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Amyotrophic Lateral Sclerosis Volume 9, 2008 - Issue 3
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INVITED REVIEW

Therapy development for ALS: Lessons learned and path forward

Veena Lanka Neurology Clinical Trials Unit, Massachusetts General Hospital, Harvard Medical School, , Charlestown, Massachusetts, USA
&
Merit Cudkowicz Neurology Clinical Trials Unit, Massachusetts General Hospital, Harvard Medical School, , Charlestown, Massachusetts, USACorrespondence[email protected]
Pages 131-140 | Received 04 Apr 2008, Published online: 10 Jul 2009

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Philip Van Damme & Wim Robberecht. (2014) Developments in treatments for amyotrophic lateral sclerosis via intracerebroventricular or intrathecal delivery. Expert Opinion on Investigational Drugs 23:7, pages 955-963.
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Magdalena Kuzma-Kozakiewicz & Hubert Kwiecinski. (2011) New therapeutic targets for amyotrophic lateral sclerosis. Expert Opinion on Therapeutic Targets 15:2, pages 127-143.
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Orla Hardiman. (2009) Ten years of the ALS journal. Amyotrophic Lateral Sclerosis 10:5-6, pages 257-257.
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Vincent Meininger, Vivian E. Drory, P. Nigel Leigh, Albert Ludolph, Wim Robberecht & Vincenzo Silani. (2009) Glatiramer acetate has no impact on disease progression in ALS at 40 mg/day: A double- blind, randomized, multicentre, placebo-controlled trial. Amyotrophic Lateral Sclerosis 10:5-6, pages 378-383.
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Articles from other publishers (24)

