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Origninal papers

In vitro study of the efficacy of acrylic bone cement loaded with supplementary amounts of gentamicin: Effect on mechanical properties, antibiotic release, and biofilm formation

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Pages 774-785 | Received 01 Dec 2006, Accepted 04 Jun 2007, Published online: 08 Jul 2009

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Denghui Liu, Chongru He, Zhongtang Liu & Weidong Xu. (2017) Gentamicin coating of nanotubular anodized titanium implant reduces implant-related osteomyelitis and enhances bone biocompatibility in rabbits. International Journal of Nanomedicine 12, pages 5461-5471.
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Wen-tao Lin, Hong-lue Tan, Zhao-ling Duan, Bing Yue, Rui Ma, Guo He & Ting-ting Tang. (2014) Inhibited bacterial biofilm formation and improved osteogenic activity on gentamicin-loaded titania nanotubes with various diameters. International Journal of Nanomedicine 9, pages 1215-1230.
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Nicholas Dunne, Fraser Buchanan, Janet Hill, Caroline Newe, Michael Tunney, Aaron Brady & Gavin Walker. (2008) In vitro testing of chitosan in gentamicin-loaded bone cement No antimicrobial effect and reduced mechanical performance. Acta Orthopaedica 79:6, pages 851-860.
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Articles from other publishers (73)

Mahsa Alimohammadi, Hassan Mirzabozorg, Farzam Farahmand, Sunjung Kim, Caroline Baril & Heidi-Lynn Ploeg. (2023) Statistical distribution of micro and macro pores in acrylic bone cement- effect of amount of antibiotic content. Journal of the Mechanical Behavior of Biomedical Materials, pages 106297.
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Abdullah M. Alhammad, Thamer A. Almangour, Imtinan Almasoudi, Wesal Alalayet, Mansour Almuqbil, Yazed S. Alsowaida & Naif H Alotaibi. (2023) Effectiveness of antibiotic-loaded bone cement in total joint arthroplasty at a tertiary medical center: A retrospective cohort study. Saudi Pharmaceutical Journal 31:9, pages 101739.
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N Nazemi, N Rajabi, Z Aslani, M Kharaziha, M Kasiri-Asgarani, HR Bakhsheshi-Rad, A Najafinezhad, AF Ismail, S Sharif & F Berto. (2022) Synthesis and characterization of gentamicin loaded ZSM-5 scaffold: Cytocompatibility and antibacterial activity. Journal of Biomaterials Applications 37:6, pages 979-991.
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Alexa A. Ciarolla, Norman Lapin, Dustin Williams, Rajiv Chopra & David E. Greenberg. (2022) Physical Approaches to Prevent and Treat Bacterial Biofilm. Antibiotics 12:1, pages 54.
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Ting Xu, Ke-Liang Wu & Ke Jie. (2022) Comprehensive meta-analysis of antibiotic-impregnated bone cement versus plain bone cement in primary total knee arthroplasty for preventing periprosthetic joint infection. Chinese Journal of Traumatology 25:6, pages 325-330.
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Panagiotis V Samelis, Eftychios Papagrigorakis, Eleni Sameli, Andreas Mavrogenis, Olga Savvidou & Panagiotis Koulouvaris. (2022) Current Concepts on the Application, Pharmacokinetics and Complications of Antibiotic-Loaded Cement Spacers in the Treatment of Prosthetic Joint Infections. Cureus.
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Nicholas Mannering, Raj Narulla & Benjamin Lenane. 2022. Infection in Knee Replacement. Infection in Knee Replacement 41 47 .
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Christof Ernst Berberich, Jérôme Josse, Frédéric Laurent & Tristan Ferry. (2021) Dual antibiotic loaded bone cement in patients at high infection risks in arthroplasty: Rationale of use for prophylaxis and scientific evidence. World Journal of Orthopedics 12:3, pages 119-128.
