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Review

Novel approaches for designing drugs that interfere with pH regulation

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Pages 231-248 | Received 04 Nov 2018, Accepted 07 Jan 2019, Published online: 25 Jan 2019

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Alane Beatriz Vermelho, Giseli Capaci Rodrigues, Alessio Nocentini, Felipe R. P. Mansoldo & Claudiu T. Supuran. (2022) Discovery of novel drugs for Chagas disease: is carbonic anhydrase a target for antiprotozoal drugs?. Expert Opinion on Drug Discovery 17:10, pages 1147-1158.
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Claudiu T Supuran. (2020) Experimental Carbonic Anhydrase Inhibitors for the Treatment of Hypoxic Tumors. Journal of Experimental Pharmacology 12, pages 603-617.
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Claudiu T. Supuran. (2020) Exploring the multiple binding modes of inhibitors to carbonic anhydrases for novel drug discovery. Expert Opinion on Drug Discovery 15:6, pages 671-686.
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Claudiu T. Supuran. (2020) An update on drug interaction considerations in the therapeutic use of carbonic anhydrase inhibitors. Expert Opinion on Drug Metabolism & Toxicology 16:4, pages 297-307.
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Paolo Guglielmi, Giulia Rotondi, Daniela Secci, Andrea Angeli, Paola Chimenti, Alessio Nocentini, Alessandro Bonardi, Paola Gratteri, Simone Carradori & Claudiu T. Supuran. (2020) Novel insights on saccharin- and acesulfame-based carbonic anhydrase inhibitors: design, synthesis, modelling investigations and biological activity evaluation. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 1891-1905.
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Mehmet Oguz, Erbay Kalay, Suleyman Akocak, Alessio Nocentini, Nebih Lolak, Mehmet Boga, Mustafa Yilmaz & Claudiu T. Supuran. (2020) Synthesis of calix[4]azacrown substituted sulphonamides with antioxidant, acetylcholinesterase, butyrylcholinesterase, tyrosinase and carbonic anhydrase inhibitory action. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 1215-1223.
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Jeremie Brichet, Rodrigo Arancibia, Emanuela Berrino & Claudiu T. Supuran. (2020) Bioorganometallic derivatives of 4-hydrazino-benzenesulphonamide as carbonic anhydrase inhibitors: synthesis, characterisation and biological evaluation. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 622-628.
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Alessio Nocentini & Claudiu T. Supuran. (2019) Advances in the structural annotation of human carbonic anhydrases and impact on future drug discovery. Expert Opinion on Drug Discovery 14:11, pages 1175-1197.
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Articles from other publishers (25)

Amit Kumar, Priyanka Arya, Vikas Sharma, Simone Giovannuzzi, Neera Raghav, Claudiu T. Supuran & Pawan K. Sharma. (2023) Potent inhibitors of tumor associated carbonic anhydrases endowed with cathepsin B inhibition. Archiv der Pharmazie 356:11.
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Jaber Haj Ali & Michael Walter. (2023) Combining old and new concepts in targeting telomerase for cancer therapy: transient, immediate, complete and combinatory attack (TICCA). Cancer Cell International 23:1.
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Vasilisa Krivovicheva, Andrey Bubyrev, Stanislav Kalinin, Dmitry Dar'in, Maxim Gureev, Valeria Burianova, Daniella Vullo, Mikhail Krasavin & Claudiu T. Supuran. (2023) Versatile Diazomethane Sulfonamide for Expedited Exploration of Azole‐Based Carbonic Anhydrase Inhibitors via [3+2] Cycloaddition. ChemMedChem 18:10.
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Vasilisa Krivovicheva, Andrey Bubyrev, Stanislav Kalinin, Dmitry Dar'in, Maxim Gureev, Daniela Vullo, Mikhail Krasavin, Mikhail Korsakov & Claudiu T. Supuran. (2023) A new way of synthesizing heterocyclic primary sulfonamide probes for carbonic anhydrase. Mendeleev Communications 33:3, pages 325-327.