Belgin Sever, Halilibrahim Ciftci, Hasan DeMirci, Hilal Sever, Firdevs Ocak, Burak Yulug, Hiroshi Tateishi, Takahisa Tateishi, Masami Otsuka, Mikako Fujita & Ayşe Nazlı Başak. (2022) Comprehensive Research on Past and Future Therapeutic Strategies Devoted to Treatment of Amyotrophic Lateral Sclerosis. International Journal of Molecular Sciences 23:5, pages 2400.
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Nuno Jorge Lamas & Laurent Roybon. (2021) Harnessing the Potential of Human Pluripotent Stem Cell-Derived Motor Neurons for Drug Discovery in Amyotrophic Lateral Sclerosis: From the Clinic to the Laboratory and Back to the Patient. Frontiers in Drug Discovery 1.
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Xueping Chen, Qian-Qian Wei, Yongping Chen, Bei Cao, RuWei Ou, Yanbing Hou, Xiaoqin Yuan, Lingyu Zhang, Hui Liu & Huifang Shang. (2018) Clinical Staging of Amyotrophic Lateral Sclerosis in Chinese Patients. Frontiers in Neurology 9.
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J. Gamez, M. Salvado, A. Martínez de la Ossa & M. Badia. (2016) Lithium for treatment of amyotrophic lateral sclerosis: Much ado about nothing. Neurología (English Edition) 31:8, pages 550-561.
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J. Gamez, M. Salvado, A. Martínez de la Ossa & M. Badia. (2016) Litio para el tratamiento de la esclerosis lateral amiotrófica: mucho ruido para nada. Neurología 31:8, pages 550-561.
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Takehisa Isobe, Norie Tooi, Norio Nakatsuji & Kazuhiro Aiba. (2015) Amyotrophic lateral sclerosis models derived from human embryonic stem cells with different superoxide dismutase 1 mutations exhibit differential drug responses. Stem Cell Research 15:3, pages 459-468.
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Francesco Pagnini, Gian Mauro Manzoni, Aurora Tagliaferri & Chris J Gibbons. (2014) Depression and disease progression in amyotrophic lateral sclerosis: A comprehensive meta-regression analysis. Journal of Health Psychology 20:8, pages 1107-1128.
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Zachary Simmons. (2014) Patient-Perceived Outcomes and Quality of Life in ALS. Neurotherapeutics 12:2, pages 394-402.
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Agavni Petrosyan, I-Hui Hsieh, John P. Phillips & Kourosh Saberi. (2015) Enhanced tethered-flight duration and locomotor activity by overexpression of the human gene SOD1 in Drosophila motorneurons. Genetics and Molecular Biology 38:1, pages 107-114.
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Rubika Balendra, Ashley Jones, Naheed Jivraj, I Nick Steen, Carolyn A Young, Pamela J Shaw, Martin R Turner, P Nigel Leigh & Ammar Al-Chalabi. (2015) Use of clinical staging in amyotrophic lateral sclerosis for phase 3 clinical trials. Journal of Neurology, Neurosurgery & Psychiatry 86:1, pages 45-49.
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Matilde Yáñez, Jorge Matías-Guiu, Juan-Alberto Arranz-Tagarro, Lucía Galán, Dolores Viña, Ulises Gómez-Pinedo, Álvaro Vela, Antonio Guerrero, Eduardo Martínez-Vila & Antonio G. García. (2014) The Neuroprotection Exerted by Memantine, Minocycline and Lithium, against Neurotoxicity of CSF from Patients with Amyotrophic Lateral Sclerosis, Is Antagonized by Riluzole. Neurodegenerative Diseases 13:2-3, pages 171-179.
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Antonio Musarò. (2013) Understanding ALS: new therapeutic approaches. FEBS Journal 280:17, pages 4315-4322.
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Yu WangJack WintersShankar Subramaniam. (2012) Functional classification of skeletal muscle networks. II. Applications to pathophysiology. Journal of Applied Physiology 113:12, pages 1902-1920.
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Mauro CozzolinoMaria Grazia PesaresiValeria GerbinoJulian GrosskreutzMaria Teresa Carrì. (2012) Amyotrophic Lateral Sclerosis: New Insights into Underlying Molecular Mechanisms and Opportunities for Therapeutic Intervention. Antioxidants & Redox Signaling 17:9, pages 1277-1330.
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Nazem Atassi, David Schoenfeld & Merit Cudkowicz. 2012. Clinical Trials in Neurology. Clinical Trials in Neurology 273 283 .
. 2012. Clinical Trials in Neurology. Clinical Trials in Neurology 215 308 .
Dan H Moore, Jonathan S Katz & Robert G Miller. (2011) A review of clinical trial designs in amyotrophic lateral sclerosis. Neurodegenerative Disease Management 1:6, pages 481-490.
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Orla Hardiman, Leonard H. van den Berg & Matthew C. Kiernan. (2011) Clinical diagnosis and management of amyotrophic lateral sclerosis. Nature Reviews Neurology 7:11, pages 639-649.
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Orla Hardiman. (2010) Management of respiratory symptoms in ALS. Journal of Neurology 258:3, pages 359-365.
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Thomas E. Lloyd & Vinay Chaudhry. 2011. Neuromuscular Disorders: Treatment and Management. Neuromuscular Disorders: Treatment and Management 191 213 .
Christopher D. Lee, Yanna Song, Amanda C. Peltier, Adrian A. Jarquin-Valdivia & Peter D. Donofrio. (2010) Muscle ultrasound quantifies the rate of reduction of muscle thickness in amyotrophic lateral sclerosis. Muscle & Nerve 42:5, pages 814-819.
Crossref
Orla Hardiman. 2005. Encyclopedia of Life Sciences. Encyclopedia of Life Sciences.
Barrie J. CarterPervin AnklesariaStephanie ChoiJohn F. Engelhardt. (2009) Redox Modifier Genes and Pathways in Amyotrophic Lateral Sclerosis. Antioxidants & Redox Signaling 11:7, pages 1569-1586.
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J. Phukan & O. Hardiman. (2009) The management of amyotrophic lateral sclerosis. Journal of Neurology 256:2, pages 176-186.
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