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ORIGINAL ARTICLE

Guidelines for the preclinical in vivo evaluation of pharmacological active drugs for ALS/MND: Report on the 142nd ENMC international workshop

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Pages 217-223 | Received 19 Feb 2007, Accepted 19 Feb 2007, Published online: 10 Jul 2009

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Svitlana Garbuzova-Davis, Avery Thomson, Crupa Kurien, R. Douglas Shytle & Paul R. Sanberg. (2016) Potential new complication in drug therapy development for amyotrophic lateral sclerosis. Expert Review of Neurotherapeutics 16:12, pages 1397-1405.
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Melissa Nassif, Vicente Valenzuela, Diego Rojas-Rivera, René Vidal, Soledad Matus, Karen Castillo, Yerko Fuentealba, Guido Kroemer, Beth Levine & Claudio Hetz. (2014) Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis. Autophagy 10:7, pages 1256-1271.
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Stefanie Saenger, Bettina Holtmann, Mark R. Nilges, Susanne Schroeder, Andreas Hoeflich, Heidemarie Kletzl, Will Spooren, Susanne Ostrowitzki, Taleen Hanania, Michael Sendtner & Friedrich Metzger. (2012) Functional improvement in mouse models of familial amyotrophic lateral sclerosis by PEGylated insulin-like growth factor I treatment depends on disease severity. Amyotrophic Lateral Sclerosis 13:5, pages 418-429.
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Jia Li, Jill M. Paulson, Felix D. Ye, Minhee Sung, Anthony N. Hollenberg & Seward B. Rutkove. (2012) Reducing systemic hypermetabolism by inducing hypothyroidism does not prolong survival in the SOD1-G93A mouse. Amyotrophic Lateral Sclerosis 13:4, pages 372-377.
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Albert C. Ludolph, Caterina Bendotti, Eran Blaugrund, Adriano Chio, Linda Greensmith, Jean-Philippe Loeffler, Richard Mead, Heiko G. Niessen, Susanne Petri, Pierre-Francois Pradat, Wim Robberecht, Markus Ruegg, Birgit Schwalenstöcker, Detlev Stiller, Leonard van den Berg, Fernando Vieira & Stephan von Horsten. (2010) Guidelines for preclinical animal research in ALS/MND: A consensus meeting. Amyotrophic Lateral Sclerosis 11:1-2, pages 38-45.
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Vincent Meininger, Vivian E. Drory, P. Nigel Leigh, Albert Ludolph, Wim Robberecht & Vincenzo Silani. (2009) Glatiramer acetate has no impact on disease progression in ALS at 40 mg/day: A double- blind, randomized, multicentre, placebo-controlled trial. Amyotrophic Lateral Sclerosis 10:5-6, pages 378-383.
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Masahiko Yamamoto, Fumiaki Tanaka, Hiroshi Tatsumi & Gen Sobue. (2008) A strategy for developing effective amyotropic lateral sclerosis pharmacotherapy: from clinical trials to novel pharmacotherapeutic strategies. Expert Opinion on Pharmacotherapy 9:11, pages 1845-1857.
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. (2008) SESSION 6A USE OF THE G93A SOD1 MOUSE IN THERAPEUTIC TESTING. Amyotrophic Lateral Sclerosis 9:sup1, pages 19-20.
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Crossref
Alexander McGown, Dame Pamela J. Shaw & Tennore Ramesh. (2016) ZNStress: a high-throughput drug screening protocol for identification of compounds modulating neuronal stress in the transgenic mutant sod1G93R zebrafish model of amyotrophic lateral sclerosis. Molecular Neurodegeneration 11:1.
Crossref
Tamara Seredenina, Zeynab Nayernia, Silvia Sorce, Ghassan J. Maghzal, Aleksandra Filippova, Shuo-Chien Ling, Olivier Basset, Olivier Plastre, Youssef Daali, Elisabeth J. Rushing, Maria T. Giordana, Don W. Cleveland, Adriano Aguzzi, Roland Stocker, Karl-Heinz Krause & Vincent Jaquet. (2016) Evaluation of NADPH oxidases as drug targets in a mouse model of familial amyotrophic lateral sclerosis. Free Radical Biology and Medicine 97, pages 95-108.
