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Journal Of Herbal Pharmacotherapy Volume 5, 2005 - Issue 1
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Original Article

Evidence-Based Systematic Review of Dandelion (Taraxacum officinale) by Natural Standard Research Collaboration

Brooke Sweeney Massachusetts College of Pharmacy,View further author information
,
Mamta Vora Northeastern University,
,
Catherine Ulbricht Massachusetts General Hospital,
&
Ethan Basch Memorial Sloan Kettering Cancer Center. Natural Standard,
Pages 79-93 | Published online: 20 Aug 2009

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Hyun Joo Chung, Yoohun Noh, Min Su Kim, Ara Jang, Chae Eun Lee & Soon Chul Myung. (2018) Steroidogenic effects of Taraxacum officinale extract on the levels of steroidogenic enzymes in mouse Leydig cells. Animal Cells and Systems 22:6, pages 407-414.
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C. O. Tettey, A. Ocloo, P. C. Nagajyothi & K. D. Lee. (2014) Antioxidant Activity of Solvent Fractions of Taraxacum officinale (Dandelion) Leaves. Journal of Herbs, Spices & Medicinal Plants 20:4, pages 329-340.
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Xuemei Zhang, Huanzhang Xiong, Hongyu Li & Yao Cheng. (2014) Protective effect of taraxasterol against LPS-induced endotoxic shock by modulating inflammatory responses in mice. Immunopharmacology and Immunotoxicology 36:1, pages 11-16.
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Articles from other publishers (57)

Cuili Liang, Yitong Yan, Yingchao Tan, Xue Yang, Jie Cao, Chaorong Tang & Kaiye Liu. (2023) Identification of miRNAs and their targets in two Taraxacum species with contrasting rubber-producing ability. Frontiers in Plant Science 14.
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Tong Zhang, Chao Sun, Shubin Yang, Zimin Cai, Sifeng Zhu, Wendian Liu, Yun Luan & Cheng Wang. (2023) Inhalation of taraxasterol loaded mixed micelles for the treatment of idiopathic pulmonary fibrosis. Chinese Chemical Letters, pages 109248.
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Charles Spence & Simon Spence. (2023) ‘Weeds from the yard’: A seasonal salad. International Journal of Gastronomy and Food Science 33, pages 100776.
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Satı Bilge KAYA & Berrin KOCAOĞLU GÜÇLÜ. (2023) Yumurta Tavuğu Karma Yemlerine İlave Edilen Karahindiba Ekstresinin Performans ve Yumurta Kalitesine EtkisiEffect of Dandelion Extracts Supplementation to Laying Hen Diet on Performance and Egg Quality. Erciyes Üniversitesi Veteriner Fakültesi Dergisi, pages 178-185.
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Umair AkhtarAnjali M. WankhadeJugalkishor V. VyasVivek V. Paithankar. (2023) A Review on: Phytoconstituents, Traditional and Medicinal uses of Taraxacum offinale (Dandelion). Research Journal of Pharmacognosy and Phytochemistry, pages 139-144.
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Gulzat Berganayeva, Bates Kudaibergenova, Yuliya Litvinenko, Irada Nazarova, Sandugash Sydykbayeva, Gulzira Vassilina, Nazerke Izdik & Moldyr Dyusebaeva. (2023) Medicinal Plants of the Flora of Kazakhstan Used in the Treatment of Skin Diseases. Molecules 28:10, pages 4192.
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Ping Xu, Xiaobo Xu, Hanna Fotina & Tetiana Fotina. (2023) Anti-inflammatory effects of chlorogenic acid from Taraxacum officinale on LTA-stimulated bovine mammary epithelial cells via the TLR2/NF-κB pathway. PLOS ONE 18:3, pages e0282343.
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Chen Feng, Yao Wenlin, Kou Qiangyong, Lanting Li & Qi Jingjing. (2023) Clinical efficacy of combination therapy of FuXi-Tiandi-Wuxing Decoction and anti-viral drugs in the treatment of novel coronavirus pneumonia: A prospective interventional study. Journal of Herbal Medicine 38, pages 100627.
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Mustafa YAŞAR, Güliz SARAÇ, Ali GÖK, Nisa SİPAHİ & Aydan Fülden AĞAN. (2022) Investigation of the Acute Subacute Toxicity of KL-21® Supplementary Food Product in Rats. International Journal of Traditional and Complementary Medicine Research 3:3, pages 190-196.
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Ana Isabel Oliveira, Cláudia Pinho, Filipa Quintela Vieira, Regina Silva & Agostinho Cruz. (2022) Taraxacum spp. in vitro and in vivo anticancer activity – A review. Journal of Herbal Medicine 36, pages 100612.
