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Original Article

Fatigue in amyotrophic lateral sclerosis: Frequency and associated factors

, , &
Pages 75-80 | Received 10 May 2007, Accepted 09 Aug 2007, Published online: 10 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (10)

Adriano Chiò, Antonio Canosa, Andrea Calvo, Cristina Moglia, Alessandro Cicolin & Gabriele Mora. (2021) Developments in the assessment of non-motor disease progression in amyotrophic lateral sclerosis. Expert Review of Neurotherapeutics 21:12, pages 1419-1440.
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Diana Lucia, Pamela A. McCombe, Robert D. Henderson & Shyuan T. Ngo. (2021) Disorders of sleep and wakefulness in amyotrophic lateral sclerosis (ALS): a systematic review. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 22:3-4, pages 161-169.
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Leif Simmatis, Ghada Atallah, Stephen H. Scott & Sean Taylor. (2019) The feasibility of using robotic technology to quantify sensory, motor, and cognitive impairments associated with ALS. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 20:1-2, pages 43-52.
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A. Wagle Shukla, R. Brown, K. Heese, J. Jones, R. L. Rodriguez, I. M. Malaty, M. S. Okun & B. M. Kluger. (2016) High rates of fatigue and sleep disturbances in dystonia. International Journal of Neuroscience 126:10, pages 928-935.
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Gail Houseman & Mary Kelley. (2015) Palliative care for patients in the USA with amyotrophic lateral sclerosis: current challenges. Nursing: Research and Reviews 5, pages 119-127.
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Femke Nijboer, Danny Plass-Oude Bos, Yvonne Blokland, René van Wijk & Jason Farquhar. (2014) Design requirements and potential target users for brain-computer interfaces – recommendations from rehabilitation professionals. Brain-Computer Interfaces 1:1, pages 50-61.
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Chris Gibbons, Everard Thornton, John Ealing, Pamela Shaw, Kevin Talbot, Alan Tennant & Carolyn Young. (2013) The impact of fatigue and psychosocial variables on quality of life for patients with motor neuron disease. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 14:7-8, pages 537-545.
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Ettore Beghi, Elisabetta Pupillo, Virginio Bonito, Paolo Buzzi, Claudia Caponnetto, Adriano Chiò, Massimo Corbo, Fabio Giannini, Maurizio Inghilleri, Vincenzo La Bella, Giancarlo Logroscino, Lorenzo Lorusso, Christian Lunetta, Letizia Mazzini, Paolo Messina, Gabriele Mora, Michele Perini, Maria Lidia Quadrelli, Vincenzo Silani, Isabella L. Simone & Lucio Tremolizzo. (2013) Randomized double-blind placebo-controlled trial of acetyl-L-carnitine for ALS. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 14:5-6, pages 397-405.
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Antonio Merico & Marianna Cavinato. (2011) Autonomic dysfunction in the early stage of ALS with bulbar involvement. Amyotrophic Lateral Sclerosis 12:5, pages 363-367.
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Stephanie H. Felgoise, Beatrice H. Chakraborty, Elisabeth Bond, Jamie Rodriguez, Barbara A. Bremer, Susan M. Walsh, Eugene C. Lai, Leo McCluskey & Zachary Simmons. (2010) Psychological morbidity in ALS: The importance of psychological assessment beyond depression alone. Amyotrophic Lateral Sclerosis 11:4, pages 351-358.
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Valentina Gnoni, Stefano Zoccolella, Alessia Giugno, Daniele Urso, Ludovica Tamburrino, Marco Filardi & Giancarlo Logroscino. (2023) Hypothalamus and amyotrophic lateral sclerosis: potential implications in sleep disorders. Frontiers in Aging Neuroscience 15.
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Francesca Trojsi, Federica Di Nardo, Giulia D'Alvano, Carla Passaniti, Minoo Sharbafshaaer, Fabrizio Canale, Antonio Russo, Marcello Silvestro, Luigi Lavorgna, Mario Cirillo, Fabrizio Esposito, Gioacchino Tedeschi & Mattia Siciliano. (2023) Cognitive, behavioral, and brain functional connectivity correlates of fatigue in amyotrophic lateral sclerosis. Brain and Behavior 13:7.
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Trinh Sia, Karol A. Connors & Prue Morgan. (2023) Physical Activity in People With Motor Neuron Disease: Validity of the Physical Activity Scale for the Elderly as a Measuring Tool. Archives of Physical Medicine and Rehabilitation 104:1, pages 102-107.
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Takehisa Hirayama, Mari Shibukawa, Masaru Yanagihashi, Hitoshi Warita, Naoki Atsuta, Koji Yamanaka & Osamu Kano. (2022) Investigation of non-motor symptoms in patients with amyotrophic lateral sclerosis. Acta Neurologica Belgica.
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Ran An, Cheng Li, Xin Li, Yuan Wu, Xianghua He, Shaolong Ai, Yanming Xu & Chengqi He. (2022) Fatigue in Chinese Patients With Amyotrophic Lateral Sclerosis: Associated Factors and Impact on Quality of Life. Frontiers in Neurology 13.
