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Original Articles

Lactobacillus GG—a human probiotic strain with thorough clinical documentation

Pages 293-313 | Published online: 03 Nov 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Parisa Shokryazdan, Mohammad Faseleh Jahromi, Juan Boo Liang & Yin Wan Ho. (2017) Probiotics: From Isolation to Application. Journal of the American College of Nutrition 36:8, pages 666-676.
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A. Orlando, M.G. Refolo, C. Messa, L. Amati, P. Lavermicocca, V. Guerra & F. Russo. (2012) Antiproliferative and Proapoptotic Effects of Viable or Heat-Killed Lactobacillus paracasei IMPC2.1 and Lactobacillus rhamnosus GG in HGC-27 Gastric and DLD-1 Colon Cell Lines. Nutrition and Cancer 64:7, pages 1103-1111.
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R. Mohammadi & A.M. Mortazavian. (2011) Review Article: Technological Aspects of Prebiotics in Probiotic Fermented Milks. Food Reviews International 27:2, pages 192-212.
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Da Shen, Yunwo Zhu, Yuqing Hao & Junjun Lu. (2011) Polymerase chain reaction detection of Lactobacillus acidophilus in human oral cavity and fecal samples after 2-week consumption of yoghurt. Acta Odontologica Scandinavica 69:1, pages 27-32.
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Gregor Reid & Robert Friendship. (2002) ALTERNATIVES TO ANTIBIOTIC USE: PROBIOTICS FOR THE GUT. Animal Biotechnology 13:1, pages 97-112.
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Lode J. A. Nollet, Dora I. Pereira, Willy Verstraete. (1999) Effect of a Probiotic Bile Salt Hydrolytic Lactobacillus reuteri on the Human Gastrointestinal Microbiota as Simulated in the SHIME Reactor System. Microbial Ecology in Health and Disease 11:1, pages 13-21.
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Articles from other publishers (108)

Wei Zhao, Yuhan Yao, Tong Zhang, Huijun Lu, Xinlian Zhang, Linlin Zhao, Xi Chen, Jinhui Zhu, Guodong Sui & Wang Zhao. (2022) Primary exploration of host–microorganism interaction and enteritis treatment with an embedded membrane microfluidic chip of the human intestinal–vascular microsystem. Frontiers in Bioengineering and Biotechnology 10.
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Amin Yousefvand, Xin Huang, Mehdi Zarei & Per Erik Joakim Saris. (2022) Lacticaseibacillus rhamnosus GG Survival and Quality Parameters in Kefir Produced from Kefir Grains and Natural Kefir Starter Culture. Foods 11:4, pages 523.
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Youcef Shahali, Naheed Mojgani & Maryam Dadar. 2022. Probiotics in the Prevention and Management of Human Diseases. Probiotics in the Prevention and Management of Human Diseases 147 159 .
Samia Zrelli, Safa Amairia & Malek Zrelli. (2020) Respiratory syndrome coronavirus‐2 response: Microbiota as lactobacilli could make the difference. Journal of Medical Virology 93:6, pages 3288-3293.
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Xiangshu Suo, Song Huang, Juan Wang, Nan Fu, Romain Jeantet & Xiao Dong Chen. (2021) Effect of culturing lactic acid bacteria with varying skim milk concentration on bacteria survival during heat treatment. Journal of Food Engineering 294, pages 110396.
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Priyanka Parhi, Keang Peng Song & Wee Sim Choo. (2021) Effect of inulin and fructooligosaccharide supplementation on the growth and survival of Lactobacillus casei in model sugar systems . Journal of Food Processing and Preservation 45:3.
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Regina Haindl, Alexandra Neumayr, Anika Frey & Ulrich Kulozik. (2020) Impact of cultivation strategy, freeze-drying process, and storage conditions on survival, membrane integrity, and inactivation kinetics of Bifidobacterium longum. Folia Microbiologica 65:6, pages 1039-1050.
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Antonia Terpou, Aikaterini Papadaki, Iliada Lappa, Vasiliki Kachrimanidou, Loulouda Bosnea & Nikolaos Kopsahelis. (2019) Probiotics in Food Systems: Significance and Emerging Strategies Towards Improved Viability and Delivery of Enhanced Beneficial Value. Nutrients 11:7, pages 1591.