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Mayada R. Farag, Mahmoud Alagawany, Mohamed E. Abd El-Hack, Sameh A. Abdelnour, Kuldeep Dhama, Ayman A. Swelum & Alessandro Di Cerbo. 2022. Antibiotic Alternatives in Poultry and Fish Feed. Antibiotic Alternatives in Poultry and Fish Feed 124 136 .
Meichao Liao, Yang Zhao, Xiaoyue Yang, Lin Yang, E-Hu Liu, Bin Lu, Jiye Wang, Xiaopeng Liu, Yanzhong Chang & Li Duan. (2022) A greener and sustainable route for medicinal plant analysis: Recycle utilization of hydrophobic deep eutectic solvent. Microchemical Journal 178, pages 107372.
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Yanni Li, Yilun Chen & Dongxiao Sun-Waterhouse. (2022) The potential of dandelion in the fight against gastrointestinal diseases: A review. Journal of Ethnopharmacology 293, pages 115272.
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Alexandra G. Durán, Carlos Rial, M. Teresa Gutiérrez, José M. G. Molinillo & Francisco A. Macías. 2021. Handbook of Dietary Phytochemicals. Handbook of Dietary Phytochemicals 477 542 .
Ying Yang, Gaoxiang Ying, Shanshan Wu, Fengtian Wu & Zhi Chen. (2020) In vitro inhibition effects of hepatitis B virus by dandelion and taraxasterol. Infectious Agents and Cancer 15:1.
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Lana YM. Juee & Alaadin M. Naqishbandi. (2020) In vivo and in vitro antidiabetic potential of Taraxacum officinale root extracts . Current Issues in Pharmacy and Medical Sciences 33:3, pages 168-175.
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Li Duan, Chenmeng Zhang, Yang Zhao, Yanzhong Chang & Long Guo. (2020) Comparison of Bioactive Phenolic Compounds and Antioxidant Activities of Different Parts of Taraxacum mongolicum. Molecules 25:14, pages 3260.
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Alexandra G. Durán, Carlos Rial, M. Teresa Gutiérrez, José M. G. Molinillo & Francisco A. Macías. 2019. Handbook of Dietary Phytochemicals. Handbook of Dietary Phytochemicals 1 66 .
Nourah Z. Alzoman, Hadir M. Maher, Shereen M. Shehata & Norah O. Abanmy. (2019) UPLC–MS/MS study of the effect of dandelion root extract on the plasma levels of the selected irreversible tyrosine kinase inhibitors dasatinib, imatinib and nilotinib in rats: Potential risk of pharmacokinetic interactions. Biomedical Chromatography 33:12.
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Nadia Abdel-Magied, Salma M. Abdel Fattah & Ahmed A. Elkady. (2019) Differential effect of Taraxacum officinale L. (dandelion) root extract on hepatic and testicular tissues of rats exposed to ionizing radiation. Molecular Biology Reports 46:5, pages 4893-4907.
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Bernadetta Lis & Beata Olas. (2019) Pro-health activity of dandelion (Taraxacum officinale L.) and its food products – history and present. Journal of Functional Foods 59, pages 40-48.
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Amira Badr, Dalia Fouad & Hala Attia. (2019) Insights Into Protective Mechanisms of Dandelion Leaf Extract Against Cisplatin-Induced Nephrotoxicity in Rats: Role of Inhibitory Effect on Inflammatory and Apoptotic Pathways. Dose-Response 17:3, pages 155932581987489.
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Feng Ren, Jian Li, Xiang Yuan, Yanglin Wang, Kaixuan Wu, Lixia Kang, Yanyan Luo, Huimin Zhang & Zhiqing Yuan. (2019) Dandelion polysaccharides exert anticancer effect on Hepatocellular carcinoma by inhibiting PI3K/AKT/mTOR pathway and enhancing immune response. Journal of Functional Foods 55, pages 263-274.
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Pulok K. Mukherjee. 2019. Quality Control and Evaluation of Herbal Drugs. Quality Control and Evaluation of Herbal Drugs 655 683 .
K. Menke, M. Schwermer, J. Felenda, C. Beckmann, F. Stintzing, A. Schramm & T.J. Zuzak. (2018) Taraxacum officinale extract shows antitumor effects on pediatric cancer cells and enhance mistletoe therapy. Complementary Therapies in Medicine 40, pages 158-164.
