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Critical Reviews in Toxicology Volume 32, 2002 - Issue 2
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Research Article

In Silico Approaches to Mechanistic and Predictive Toxicology: An Introduction to Bioinformatics for Toxicologists

Mark R. Fielden Department of Biochemistry and Molecular Biology, National Food Safety and Toxicology Center and Institute for Environmental Toxicology, Michigan State University, East Lansing, MI, U.S.A
,
Jason B. Matthews Department of Biochemistry and Molecular Biology, National Food Safety and Toxicology Center and Institute for Environmental Toxicology, Michigan State University, East Lansing, MI, U.S.A
,
Kirsten C. Fertuck Department of Biochemistry and Molecular Biology, National Food Safety and Toxicology Center and Institute for Environmental Toxicology, Michigan State University, East Lansing, MI, U.S.A
,
Robert G. Halgren Department of Biochemistry and Molecular Biology, National Food Safety and Toxicology Center and Institute for Environmental Toxicology, Michigan State University, East Lansing, MI, U.S.A
&
Tim R. Zacharewski Department of Biochemistry and Molecular Biology, National Food Safety and Toxicology Center and Institute for Environmental Toxicology, Michigan State University, East Lansing, MI, U.S.ACorrespondenceE-mail: [email protected]
Pages 67-112 | Published online: 29 Sep 2008

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Wilbert HM Heijne, Anne S Kienhuis, Ben van Ommen, Rob H Stierum & John P Groten. (2005) Systems toxicology: applications of toxicogenomics, transcriptomics, proteomics and metabolomics in toxicology. Expert Review of Proteomics 2:5, pages 767-780.
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J. E. Eckel, C. Gennings, V. M. Chinchilli, L. D. Burgoon & T. R. Zacharewski. (2004) Empirical Bayes Gene Screening Tool for Time-Course or Dose–Response Microarray Data. Journal of Biopharmaceutical Statistics 14:3, pages 647-670.
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Jasdeep S Mutti, Ramanjot K Bhullar & Kulvinder S Gill. (2017) Evolution of Gene Expression Balance Among Homeologs of Natural Polyploids. G3 Genes|Genomes|Genetics 7:4, pages 1225-1237.
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Jacob A. S. Vorstman, Will Spooren, Antonio M. Persico, David A. Collier, Stefan Aigner, Ravi Jagasia, Jeffrey C. Glennon & Jan K. Buitelaar. (2013) Using genetic findings in autism for the development of new pharmaceutical compounds. Psychopharmacology 231:6, pages 1063-1078.
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Aleš Prokop & Seth MichelsonAleš Prokop & Seth Michelson. 2012. Systems Biology in Biotech & Pharma. Systems Biology in Biotech & Pharma 69 76 .
Yu-Mei Tan, Rory Conolly, Daniel T. Chang, Rogelio Tornero-Velez, Michael R. Goldsmith, Shane D. Peterson & Curtis C. Dary. 2012. Computational Toxicology. Computational Toxicology 9 19 .
Seth Michelson. 2011. Systems Biology in Drug Discovery and Development. Systems Biology in Drug Discovery and Development 135 145 .
Anne S. Kienhuis, Joost H. M. van Delft & Jos C. S. Kleinjans. 2011. Applications of Toxicogenomics in Safety Evaluation and Risk Assessment. Applications of Toxicogenomics in Safety Evaluation and Risk Assessment 267 291 .
X.Y. Li, J.L. Zhang & S.W. Zhu. (2011) Improved thermostable α-amylase activity of Bacillus amyloliquefaciens by low-energy ion implantation. Genetics and Molecular Research 10:3, pages 2181-2189.
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Stephanie Holmgren. 2009. Information Resources in Toxicology. Information Resources in Toxicology 1231 1250 .
Sudhakar Jonnalagadda & Rajagopalan Srinivasan. (2008) Principal components analysis based methodology to identify differentially expressed genes in time-course microarray data. BMC Bioinformatics 9:1.
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Seth Michelson, Anil Sehgal & Christina Friedrich. (2006) In silico prediction of clinical efficacy. Current Opinion in Biotechnology 17:6, pages 666-670.
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Mingyue Zheng, Zhiguo Liu, Chunxia Xue, Weiliang Zhu, Kaixian Chen, Xiaomin Luo & Hualiang Jiang. (2006) Mutagenic probability estimation of chemical compounds by a novel molecular electrophilicity vector and support vector machine. Bioinformatics 22:17, pages 2099-2106.
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M. Noji, C. Goulart Kawashima, T. Obayashi & K. Saito. (2006) In silico assessment of gene function involved in cysteine biosynthesis in Arabidopsis: expression analysis of multiple isoforms of serine acetyltransferase. Amino Acids 30:2, pages 163-171.
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Kenneth B. Knudsen, Amar V. Singh & Thomas B. Knudsen. (2005) Data input module for Birth Defects Systems Manager. Reproductive Toxicology 20:3, pages 369-375.
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Audrey Cummings & Robert Kavlock. (2005) A systems biology approach to developmental toxicology. Reproductive Toxicology 19:3, pages 281-290.
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Kartik Shankar & Harihara M. Mehendale. 2005. Encyclopedia of Toxicology. Encyclopedia of Toxicology 285 .
Nick Plant. (2004) Interaction networks: coordinating responses to xenobiotic exposure. Toxicology 202:1-2, pages 21-32.
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Melissa C Rhodes, Frederic J Seidler, Dan Qiao, Charlotte A Tate, Mandy M Cousins & Theodore A Slotkin. (2004) Does pharmacotherapy for preterm labor sensitize the developing brain to environmental neurotoxicants? Cellular and synaptic effects of sequential exposure to terbutaline and chlorpyrifos in neonatal rats. Toxicology and Applied Pharmacology 195:2, pages 203-217.
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Cécile Michel, Chantal Desdouets, Béatrice Sacre-Salem, Jean-Charles Gautier, Ruth Roberts & Eric Boitier. (2003) Liver Gene Expression Profiles of Rats Treated with Clofibric Acid. The American Journal of Pathology 163:6, pages 2191-2199.
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Michael A Costa, R.Eric Collins, Aldwin M Anterola, Fiona C Cochrane, Laurence B Davin & Norman G Lewis. (2003) An in silico assessment of gene function and organization of the phenylpropanoid pathway metabolic networks in Arabidopsis thaliana and limitations thereof. Phytochemistry 64:6, pages 1097-1112.
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Paul A Whittaker. (2003) What is the relevance of bioinformatics to pharmacology?. Trends in Pharmacological Sciences 24:8, pages 434-439.
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Robert Dunn & Kyle Kolaja. 2003. An Introduction to Toxicogenomics. An Introduction to Toxicogenomics.
. (2002) Current Awareness on Comparative and Functional Genomics. Comparative and Functional Genomics 3:5, pages 461-468.
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