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Wei Di, Lanwei Zhang, Huaxi Yi, Xue Han, Yingchun Zhang & Liang Xin. (2018) Exopolysaccharides produced by Lactobacillus strains suppress HT‑29 cell growth via induction of G0/G1 cell cycle arrest and apoptosis. Oncology Letters.
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Ruchi Jariwala, Hemanti Mandal & Tamishraha Bagchi. (2017) Indigenous lactobacilli strains of food and human sources reverse enteropathogenic E. coli O26:H11-induced damage in intestinal epithelial cell lines: effect on redistribution of tight junction proteins. Microbiology 163:9, pages 1263-1272.
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Varsha Gupta, Deepika Nag & Pratibha Garg. (2017) Recurrent Urinary Tract Infections in Women: How Promising is the Use of Probiotics?. Indian Journal of Medical Microbiology 35:3, pages 347-354.
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Mariantonietta Succi, Patrizio Tremonte, Gianfranco Pannella, Luca Tipaldi, Autilia Cozzolino, Rossana Romaniello, Elena Sorrentino & Raffaele Coppola. (2017) Pre-cultivation with Selected Prebiotics Enhances the Survival and the Stress Response of Lactobacillus rhamnosus Strains in Simulated Gastrointestinal Transit. Frontiers in Microbiology 8.
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L. Pastrana, R. González, N. Estévez, L. Pereira, I. Rodríguez Amado, P. Fuciños, C. Fuciños, M.L. Rúa, E. Alonso & R. Troncoso. 2017. Current Developments in Biotechnology and Bioengineering. Current Developments in Biotechnology and Bioengineering 165 200 .
Bong Soo Ko, Sang Ho Lim & Sung Hee Han. (2016) Selection of Lactic Acid Bacteria suitable for Manufacture of Freeze-dried Coffee. The Korean Journal of Food And Nutrition 29:6, pages 1023-1029.
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Eva H. Clark & Jayasimha N. Murthy. 2016. Probiotics, Prebiotics, and Synbiotics. Probiotics, Prebiotics, and Synbiotics 723 739 .
Ramona Massoud, Vajiheh Fadaei, Kianoush Khosravi-Darani & Hamid Reza Nikbakht. (2015) Improving the Viability of Probiotic Bacteria in Yoghurt by Homogenization. Journal of Food Processing and Preservation 39:6, pages 2984-2990.
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I. Sadowska-Krawczenko, M. Paprzycka, P. Korbal, A. Wiatrzyk, K. Krysztopa-Grzybowska, M. Polak, U. Czajka & A. Lutyńska. (2014) Lactobacillus rhamnosus GG suspected infection in a newborn with intrauterine growth restriction . Beneficial Microbes 5:4, pages 397-402.
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Shu-Mei Wang, Lan-Wei Zhang, Rong-Bo Fan, Xue Han, Hua-Xi Yi, Li-Li Zhang, Chao-Hui Xue, Hong-Bo Li, Yan-He Zhang & Nditange Shigwedha. (2014) Induction of HT-29 cells apoptosis by lactobacilli isolated from fermented products. Research in Microbiology 165:3, pages 202-214.
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Poonam Sharma, Sudhir Kumar Tomar, Pawas Goswami, Vikas Sangwan & Rameshwar Singh. (2014) Antibiotic resistance among commercially available probiotics. Food Research International 57, pages 176-195.
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Martin H Floch & Adam KimCatherine Tomaro-DuchesneauShyamali SahaSatya Prakash. 2014. Clinical Insights: Probiotics, Prebiotics and Gut Health. Clinical Insights: Probiotics, Prebiotics and Gut Health 15 34 .
Raquel Rubio, Teresa Aymerich, Sara Bover-Cid, M. Dolors Guàrdia, Jacint Arnau & Margarita Garriga. (2013) Probiotic strains Lactobacillus plantarum 299V and Lactobacillus rhamnosus GG as starter cultures for fermented sausages. LWT - Food Science and Technology 54:1, pages 51-56.
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Hao Zhang, Yu Wang, Jing Sun, Zirui Guo, Huiyuan Guo & Fazheng Ren. (2013) Safety evaluation of Lactobacillus paracasei subsp. paracasei LC-01, a probiotic bacterium. Journal of Microbiology 51:5, pages 633-638.