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Serkan Inceoglu, Gary Botimer & Victoria K. Maskiewicz. (2020) Novel microcomposite implant for the controlled delivery of antibiotics in the treatment of osteomyelitis following total joint replacement. Journal of Orthopaedic Research 39:2, pages 365-375.
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Zuoxin Zhou, Alex Lennon, Fraser Buchanan, Helen O. McCarthy & Nicholas Dunne. (2020) Binder jetting additive manufacturing of hydroxyapatite powders: Effects of adhesives on geometrical accuracy and green compressive strength. Additive Manufacturing 36, pages 101645.
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Mayra Eliana Valencia Zapata, Carlos David Grande Tovar & José Herminsul Mina Hernandez. (2020) The Role of Chitosan and Graphene Oxide in Bioactive and Antibacterial Properties of Acrylic Bone Cements. Biomolecules 10:12, pages 1616.
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Nima Razii, Rahul Kakar & Rhidian Morgan-Jones. (2020) The ‘apple core’ cement spacer for the management of massive bone loss in two-stage revision knee arthroplasty for infection. Journal of Orthopaedics 20, pages 301-304.
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Jae Hoo Lee, Sung Jae Shin, Sang-Nae Cho, Seung-Hun Baek, Do Hyun Kim & Kwan Kyu Park. (2020) Does the Effectiveness and Mechanical Strength of Kanamycin-Loaded Bone Cement in Musculoskeletal Tuberculosis Compare to Vancomycin-Loaded Bone Cement. The Journal of Arthroplasty 35:3, pages 864-869.
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Rema A Oliver, Vedran Lovric, Chris Christou & William R Walsh. (2019) Evaluation of comparative soft tissue response to bone void fillers with antibiotics in a rabbit intramuscular model. Journal of Biomaterials Applications 34:1, pages 117-129.
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Dongli Zhang, Wen Liu, Xiang-Dong Wu, Xiaoqiang He, Xiao Lin, Han Wang, Jidong Li, Jiaxing Jiang & Wei Huang. (2019) Efficacy of novel nano-hydroxyapatite/polyurethane composite scaffolds with silver phosphate particles in chronic osteomyelitis. Journal of Materials Science: Materials in Medicine 30:6.
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Haiyong Ao, Shengbing Yang, Bin’en Nie, Qiming Fan, Quanchao Zhang, Jiajia Zong, Shengrong Guo, Xuebin Zheng & Tingting Tang. (2019) Improved antibacterial properties of collagen I/hyaluronic acid/quaternized chitosan multilayer modified titanium coatings with both contact-killing and release-killing functions. Journal of Materials Chemistry B 7:11, pages 1951-1961.
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Shou-Cang Shen, Kumaran Letchmanan, Pui Shan Chow & Reginald Beng Hee Tan. (2019) Antibiotic elution and mechanical property of TiO2 nanotubes functionalized PMMA-based bone cements. Journal of the Mechanical Behavior of Biomedical Materials 91, pages 91-98.
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Zhenyang Mao, Yang Li, Yunqi Yang, Zhiwei Fang, Xuan Chen, Yugang Wang, Jian Kang, Xinhua Qu, Weien Yuan, Kerong Dai & Bing Yue. (2018) Osteoinductivity and Antibacterial Properties of Strontium Ranelate-Loaded Poly(Lactic-co-Glycolic Acid) Microspheres With Assembled Silver and Hydroxyapatite Nanoparticles. Frontiers in Pharmacology 9.
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Haolin Sun, Xiaoxiao Wen, Xiang Zhang, Donglei Wei, Huilin Yang, Chunde Li & Lei Yang. (2018) Biocompatible Silver Nanoparticle-Modified Natural Diatomite with Anti-Infective Property. Journal of Nanomaterials 2018, pages 1-8.
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C. Scheuermann-Poley, C. Wagner, J. Hoffmann, A. Moter & C. Willy. (2017) Bedeutung des Biofilms für die Infektbehandlung in der UnfallchirurgieThe significance of biofilm for the treatment of infections in orthopedic surgery. Der Unfallchirurg 120:6, pages 461-471.
