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Journal Of Herbal Pharmacotherapy Volume 5, 2005 - Issue 4
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Review Article

Catherine Ulbricht, PharmD, MBA(C), Column Editor Lemon Balm (Melissa officinalis L.)

An Evidence-Based Systematic Review by the Natural Standard Research Collaboration

Thomas Brendler PlantaPhile, BerlinView further author information
,
Joerg Gruenwald Phytopharm Consulting,
,
Benjamin Kligler Continuum Center for Health and Healing,
,
David Keifer University of Arizona, USA
,
Tracee Rae Abrams University of Rhode Island,
,
Jen Woods Northeastern University,
,
Heather Boon University of Toronto,
,
Catherine DeFranco Kirkwood MD Anderson Cancer Center,
,
Ethan Basch Memorial Sloan-Kettering Cancer Center,
,
Hope J. Lafferty Memorial Sloan-Kettering Cancer Center,
,
Catherine Ulbricht Massachusetts General Hospital, USA
&
Dana A. Hackman Northeastern University,
 show all
Pages 71-114 | Published online: 24 Aug 2009

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Behjat Javadi. (2018) Diet Therapy for Cancer Prevention and Treatment Based on Traditional Persian Medicine. Nutrition and Cancer 70:3, pages 376-403.
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Siyavash Joukar, Haleh Asadipour, Mohammad Sheibani, Hamid Najafipour & Shahriar Dabiri. (2016) The effects of Melissa officinalis (lemon balm) pretreatment on the resistance of the heart to myocardial injury. Pharmaceutical Biology 54:6, pages 1005-1013.
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Salimeh Ebrahimnezhad Darzi & Zahra Amirghofran. (2013) Dichloromethane fraction of Melissa officinalis induces apoptosis by activation of intrinsic and extrinsic pathways in human leukemia cell lines. Immunopharmacology and Immunotoxicology 35:3, pages 313-320.
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Articles from other publishers (43)

Aasiya Bano, Piril Hepsomali, Fazle Rabbani, Umer Farooq, Ayesha Kanwal, Aisha Saleem, Ali Akbar Bugti, Aftab Alam Khan, Zainab Khalid, Mahroo Bugti, Shah Mureed, Saeed Khan, Ikram Din Ujjan, Sümeyye Şahin, Mehtap Kara & Amjad Khan. (2023) The possible “calming effect” of subchronic supplementation of a standardised phospholipid carrier-based Melissa officinalis L. extract in healthy adults with emotional distress and poor sleep conditions: results from a prospective, randomised, double-blinded, placebo-controlled clinical trial. Frontiers in Pharmacology 14.
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Nikola M. Stojanović, Marko Z. Mladenović, Pavle J. Randjelović & Niko S. Radulović. (2023) The potential of lemon balm (Melissa officinalis L.) essential oil as an anti-anxiety agent – is the citronellal the activity carrier?. Journal of Ethnopharmacology 314, pages 116661.
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Nikola StojanovićM.M., Sara Mladenović, Bogdan Stojiljković, Aleksandar Marković, Dragana Pavlović, Pavle Ranđelović, Jelena Zvezdanović & Ljiljana Stanojević. (2023) Lemon balm (Melissa officinalis L.) hydrolate poorly influences isolated rat gastric fundus motility. Acta Facultatis Medicae Naissensis 40:1, pages 80-89.
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Tiago Agostinho Ferreira, Ydia Mariele Valadares, Jullyana Bicalho Costa, Andressa Barros Paschoalim, Jéssica Aline Silva Soares, Mariana Cristina de Assis Ramos & Maria Ludmila da Silva. (2022) Interações entre plantas medicinais e medicamentos em portadores de hipertensão arterial sistêmica e Diabetes mellitus. Revista Fitos 16:4, pages 490-507.
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K. O. Shnaider, M. L. Maksimov & V. A. Baranova. (2022) The effect of lemon balm (Melissa officinalis L.) on anxiety and depression. Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology):5, pages 12-20.
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Krutika Sawarkar, Sachin More, Amruta Shete, Nivedita S. Parkarwar, Samiksha C. Bhimgade & Ketki D. Mulekar. (2022) Overview of Chemicals in Cosmetics and their Associated Adverse Effects. International Journal of Pharmaceutical Sciences Review and Research, pages 79-89.