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Geert Huys, Nadine Botteldoorn, Frank Delvigne, Luc De Vuyst, Marc Heyndrickx, Bruno Pot, Jean‐Jacques Dubois & Georges Daube. (2013) Microbial characterization of probiotics–Advisory report of the W orking G roup “8651 Probiotics” of the B elgian S uperior H ealth C ouncil ( SHC ) . Molecular Nutrition & Food Research 57:8, pages 1479-1504.
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Shan Liu, PengWei Hu, Xiaoxin Du, Tao Zhou & Xiaofang Pei. (2013) Lactobacillus rhamnosus GG supplementation for preventing respiratory infections in children: A Meta-analysis of Randomized, Placebo-controlled Trials. Indian Pediatrics 50:4, pages 377-381.
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Hyun Jung Kim, Dongeun Huh, Geraldine Hamilton & Donald E. Ingber. (2012) Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow. Lab on a Chip 12:12, pages 2165.
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Reza Mohammadi, Amir Mohammad Mortazavian, Roya Khosrokhavar & Adriano Gomes da Cruz. (2011) Probiotic ice cream: viability of probiotic bacteria and sensory properties. Annals of Microbiology 61:3, pages 411-424.
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Huanyi Jiang, Joseph Przybyszewski, Debjani Mitra, Chad Becker, Byron Brehm-Stecher, Amy Tentinger & Ruth S. MacDonald. (2011) Soy Protein Diet, but Not Lactobacillus rhamnosus GG, Decreases Mucin-1, Trefoil Factor-3, and Tumor Necrosis Factor-α in Colon of Dextran Sodium Sulfate-Treated C57BL/6 Mice,. The Journal of Nutrition 141:7, pages 1239-1246.
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Lauková A.. 2011. Processed Meats. Processed Meats 299 330 .
Suzie Ferrie & Mark Daley. (2010) Lactobacillus GG as Treatment for Diarrhea During Enteral Feeding in Critical Illness . Journal of Parenteral and Enteral Nutrition 35:1, pages 43-49.
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Miroslava Marciňáková, Trine Danø Klingberg, Andrea Lauková & Birgitte Bjørn Budde. (2010) The effect of pH, bile and calcium on the adhesion ability of probiotic enterococci of animal origin to the porcine jejunal epithelial cell line IPEC-J2. Anaerobe 16:2, pages 120-124.
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JONATHAN D N LEWIS, LINDA V THOMAS & WILLIAM WEIR. (2009) The potential of probiotic fermented milk products in reducing risk of antibiotic-associated diarrhoea and Clostridium difficile disease . International Journal of Dairy Technology 62:4, pages 461-471.
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V Gupta & R Garg. (2009) PROBIOTICS. Indian Journal of Medical Microbiology 27:3, pages 202-209.
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Vanessa Hamme, Frederic Sannier, Jean-Marie Piot, Sandrine Didelot & Stephanie Bordenave-Juchereau. (2009) Crude goat whey fermentation by Kluyveromyces marxianus and Lactobacillus rhamnosus : contribution to proteolysis and ACE inhibitory activity . Journal of Dairy Research 76:2, pages 152-157.
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Camilla Hoppe, Charlotte Nexmann Larsen, Rangne Fondén, Ulla Svensson, Arthur Ouwehand, Sampo Lahtinen, Mayumi Kiwaki, Koji Nomoto, Katsunori Kimura, Dorte Eskesen, Maija Saxelin, Kajsa Kajander, Gregor Reid, Andrew W. Bruce, Päivi Nurminen, Riitta Korpela, Hirokazu Tsuji, Jin‐Zhong Xiao & Seppo Salminen. 2008. Handbook of Probiotics and Prebiotics. Handbook of Probiotics and Prebiotics 441 532 .
Minja Miettinen, Ville Veckman, Sinikka Latvala, Timo Sareneva, Sampsa Matikainen & Ilkka Julkunen. (2008) Live Lactobacillus rhamnosus and Streptococcus pyogenes differentially regulate Toll-like receptor (TLR) gene expression in human primary macrophages . Journal of Leukocyte Biology 84:4, pages 1092-1100.
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Marcus Volkert, Edwin Ananta, Cornelius Luscher & Dietrich Knorr. (2008) Effect of air freezing, spray freezing, and pressure shift freezing on membrane integrity and viability of Lactobacillus rhamnosus GG. Journal of Food Engineering 87:4, pages 532-540.