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Andrea Angeli, Laura Micheli, Fabrizio Carta, Marta Ferraroni, Tracey Pirali, Asia Fernandez Carvajal, Antonio Ferrer Montiel, Lorenzo Di Cesare Mannelli, Carla Ghelardini & Claudiu T. Supuran. (2023) First-in-Class Dual Hybrid Carbonic Anhydrase Inhibitors and Transient Receptor Potential Vanilloid 1 Agonists Revert Oxaliplatin-Induced Neuropathy. Journal of Medicinal Chemistry 66:2, pages 1616-1633.
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Claudiu T. Supuran. 2022. Flavonoids and Phenolics. Flavonoids and Phenolics 298 329 .
Jing Yang, Da-Lei Chen, Peng-Chao Wang, Bo Yang & Chuan-Zhu Gao. (2022) NIR phosphorescent cyclometalated platinum (II) complexes with CAIX targeted and nuclear penetration as potent anticancer theragnostic agents. European Journal of Medicinal Chemistry 243, pages 114702.
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Pavitra S. Thacker, Vaishnavi Newaskar, Andrea Angeli, Dilep Kumar Sigalapalli, Nerella Sridhar Goud, Hepsibha Chirra, Afzal B. Shaik, Mohammed Arifuddin & Claudiu T. Supuran. (2022) Synthesis and biological evaluation of coumarin‐thiazole hybrids as selective carbonic anhydrase IX and XII inhibitors. Archiv der Pharmazie 355:12.
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Virginia Pontecorvi, Mattia Mori, Francesca Picarazzi, Susi Zara, Simone Carradori, Amelia Cataldi, Andrea Angeli, Emanuela Berrino, Paola Chimenti, Alessia Ciogli, Daniela Secci, Paolo Guglielmi & Claudiu T. Supuran. (2022) Novel Insights on Human Carbonic Anhydrase Inhibitors Based on Coumalic Acid: Design, Synthesis, Molecular Modeling Investigation, and Biological Studies. International Journal of Molecular Sciences 23:14, pages 7950.
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Amit Kumar, Kiran Siwach, Tanmay Rom, Rajiv Kumar, Andrea Angeli, Avijit Kumar Paul, Claudiu T. Supuran & Pawan K. Sharma. (2022) Tail-approach based design and synthesis of Arylthiazolylhydrazono-1,2,3-triazoles incorporating sulfanilamide and metanilamide as human carbonic anhydrase I, II, IV and IX inhibitors. Bioorganic Chemistry 123, pages 105764.
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Javier Rivera-Araya, Thomas Heine, Renato Chávez, Michael Schlömann & Gloria Levicán. (2022) Transcriptomic analysis of chloride tolerance in Leptospirillum ferriphilum DSM 14647 adapted to NaCl. PLOS ONE 17:4, pages e0267316.
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Pengcheng Lv, Yinyi Cai, Jiayi Luo & Kun Chen. (2022) Recent Advances in the Design and Synthesis of Small Molecule Carbonic Anhydrase IX Inhibitors. Current Topics in Medicinal Chemistry 22:7, pages 550-560.
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Simone Carradori & Claudiu T. Supuran. 2021. pH-Interfering Agents as Chemosensitizers in Cancer Therapy. pH-Interfering Agents as Chemosensitizers in Cancer Therapy 79 94 .
Alessio Nocentini & Stefano Fais. 2021. pH-Interfering Agents as Chemosensitizers in Cancer Therapy. pH-Interfering Agents as Chemosensitizers in Cancer Therapy 47 62 .
Claudiu T. Supuran. 2021. New Trends in Macromolecular and Supramolecular Chemistry for Biological Applications. New Trends in Macromolecular and Supramolecular Chemistry for Biological Applications 115 131 .
