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Journal Of Herbal Pharmacotherapy Volume 5, 2005 - Issue 1
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Original Article

A Preliminary Investigation of the Enzymatic Inhibition of 5α-Reductase and Growth of Prostatic Carcinoma Cell Line LNCap-FGC by Natural Astaxanthin and Saw Palmetto Lipid Extract In Vitro

Mark L. Anderson Triarco Industries, 400 Hamburg Turnpike, Wayne, NJ, 07470, USACorrespondence[email protected]
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(Director of Research and Development)
Pages 17-26 | Published online: 20 Aug 2009

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Phaniendra Alugoju, V. K. D. Krishna Swamy, Naga Venkata Anusha Anthikapalli & Tewin Tencomnao. (2023) Health benefits of astaxanthin against age-related diseases of multiple organs: A comprehensive review. Critical Reviews in Food Science and Nutrition 63:31, pages 10709-10774.
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Mark L Anderson. (2014) Evaluation of Resettin® on serum hormone levels in sedentary males. Journal of the International Society of Sports Nutrition 11:1.
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Fru Angwafor$suffix/text()$suffix/text() & Mark L Anderson. (2008) An open label, dose response study to determine the effect of a dietary supplement on dihydrotestosterone, testosterone and estradiol levels in healthy males. Journal of the International Society of Sports Nutrition 5:1.
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Ayman E. El-Sahar, Nadine Bekhit, Noha M. Eissa, Rania M. Abdelsalam & Reham M. Essam. (2023) Targeting HMGB1/PI3K/Akt and NF-κB/Nrf-2 signaling pathways by vildagliptin mitigates testosterone-induced benign prostate hyperplasia in rats. Life Sciences 322, pages 121645.
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Alexander L. Semenov, Margarita L. Tyndyk, Julia D. Von, Elena D. Ermakova, Anastasia A. Dorofeeva, Irina A. Tumanyan, Ekaterina A. Radetskaya, Maria N. Yurova, Alexander Zherebker, Alexander Yu. Gorbunov, Elena I. Fedoros, Andrey V. Panchenko & Vladimir N. Anisimov. (2023) Effects of Isoflavone-Rich NADES Extract of Pueraria lobata Roots and Astaxanthin-Rich Phaffia rhodozyma Extract on Prostate Carcinogenesis in Rats. Plants 12:3, pages 564.
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C. Fiore Apuzzo & Marjorie A. Jones. 2023. Palm Trees and Fruits Residues. Palm Trees and Fruits Residues 153 191 .
Eric D. Salinas-Arellano, Ines Y. Castro-Dionicio, Jonathan G. Jeyaraj, Nathan P. Mirtallo Ezzone & Esperanza J. Carcache de Blanco. 2023. Progress in the Chemistry of Organic Natural Products 122. Progress in the Chemistry of Organic Natural Products 122 1 162 .
Zhonglian Yu, Mengqin Xia, Xueping Li, Rui Wang, Wenjing Liu, Ruirong Zheng, Zhengtao Wang, Li Yang & Yanhong Shi. (2022) Characterization of carotenoids in Lycium barbarum fruit by using UPC2-PDA-Q-TOF-MSE couple with deep eutectic solvents extraction and evaluation of their 5α-reductase inhibitory activity. Frontiers in Chemistry 10.
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Zohreh Jafari, Ashkan Bigham, Sahar Sadeghi, Sayed Mehdi Dehdashti, Navid Rabiee, Alireza Abedivash, Mojtaba Bagherzadeh, Behzad Nasseri, Hassan Karimi-Maleh, Esmaeel Sharifi, Rajender S. Varma & Pooyan Makvandi. (2021) Nanotechnology-Abetted Astaxanthin Formulations in Multimodel Therapeutic and Biomedical Applications. Journal of Medicinal Chemistry 65:1, pages 2-36.
