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Amyotrophic Lateral Sclerosis Volume 10, 2009 - Issue 4
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Original Article

Open-label pilot trial of levetiracetam for cramps and spasticity in patients with motor neuron disease

Richard S. Bedlack Duke University Medical Center, Durham, North Carolina, USACorrespondence[email protected]
,
Daniel M. Pastula Duke University Medical Center, Durham, North Carolina, USA
,
Jodi Hawes Duke University Medical Center, Durham, North Carolina, USA
&
Debra Heydt Duke University Medical Center, Durham, North Carolina, USA
Pages 210-215 | Received 18 Jun 2008, Published online: 18 Nov 2009

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Marina de Tommaso, Miriam Kunz & Massimiliano Valeriani. (2017) Therapeutic approach to pain in neurodegenerative diseases: current evidence and perspectives. Expert Review of Neurotherapeutics 17:2, pages 143-153.
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Helen E. Stephens, Nanette C. Joyce & Björn Oskarsson. (2017) National Study of Muscle Cramps in ALS in the USA. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 18:1-2, pages 32-36.
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Articles from other publishers (39)

Jane Marice S. Pascual, Karen Joy B. Adiao & Mario B. PradoJrJr. (2023) Efficacy and Safety of Levetiracetam on the Treatment of Spasticity in Neurologic Disorders: a Systematic Review. SN Comprehensive Clinical Medicine 5:1.
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Kakarla Ramakrishna, Lakshmi Vineela Nalla, Dumala Naresh, Kojja Venkateswarlu, Matte Kasi Viswanadh, Buchi N. Nalluri, Guntupalli Chakravarthy, Sajusha Duguluri, Payal Singh, Sachchida Nand Rai, Ashish Kumar, Veer Singh & Santosh Kumar Singh. (2023) WNT-β Catenin Signaling as a Potential Therapeutic Target for Neurodegenerative Diseases: Current Status and Future Perspective. Diseases 11:3, pages 89.
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Reza Boostani, Nahid Olfati, Hosein Shamshiri, Zanireh Salimi, Farzad Fatehi, Seyed Arya Hedjazi, Atefeh Fakharian, Majid Ghasemi, Ali Asghar Okhovat, Keivan Basiri, Bahram Haghi Ashtiani, Behnaz Ansari, Gholam Reza Raissi, Seyed Ahmadreza Khatoonabadi, Payam Sarraf, Sara Movahed, Akram Panahi, Bentolhoda Ziaadini, Mohammad Yazdchi, Jalal Bakhtiyari & Shahriar Nafissi. (2023) Iranian clinical practice guideline for amyotrophic lateral sclerosis. Frontiers in Neurology 14.
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Ileana M. Howard & Atul T. Patel. (2023) Spasticity evaluation and management tools. Muscle & Nerve 67:4, pages 272-283.
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Jildou N. Dijkstra, Eline Boon, Nick Kruijt, Esther Brusse, Sithara Ramdas, Heinz Jungbluth, Baziel G.M. van Engelen, Jon Walters & Nicol C. Voermans. (2023) Muscle cramps and contractures: causes and treatment. Practical Neurology 23:1, pages 23-34.
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Christen Shoesmith. 2023. Neuropalliative Care, Part II. Neuropalliative Care, Part II 139 155 .
Elaine Magat, Isaac Hernandez Jimenez, Haresh Sampathkumar, Joanne Delgado & Gerard E. Francisco. 2022. Spasticity and Muscle Stiffness. Spasticity and Muscle Stiffness 193 224 .
Colin J. Mahoney, Rebekah M. Ahmed, William Huynh, Sicong Tu, Jonathan D. Rohrer, Richard S. Bedlack, Orla Hardiman & Matthew C. Kiernan. (2021) Pathophysiology and Treatment of Non-motor Dysfunction in Amyotrophic Lateral Sclerosis. CNS Drugs 35:5, pages 483-505.
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A. Hermann & J. Prudlo. (2021) Medikamentöse Therapie der amyotrophen Lateralsklerose: ein UpdatePharmacological treatment of amyotrophic lateral sclerosis: an update. DGNeurologie 4:2, pages 80-86.
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Karen Joy B Adiao, Adrian I Espiritu & Marjorie Anne C Bagnas. (2020) Efficacy and safety of mexiletine in amyotrophic lateral sclerosis: a systematic review of randomized controlled trials. Neurodegenerative Disease Management 10:6, pages 397-407.
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Katharina Kneppe & David Czell. (2020) Brivaracetam – eine gute Alternative zur Behandlung von MuskelkrämpfenBrivaracetam—A good alternative for the treatment of muscle cramps. Der Nervenarzt 91:12, pages 1130-1133.
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Cuiping Zhao, Dale J. Lange & James P. Wymer. (2020) Management of Primary Lateral Sclerosis. Current Treatment Options in Neurology 22:10.
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Valeria Pingue, Marta Gentili, Anna Losurdo, Emilio Clementi & Antonio Nardone. (2020) Levetiracetam Improves Upper Limb Spasticity in a Patient With Unresponsive Wakefulness Syndrome: A Case Report. Frontiers in Neuroscience 14.
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Vladislav B. Voitenkov & E. V. Ekusheva. (2019) Pain in amyotrophic lateral sclerosis. Journal of Clinical Practice 10:2, pages 66-73.
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Diana Greene-Chandos & Michel Torbey. (2018) Critical Care of Neuromuscular Disorders. CONTINUUM: Lifelong Learning in Neurology 24:6, pages 1753-1775.
