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Original paper

Persistence of bacterial growth on antibiotic-loaded beads: Is it actually a problem?

, , , &
Pages 302-307 | Received 12 Feb 2007, Accepted 02 Sep 2007, Published online: 08 Jul 2009

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Crossref
A. de Breij, M. Riool, P.H.S. Kwakman, L. de Boer, R.A. Cordfunke, J.W. Drijfhout, O. Cohen, N. Emanuel, S.A.J. Zaat, P.H. Nibbering & T.F. Moriarty. (2016) Prevention of Staphylococcus aureus biomaterial-associated infections using a polymer-lipid coating containing the antimicrobial peptide OP-145. Journal of Controlled Release 222, pages 1-8.
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Ping Zhu, Zhengyang Weng, Xia Li, Xiangmei Liu, Shuilin Wu, K. W. K. Yeung, Xianbao Wang, Zhenduo Cui, Xianjin Yang & Paul. K. Chu. (2016) Biomedical Applications of Functionalized ZnO Nanomaterials: from Biosensors to Bioimaging. Advanced Materials Interfaces 3:1, pages 1500494.
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Willem-Jan Metsemakers, Noam Emanuel, Or Cohen, Malka Reichart, Inga Potapova, Tanja Schmid, David Segal, Martijn Riool, Paulus H.S. Kwakman, Leonie de Boer, Anna de Breij, Peter H. Nibbering, R. Geoff Richards, Sebastian A.J. Zaat & T. Fintan Moriarty. (2015) A doxycycline-loaded polymer-lipid encapsulation matrix coating for the prevention of implant-related osteomyelitis due to doxycycline-resistant methicillin-resistant Staphylococcus aureus. Journal of Controlled Release 209, pages 47-56.
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Abbas Monzavi, Saeed Eshraghi, Roxana Hashemian & Fatemeh Momen-Heravi. (2014) In vitro and ex vivo antimicrobial efficacy of nano-MgO in the elimination of endodontic pathogens. Clinical Oral Investigations 19:2, pages 349-356.
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Sean S. AikenJohn J. CooperHannah FloranceMatthew T. RobinsonStephen Michell. (2015) Local Release of Antibiotics for Surgical Site Infection Management Using High-Purity Calcium Sulfate: An In Vitro Elution Study. Surgical Infections 16:1, pages 54-61.
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Patricio Peñalba Arias, Ulrika Furustrand Tafin, Bertrand Bétrisey, Sebastian Vogt, Andrej Trampuz & Olivier Borens. (2015) Activity of bone cement loaded with daptomycin alone or in combination with gentamicin or PEG600 against Staphylococcus epidermidis biofilms. Injury 46:2, pages 249-253.
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G. Massazza, A. Bistolfi, E. Verné, M. Miola, L. Ravera & F. Rosso. 2015. Biomaterials and Medical Device - Associated Infections. Biomaterials and Medical Device - Associated Infections 185 197 .
Marcin K. Wasko & Rafal Kaminski. (2015) Custom-Made Antibiotic Cement Nails in Orthopaedic Trauma: Review of Outcomes, New Approaches, and Perspectives. BioMed Research International 2015, pages 1-12.
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Nusret Kose & Aydan Ayse Kose. 2015. Nanotechnology in Diagnosis, Treatment and Prophylaxis of Infectious Diseases. Nanotechnology in Diagnosis, Treatment and Prophylaxis of Infectious Diseases 107 117 .
Sarita R. Shah, Allan M. Henslee, Patrick P. Spicer, Shun Yokota, Sophia Petrichenko, Sachin Allahabadi, George N. Bennett, Mark E. Wong, F. Kurtis Kasper & Antonios G. Mikos. (2014) Effects of Antibiotic Physicochemical Properties on Their Release Kinetics from Biodegradable Polymer Microparticles. Pharmaceutical Research 31:12, pages 3379-3389.
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Pablo S. Corona, Laia Espinal, Dolors Rodríguez-Pardo, Carles Pigrau, Nieves Larrosa & Xavier Flores. (2014) Antibiotic Susceptibility in Gram-Positive Chronic Joint Arthroplasty Infections: Increased Aminoglycoside Resistance Rate in Patients With Prior Aminoglycoside-Impregnated Cement Spacer Use. The Journal of Arthroplasty 29:8, pages 1617-1621.
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N. FleiterG. WalterH. BösebeckS. VogtH. BüchnerW. HirschbergerR. Hoffmann. (2014) Clinical use and safety of a novel gentamicin-releasing resorbable bone graft substitute in the treatment of osteomyelitis/osteitis. Bone & Joint Research 3:7, pages 223-229.
Crossref
C. L. RomanòN. LogolusoE. MeaniD. RomanòE. De VecchiC. VassenaL. Drago. (2014) A comparative study of the use of bioactive glass S53P4 and antibiotic-loaded calcium-based bone substitutes in the treatment of chronic osteomyelitis. The Bone & Joint Journal 96-B:6, pages 845-850.
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Yuan-Ming Hsu, Chun-Hsing Liao, Yu-Hong Wei, Hsu-Wei Fang, Hsiang-Huan Hou, Chia-Chun Chen & Chih-Hung Chang. (2014) Daptomycin-Loaded Polymethylmethacrylate Bone Cement for Joint Arthroplasty Surgery. Artificial Organs 38:6, pages 484-492.
Crossref
Massimo Varisco, Nina Khanna, Priscilla S. Brunetto & Katharina M. Fromm. (2014) New Antimicrobial and Biocompatible Implant Coating with Synergic Silver-Vancomycin Conjugate Action. ChemMedChem 9:6, pages 1221-1230.