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Zhuo Tan, Edward A. Havell, Paul E. Orndorff & Rohan A. Shirwaiker. (2017) Antibacterial efficacy and cytotoxicity of low intensity direct current activated silver–titanium implant system prototype. BioMetals 30:1, pages 113-125.
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L.D.T. Topoleski & R. Rodriguez-Pinto. 2017. Comprehensive Biomaterials II. Comprehensive Biomaterials II 12 33 .
Wayne Nishio Ayre, James C. Birchall, Samuel L. Evans & Stephen P. Denyer. (2015) A novel liposomal drug delivery system for PMMA bone cements. Journal of Biomedical Materials Research Part B: Applied Biomaterials 104:8, pages 1510-1524.
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Jason D. Tsung, James A.L. Rohrsheim, Sarah L. Whitehouse, Matthew J. Wilson & Jonathan R. Howell. (2014) Management of Periprosthetic Joint Infection After Total Hip Arthroplasty Using a Custom Made Articulating Spacer (CUMARS); the Exeter Experience. The Journal of Arthroplasty 29:9, pages 1813-1818.
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Zuoxin Zhou, Fraser Buchanan, Christina Mitchell & Nicholas Dunne. (2014) Printability of calcium phosphate: Calcium sulfate powders for the application of tissue engineered bone scaffolds using the 3D printing technique. Materials Science and Engineering: C 38, pages 1-10.
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Ya-Ping Guo, Teng Long, Zhen-Fu Song & Zhen-An Zhu. (2014) Hydrothermal fabrication of ZSM-5 zeolites: Biocompatibility, drug delivery property, and bactericidal property. Journal of Biomedical Materials Research Part B: Applied Biomaterials 102:3, pages 583-591.
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Claudio Carlo Castelli, Valerio Gotti & Roberto Ferrari. (2014) Two-stage treatment of infected total knee arthroplasty: two to thirteen year experience using an articulating preformed spacer. International Orthopaedics 38:2, pages 405-412.
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Ya-Ping Guo, Teng Long, Sha Tang, Ya-Jun Guo & Zhen-An Zhu. (2014) Hydrothermal fabrication of magnetic mesoporous carbonated hydroxyapatite microspheres: biocompatibility, osteoinductivity, drug delivery property and bactericidal property. Journal of Materials Chemistry B 2:19, pages 2899.
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Eric Bohm, Naisu Zhu, Jing Gu, Nicole de Guia, Cassandra Linton, Tammy Anderson, David Paton & Michael Dunbar. (2013) Does Adding Antibiotics to Cement Reduce the Need for Early Revision in Total Knee Arthroplasty?. Clinical Orthopaedics and Related Research® 472:1, pages 162-168.
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Patrick P. Spicer, Sarita R. Shah, Allan M. Henslee, Brendan M. Watson, Lucas A. Kinard, James D. Kretlow, Kristin Bevil, Lauren Kattchee, George N. Bennett, Nagi Demian, Katrin Mende, Clinton K. Murray, John A. Jansen, Mark E. Wong, Antonios G. Mikos & F. Kurtis Kasper. (2013) Evaluation of antibiotic releasing porous polymethylmethacrylate space maintainers in an infected composite tissue defect model. Acta Biomaterialia 9:11, pages 8832-8839.
Crossref
Ya-Jun Guo, Teng Long, Wei Chen, Cong-Qin Ning, Zhen-An Zhu & Ya-Ping Guo. (2013) Bactericidal property and biocompatibility of gentamicin-loaded mesoporous carbonated hydroxyapatite microspheres. Materials Science and Engineering: C 33:7, pages 3583-3591.
Crossref
Honglue Tan, Haiyong Ao, Rui Ma & Tingting Tang. (2013) Quaternised chitosan-loaded polymethylmethacrylate bone cement: Biomechanical and histological evaluations. Journal of Orthopaedic Translation 1:1, pages 57-66.