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David R. Snydman. (2008) The Safety of Probiotics. Clinical Infectious Diseases 46:s2, pages S104-S111.
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C Wenus, R Goll, E B Loken, A S Biong, D S Halvorsen & J Florholmen. (2007) Prevention of antibiotic-associated diarrhoea by a fermented probiotic milk drink. European Journal of Clinical Nutrition 62:2, pages 299-301.
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Mariantonietta Succi, Patrizio Tremonte, Anna Reale, Elena Sorrentino & Raffaele Coppola. (2007) Preservation by freezing of potentially probiotic strains ofLactobacillus rhamnosus. Annals of Microbiology 57:4, pages 537-544.
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M.Perea Vélez, K. Hermans, T.L.A. Verhoeven, S.E. Lebeer, J. Vanderleyden & S.C.J. De Keersmaecker. (2007) Identification and characterization of starter lactic acid bacteria and probiotics from Columbian dairy products. Journal of Applied Microbiology 103:3, pages 666-674.
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K. HatakkaA.J. AholaH. Yli-KnuuttilaM. RichardsonT. PoussaJ.H. MeurmanR. Korpela. (2016) Probiotics Reduce the Prevalence of Oral Candida in the Elderly—a Randomized Controlled Trial . Journal of Dental Research 86:2, pages 125-130.
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A.R. Desai, N.P. Shah & I.B. Powell. (2006) Discrimination of Dairy Industry Isolates of the Lactobacillus casei Group. Journal of Dairy Science 89:9, pages 3345-3351.
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M. Vancanneyt, G. Huys, K. Lefebvre, V. Vankerckhoven, H. Goossens & J. Swings. (2006) Intraspecific Genotypic Characterization of Lactobacillus rhamnosus Strains Intended for Probiotic Use and Isolates of Human Origin . Applied and Environmental Microbiology 72:8, pages 5376-5383.
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Sigrid C. J. De Keersmaecker, Kristien Braeken, Tine L. A. Verhoeven, Mónica Perea Vélez, Sarah Lebeer, Jos Vanderleyden & Pascal Hols. (2006) Flow Cytometric Testing of Green Fluorescent Protein-Tagged Lactobacillus rhamnosus GG for Response to Defensins . Applied and Environmental Microbiology 72:7, pages 4923-4930.
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S. Parvez, K.A. Malik, S. Ah Kang & H.-Y. Kim. (2006) Probiotics and their fermented food products are beneficial for health. Journal of Applied Microbiology 100:6, pages 1171-1185.
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H. Yli-Knuuttila, J. Snall, K. Kari & J. H. Meurman. (2006) Colonization of Lactobacillus rhamnosus GG in the oral cavity. Oral Microbiology and Immunology 21:2, pages 129-131.
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Régine Talon & Sabine Leroy. 2006. Advanced Technologies For Meat Processing. Advanced Technologies For Meat Processing 401 418 .
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S-M Hongisto, L Paajanen, M Saxelin & R Korpela. (2005) A combination of fibre-rich rye bread and yoghurt containing Lactobacillus GG improves bowel function in women with self-reported constipation. European Journal of Clinical Nutrition 60:3, pages 319-324.
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N. Vendt, H. Grunberg, T. Tuure, O. Malminiemi, E. Wuolijoki, V. Tillmann, E. Sepp & R. Korpela. (2006) Growth during the first 6 months of life in infants using formula enriched with Lactobacillus rhamnosus GG: double-blind, randomized trial. Journal of Human Nutrition and Dietetics 19:1, pages 51-58.
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J. S. ZHOU, K. J. RUTHERFURD & H. S. GILL. (2005) Inability of Probiotic Bacterial Strains Lactobacillus rhamnosus HN001 and Bifidobacterium lactis HN019 To Induce Human Platelet Aggregation In Vitro. Journal of Food Protection 68:11, pages 2459-2464.
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CRISTINA ALAMPRESE, ROBERTO FOSCHINO, MARGHERITA ROSSI, CARLO POMPEI & SILVIA CORTI. (2005) Effects of Lactobacillus rhamnosus GG addition in ice cream. International Journal of Dairy Technology 58:4, pages 200-206.
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