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Mahsa Maghalian, Mojgan Mirghafourvand & Nafiseh Ghassab-Abdollahi. (2022) The Effect of Melissa officinalis on Premenstrual Syndrome and Primary Dysmenorrhea in Women of Reproductive Age: A Systematic Review and Meta-Analysis. Current Womens Health Reviews 18:3.
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Rutuja R. Khatode & Pratiksha Deshmukh. (2022) Review on Lemon Balm Herb and its Evaluation. International Journal of Advanced Research in Science, Communication and Technology, pages 675-683.
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Khushboo, Abhishek Kumar & Bechan Sharma. (2022) Biomedical Implications of Plant-based Principles as Antidepressants: Prospects for Novel Drug Development. Mini-Reviews in Medicinal Chemistry 22:6, pages 904-926.
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Antonios Chrysargyris, Spyridon A. Petropoulos & Nikolaos Tzortzakis. (2022) Essential Oil Composition and Bioactive Properties of Lemon Balm Aerial Parts as Affected by Cropping System and Irrigation Regime. Agronomy 12:3, pages 649.
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Nikola M. Stojanović, Marko Z. Mladenović, Aleksandra Maslovarić, Nenad I. Stojiljković, Pavle J. Randjelović & Niko S. Radulović. (2022) Lemon balm (Melissa officinalis L.) essential oil and citronellal modulate anxiety-related symptoms – In vitro and in vivo studies. Journal of Ethnopharmacology 284, pages 114788.
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Bilge Aydin. 2022. Novel Drug Targets With Traditional Herbal Medicines. Novel Drug Targets With Traditional Herbal Medicines 401 422 .
Javad Sharifi-Rad, Cristina Quispe, Jesús Herrera-Bravo, Muhammad Akram, Wafa Abbaass, Prabhakar Semwal, Sakshi Painuli, Dmitry Alekseevich Konovalov, Mary Angelia Alfred, Nanjangud Venkatesh Anil Kumar, Muhammad Imran, Muhammad Nadeem, Barbara Sawicka, Piotr Pszczółkowski, Bernadetta Bienia, Piotr Barbaś, Shafi Mahmud, Alessandra Durazzo, Massimo Lucarini, Antonello Santini, Miquel Martorell & Daniela Calina. (2021) Phytochemical Constituents, Biological Activities, and Health-Promoting Effects of the Melissa officinalis. Oxidative Medicine and Cellular Longevity 2021, pages 1-20.
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Javid Ghazizadeh, Saeed Sadigh‐Eteghad, Wolfgang Marx, Ali Fakhari, Sanaz Hamedeyazdan, Mohammadali Torbati, Somaiyeh Taheri‐Tarighi, Mostafa Araj‐khodaei & Mojgan Mirghafourvand. (2021) The effects of lemon balm ( Melissa officinalis L.) on depression and anxiety in clinical trials: A systematic review and meta‐analysis . Phytotherapy Research 35:12, pages 6690-6705.
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Nevena Draginic, Vladimir Jakovljevic, Marijana Andjic, Jovana Jeremic, Ivan Srejovic, Marina Rankovic, Marina Tomovic, Tamara Nikolic Turnic, Andrey Svistunov, Sergey Bolevich & Isidora Milosavljevic. (2021) Melissa officinalis L. as a Nutritional Strategy for Cardioprotection. Frontiers in Physiology 12.
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Mehdi Mansouri & Fatemeh Mohammadi. (2021) Transcriptome analysis to identify key genes involved in terpenoid and rosmarinic acid biosynthesis in lemon balm (Melissa officinalis). Gene, pages 145417.
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Sara Zafar, Shagufta Perveen, Naeem Iqbal, M. Kamran Khan, Modhi O. Alotaibi & Afrah E. Mohammed. 2021. Alternative Medicine Interventions for COVID-19. Alternative Medicine Interventions for COVID-19 33 61 .
Shima Afshar, Fariba Afshar, Amir Rezazade, Zeinab Shaker Ardakani, Zahra Jafari Azar, Gholamreza Amin, Mamak Shariat & Fedyeh Haghollahi. (2020) Effects of a Combination of Foeniculum vulgare, Melissa officinalis Extract, and Nigella saliva Powder on Healthy Menopausal Women with Sexual Dysfunction: A Randomized Clinical Trial. Jundishapur Journal of Natural Pharmaceutical Products 15:3.
