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Original

Role of zinc in ALS

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Pages 131-143 | Received 15 Feb 2006, Accepted 30 Jan 2007, Published online: 10 Jul 2009

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Su-Fang Wang, Jinhyuk Lee, Wei Wang, Yue-Xiu Si, Caiyan Li, Tae-Rae Kim, Jun-Mo Yang, Shang-Jun Yin & Guo-Ying Qian. (2013) The effect of Zn2+ on Pelodiscus sinensis creatine kinase: unfolding and aggregation studies. Journal of Biomolecular Structure and Dynamics 31:6, pages 572-590.
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Roberto Madeddu, Giovanni Forte, Beatrice Bocca, Paola Tolu, Maria Alessandra Sotgiu, Giovanni Sotgiu, Juan Antonio Marchal, Stefano Sotgiu & Andrea Montella. (2011) Heavy Metals and Multiple Sclerosis in Sardinian Population (Italy). Analytical Letters 44:9, pages 1699-1712.
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Joan Isabel Post, Joseph Karl Eibl & Gregory Michiel Ross. (2008) Zinc induces motor neuron death via a selective inhibition of brain-derived neurotrophic factor activity. Amyotrophic Lateral Sclerosis 9:3, pages 149-155.
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Jingxuan Zhu, Juexin Wang, Weiwei Han & Dong Xu. (2022) Neural relational inference to learn long-range allosteric interactions in proteins from molecular dynamics simulations. Nature Communications 13:1.
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Ibrahim Mortada, Raymond Farah, Sanaa Nabha, David M. Ojcius, Youssef Fares, Wassim Y. Almawi & Najwane Said Sadier. (2021) Immunotherapies for Neurodegenerative Diseases. Frontiers in Neurology 12.
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Vinayak Juvekar, Sang Jun Park, Juyoung Yoon & Hwan Myung Kim. (2021) Recent progress in the two-photon fluorescent probes for metal ions. Coordination Chemistry Reviews 427, pages 213574.
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Siju Ellickal Narayanan, Nisha Abdul Rehuman, Seetha Harilal, Anju Vincent, Rajalakshmi Ganesan Rajamma, Tapan Behl, Md. Sahab Uddin, Ghulam Md Ashraf & Bijo Mathew. (2020) Molecular mechanism of zinc neurotoxicity in Alzheimer’s disease. Environmental Science and Pollution Research 27:35, pages 43542-43552.
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Claudia Figueroa‐Romero, Kristen A. Mikhail, Chris Gennings, Paul Curtin, Ghalib A. Bello, Tatiana M. Botero, Stephen A. Goutman, Eva L. Feldman, Manish Arora & Christine Austin. (2020) Early life metal dysregulation in amyotrophic lateral sclerosis. Annals of Clinical and Translational Neurology 7:6, pages 872-882.
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Paulo C. T. Souza, Sebastian Thallmair, Siewert J. Marrink & Raúl Mera-Adasme. (2019) An Allosteric Pathway in Copper, Zinc Superoxide Dismutase Unravels the Molecular Mechanism of the G93A Amyotrophic Lateral Sclerosis-Linked Mutation. The Journal of Physical Chemistry Letters 10:24, pages 7740-7744.
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Raúl Mera-Adasme, Moisés Domínguez & Otoniel Denis-Alpizar. (2019) A benchmark for the size of the QM system required for accurate hybrid QM/MM calculations on the metal site of the protein copper, zinc superoxide dismutase. Journal of Molecular Modeling 25:6.
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Jolene M. Kim, Elizabeth Billington, Ada Reyes, Tara Notarianni, Jessica Sage, Emre Agbas, Michael Taylor, Ian Monast, John A. Stanford & Abdulbaki Agbas. (2018) Impaired Cu–Zn Superoxide Dismutase (SOD1) and Calcineurin (Cn) Interaction in ALS: A Presumed Consequence for TDP-43 and Zinc Aggregation in Tg SOD1G93A Rodent Spinal Cord Tissue. Neurochemical Research 44:1, pages 228-233.
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Stuart D. Portbury, Ashley I. Bush & Paul A. Adlard. 2019. Zinc Signaling. Zinc Signaling 201 228 .
Ankur Anand, Chih‐Hung Chi, Subhasree Banerjee, Ming‐Yi Chou, Fan‐Gang Tseng, Chien‐Yuan Pan & Yit‐Tsong Chen. (2018) The Extracellular Zn 2+ Concentration Surrounding Excited Neurons Is High Enough to Bind Amyloid‐β Revealed by a Nanowire Transistor . Small 14:24.