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Alexander Semenov, Ekaterina Gubareva, Elena Ermakova, Anastasia Dorofeeva, Irina Tumanyan, Ekaterina Radetskaya, Maria Yurova, Saied Aboushanab, Osman Kanwugu, Elena Fedoros & Andrey Panchenko. (2021) Astaxantin and Isoflavones Inhibit Benign Prostatic Hyperplasia in Rats by Reducing Oxidative Stress and Normalizing Ca/Mg Balance. Plants 10:12, pages 2735.
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Liping Wang, Yiwen Hou, Rong Wang, Qi Pan, Debao Li, Han Yan & Zuyue Sun. (2021) Inhibitory Effect of Astaxanthin on Testosterone-Induced Benign Prostatic Hyperplasia in Rats. Marine Drugs 19:12, pages 652.
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Zhen Lin, Fangping Li, Yu Zhang, Xiaohui Tan, Ping Luo & Huazhong Liu. (2021) Analysis of astaxanthin molecular targets based on network pharmacological strategies. Journal of Food Biochemistry 45:5.
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Nima Montazeri‐Najafabady, Nazanin Chatrabnous, Mohammad‐Reza Arabnezhad & Negar Azarpira. (2021) Anti‐androgenic effect of astaxanthin in LNCaP cells is mediated through the aryl hydrocarbon‐androgen receptors cross talk. Journal of Food Biochemistry 45:4.
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Gustavo F. Gonzales, Manuel Gasco, Cinthya Vasquez-Velasquez, Diego Fano-Sizgorich & Dulce Esperanza Alarcón-Yaquetto. 2021. Herbal Medicine in Andrology. Herbal Medicine in Andrology 47 66 .
Selim DEMİR, Elif AYAZOGLU DEMİR & Yüksel ALİYAZICIOĞLU. (2020) Selective Cytotoxic Effect of Astaxanthin on Human Lung and Colon Cancer CellsAstaksantinin İnsan Akciğer ve Kolon Kanseri Hücrelerindeki Seçici Sitotoksik Etkisi. Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi 23:6, pages 1489-1494.
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Ankita Jain & V.L. Sirisha. 2020. Encyclopedia of Marine Biotechnology. Encyclopedia of Marine Biotechnology 33 64 .
Immacolata Faraone, Chiara Sinisgalli, Angela Ostuni, Maria Francesca Armentano, Monica Carmosino, Luigi Milella, Daniela Russo, Fabiana Labanca & Haroon Khan. (2020) Astaxanthin anticancer effects are mediated through multiple molecular mechanisms: A systematic review. Pharmacological Research 155, pages 104689.
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Youngjoo Kwon. (2019) Use of saw palmetto (Serenoa repens) extract for benign prostatic hyperplasia. Food Science and Biotechnology 28:6, pages 1599-1606.
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Linlin Wang, Feng Yang, Yali Rong, Yuan Yuan, Yatao Ding, Wenzheng Shi & Zhihe Wang. (2019) Effects of different proteases enzymatic extraction on the lipid yield and quality of Antarctic krill oil. Food Science & Nutrition 7:7, pages 2224-2230.
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David Vollmer, Virginia West & Edwin Lephart. (2018) Enhancing Skin Health: By Oral Administration of Natural Compounds and Minerals with Implications to the Dermal Microbiome. International Journal of Molecular Sciences 19:10, pages 3059.
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Meiqi Fan, Amit Nath, Yujiao Tang, Young-Jin Choi, Trishna Debnath, Eun-Ju Choi & Eun-Kyung Kim. (2018) Investigation of the Anti-Prostate Cancer Properties of Marine-Derived Compounds. Marine Drugs 16:5, pages 160.
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Xiaofeng Ni, Haining Yu, Shanshan Wang, Chengcheng Zhang & Shengrong Shen. (2017) Astaxanthin Inhibits PC-3 Xenograft Prostate Tumor Growth in Nude Mice. Marine Drugs 15:3, pages 66.
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F. Comhaire & A. Mahmoud. (2016) The andrologist's contribution to a better life for ageing men: part 2. Andrologia 48:1, pages 99-110.