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Colin J. Mahoney, Rebekah M. Ahmed, William Huynh, Sicong Tu, Jonathan D. Rohrer, Richard S. Bedlack, Orla Hardiman & Matthew C. Kiernan. (2021) Pathophysiology and Treatment of Non-motor Dysfunction in Amyotrophic Lateral Sclerosis. CNS Drugs 35:5, pages 483-505.
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Arens Taga, Paride Schito, Maria Claudia Trapasso, Lucia Zinno & Giovanni Pavesi. (2019) Pain at the onset of Amyotrophic Lateral Sclerosis: a cross-sectional study. Clinical Neurology and Neurosurgery 186, pages 105540.
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LEEGYESEUNG. (2018) A Study on the Anxiety Experience of Disabled Person with Progressive Rare Disease. Korean Journal of Social Welfare 70:2, pages 247-273.
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Chris Gibbons, Francesco Pagnini, Tim Friede & Carolyn A Young. (2018) Treatment of fatigue in amyotrophic lateral sclerosis/motor neuron disease. Cochrane Database of Systematic Reviews 2018:1.
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Satish V. Khadilkar, Rakhil S. Yadav & Bhagyadhan A. PatelSatish V. Khadilkar, Rakhil S. Yadav & Bhagyadhan A. Patel. 2018. Neuromuscular Disorders. Neuromuscular Disorders 15 32 .
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C. Tard, L. Defebvre, C. Moreau, D. Devos & V. Danel-Brunaud. (2017) Clinical features of amyotrophic lateral sclerosis and their prognostic value. Revue Neurologique 173:5, pages 263-272.
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Carlayne E. Jackson, April L. McVey, Stacy Rudnicki, Mazen M. Dimachkie & Richard J. Barohn. (2015) Symptom Management and End-of-Life Care in Amyotrophic Lateral Sclerosis. Neurologic Clinics 33:4, pages 889-908.
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Francesco Pagnini, Gian Mauro Manzoni, Aurora Tagliaferri & Chris J Gibbons. (2014) Depression and disease progression in amyotrophic lateral sclerosis: A comprehensive meta-regression analysis. Journal of Health Psychology 20:8, pages 1107-1128.
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S. Panitz, M. Kornhuber & F. Hanisch. (2015) The checklist individual strength (CIS20-R) in patients with amyotrophic lateral sclerosis - A longitudinal study. Acta Neurologica Scandinavica 131:6, pages 372-380.
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Josef Finsterer & Sinda Zarrouk Mahjoub. (2013) Fatigue in Healthy and Diseased Individuals. American Journal of Hospice and Palliative Medicine® 31:5, pages 562-575.
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Carolyn A Young, Chris Gibbons, Francesco Pagnini & Tim Friede. (2014) Treatment for fatigue in amyotrophic lateral sclerosis/motor neuron disease (ALS/MND). Cochrane Database of Systematic Reviews.
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Sushanth Bhat & Sudhansu Chokroverty. (2013) Fatigue in Neurologic Disorders. Sleep Medicine Clinics 8:2, pages 191-212.
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Benzi M. KlugerLauren B. KruppRoger M. Enoka. (2013) Fatigue and fatigability in neurologic illnesses. Neurology 80:4, pages 409-416.
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Alon Abraham & Vivian E. Drory. (2012) Fatigue in motor neuron diseases. Neuromuscular Disorders 22, pages S198-S202.
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Chris J Gibbons & Carolyn A Young. (2012) Assessing and managing depression and fatigue in motor neuron disease. Neurodegenerative Disease Management 2:4, pages 401-409.
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D. Lo Coco & V. La Bella. (2012) Fatigue, sleep, and nocturnal complaints in patients with amyotrophic lateral sclerosis. European Journal of Neurology 19:5, pages 760-763.
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Chris J Gibbons, Roger J Mills, Everard W Thornton, John Ealing, John D Mitchell, Pamela J Shaw, Kevin Talbot, A Tennant & Carolyn A Young. (2011) Development of a patient reported outcome measure for fatigue in motor neurone disease: the Neurological Fatigue Index (NFI-MND). Health and Quality of Life Outcomes 9:1.
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Matthew C Kiernan, Steve Vucic, Benjamin C Cheah, Martin R Turner, Andrew Eisen, Orla Hardiman, James R Burrell & Margaret C Zoing. (2011) Amyotrophic lateral sclerosis. The Lancet 377:9769, pages 942-955.
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Joseph H. Friedman, Guido Alves, Peter Hagell, Johan Marinus, Laura Marsh, Pablo Martinez-Martin, Christopher G. Goetz, Werner Poewe, Olivier Rascol, Cristina Sampaio, Glenn Stebbins & Anette Schrag. (2010) Fatigue rating scales critique and recommendations by the Movement Disorders Society task force on rating scales for Parkinson's disease. Movement Disorders 25:7, pages 805-822.
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