Crossref
Sebastian A. Lewandowski, Ingrid Nilsson, Linda Fredriksson, Peter Lönnerberg, Lars Muhl, Manuel Zeitelhofer, Milena Z. Adzemovic, Susanne Nichterwitz, Daniel A. Lawrence, Eva Hedlund & Ulf Eriksson. (2015) Presymptomatic activation of the PDGF-CC pathway accelerates onset of ALS neurodegeneration. Acta Neuropathologica 131:3, pages 453-464.
Crossref
Sagit Golko-Perez, Silvia Mandel, Tamar Amit, Lana Kupershmidt, Moussa B. H. Youdim & Orly Weinreb. (2015) Additive Neuroprotective Effects of the Multifunctional Iron Chelator M30 with Enriched Diet in a Mouse Model of Amyotrophic Lateral Sclerosis. Neurotoxicity Research 29:2, pages 208-217.
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Melissa M. Haulcomb, Nichole A. Mesnard-Hoaglin, Richard J. Batka, Rena M. Meadows, Whitney M. Miller, Kathryn P. Mcmillan, Todd J. Brown, Virginia M. Sanders & Kathryn J. Jones. (2015) Identification of B6SJL mSOD1 G93A mouse subgroups with different disease progression rates . Journal of Comparative Neurology 523:18, pages 2752-2768.
Crossref
Jia Y Lee, John D Lee, Simon Phipps, Peter G Noakes & Trent M Woodruff. (2015) Absence of toll-like receptor 4 (TLR4) extends survival in the hSOD1G93A mouse model of amyotrophic lateral sclerosis. Journal of Neuroinflammation 12:1.
Crossref
Renzo Mancuso & Xavier Navarro. (2015) Amyotrophic lateral sclerosis: Current perspectives from basic research to the clinic. Progress in Neurobiology 133, pages 1-26.
Crossref
Fernando G. Vieira, Qinggong Ping, Andy J. Moreno, Joshua D. Kidd, Kenneth Thompson, Bingbing Jiang, John M. Lincecum, Monica Z. Wang, Gerard S. De Zutter, Valerie R. Tassinari, Beth Levine, Theo Hatzipetros, Alan Gill & Steven Perrin. (2015) Guanabenz Treatment Accelerates Disease in a Mutant SOD1 Mouse Model of ALS. PLOS ONE 10:8, pages e0135570.
Crossref
Y. Li, Y. Guo, X. Wang, X. Yu, W. Duan, K. Hong, J. Wang, H. Han & C. Li. (2015) Trehalose decreases mutant SOD1 expression and alleviates motor deficiency in early but not end-stage amyotrophic lateral sclerosis in a SOD1-G93A mouse model. Neuroscience 298, pages 12-25.
Crossref
Kevin X. Liu, Benjamin Edwards, Sheena Lee, Mattéa J. Finelli, Ben Davies, Kay E. Davies & Peter L. Oliver. (2015) Neuron-specific antioxidant OXR1 extends survival of a mouse model of amyotrophic lateral sclerosis. Brain 138:5, pages 1167-1181.
Crossref
Michael Jablonski, David S. Miller, Piera Pasinelli & Davide Trotti. (2015) ABC transporter-driven pharmacoresistance in Amyotrophic Lateral Sclerosis. Brain Research 1607, pages 1-14.
Crossref
Eiichi Tokuda, Shunsuke Watanabe, Eriko Okawa & Shin-ichi Ono. (2015) Regulation of Intracellular Copper by Induction of Endogenous Metallothioneins Improves the Disease Course in a Mouse Model of Amyotrophic Lateral Sclerosis. Neurotherapeutics 12:2, pages 461-476.
Crossref
Julie A. Kelly, Noreen T. Boyle, Natalie Cole, Gillian R. Slator, M. Alessandra Colivicchi, Chiara Stefanini, Oliviero L. Gobbo, Gaia A. Scalabrino, Sinead M. Ryan, Marwa Elamin, Cathal Walsh, Alice Vajda, Margaret M. Goggin, Matthew Campbell, Deborah C. Mash, Shane M. O'Mara, David J. Brayden, John J. Callanan, Keith F. Tipton, Laura Della Corte, Jackie Hunter, Kathy M. O'Boyle, Carvell H. Williams & Orla Hardiman. (2015) First-in-class thyrotropin-releasing hormone (TRH)-based compound binds to a pharmacologically distinct TRH receptor subtype in human brain and is effective in neurodegenerative models. Neuropharmacology 89, pages 193-203.