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Muhammet Ali TUNÇ. (2018) Sıcaklık Stresi Oluşturulan Broilerde Yeme İlave Edilen Hypericum scabrum L. (Mayasıl Otu) ve Taraxacum officinale L. (Karahindiba) Bitki Ekstraktlarının Performans Değerleri ile Karaciğer ve Bağırsak Ağırlığı Üzerine EtkileriEffects on Performance Values with Liver and Intestinal Weight of Taraxacum officinale L. and Hypericum scabrum L. Plant Extracts Feed Added to Heat Stress Broilers. Alınteri Zirai Bilimler Dergisi 33:1, pages 1-6.
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Bernadetta Lis, Dariusz Jędrejek, Anna Stochmal & Beata Olas. (2018) Assessment of effects of phenolic fractions from leaves and petals of dandelion in selected components of hemostasis. Food Research International 107, pages 605-612.
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Appachanda Thimmaiah & Jessica A Hernandez. (2018) Meta-analysis of 10 herbs of Iowa for traditional, homeopathic and modern medicinal uses. International Journal of Complementary & Alternative Medicine 11:4.
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Daun Jeon, Seok Joong Kim & Hong Seok Kim. (2017) Anti-inflammatory evaluation of the methanolic extract of Taraxacum officinale in LPS-stimulated human umbilical vein endothelial cells. BMC Complementary and Alternative Medicine 17:1.
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Ge Hu, Junjie Wang, Dong Hong, Tao Zhang, Huiqin Duan, Xiang Mu & Zuojun Yang. (2017) Effects of aqueous extracts of Taraxacum Officinale on expression of tumor necrosis factor-alpha and intracellular adhesion molecule 1 in LPS-stimulated RMMVECs. BMC Complementary and Alternative Medicine 17:1.
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Dariusz Jędrejek, Bogdan Kontek, Bernadetta Lis, Anna Stochmal & Beata Olas. (2017) Evaluation of antioxidant activity of phenolic fractions from the leaves and petals of dandelion in human plasma treated with H2O2 and H2O2/Fe. Chemico-Biological Interactions 262, pages 29-37.
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Hae Nim Lee, Seong Ah Shin, Gang Sik Choo, Hyeong Jin Kim, Young Seok Park, Byung Kwon Park, Byeong Soo Kim, Sang Ki Kim, Sung Dae Cho, Jeong Seok Nam, Chang Sun Choi & Ji Youn Jung. (2016) Anticancer effects of Ixeris dentata (Thunb. ex Thunb.) nakai extract on human melanoma cells A375P and A375SM. Journal of Ethnopharmacology 194, pages 1022-1031.
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Shasha Wang, Ying Wang, Xinyu Liu, Lizeng Guan, Longzheng Yu & Xuemei Zhang. (2016) Anti-inflammatory and anti-arthritic effects of taraxasterol on adjuvant-induced arthritis in rats. Journal of Ethnopharmacology 187, pages 42-48.
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M. Martinez, P. Poirrier, R. Chamy, D. Prüfer, C. Schulze-Gronover, L. Jorquera & G. Ruiz. (2015) Taraxacum officinale and related species—An ethnopharmacological review and its potential as a commercial medicinal plant. Journal of Ethnopharmacology 169, pages 244-262.
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Deshani C. Mudannayake, Kuruppu M.S. Wimalasiri, Kahandage F.S.T. Silva & Said Ajlouni. (2015) Comparison of Properties of New Sources of Partially Purified Inulin to Those of Commercially Pure Chicory Inulin. Journal of Food Science 80:5, pages C950-C960.
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Huanzhang Xiong, Yao Cheng, Xian Zhang & Xuemei Zhang. (2014) Effects of taraxasterol on iNOS and COX-2 expression in LPS-induced RAW 264.7 macrophages. Journal of Ethnopharmacology 155:1, pages 753-757.
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Maria In?s Dias, Lillian Barros, Rita C. Alves, M. Beatriz P.P. Oliveira, Celestino Santos-Buelga & Isabel C.F.R. Ferreira. (2014) Nutritional composition, antioxidant activity and phenolic compounds of wild Taraxacum sect. Ruderalia. Food Research International 56, pages 266-271.
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Jingtao Liu, Huanzhang Xiong, Yao Cheng, Chengdu Cui, Xian Zhang, Lu Xu & Xuemei Zhang. (2013) Effects of taraxasterol on ovalbumin-induced allergic asthma in mice. Journal of Ethnopharmacology 148:3, pages 787-793.
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Paul Posadzki, Leala Watson & Edzard Ernst. (2013) Herb-drug interactions: an overview of systematic reviews. British Journal of Clinical Pharmacology 75:3, pages 603-618.
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Paul Posadzki, Leala Watson & Edzard Ernst. (2012) Contamination and adulteration of herbal medicinal products (HMPs): an overview of systematic reviews. European Journal of Clinical Pharmacology 69:3, pages 295-307.
