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(RG) Obstetrics and Gynaecology

Comparison of the proliferative effects of estradiol and conjugated equine estrogens on human breast cancer cells and impact of continuous combined progestogen addition

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Pages 221-227 | Published online: 03 Jul 2009

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Read on this site (6)

X. Ruan & A. O. Mueck. (2023) The WHO claims estrogens are ‘carcinogenic’: is this true?. Climacteric 26:3, pages 263-270.
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Sebastian Mirkin, Barry S Komm & James H Pickar. (2014) Conjugated estrogens for the treatment of menopausal symptoms: a review of safety data. Expert Opinion on Drug Safety 13:1, pages 45-56.
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X. Ruan, H. Neubauer, Y. Yang, H. Schneck, S. Schultz, T. Fehm, M. A. Cahill, H. Seeger & A. O. Mueck. (2012) Progestogens and membrane-initiated effects on the proliferation of human breast cancer cells. Climacteric 15:5, pages 467-472.
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F.-P. Chen, M.-H. Chien, H.-Y. Chen & Y.-T. Ng. (2011) Effects of different progestogens on human breast tumor cell growth. Climacteric 14:3, pages 345-351.
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Articles from other publishers (32)

Meghan S. Perkins, Renate Louw-du Toit, Hayley Jackson, Mishkah Simons & Donita Africander. (2022) Upregulation of an estrogen receptor-regulated gene by first generation progestins requires both the progesterone receptor and estrogen receptor alpha. Frontiers in Endocrinology 13.
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Xiangyan Ruan, Muqing Gu, Guiju Cai, Yue Zhao, Lijuan Wang, Xue Li & Alfred O. Mueck. (2019) Progestogens and PGRMC1-dependent breast cancer tumor growth: An in-vitro and xenograft study. Maturitas 123, pages 1-8.
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Fernando P. Filgueira, Núbia S. Lobato, Denise L. Nascimento, Graziela S. Ceravolo, Fernanda R.C. Giachini, Victor V. Lima, Ana Paula Dantas, Zuleica B. Fortes, R. Clinton Webb, Rita C. Tostes & Maria Helena C. Carvalho. (2019) Equilin displays similar endothelium-independent vasodilator potential to 17β-estradiol regardless of lower potential to inhibit calcium entry. Steroids 141, pages 46-54.
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Craig S. Atwood & Samuel F. Ekstein. (2019) Human versus non-human sex steroid use in hormone replacement therapies part 1: Preclinical data. Molecular and Cellular Endocrinology 480, pages 12-35.
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Meghan S Perkins, Renate Louw-du Toit & Donita Africander. (2018) Hormone therapy and breast cancer: emerging steroid receptor mechanisms. Journal of Molecular Endocrinology 61:4, pages R133-R160.
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Jiong Chen, Wei Feng & Yue Zhao. (2017) Secretory expression, purification and functional characterization of 17β-hydroxysteroid dehydrogenase type 1 from mammalian HEK293T cells. Protein Expression and Purification 137, pages 52-57.
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Alfred O. Mueck. (2017) Transdermales Östradiol und ProgesteronTransdermal estradiol and progesterone. Gynäkologische Endokrinologie 15:1, pages 65-72.
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Sebastian Mirkin, Julia M. Amadio, Brian A. Bernick, James H. Pickar & David F. Archer. (2015) 17β-Estradiol and natural progesterone for menopausal hormone therapy: REPLENISH phase 3 study design of a combination capsule and evidence review. Maturitas 81:1, pages 28-35.
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Ki Hoon Ahn, Kyung Wook Yi, Hyun Tae Park, Jung Ho Shin, Jun Young Hur, Sun Haeng Kim & Tak Kim. (2013) Anti-proliferative effect of Klimaktoplan® on human breast cancer cells. Archives of Gynecology and Obstetrics 288:4, pages 833-838.
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Fang-Ping Chen, Mei-Hua Chien, Huang-Yang Chen, Ting-Shuo Huang & Yuet-Tong Ng. (2013) Effects of estradiol and progestogens on human breast cells: Regulation of sex steroid receptors. Taiwanese Journal of Obstetrics and Gynecology 52:3, pages 365-373.
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John A. Eden. 2012. Stem Cells and Cancer Stem Cells, Volume 2. Stem Cells and Cancer Stem Cells, Volume 2 231 240 .
Anieta M. Sieuwerts, Giuseppina De Napoli, Anne van Galen, Helenius J. Kloosterboer, Vanja de Weerd, Hong Zhang, John W.M. Martens, John A. Foekens & Christian De Geyter. (2011) Hormone replacement therapy dependent changes in breast cancer‐related gene expression in breast tissue of healthy postmenopausal women. Molecular Oncology 5:6, pages 504-516.
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Erika Schwartz & Kent Holtorf. (2011) Hormone Replacement Therapy in the Geriatric Patient: Current State of the Evidence and Questions for the Future. Estrogen, Progesterone, Testosterone, and Thyroid Hormone Augmentation in Geriatric Clinical Practice: Part 1. Clinics in Geriatric Medicine 27:4, pages 541-559.
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?. Star?evi?P. Kocbek, G. Hribar, T. Lani?nik Ri?ner & S. Gobec. (2011) Biochemical and biological evaluation of novel potent coumarin inhibitor of 17?-HSD type 1. Chemico-Biological Interactions 191:1-3, pages 60-65.
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John A. Eden. (2011) Breast cancer, stem cells and sex hormones. Part 3: The impact of the menopause and hormone replacement. Maturitas 68:2, pages 129-136.