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Javid Ghazizadeh, Sanaz Hamedeyazdan, Mohammadali Torbati, Fereshteh Farajdokht, Ali Fakhari, Javad Mahmoudi, Mostafa Araj‐khodaei & Saeed Sadigh‐Eteghad. (2020) Melissa officinalis L. hydro‐alcoholic extract inhibits anxiety and depression through prevention of central oxidative stress and apoptosis . Experimental Physiology 105:4, pages 707-720.
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E. V. Skazyayeva, I. G. Bakulin, E. B. Avalueva, M. I. Skalinskaya, M. S. Zhuravleva & I. V. Lapinskii. (2020) The possibilities of phytotherapy in the treatment of patients with functional disorders of the digestive tract. Experimental and Clinical Gastroenterology 1:10, pages 72-78.
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Nikola M. Stojanović, Pavle J. Randjelović, Marko Z. Mladenović, Ivan R. Ilić, Vladimir Petrović, Nenad Stojiljković, Sonja Ilić & Niko S. Radulović. (2019) Toxic essential oils, part VI: Acute oral toxicity of lemon balm (Melissa officinalis L.) essential oil in BALB/c mice. Food and Chemical Toxicology 133, pages 110794.
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Neda Nayebi, Alireza Esteghamati, Alipasha Meysamie, Nahid KhaliliMohammad Kamalinejad, Majid Emtiazy & Mohammad Hashem Hashempur. (2019) The effects of a Melissa officinalis L. based product on metabolic parameters in patients with type 2 diabetes mellitus: A randomized double-blinded controlled clinical trial . Journal of Complementary and Integrative Medicine 16:3.
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Alireza Soltanpour, Fatemeh Alijaniha, Mohsen Naseri, Anoshirvan Kazemnejad & Mohammad Reza Heidari. (2019) Effects of Melissa officinalis on anxiety and sleep quality in patients undergoing coronary artery bypass surgery: A double-blind randomized placebo controlled trial. European Journal of Integrative Medicine 28, pages 27-32.
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Zahra Dehbani, Alireza Komaki, Farshid Etaee, Siamak Shahidi, Masoumeh Taheri, Somayeh Komaki & Nafiseh Faraji. (2019) Effect of a hydro-alcoholic extract of Melissa officinalis on passive avoidance learning and memory. Journal of Herbmed Pharmacology 8:2, pages 120-125.
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Karen Savage, Joseph Firth, Con Stough & Jerome Sarris. (2018) GABA-modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence. Phytotherapy Research 32:1, pages 3-18.
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Mojgan Mirghafourvand, Jamileh Malakouti, Sakineh Mohammad Alizadeh Charandabi, Azizeh Farshbaf Khalili & Solmaz Ghanbari Homayi. (2016) The efficacy of lemon balm (Melissa officinalis L.) alone and combined with lemon balm—Nepeta menthoides on premenstrual syndrome and quality of life among students: A randomized controlled trial. Journal of Herbal Medicine 6:3, pages 142-148.
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Parvane Jalali, Afagh Moattari, Ali Mohammadi, Nima Ghazanfari & Gholamhosein Pourghanbari. (2016) Melissa officinalis efficacy against human influenza virus (New H1N1) in comparison with oseltamivir. Asian Pacific Journal of Tropical Disease 6:9, pages 714-717.
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Mojgan Mirghafourvand, Jamileh Malakouti, Sakineh Mohammad-Alizadeh Charandabi, Azizeh Farshbaf-Khalili & Solmaz Ghanbari-Homayi. (2016) The Effects of Lemon balm (Melissa officinalis L.) Alone and in Combination With Nepeta menthoides on the Menstrual Bleeding in Students With Premenstrual Syndrome: A Randomized Controlled Trial. Iranian Red Crescent Medical Journal 18:12.
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Bernhard Deckers, Tido von Schoen-Angerer, Bernd Voggenreiter & Jan Vagedes. (2016) External Nursing Applications in the Supportive Management of Prolonged Postoperative Ileus. Holistic Nursing Practice 30:4, pages 216-221.