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Björn Oskarsson, Dan Moore, Tahseen Mozaffar, John Ravits, Martina Wiedau-Pazos, Nicholas Parziale, Nanette C. Joyce, Ross Mandeville, Namita Goyal, Merit E. Cudkowicz, Michael Weiss, Robert G. Miller & Craig M. McDonald. (2018) Mexiletine for muscle cramps in amyotrophic lateral sclerosis: A randomized, double-blind crossover trial. Muscle & Nerve 58:1, pages 42-48.
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Satish V. Khadilkar, Rakhil S. Yadav & Bhagyadhan A. PatelSatish V. Khadilkar, Rakhil S. Yadav & Bhagyadhan A. Patel. 2018. Neuromuscular Disorders. Neuromuscular Disorders 15 32 .
Steven M. Bailey & Claire M. Rice. 2018. Progressive Multiple Sclerosis. Progressive Multiple Sclerosis 155 205 .
M.-H. Soriani & C. Desnuelle. (2017) Care management in amyotrophic lateral sclerosis. Revue Neurologique 173:5, pages 288-299.
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Adriano Chiò, Gabriele Mora & Giuseppe Lauria. (2017) Pain in amyotrophic lateral sclerosis. The Lancet Neurology 16:2, pages 144-157.
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Mario E. Lacouture, Brigitte Dréno, Paolo Antonio Ascierto, Reinhard Dummer, Nicole Basset-Seguin, Kate Fife, Scott Ernst, Lisa Licitra, Rogerio I. Neves, Ketty Peris, Susana Puig, Jonas Sokolof, Aleksandar Sekulic, Axel Hauschild & Rainer Kunstfeld. (2016) Characterization and Management of Hedgehog Pathway Inhibitor-Related Adverse Events in Patients With Advanced Basal Cell Carcinoma. The Oncologist 21:10, pages 1218-1229.
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Esther V. Hobson & Christopher J. McDermott. (2016) Supportive and symptomatic management of amyotrophic lateral sclerosis. Nature Reviews Neurology 12:9, pages 526-538.
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James B. Caress, Stephanie L. Ciarlone, Elizabeth A. Sullivan, Leah P. Griffin & Michael S. Cartwright. (2015) Natural history of muscle cramps in amyotrophic lateral sclerosis. Muscle & Nerve 53:4, pages 513-517.
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Carlayne E. Jackson, April L. McVey, Stacy Rudnicki, Mazen M. Dimachkie & Richard J. Barohn. (2015) Symptom Management and End-of-Life Care in Amyotrophic Lateral Sclerosis. Neurologic Clinics 33:4, pages 889-908.
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Cumara B. O'Carroll, Amelia K. Adcock & Bart M. Demaerschalk. 2015. Evidence‐Based Neurology: Management of Neurological Disorders. Evidence‐Based Neurology: Management of Neurological Disorders 219 234 .
Sabrina Paganoni, Chafic Karam, Nanette Joyce, Richard Bedlack & Gregory T. Carter. (2015) Comprehensive rehabilitative care across the spectrum of amyotrophic lateral sclerosis. NeuroRehabilitation 37:1, pages 53-68.
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Frank Hanisch, Anika Skudlarek, Janine Berndt & Malte E. Kornhuber. (2015) Characteristics of pain in amyotrophic lateral sclerosis. Brain and Behavior 5:3.
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U. E. Williams, E. E. Philip-Ephraim & S. K. Oparah. (2014) Multidisciplinary Interventions in Motor Neuron Disease. Journal of Neurodegenerative Diseases 2014, pages 1-10.
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Subbappa Ribeiro. (2014) Iyengar Yoga Therapy as an Intervention for Cramp Management in Individuals with Amyotrophic Lateral Sclerosis: Three Case Reports. The Journal of Alternative and Complementary Medicine 20:4, pages 322-326.
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James B. Caress & Bandhu Paudyal. 2014. Neuromuscular Disorders in Clinical Practice. Neuromuscular Disorders in Clinical Practice 1455 1464 .
Johannes Brettschneider, Jerome Kurent & Albert Ludolph. (2013) Drug therapy for pain in amyotrophic lateral sclerosis or motor neuron disease. Cochrane Database of Systematic Reviews.
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Claire M. Rice & Alastair Wilkins. 2013. Progressive Multiple Sclerosis. Progressive Multiple Sclerosis 147 186 .
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Reto Baldinger, Hans Dieter Katzberg & Markus Weber. (2012) Treatment for cramps in amyotrophic lateral sclerosis/motor neuron disease. Cochrane Database of Systematic Reviews.
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Peter M. Andersen, Sharon Abrahams, Gian D. Borasio, Mamede de Carvalho, Adriano Chio, Philip Van Damme, Orla Hardiman, Katja Kollewe, Karen E. Morrison, Susanne Petri, Pierre‐Francois Pradat, Vincenzo Silani, Barbara Tomik, Maria Wasner & Markus Weber. (2011) EFNS guidelines on the Clinical Management of Amyotrophic Lateral Sclerosis (MALS) – revised report of an EFNS task force. European Journal of Neurology 19:3, pages 360-375.
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Richard S Bedlack. (2010) Amyotrophic lateral sclerosis: current practice and future treatments. Current Opinion in Neurology 23:5, pages 524-529.
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Zachary Simmons. (2010) What's in the Literature?. Journal of Clinical Neuromuscular Disease 11:4, pages 223-228.
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. (2010) What's in the Literature?. Journal of Clinical Neuromuscular Disease 11:3, pages 158-163.
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Johannes Brettschneider, Jerome Kurent, Albert Ludolph & J D Mitchell. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.

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