Crossref
Pablo S. Corona, Victor Barro, Marye Mendez, Enric Cáceres & Xavier Flores. (2013) Industrially Prefabricated Cement Spacers: Do Vancomycin- and Gentamicin-impregnated Spacers Offer Any Advantage?. Clinical Orthopaedics and Related Research® 472:3, pages 923-932.
Crossref
Massimo Mariconda, Tiziana Ascione, Giovanni Balato, Renato Rotondo, Francesco Smeraglia, Giovan Giuseppe Costa & Marco Conte. (2013) Sonication of antibiotic-loaded cement spacers in a two-stage revision protocol for infected joint arthroplasty. BMC Musculoskeletal Disorders 14:1.
Crossref
Sarita R. Shah, F. Kurtis Kasper & Antonios G. Mikos. (2013) Perspectives on the prevention and treatment of infection for orthopedic tissue engineering applications. Chinese Science Bulletin 58:35, pages 4342-4348.
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Sarita R. Shah, Alexander M. Tatara, Rena N. D'Souza, Antonios G. Mikos & F. Kurtis Kasper. (2013) Evolving strategies for preventing biofilm on implantable materials. Materials Today 16:5, pages 177-182.
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Antony Ananth, Subramanian Dharaneedharan, Mani Sanjeeva Gandhi, Moon-Soo Heo & Young Sun Mok. (2013) Novel RuO2 nanosheets – Facile synthesis, characterization and application. Chemical Engineering Journal 223, pages 729-736.
Crossref
Jasmina Vidic, Slavica Stankic, Francia Haque, Danica Ciric, Ronan Le Goffic, Aurore Vidy, Jacques Jupille & Bernard Delmas. (2013) Selective antibacterial effects of mixed ZnMgO nanoparticles. Journal of Nanoparticle Research 15:5.
Crossref
G. Hayes, N. Moens & T. Gibson. (2013) A review of local antibiotic implants and applications to veterinary orthopaedic surgery. Veterinary and Comparative Orthopaedics and Traumatology 26:4, pages 251-259.
Crossref
H. L. Tan, W. T. Lin & T. T. Tang. (2012) The use of Antimicrobial-Impregnated PMMA to Manage Periprosthetic Infections: Controversial Issues and the Latest Developments. The International Journal of Artificial Organs 35:10, pages 832-839.
Crossref
Konstantinos Anagnostakos & Katrin Schr?der. (2012) Antibiotic-Impregnated Bone Grafts in Orthopaedic and Trauma Surgery: A Systematic Review of the Literature. International Journal of Biomaterials 2012, pages 1-9.
Crossref
E. Bertazzoni Minelli, T. Della Bora & A. Benini. (2011) Different microbial biofilm formation on polymethylmethacrylate (PMMA) bone cement loaded with gentamicin and vancomycin. Anaerobe 17:6, pages 380-383.
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Daniëlle Neut, René J.B. Dijkstra, Jonathan I. Thompson, Henny C. van der Mei & Henk J. Busscher. (2011) Antibacterial efficacy of a new gentamicin-coating for cementless prostheses compared to gentamicin-loaded bone cement. Journal of Orthopaedic Research 29:11, pages 1654-1661.
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Alessandro Bistolfi, Giuseppe Massazza, Enrica Verné, Alessandro Massè, Davide Deledda, Sara Ferraris, Marta Miola, Fabrizio Galetto & Maurizio Crova. (2011) Antibiotic-Loaded Cement in Orthopedic Surgery: A Review. ISRN Orthopedics 2011, pages 1-8.
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S. Ghosh, R. Kaushik, K. Nagalakshmi, S.L. Hoti, G.A. Menezes, B.N. Harish & H.N. Vasan. (2010) Antimicrobial activity of highly stable silver nanoparticles embedded in agar–agar matrix as a thin film. Carbohydrate Research 345:15, pages 2220-2227.
Crossref
I. Perelshtein, G. Applerot, N. Perkas, J. Grinblat, E. Hulla, E. Wehrschuetz-Sigl, A. Hasmann, G. Guebitz & A. Gedanken. (2010) Ultrasound Radiation as a “Throwing Stones” Technique for the Production of Antibacterial Nanocomposite Textiles. ACS Applied Materials & Interfaces 2:7, pages 1999-2004.
Crossref
DAVID N. GILBERT & JAMES E. LEGGETT. 2010. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases 359 384 .
Guy Applerot, Nina Perkas, Galina Amirian, Olga Girshevitz & Aharon Gedanken. (2009) Coating of glass with ZnO via ultrasonic irradiation and a study of its antibacterial properties. Applied Surface Science 256:3, pages S3-S8.
Crossref
F. Kipp. (2009) Posttraumatische OsteitisPosttraumatic osteitis. Trauma und Berufskrankheit 11:S2, pages 232-235.
Crossref
Xun-Zi Cai, Xian-Zhen Chen, Shi-Gui Yan, Zou-Rong Ruan, Rui-Jian Yan, Kang Ji & Jia Xu. (2008) Intermittent watt-level ultrasonication facilitates vancomycin release from therapeutic acrylic bone cement. Journal of Biomedical Materials Research Part B: Applied Biomaterials 90B:1, pages 11-17.
Crossref
Konstantinos Anagnostakos & Jens Kelm. (2009) Enhancement of antibiotic elution from acrylic bone cement. Journal of Biomedical Materials Research Part B: Applied Biomaterials 90B:1, pages 467-475.
Crossref
Guy Applerot, Anat Lipovsky, Rachel Dror, Nina Perkas, Yeshayahu Nitzan, Rachel Lubart & Aharon Gedanken. (2009) Enhanced Antibacterial Activity of Nanocrystalline ZnO Due to Increased ROS-Mediated Cell Injury. Advanced Functional Materials 19:6, pages 842-852.
Crossref

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