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Paul Posadzki, Leala K Watson & Edzard Ernst. (2013) Adverse effects of herbal medicines: an overview of systematic reviews. Clinical Medicine 13:1, pages 7-12.
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Mi Jang, Seung-Weon Jeong, Somi K. Cho, Kwang-Seok Ahn, Bum-Keun Kim & Jong-Chan Kim. (2013) Anti-inflammatory effects of 4 medicinal plant extracts in lipopolysaccharide-induced RAW 264.7 cells. Food Science and Biotechnology 22:S1, pages 213-220.
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Manel Gargouri, Fatma Ghorbel-Koubaa, Michèle Bonenfant-Magné, Christian Magné, Xavier Dauvergne, Riadh Ksouri, Yousef Krichen, Chedly Abdelly & Abdelfattah El Feki. (2012) Spirulina or dandelion-enriched diet of mothers alleviates lead-induced damages in brain and cerebellum of newborn rats. Food and Chemical Toxicology 50:7, pages 2303-2310.
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Xuemei Zhang, Huanzhang Xiong & Liben Liu. (2012) Effects of taraxasterol on inflammatory responses in lipopolysaccharide-induced RAW 264.7 macrophages. Journal of Ethnopharmacology 141:1, pages 206-211.
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Sushim Kumar Gupta, Chao-Lin Kuo, Hung-Chi Chang, Hsiao-Sung Chan, Emily Chin-Fun Chen, Fu-Shin Chueh & Hsin-Sheng Tsay. 2012. Recent Trends in Medicinal Plants Research. Recent Trends in Medicinal Plants Research 35 55 .
Wen He, Huamin Han, Wei Wang & Bin Gao. (2011) Anti-influenza virus effect of aqueous extracts from dandelion. Virology Journal 8:1.
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Sullim Lee, Saem Han, Hye Min Kim, Jeong Min Lee, Jongkee Kim, Chun-Geon Park & Sanghyun Lee. (2011) Simultaneous determination of luteolin and luteoloside in dandelions using HPLC. Horticulture, Environment, and Biotechnology 52:5, pages 536-540.
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Y.-R. Jin, J. Jin, X.-X. Piao & N. G. Jin. (2011) The effect of Taraxacum officinale on gastric emptying and smooth muscle motility in Rodents. Neurogastroenterology & Motility 23:8, pages 766-e333.
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Yan-Lin Sun, Jae-Hak Kim & Soon-Kwan Hong. (2011) Establishment of Cell Suspension Cultures and Plant Regeneration in White Dandelion (Taraxacum coreanum NAKAI.). Korean Journal of Plant Resources 24:3, pages 280-285.
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Petra L?thje, Dang Ngoc Dzung & Annelie Brauner. (2011) Lactuca indica extract interferes with uroepithelial infection by Escherichia coli. Journal of Ethnopharmacology 135:3, pages 672-677.
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S. J. Chatterjee, P. Ovadje, M. Mousa, C. Hamm & S. Pandey. (2011) The Efficacy of Dandelion Root Extract in Inducing Apoptosis in Drug-Resistant Human Melanoma Cells. Evidence-Based Complementary and Alternative Medicine 2011, pages 1-11.
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P. Ovadje, S. Chatterjee, C. Griffin, C. Tran, C. Hamm & S. Pandey. (2011) Selective induction of apoptosis through activation of caspase-8 in human leukemia cells (Jurkat) by dandelion root extract. Journal of Ethnopharmacology 133:1, pages 86-91.
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Hyo-Yeon Kim, Seok-Joo Kim, Kyung Nam Kim, Sin Gu Lee & Sun-Mee Lee. (2011) Protective effect of HV-P411, an herbal mixture, on carbon tetrachloride-induced liver fibrosis. Food Chemistry 124:1, pages 248-253.
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Liben Liu, Huanzhang Xiong, Jiaqi Ping, Yulin Ju & Xuemei Zhang. (2010) Taraxacum officinale protects against lipopolysaccharide-induced acute lung injury in mice. Journal of Ethnopharmacology 130:2, pages 392-397.
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Shuyun Shi, Kelong Huang, Yuping Zhang & Suqin Liu. (2008) Preparative isolation and purification of two flavonoid glycosides from Taraxacum mongolicum by high-speed counter-current chromatography. Separation and Purification Technology 60:1, pages 81-85.
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Katrin Schütz, Reinhold Carle & Andreas Schieber. (2006) Taraxacum—A review on its phytochemical and pharmacological profile. Journal of Ethnopharmacology 107:3, pages 313-323.
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