Crossref
Marianna Marino, Simonetta Papa, Valeria Crippa, Giovanni Nardo, Marco Peviani, Cristina Cheroni, Maria Chiara Trolese, Eliana Lauranzano, Valentina Bonetto, Angelo Poletti, Silvia DeBiasi, Laura Ferraiuolo, Pamela J. Shaw & Caterina Bendotti. (2015) Differences in protein quality control correlate with phenotype variability in 2 mouse models of familial amyotrophic lateral sclerosis. Neurobiology of Aging 36:1, pages 492-504.
Crossref
Daniel Cacabelos, Victoria Ayala, Omar Ramírez-Nunez, Ana Belen Granado-Serrano, Jordi Boada, Jose C. E. Serrano, Rosanna Cabré, Gisela Nadal-Rey, Maria Josep Bellmunt, Isidro Ferrer, Reinald Pamplona & Manuel Portero-Otin. (2014) Dietary Lipid Unsaturation Influences Survival and Oxidative Modifications of an Amyotrophic Lateral Sclerosis Model in a Gender-Specific Manner. NeuroMolecular Medicine 16:4, pages 669-685.
Crossref
Renzo Mancuso, Rosario Osta & Xavier Navarro. (2014) Presymptomatic electrophysiological tests predict clinical onset and survival in SOD1 G93A ALS mice . Muscle & Nerve 50:6, pages 943-949.
Crossref
Ellen J. Bennett, Richard J. Mead, Mimoun Azzouz, Pamela J. Shaw & Andrew J. Grierson. (2014) Early Detection of Motor Dysfunction in the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis (ALS) Using Home Cage Running Wheels. PLoS ONE 9:9, pages e107918.
Crossref
H.-Q. Jiang, M. Ren, H.-Z. Jiang, J. Wang, J. Zhang, X. Yin, S.-Y. Wang, Y. Qi, X.-D. Wang & H.-L. Feng. (2014) Guanabenz delays the onset of disease symptoms, extends lifespan, improves motor performance and attenuates motor neuron loss in the SOD1 G93A mouse model of amyotrophic lateral sclerosis. Neuroscience 277, pages 132-138.
Crossref
Qiongman Kong, Ling-Chu Chang, Kou Takahashi, Qibing Liu, Delanie A. Schulte, Liching Lai, Brian Ibabao, Yuchen Lin, Nathan Stouffer, Chitra Das Mukhopadhyay, Xuechao Xing, Kathleen I. Seyb, Gregory D. Cuny, Marcie A. Glicksman & Chien-Liang Glenn Lin. (2014) Small-molecule activator of glutamate transporter EAAT2 translation provides neuroprotection. Journal of Clinical Investigation 124:3, pages 1255-1267.
Crossref
Marco Peviani, Eleonora Salvaneschi, Leonardo Bontempi, Alessandro Petese, Antonio Manzo, Daniela Rossi, Mario Salmona, Simona Collina, Paolo Bigini & Daniela Curti. (2014) Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation. Neurobiology of Disease 62, pages 218-232.
Crossref
Alan E Renton, Adriano Chiò & Bryan J Traynor. (2013) State of play in amyotrophic lateral sclerosis genetics. Nature Neuroscience 17:1, pages 17-23.
Crossref
Ana Catarina Vieira de Castro & I. Anna S. Olsson. 2015. Ethical Issues in Behavioral Neuroscience. Ethical Issues in Behavioral Neuroscience 47 78 .
Yan Jouroukhin, Regina Ostritsky, Yaniv Assaf, Galit Pelled, Eliezer Giladi & Illana Gozes. (2013) NAP (davunetide) modifies disease progression in a mouse model of severe neurodegeneration: Protection against impairments in axonal transport. Neurobiology of Disease 56, pages 79-94.
Crossref
Eiichi Tokuda, Eriko Okawa, Shunsuke Watanabe, Shin-ichi Ono & Stefan L. Marklund. (2013) Dysregulation of intracellular copper homeostasis is common to transgenic mice expressing human mutant superoxide dismutase-1s regardless of their copper-binding abilities. Neurobiology of Disease 54, pages 308-319.