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Riccardo Oggiano, Giuliana Solinas, Giovanni Forte, Beatrice Bocca, Cristiano Farace, Andrea Pisano, Maria Alessandra Sotgiu, Simonetta Clemente, Michele Malaguarnera, Alessandro Giuseppe Fois, Pietro Pirina, Andrea Montella & Roberto Madeddu. (2018) Trace elements in ALS patients and their relationships with clinical severity. Chemosphere 197, pages 457-466.
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Giovanni Forte, Beatrice Bocca, Riccardo Oggiano, Simonetta Clemente, Yolande Asara, Maria Alessandra Sotgiu, Cristiano Farace, Andrea Montella, Alessandro Giuseppe Fois, Michele Malaguarnera, Pietro Pirina & Roberto Madeddu. (2017) Essential trace elements in amyotrophic lateral sclerosis (ALS): Results in a population of a risk area of Italy. Neurological Sciences 38:9, pages 1609-1615.
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Kelsey L. Veldkamp, Philip J. Tubergen, Mason A. Swartz, Jodie T. DeVries & Chad D. Tatko. (2017) Zinc binding with l-dopa peptides. Inorganica Chimica Acta 461, pages 120-126.
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Per M. Roos. 2017. Biometals in Neurodegenerative Diseases. Biometals in Neurodegenerative Diseases 175 193 .
Raúl Mera-Adasme, Hannes Erdmann, Tomasz Bereźniak & Christian Ochsenfeld. (2016) Destabilization of the metal site as a hub for the pathogenic mechanism of five ALS-linked mutants of copper, zinc superoxide dismutase. Metallomics 8:10, pages 1141-1150.
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Alida Spalloni & Patrizia Longone. (2016) Cognitive impairment in amyotrophic lateral sclerosis, clues from the SOD1 mouse. Neuroscience & Biobehavioral Reviews 60, pages 12-25.
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Yingying Xu, Jinhyuk Lee, Zhi-Rong Lü, Jing Jing Wang, Xi Xi Wang, Li Yan, Hai-Meng Zhou, Yong-Doo Park, Qian Zhang & Jun-Mo Yang. (2015) Integration of inhibition kinetics and molecular dynamics simulations to determine the effects of Zn2+ on acetaldehyde dehydrogenase 1. Process Biochemistry 50:11, pages 1878-1884.
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Sónia S. Leal, Joana S. Cristóvão, Antje Biesemeier, Isabel Cardoso & Cláudio M. Gomes. (2015) Aberrant zinc binding to immature conformers of metal-free copper–zinc superoxide dismutase triggers amorphous aggregation. Metallomics 7:2, pages 333-346.
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Raúl Mera-Adasme, Keyarash Sadeghian, Dage Sundholm & Christian Ochsenfeld. (2014) Effect of Including Torsional Parameters for Histidine–Metal Interactions in Classical Force Fields for Metalloproteins. The Journal of Physical Chemistry B 118:46, pages 13106-13111.
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Megan W. Bourassa, Hilda H. Brown, David R. Borchelt, Stefan Vogt & Lisa M. Miller. (2014) Metal-deficient aggregates and diminished copper found in cells expressing SOD1 mutations that cause ALS. Frontiers in Aging Neuroscience 6.
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Raúl Mera-Adasme, Carl-Mikael Suomivuori, Angélica Fierro, Janne Pesonen & Dage Sundholm. (2013) The role of solvent exclusion in the interaction between D124 and the metal site in SOD1: implications for ALS. JBIC Journal of Biological Inorganic Chemistry 18:8, pages 931-938.
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Per M. Roos, Olof Vesterberg, Tore Syversen, Trond Peder Flaten & Monica Nordberg. (2012) Metal Concentrations in Cerebrospinal Fluid and Blood Plasma from Patients with Amyotrophic Lateral Sclerosis. Biological Trace Element Research 151:2, pages 159-170.
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Raúl Mera-Adasme, Fernando Mendizábal, Mauricio Gonzalez, Sebastián Miranda-Rojas, Claudio Olea-Azar & Dage Sundholm. (2012) Computational Studies of the Metal-Binding Site of the Wild-Type and the H46R Mutant of the Copper, Zinc Superoxide Dismutase. Inorganic Chemistry 51:10, pages 5561-5568.
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Lina Leinartaitė, Kadhirvel Saraboji, Anna Nordlund, Derek T. Logan & Mikael Oliveberg. (2010) Folding Catalysis by Transient Coordination of Zn 2+ to the Cu Ligands of the ALS-Associated Enzyme Cu/Zn Superoxide Dismutase 1 . Journal of the American Chemical Society 132:38, pages 13495-13504.
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