Ei Thu, Ibrahim Elsayed, Mohammed A.S. Abourehab, Shahzeb Khan, Mohammad Sohail, Rai Muhammad Sarfraz & Muhammad Asim Farooq. (2020) Nano-scaled materials may induce severe neurotoxicity upon chronic exposure to brain tissues: A critical appraisal and recent updates on predisposing factors, underlying mechanism, and future prospects. Journal of Controlled Release 328, pages 873-894.
Crossref
Hamidreza Arzaghi, Bashir Adel, Hossein Jafari, Shaghayegh Askarian-Amiri, Amin Shiralizadeh Dezfuli, Abolfazl Akbarzadeh & Hamidreza Pazoki-Toroudi. (2020) Nanomaterial integration into the scaffolding materials for nerve tissue engineering: a review. Reviews in the Neurosciences 31:8, pages 843-872.
Crossref
Yujun Zeng, Zhiqian Li, Hongyan Zhu, Zhongwei Gu, Hu Zhang & Kui Luo. (2020) Recent Advances in Nanomedicines for Multiple Sclerosis Therapy. ACS Applied Bio Materials 3:10, pages 6571-6597.
Crossref
Encarnación Fuster, Héctor Candela, Jorge Estévez, Ariel J. Arias, Eugenio Vilanova & Miguel A. Sogorb. (2020) Effects of silver nanoparticles on T98G human glioblastoma cells. Toxicology and Applied Pharmacology 404, pages 115178.
Crossref
K.-F. Chen, P. Milgrom & Y.S. Lin. (2020) Silver Diamine Fluoride in Children Using Physiologically Based PK Modeling. Journal of Dental Research 99:8, pages 907-913.
Crossref
Bowen Hu, Nuoya Yin, Renjun Yang, Shengxian Liang, Shaojun Liang & Francesco Faiola. (2020) Silver nanoparticles (AgNPs) and AgNO3 perturb the specification of human hepatocyte-like cells and cardiomyocytes. Science of The Total Environment 725, pages 138433.
Crossref
Bingjie Zhang, Na Liu, Qian S. Liu, Jianqing Zhang, Qunfang Zhou & Guibin Jiang. (2020) Silver nanoparticles induce size-dependent and particle-specific neurotoxicity to primary cultures of rat cerebral cortical neurons. Ecotoxicology and Environmental Safety 198, pages 110674.
Crossref
K.M. Asha Spandana, Mahendran Bhaskaran, V.V.S.N.Reddy Karri & Jawahar Natarajan. (2020) A comprehensive review of nano drug delivery system in the treatment of CNS disorders. Journal of Drug Delivery Science and Technology 57, pages 101628.
Crossref
Le Hu, Yan Fu, Liyuan Rong, Xinji Yang, Yueyue Li, Liqiang Wang & Wei Wu. (2020) Evaluating the cytotoxicity of graphene oxide using embryonic stem cells‐derived cells. Journal of Biomedical Materials Research Part A 108:6, pages 1321-1328.
Crossref
William K. Boyes & Christoph van Thriel. (2020) Neurotoxicology of Nanomaterials. Chemical Research in Toxicology 33:5, pages 1121-1144.
Crossref
Hannah Calcaterra, Nara Shin, Phillip L. Quirk & Candace S.J. Tsai. (2020) Low Concentration Analysis of Silver Nanoparticles in Consumer Spray Products. Atmosphere 11:4, pages 403.
Crossref
M.I. Teixeira, C.M. Lopes, M.H. Amaral & P.C. Costa. (2020) Current insights on lipid nanocarrier-assisted drug delivery in the treatment of neurodegenerative diseases. European Journal of Pharmaceutics and Biopharmaceutics 149, pages 192-217.
Crossref
Tahereh Esmaeilpour, Esmaeil Fereydouni, Farzaneh Dehghani, Istvan Bókkon, Mohammad-Reza Panjehshahin, Noemi Császár-Nagy, Mehdi Ranjbar & Vahid Salari. (2020) An Experimental Investigation of Ultraweak Photon Emission from Adult Murine Neural Stem Cells. Scientific Reports 10:1.
Crossref
Wataru Minoshima, Chie Hosokawa, Suguru N. Kudoh & Keiko Tawa. (2020) Real-time fluorescence measurement of spontaneous activity in a high-density hippocampal network cultivated on a plasmonic dish. The Journal of Chemical Physics 152:1.
Crossref
Yasemin Budama-Kilinc, Burak Ozdemir, Tolga Zorlu, Bahar Gok & Abdurrahim Can Egil. 2020. Neural Regenerative Nanomedicine. Neural Regenerative Nanomedicine 25 45 .
Daeha Joung, Nicolas S. Lavoie, Shuang‐Zhuang Guo, Sung Hyun Park, Ann M. Parr & Michael C. McAlpine. (2019) 3D Printed Neural Regeneration Devices. Advanced Functional Materials 30:1, pages 1906237.
Crossref
Wataru Minoshima, Chie Hosokawa, Suguru N. Kudoh & Keiko Tawa. (2019) Long-term real-time imaging of a voltage sensitive dye in cultured hippocampal neurons using the silver plasmonic dish. Journal of Photochemistry and Photobiology A: Chemistry 384, pages 111949.
Crossref
Bhavesh D. Kevadiya, Brendan M. Ottemann, Midhun Ben Thomas, Insiya Mukadam, Saumya Nigam, JoEllyn McMillan, Santhi Gorantla, Tatiana K. Bronich, Benson Edagwa & Howard E. Gendelman. (2019) Neurotheranostics as personalized medicines. Advanced Drug Delivery Reviews 148, pages 252-289.
Crossref
Rajan Patel, Matthew Muir, Caroline Cvetkovic & Robert Krencik. (2019) Concepts toward directing human astroplasticity to promote neuroregeneration. Developmental Dynamics 248:1, pages 21-33.
Crossref
Ahmed Abdal Dayem, Soo Lee & Ssang-Goo Cho. (2018) The Impact of Metallic Nanoparticles on Stem Cell Proliferation and Differentiation. Nanomaterials 8:10, pages 761.
Crossref
Aisha Khatoon, Farheen Khan, Nabeel Ahmad, Sibhghatulla Shaikh, Syed Mohd. Danish Rizvi, Shazi Shakil, Mohammad H. Al-Qahtani, Adel M. Abuzenadah, Shams Tabrez, Abo Bakr Fathy Ahmed, Ahmed Alafnan, Hayatul Islam, Danish Iqbal & Rajiv Dutta. (2018) Silver nanoparticles from leaf extract of Mentha piperita: Eco-friendly synthesis and effect on acetylcholinesterase activity. Life Sciences 209, pages 430-434.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.