Crossref
Martin R Turner, Orla Hardiman, Michael Benatar, Benjamin R Brooks, Adriano Chio, Mamede de Carvalho, Paul G Ince, Cindy Lin, Robert G Miller, Hiroshi Mitsumoto, Garth Nicholson, John Ravits, Pamela J Shaw, Michael Swash, Kevin Talbot, Bryan J Traynor, Leonard H Van den Berg, Jan H Veldink, Steve Vucic & Matthew C Kiernan. (2013) Controversies and priorities in amyotrophic lateral sclerosis. The Lancet Neurology 12:3, pages 310-322.
Crossref
Lin ZhouYing HouQidong YangXiaoping DuMin LiMei YuanZhiwen Zhou. (2012) Tetrahydroxystilbene glucoside improves the learning and memory of amyloid-β 1–42 -injected rats and may be connected to synaptic changes in the hippocampus . Canadian Journal of Physiology and Pharmacology 90:11, pages 1446-1455.
Crossref
John Hardy. (2012) CSF biomarking for diagnosis and treatment assessment in neurodegeneration . Journal of Neurochemistry 123:3, pages 339-341.
Crossref
Yan Jouroukhin, Regina Ostritsky & Illana Gozes. (2012) D-NAP Prophylactic Treatment in the SOD Mutant Mouse Model of Amyotrophic Lateral Sclerosis: Review of Discovery and Treatment of Tauopathy. Journal of Molecular Neuroscience 48:3, pages 597-602.
Crossref
Rachel Tesla, Hamilton Parker Wolf, Pin Xu, Jordan Drawbridge, Sandi Jo Estill, Paula Huntington, LaTisha McDaniel, Whitney Knobbe, Aaron Burket, Stephanie Tran, Ruth Starwalt, Lorraine Morlock, Jacinth Naidoo, Noelle S. Williams, Joseph M. Ready, Steven L. McKnight & Andrew A. Pieper. (2012) Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis. Proceedings of the National Academy of Sciences 109:42, pages 17016-17021.
Crossref
Qiongman Kong, Sarah Carothers, Yueming Chang & Chien‐Liang Glenn Lin. (2012) The Importance of Preclinical Trial Timing – a Potential Reason for the Disconnect between mouse Studies and Human Clinical Trials in ALS . CNS Neuroscience & Therapeutics 18:9, pages 791-793.
Crossref
Luc Dupuis, Reinhard Dengler, Michael T. Heneka, Thomas Meyer, Stephan Zierz, Jan Kassubek, Wilhelm Fischer, Franziska Steiner, Eva Lindauer, Markus Otto, Jens Dreyhaupt, Torsten Grehl, Andreas Hermann, Andrea S. Winkler, Ulrich Bogdahn, Reiner Benecke, Bertold Schrank, Carsten Wessig, Julian Grosskreutz & Albert C. Ludolph. (2012) A Randomized, Double Blind, Placebo-Controlled Trial of Pioglitazone in Combination with Riluzole in Amyotrophic Lateral Sclerosis. PLoS ONE 7:6, pages e37885.
Crossref
Lana Kupershmidt, Tamar Amit, Orit Bar-Am, Moussa B.H. Youdim & Orly Weinreb. (2012) Neuroprotection by the multitarget iron chelator M30 on age-related alterations in mice. Mechanisms of Ageing and Development 133:5, pages 267-274.
Crossref
Xinhong Feng, Ying Peng, Mingsheng Liu & Liying Cui. (2012) dl-3-n-butylphthalide extends survival by attenuating glial activation in a mouse model of amyotrophic lateral sclerosis. Neuropharmacology 62:2, pages 1004-1010.
Crossref
Richard J. Mead, Ellen J. Bennett, Aneurin J. Kennerley, Paul Sharp, Claire Sunyach, Paul Kasher, Jason Berwick, Brigitte Pettmann, Guiseppe Battaglia, Mimoun Azzouz, Andrew Grierson & Pamela J. Shaw. (2011) Optimised and Rapid Pre-clinical Screening in the SOD1G93A Transgenic Mouse Model of Amyotrophic Lateral Sclerosis (ALS). PLoS ONE 6:8, pages e23244.
Crossref
Sarah Knippenberg, Nadine Thau, Reinhard Dengler & Susanne Petri. (2010) Significance of behavioural tests in a transgenic mouse model of amyotrophic lateral sclerosis (ALS). Behavioural Brain Research 213:1, pages 82-87.
