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Amyotrophic Lateral Sclerosis Volume 9, 2008 - Issue 4
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ORIGINAL ARTICLE

Are statin medications safe in patients with ALS?

Lorne Zinman ALS/Neuromuscular Clinic, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, CanadaCorrespondence[email protected]
,
Reza Sadeghi ALS/Neuromuscular Clinic, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
,
Marek Gawel ALS/Neuromuscular Clinic, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
,
Dan Patton ALS/Neuromuscular Clinic, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
&
Alex Kiss Department of Research Design and Biostatistics, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Pages 223-228 | Received 15 Jan 2008, Published online: 10 Jul 2009

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Zhiguang Li, Mei Tian, Hongning Jia, Xin Li, Qi Liu, Xiaomeng Zhou, Rui Li, Hui Dong & Yaling Liu. (2023) Genetic variation in targets of lipid-lowering drugs and amyotrophic lateral sclerosis risk: a Mendelian randomization study. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 0:0, pages 1-10.
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Alexander McGown & Matthew John Stopford. (2018) High-throughput drug screens for amyotrophic lateral sclerosis drug discovery. Expert Opinion on Drug Discovery 13:11, pages 1015-1025.
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Muhammad K. Rafiq, Ellen Lee, Michael Bradburn, Christopher J. McDermott & Pamela J. Shaw. (2015) Effect of lipid profile on prognosis in the patients with amyotrophic lateral sclerosis: Insights from the olesoxime clinical trial. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 16:7-8, pages 478-484.
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Zhenzhen Zheng, Liqin Sheng & Huifang Shang. (2013) Statins and amyotrophic lateral sclerosis: a systematic review and meta-analysis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 14:4, pages 241-245.
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Danielle Yanuck, Christos G. Mihos & Orlando Santana. (2012) Mechanisms and Clinical Evidence of the Pleiotropic Effects of the Hydroxy-Methyl-Glutaryl-CoA Reductase Inhibitors in Central Nervous System Disorders: A Comprehensive Review. International Journal of Neuroscience 122:11, pages 619-629.
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Ali Aamer Habib & Hiroshi Mitsumoto. (2011) Emerging drugs for amyotrophic lateral sclerosis. Expert Opinion on Emerging Drugs 16:3, pages 537-558.
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Konosuke Iwamoto, Yasuhiro Yoshii & Ken Ikeda. (2009) Atorvastatin treatment attenuates motor neuron degeneration in wobbler mice. Amyotrophic Lateral Sclerosis 10:5-6, pages 405-409.
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J. Schumacher, R. S. Peter, G. Nagel, D. Rothenbacher, A. Rosenbohm, A. C. Ludolph & J. Dorst. (2020) Statins, diabetes mellitus and prognosis of amyotrophic lateral sclerosis: data from 501 patients of a population‐based registry in southwest Germany. European Journal of Neurology 27:8, pages 1405-1414.
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Weijing Qi, Lina Yan, Yaling Liu, Xiaomeng Zhou, Rui Li, Yafei Wang, Lin Bai, Juan Chen & Xiangyu Nie. (2019) Simvastatin aggravates impaired autophagic flux in NSC34-hSOD1G93A cells through inhibition of geranylgeranyl pyrophosphate synthesis. Neuroscience 409, pages 130-141.
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Liam R Brunham, Steven Baker, Andrew Mammen, G B John Mancini & Robert S Rosenson. (2018) Role of genetics in the prediction of statin-associated muscle symptoms and optimization of statin use and adherence. Cardiovascular Research 114:8, pages 1073-1081.
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Xiaowei W. Su, Wint Nandar, Elizabeth B. Neely, Zachary Simmons & James R. Connor. (2016) Statins accelerate disease progression and shorten survival in SOD1 G93A mice . Muscle & Nerve 54:2, pages 284-291.
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