Salvador Harguindey, Khalid Alfarouk, Julián Polo Orozco, Stefano Fais & Jesús Devesa. (2020) Towards an Integral Therapeutic Protocol for Breast Cancer Based upon the New H+-Centered Anticancer Paradigm of the Late Post-Warburg Era. International Journal of Molecular Sciences 21:20, pages 7475.
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Baijayantimala Swain, Andrea Angeli, Priti Singh, Claudiu T. Supuran & Mohammed Arifuddin. (2020) New coumarin/sulfocoumarin linked phenylacrylamides as selective transmembrane carbonic anhydrase inhibitors: Synthesis and in-vitro biological evaluation. Bioorganic & Medicinal Chemistry 28:15, pages 115586.
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Emanuela Berrino, Andrea Angeli, Dmitry D. Zhdanov, Anna P. Kiryukhina, Andrea Milaneschi, Alessandro De Luca, Murat Bozdag, Simone Carradori, Silvia Selleri, Gianluca Bartolucci, Thomas S. Peat, Marta Ferraroni, Claudiu T. Supuran & Fabrizio Carta. (2020) Azidothymidine “Clicked” into 1,2,3-Triazoles: First Report on Carbonic Anhydrase–Telomerase Dual-Hybrid Inhibitors. Journal of Medicinal Chemistry 63:13, pages 7392-7409.
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Enrico Luchinat, Letizia Barbieri, Matteo Cremonini, Alessio Nocentini, Claudiu T. Supuran & Lucia Banci. (2020) Drug Screening in Human Cells by NMR Spectroscopy Allows the Early Assessment of Drug Potency. Angewandte Chemie International Edition 59:16, pages 6535-6539.
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Enrico Luchinat, Letizia Barbieri, Matteo Cremonini, Alessio Nocentini, Claudiu T. Supuran & Lucia Banci. (2020) Drug Screening in Human Cells by NMR Spectroscopy Allows the Early Assessment of Drug Potency. Angewandte Chemie 132:16, pages 6597-6601.
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Salvador Harguindey, Khalid Alfarouk, Julián Polo Orozco, Kévin Hardonnière, Daniel Stanciu, Stefano Fais & Jesús Devesa. (2020) A New and Integral Approach to the Etiopathogenesis and Treatment of Breast Cancer Based upon Its Hydrogen Ion Dynamics. International Journal of Molecular Sciences 21:3, pages 1110.
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Ana Podolski-Renić, Jelena Dinić, Tijana Stanković, Mirna Jovanović, Amra Ramović, Aleksandrs Pustenko, Raivis Žalubovskis & Milica Pešić. (2019) Sulfocoumarins, specific carbonic anhydrase IX and XII inhibitors, interact with cancer multidrug resistant phenotype through pH regulation and reverse P-glycoprotein mediated resistance. European Journal of Pharmaceutical Sciences 138, pages 105012.
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Salvador Harguindey, Julian Polo Orozco, Khalid O. Alfarouk & Jesús Devesa. (2019) Hydrogen Ion Dynamics of Cancer and a New Molecular, Biochemical and Metabolic Approach to the Etiopathogenesis and Treatment of Brain Malignancies. International Journal of Molecular Sciences 20:17, pages 4278.
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Damiano Tanini, Antonella Capperucci, Claudiu T. Supuran & Andrea Angeli. (2019) Sulfur, selenium and tellurium containing amines act as effective carbonic anhydrase activators. Bioorganic Chemistry 87, pages 516-522.
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Sonia Del Prete, Daniela Vullo, Cynthia Ghobril, Julien Hitce, Cécile Clavaud, Xavier Marat, Clemente Capasso & Claudiu T. Supuran. (2019) Cloning, Purification, and Characterization of a β-Carbonic Anhydrase from Malassezia restricta, an Opportunistic Pathogen Involved in Dandruff and Seborrheic Dermatitis. International Journal of Molecular Sciences 20:10, pages 2447.
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