Crossref
Petra Steinacker, Andreas Hawlik, Stefan Lehnert, Olaf Jahn, Stephen Meier, Evamaria Görz, Kerstin E. Braunstein, Marija Krzovska, Birgit Schwalenstöcker, Sarah Jesse, Christian Pröpper, Tobias Böckers, Albert Ludolph & Markus Otto. (2010) Neuroprotective Function of Cellular Prion Protein in a Mouse Model of Amyotrophic Lateral Sclerosis. The American Journal of Pathology 176:3, pages 1409-1420.
Crossref
R. W. Orrell. (2009) Motor neuron disease: systematic reviews of treatment for ALS and SMA. British Medical Bulletin 93:1, pages 145-159.
Crossref
Anne K. Meyer, Martina Maisel, Andreas Hermann, Katja Stirl & Alexander Storch. (2010) Restorative approaches in Parkinson's Disease: Which cell type wins the race?. Journal of the Neurological Sciences 289:1-2, pages 93-103.
Crossref
Lana Kupershmidt, Orly Weinreb, Tamar Amit, Silvia Mandel, Maria Teresa Carri & Moussa B. H. Youdim. (2009) Neuroprotective and neuritogenic activities of novel multimodal iron‐chelating drugs in motor‐neuron‐like NSC‐34 cells and transgenic mouse model of amyotrophic lateral sclerosis. The FASEB Journal 23:11, pages 3766-3779.
Crossref
Albert C. LudolphSarah Jesse. (2009) Review: Evidence-based drug treatment in amyotrophic lateral sclerosis and upcoming clinical trials. Therapeutic Advances in Neurological Disorders 2:5, pages 319-326.
Crossref
A. C. Ludolph, J. Kassubek, B. G. Landwehrmeyer, E. Mandelkow, E.-M. Mandelkow, D. J. Burn, D. Caparros-Lefebvre, K. A. Frey, J. G. de Yebenes, T. Gasser, P. Heutink, G. Höglinger, Z. Jamrozik, K. A. Jellinger, A. Kazantsev, H. Kretzschmar, A. E. Lang, I. Litvan, J. J. Lucas, P. L. McGeer, S. Melquist, W. Oertel, M. Otto, D. Paviour, T. Reum, A. Saint-Raymond, J. C. Steele, M. Tolnay, H. Tumani, J. C. van Swieten, M. T. Vanier, J.-P. Vonsattel, S. Wagner & Z. K. Wszolek. (2009) Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options. European Journal of Neurology 16:3, pages 297-309.
Crossref
Martin R Turner, Matthew C Kiernan, P Nigel Leigh & Kevin Talbot. (2009) Biomarkers in amyotrophic lateral sclerosis. The Lancet Neurology 8:1, pages 94-109.
Crossref
Bernadett Kalmar, Sergey Novoselov, Anna Gray, Michael E. Cheetham, Boris Margulis & Linda Greensmith. (2008) Late stage treatment with arimoclomol delays disease progression and prevents protein aggregation in the SOD1G93A mouse model of ALS. Journal of Neurochemistry 107:2, pages 339-350.
Crossref
Vincenzo Silani & Lidia Cova. (2008) Stem cell transplantation in Multiple Sclerosis: Safety and Ethics. Journal of the Neurological Sciences 265:1-2, pages 116-121.
Crossref
Jacqueline Montes, Caterina Bendotti, Massimo Tortarolo, Cristina Cheroni, Hussein Hallak, Zipora Speiser, Sari Goren, Eran Blaugrund & Paul H. Gordon. 2008. Animal and Translational Models for CNS Drug Discovery. Animal and Translational Models for CNS Drug Discovery 267 310 .
Trent M. Woodruff, Kerina J. Costantini, Steve M. Taylor & Peter G. Noakes. 2008. Current Topics in Complement II. Current Topics in Complement II 136 151 .
Paul H Gordon, Dan H Moore, Robert G Miller, Julaine M Florence, Joseph L Verheijde, Carolyn Doorish, Joan F Hilton, G Mark Spitalny, Robert B MacArthur, Hiroshi Mitsumoto, Hans E Neville, Kevin Boylan, Tahseen Mozaffar, Jerry M Belsh, John Ravits, Richard S Bedlack, Michael C Graves, Leo F McCluskey, Richard J Barohn & Rup Tandan. (2007) Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial. The Lancet Neurology 6:12, pages 1045-1053.
Crossref

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