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Yiye ShaoYanbo NiJing YangXutao LinJun LiLixia Zhang. (2016) Astaxanthin Inhibits Proliferation and Induces Apoptosis and Cell Cycle Arrest of Mice H22 Hepatoma Cells. Medical Science Monitor 22, pages 2152-2160.
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Karin Linnewiel-Hermoni, Esther Paran & Talya Wolak. 2016. Molecular Basis of Nutrition and Aging. Molecular Basis of Nutrition and Aging 473 489 .
Gene Bruno. 2015. Nutraceuticals and Functional Foods in Human Health and Disease Prevention. Nutraceuticals and Functional Foods in Human Health and Disease Prevention 557 590 .
Clara Grosso, Patrícia Valentão, Federico Ferreres & Paula Andrade. (2015) Alternative and Efficient Extraction Methods for Marine-Derived Compounds. Marine Drugs 13:5, pages 3182-3230.
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Olta Allkanjari & Annabella Vitalone. (2015) What do we know about phytotherapy of benign prostatic hyperplasia?. Life Sciences 126, pages 42-56.
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Jie Zhang, Zheng Sun, Peipei Sun, Tianpeng Chen & Feng Chen. (2014) Microalgal carotenoids: beneficial effects and potential in human health. Food & Function 5:3, pages 413.
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Kavitha Penugonda & Brian Lindshield. (2013) Fatty Acid and Phytosterol Content of Commercial Saw Palmetto Supplements. Nutrients 5:9, pages 3617-3633.
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Giuseppe Procida, Bruno Stancher, Francesca Cateni & Marina Zacchigna. (2012) Chemical composition and functional characterisation of commercial pumpkin seed oil. Journal of the Science of Food and Agriculture 93:5, pages 1035-1041.
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John D. Bowman, Hyunah Kim & Juan J. Bustamante. (2012) Drug‐Induced Gynecomastia. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 32:12, pages 1123-1140.
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Yoav Sharoni, Karin Linnewiel-Hermoni, Gabriel Zango, Marina Khanin, Hagar Salman, Anna Veprik, Michael Danilenko & Joseph Levy. (2012) The role of lycopene and its derivatives in the regulation of transcription systems: implications for cancer prevention. The American Journal of Clinical Nutrition 96:5, pages 1173S-1178S.
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Lim T. K.T. K. Lim. 2012. Edible Medicinal and Non-Medicinal Plants. Edible Medicinal and Non-Medicinal Plants 438 447 .
Sang-ah LimJoon Young LeeWon Ho JungEun Hye LimMoon Kyung JooBeom Jae LeeJong-Jae ParkJae Seon KimYoung-Tae BakSung Woo JungSang Woo Lee. (2011) Anticancer Effects of Astaxanthin and α-tocopherol in Esophageal Cancer Cell Lines. The Korean Journal of Helicobacter and Upper Gastrointestinal Research 11:3, pages 170.
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Joseph Levy, Shlomo Walfisch, Andrea Atzmon, Keren Hirsch, Marina Khanin, Karin Linnewiel, Yael Morag, Hagar Salman, Anna Veprik, Michael Danilenko & Yoav Sharoni. 2011. Vegetables, Whole Grains, and Their Derivatives in Cancer Prevention. Vegetables, Whole Grains, and Their Derivatives in Cancer Prevention 47 66 .
Joseph J. Wakshlag, Cheryl A. Balkman, Stewart K. Morgan & Margaret C. McEntee. (2010) Evaluation of the protective effects of all-trans-astaxanthin on canine osteosarcoma cell lines. American Journal of Veterinary Research 71:1, pages 89-96.
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Paola Palozza, Cristiana Torelli, Alma Boninsegna, Rossella Simone, Assunta Catalano, Maria Cristina Mele & Nevio Picci. (2009) Growth-inhibitory effects of the astaxanthin-rich alga Haematococcus pluvialis in human colon cancer cells. Cancer Letters 283:1, pages 108-117.
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Jillian L. Capodice & Aaron E. Katz. (2006) What patients take without telling you: holistic approach for BPH. World Journal of Urology 24:4, pages 378-382.
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