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Štefan Starčević, Petra Brožič, Samo Turk, Jožko Cesar, Tea Lanišnik Rižner & Stanislav Gobec. (2010) Synthesis and Biological Evaluation of (6- and 7-Phenyl) Coumarin Derivatives as Selective Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1. Journal of Medicinal Chemistry 54:1, pages 248-261.
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Harald Seeger, Xiangjan Ruan, Hans Neubauer & Alfred O. Mueck. (2011) Effect of drospirenone on proliferation of human benign and cancerous epithelial breast cells. Hormone Molecular Biology and Clinical Investigation 6:2.
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Alfred O. Mueck, Harald Seeger & Samuel Shapiro. (2010) Risk of breast cancer during hormone replacement therapy: mechanisms. Hormone Molecular Biology and Clinical Investigation 3:1.
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Zhican Wang, Praneeth Edirisinghe, Johann Sohn, Zhihui Qin, Nicholas E. Geacintov, Gregory R. J. Thatcher & Judy L. Bolton. (2009) Development of a Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry Method for Analysis of Stable 4-Hydroxyequilenin−DNA Adducts in Human Breast Cancer Cells. Chemical Research in Toxicology 22:6, pages 1129-1136.
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Zhican Wang, Gihani T. Wijewickrama, Kuan-wei Peng, Birgit M. Dietz, Long Yuan, Richard B. van Breemen, Judy L. Bolton & Gregory R.J. Thatcher. (2009) Estrogen Receptor α Enhances the Rate of Oxidative DNA Damage by Targeting an Equine Estrogen Catechol Metabolite to the Nucleus. Journal of Biological Chemistry 284:13, pages 8633-8642.
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Barry S. Komm. (2008) A New Approach to Menopausal Therapy: The Tissue Selective Estrogen Complex. Reproductive Sciences 15:10, pages 984-992.
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Erika T. Schwartz & Kent Holtorf. (2008) Hormones in Wellness and Disease Prevention: Common Practices, Current State of the Evidence, and Questions for the Future. Primary Care: Clinics in Office Practice 35:4, pages 669-705.
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Charles E. Wood, Thomas B. Clarkson, Haiying Chen, Timothy D. Veenstra, Xia Xu, Latanya Scott & J. Mark Cline. (2008) Comparative effects of oral conjugated equine estrogens and micronized 17β-estradiol on breast proliferation. Menopause 15:5, pages 978-983.
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Minsun Chang, Kuan-wei Peng, Irida Kastrati, Cassia R. Overk, Zhi-Hui Qin, Ping Yao, Judy L. Bolton & Gregory R. J. Thatcher. (2007) Activation of Estrogen Receptor-Mediated Gene Transcription by the Equine Estrogen Metabolite, 4-Methoxyequilenin, in Human Breast Cancer Cells. Endocrinology 148:10, pages 4793-4802.
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Adriana Stopforth, Ben V. Burger, Andrew M. Crouch & Pat Sandra. (2007) The analysis of estrone and 17β-estradiol by stir bar sorptive extraction–thermal desorption–gas chromatography/mass spectrometry: Application to urine samples after oral administration of conjugated equine estrogens. Journal of Chromatography B 856:1-2, pages 156-164.
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C. Ribot & F. Trémollieres. (2007) Traitement hormonal chez les femmes ménopausées: tous les traitements sont-ils équivalents?. Gynécologie Obstétrique & Fertilité 35:5, pages 388-397.
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Maher A. Abdallah, Huda I. Abdullah, Steven Kang, Douglas D. Taylor, Steven T. Nakajima & Cicek Gercel-Taylor. (2007) Effects of the components of hormone therapy on matrix metalloproteinases in breast-cancer cells: an in vitro study. Fertility and Sterility 87:4, pages 978-981.
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Elizabeth A. Kr?mer, Harald Seeger, Bernhard Kr?mer, Diethelm Wallwiener & Alfred O. Mueck. (2006) The effect of progesterone, testosterone and synthetic progestogens on growth factor- and estradiol-treated human cancerous and benign breast cells. European Journal of Obstetrics & Gynecology and Reproductive Biology 129:1, pages 77-83.
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Maria Grazia Modena, Piero Sismondi, Alfred O. Mueck, Frédérique Kuttenn, Bruno de Lignières, Johan Verhaeghe, Jean Michel Foidart, Anne Caufriez & Andrea Riccardo Genazzani. (2005) New evidence regarding hormone replacement therapies is urgently required. Maturitas 52:1, pages 1-10.
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Elizabeth A Krämer, Harald Seeger, Bernhard Krämer, Diethelm Wallwiener & Alfred O Mueck. (2005) The effects of progesterone, medroxyprogesterone acetate, and norethisterone on growth factor- and estradiol-treated human cancerous and noncancerous breast cells. Menopause 12:4, pages 468-474.
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Shelley S. Tworoger, Stacey A. Missmer, Robert L. Barbieri, Walter C. Willett, Graham A. Colditz & Susan E. Hankinson. (2005) Plasma Sex Hormone Concentrations and Subsequent Risk of Breast Cancer Among Women Using Postmenopausal Hormones. JNCI: Journal of the National Cancer Institute 97:8, pages 595-602.
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S. A. Missmer, A. H. Eliassen, R. L. Barbieri & S. E. Hankinson. (2004) Endogenous Estrogen, Androgen, and Progesterone Concentrations and Breast Cancer Risk Among Postmenopausal Women. JNCI Journal of the National Cancer Institute 96:24, pages 1856-1865.
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