Crossref
Changmin Hu, Shen Liu, Bin Li, Huilin Yang, Cunyi Fan & Wenguo Cui. (2013) Micro-/Nanometer Rough Structure of a Superhydrophobic Biodegradable Coating by Electrospraying for Initial Anti-Bioadhesion. Advanced Healthcare Materials 2:10, pages 1314-1321.
Crossref
Shen Liu, Shenghe Liu, Xudong Liu, Jingwen Zhao, Wenguo Cui & Cunyi Fan. (2013) Antibacterial antiadhesion membranes from silver‐nanoparticle‐doped electrospun poly( L ‐lactide) nanofibers . Journal of Applied Polymer Science 129:6, pages 3459-3465.
Crossref
Chen Zhu, Honglue Tan, Tao Cheng, Hao Shen, Junjie Shao, Yongyuan Guo, Sifeng Shi & Xianlong Zhang. (2013) Human ?-defensin 3 inhibits antibiotic-resistant Staphylococcus biofilm formation. Journal of Surgical Research 183:1, pages 204-213.
Crossref
Shen Liu, Jingwen Zhao, Hongjiang Ruan, Wei Wang, Tianyi Wu, Wenguo Cui & Cunyi Fan. (2013) Antibacterial and anti-adhesion effects of the silver nanoparticles-loaded poly(l-lactide) fibrous membrane. Materials Science and Engineering: C 33:3, pages 1176-1182.
Crossref
E.A. Abou Neel & A.M. Young. 2013. Joining and Assembly of Medical Materials and Devices. Joining and Assembly of Medical Materials and Devices 491 513 .
Tianyi Wu, Qingchun Zhang, Weiping Ren, Xiang Yi, Zubin Zhou, Xiaochun Peng, Xiaowei Yu & Meidong Lang. (2013) Controlled release of gentamicin from gelatin/genipin reinforced beta-tricalcium phosphate scaffold for the treatment of osteomyelitis. Journal of Materials Chemistry B 1:26, pages 3304.
Crossref
H. L. Tan, W. T. Lin & T. T. Tang. (2012) The use of Antimicrobial-Impregnated PMMA to Manage Periprosthetic Infections: Controversial Issues and the Latest Developments. The International Journal of Artificial Organs 35:10, pages 832-839.
Crossref
Tianyi Wu, Xiaolin Hua, Zhiwei He, Xinfu Wang, Xiaowei Yu & Weiping Ren. (2012) The bactericidal and biocompatible characteristics of reinforced calcium phosphate cements. Biomedical Materials 7:4, pages 045003.
Crossref
Honglue Tan, Shengrong Guo, Shengbing Yang, Xiaofen Xu & Tingting Tang. (2012) Physical characterization and osteogenic activity of the quaternized chitosan-loaded PMMA bone cement. Acta Biomaterialia 8:6, pages 2166-2174.
Crossref
Honglue Tan, Zhaoxiang Peng, Qingtian Li, Xiaofen Xu, Shengrong Guo & Tingting Tang. (2012) The use of quaternised chitosan-loaded PMMA to inhibit biofilm formation and downregulate the virulence-associated gene expression of antibiotic-resistant staphylococcus. Biomaterials 33:2, pages 365-377.
Crossref
Heinz Winkler. 2012. Culture Negative Orthopedic Biofilm Infections. Culture Negative Orthopedic Biofilm Infections 111 127 .
E. Bertazzoni Minelli, T. Della Bora & A. Benini. (2011) Different microbial biofilm formation on polymethylmethacrylate (PMMA) bone cement loaded with gentamicin and vancomycin. Anaerobe 17:6, pages 380-383.
Crossref
Sunghwan Kim, Robert Greenleaf, Mark Carl Miller, Latha Satish, Sandeep Kathju, Garth Ehrlich, J. Christopher Post, Nicholas G. Sotereanos & Paul Stoodley. (2011) Mechanical effects, antimicrobial efficacy and cytotoxicity of usnic acid as a biofilm prophylaxis in PMMA. Journal of Materials Science: Materials in Medicine 22:12, pages 2773-2780.