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Abolfazl Shakeri, Amirhossein Sahebkar & Behjat Javadi. (2016) Melissa officinalis L. – A review of its traditional uses, phytochemistry and pharmacology. Journal of Ethnopharmacology 188, pages 204-228.
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Ali Zarei, Saeed Changizi-Ashtiyani, Soheila Taheri & Nasser Hosseini. (2015) A Brief Overview of the Effects of Melissa officinalis L. Extract on the Function of Various Body Organs. Zahedan Journal of Research in Medical Sciences 17:7.
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Fatemeh Alijaniha, Mohsen Naseri, Suleiman Afsharypuor, Faramarz Fallahi, Ahmadali Noorbala, Mahmood Mosaddegh, Soghrat Faghihzadeh & Sima Sadrai. (2015) Heart palpitation relief with Melissa officinalis leaf extract: Double blind, randomized, placebo controlled trial of efficacy and safety. Journal of Ethnopharmacology 164, pages 378-384.
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C. Weidner, M. Rousseau, A. Plauth, S.J. Wowro, C. Fischer, H. Abdel-Aziz & S. Sauer. (2015) Melissa officinalis extract induces apoptosis and inhibits proliferation in colon cancer cells through formation of reactive oxygen species. Phytomedicine 22:2, pages 262-270.
Crossref
Cydney E. McQueen & Katherine Kelly Orr. 2015. Handbook of Nonprescription Drugs: An Interactive Approach to Self-Care, 18th Edition. Handbook of Nonprescription Drugs: An Interactive Approach to Self-Care, 18th Edition.
Christopher Weidner, Sylvia J. Wowro, Anja Freiwald, Vitam Kodelja, Heba Abdel-Aziz, Olaf Kelber & Sascha Sauer. (2014) Lemon balm extract causes potent antihyperglycemic and antihyperlipidemic effects in insulin-resistant obese mice. Molecular Nutrition & Food Research 58:4, pages 903-907.
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Jean Paul Kamdem, Adekunle Adeniran, Aline Augusti Boligon, Claudia Vargas Klimaczewski, Olusola Olalekan Elekofehinti, Waseem Hassan, Mohammed Ibrahim, Emily Pansera Waczuk, Daiane Francine Meinerz & Margareth Linde Athayde. (2013) Antioxidant activity, genotoxicity and cytotoxicity evaluation of lemon balm (Melissa officinalis L.) ethanolic extract: Its potential role in neuroprotection. Industrial Crops and Products 51, pages 26-34.
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Paul Posadzki, Leala Watson & Edzard Ernst. (2013) Herb-drug interactions: an overview of systematic reviews. British Journal of Clinical Pharmacology 75:3, pages 603-618.
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Paul Posadzki, Leala Watson & Edzard Ernst. (2012) Contamination and adulteration of herbal medicinal products (HMPs): an overview of systematic reviews. European Journal of Clinical Pharmacology 69:3, pages 295-307.
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Paul Posadzki, Leala K Watson & Edzard Ernst. (2013) Adverse effects of herbal medicines: an overview of systematic reviews. Clinical Medicine 13:1, pages 7-12.
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Izaskun Berasategi, Sheila Legarra, Mikel García-Íñiguez de Ciriano, Sheyla Rehecho, Maria Isabel Calvo, Rita Yolanda Cavero, Íñigo Navarro-Blasco, Diana Ansorena & Iciar Astiasarán. (2011) “High in omega-3 fatty acids” bologna-type sausages stabilized with an aqueous-ethanol extract of Melissa officinalis. Meat Science 88:4, pages 705-711.
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Víctor López, Sara Martín, Maria Pilar Gómez-Serranillos, Maria Emilia Carretero, Anna K. Jäger & Maria Isabel Calvo. (2009) Neuroprotective and Neurological Properties of Melissa officinalis. Neurochemical Research 34:11, pages 1955-1961.
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Rosalie Awad, Asim Muhammad, Tony Durst, Vance L. Trudeau & John T. Arnason. (2009) Bioassay‐guided fractionation of lemon balm ( Melissa officinalis L.) using an in vitro measure of GABA transaminase activity . Phytotherapy Research 23:8, pages 1075-1081.
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Diana M. Taibi & Carol A. Landis. 2009. Complementary and Alternative Therapies and the Aging Population. Complementary and Alternative Therapies and the Aging Population 57 81 .

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