Crossref
Lucio Montanaro, Pietro Speziale, Davide Campoccia, Stefano Ravaioli, Ilaria Cangini, Giampiero Pietrocola, Sandro Giannini & Carla Renata Arciola. (2011) Scenery of Staphylococcus implant infections in orthopedics . Future Microbiology 6:11, pages 1329-1349.
Crossref
Dorottya Frank, Gell?rt Cseh, Tam?s Nagy, L?szl? P?t?B?la Kocsis & Attila Miseta. (2011) Polymethyl-methacrylate?sorbitol-based capsules as local drug delivery vehicles: a preliminary study. Cell Biology International 35:5, pages 499-504.
Crossref
Ryuji Mori, Takahisa Nakai, Koichi Enomoto, Yuji Uchio & Katsumi Yoshino. (2010) Increased Antibiotic Release from a Bone Cement Containing Bacterial Cellulose. Clinical Orthopaedics and Related Research® 469:2, pages 600-606.
Crossref
Daniëlle Neut, Otto S Kluin, Jonathan Thompson, Henny C van der Mei & Henk J Busscher. (2010) Gentamicin release from commercially-available gentamicin-loaded PMMA bone cements in a prosthesis-related interfacial gap model and their antibacterial efficacy. BMC Musculoskeletal Disorders 11:1.
Crossref
Gladius Lewis, Jennifer L. Brooks, Harry S. Courtney, Yuan Li & Warren O. Haggard. (2010) An Approach for Determining Antibiotic Loading for a Physician-directed Antibiotic-loaded PMMA Bone Cement Formulation. Clinical Orthopaedics and Related Research® 468:8, pages 2092-2100.
Crossref
Todd Jaeblon. (2010) Polymethylmethacrylate: Properties and Contemporary Uses in Orthopaedics. American Academy of Orthopaedic Surgeon 18:5, pages 297-305.
Crossref
D. FARRAR, R. BENSON & R. MILNER. 2010. Drug-Device Combination Products. Drug-Device Combination Products 190 218 .
H. Winkler. (2010) One-stage revision of septic hip prosthesis with antibiotic-loaded bone grafts and cementless implants. LO SCALPELLO-OTODI Educational 23:3, pages 193-203.
Crossref
Robert S. Namba, Yuexin Chen, Elizabeth W. Paxton, Tamara Slipchenko & Donald C. Fithian. (2009) Outcomes of Routine Use of Antibiotic-Loaded Cement in Primary Total Knee Arthroplasty. The Journal of Arthroplasty 24:6, pages 44-47.
Crossref
Gladius Lewis. (2008) Properties of antibiotic‐loaded acrylic bone cements for use in cemented arthroplasties: A state‐of‐the‐art review. Journal of Biomedical Materials Research Part B: Applied Biomaterials 89B:2, pages 558-574.
Crossref
D. Campoccia, L. Montanaro, T.F. Moriarty, R.G. Richards, S. Ravaioli & CR. Arciola. (2018) The Selection of Appropriate Bacterial Strains in Preclinical Evaluation of Infection-Resistant Biomaterials. The International Journal of Artificial Organs 31:9, pages 841-847.
Crossref
Geert T. Ensing, Jim R. van Horn, Henny C. van der Mei, Henk J. Busscher & Daniëlle Neut. (2008) Copal Bone Cement Is More Effective in Preventing Biofilm Formation than Palacos R-G. Clinical Orthopaedics & Related Research 466:6, pages 1492-1498.
Crossref
Carlo Gelmetti. (2008) Local antibiotics in dermatology. Dermatologic Therapy 21:3, pages 187-195.
Crossref
N. DUNNE. 2008. Orthopaedic Bone Cements. Orthopaedic Bone Cements 233 264 .

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