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Journal of Toxicology: Clinical Toxicology Volume 37, 1999 - Issue 6
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Research Article

Activated Charcoal Reduces the Need for N-Acetylcysteine Treatment After Acetaminophen (Paracetamol) Overdose

Nicholas A. Buckley Royal Adelaide Hospital, Adelaide, SA, Australia
,
Dr. Nicholas Buckley Department of Clinical Pharmacology, Royal Adelaide Hospital, S.A., 5000, Australia
,
Ian M Whyte Newcastle Mater Misericordiae Hospital, Newcastle, Australia
,
Dianne L O'Connell University of Newcastle, Newcastle, Australia
&
Andrew H Dawson Newcastle Mater Misericordiae Hospital, Newcastle, Australia
Pages 753-757 | Published online: 18 Nov 2004

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Annabelle S Chidiac, Nicholas A Buckley, Firouzeh Noghrehchi & Rose Cairns. (2023) Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease. Expert Opinion on Drug Metabolism & Toxicology 19:5, pages 297-317.
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Miren García-Cortés, Aida Ortega-Alonso & Raúl J. Andrade. (2022) Safety of treating acute liver injury and failure. Expert Opinion on Drug Safety 21:2, pages 191-203.
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Lotte C. G. Hoegberg, Greene Shepherd, David M. Wood, Jami Johnson, Robert S. Hoffman, E. Martin Caravati, Wui Ling Chan, Silas W. Smith, Kent R. Olson & Sophie Gosselin. (2021) Systematic review on the use of activated charcoal for gastrointestinal decontamination following acute oral overdose. Clinical Toxicology 59:12, pages 1196-1227.
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Angela L. Chiew, Geoffrey K. Isbister, Katharine A. Kirby, Colin B. Page, Betty S. H. Chan & Nicholas A. Buckley. (2017) Massive paracetamol overdose: an observational study of the effect of activated charcoal and increased acetylcysteine dose (ATOM-2). Clinical Toxicology 55:10, pages 1055-1065.
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Jonathan G. Stine & James H. Lewis. (2016) Current and future directions in the treatment and prevention of drug-induced liver injury: a systematic review. Expert Review of Gastroenterology & Hepatology 10:4, pages 517-536.
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S. B. Duffull & G. K. Isbister. (2013) Predicting the requirement for N-acetylcysteine in paracetamol poisoning from reported dose. Clinical Toxicology 51:8, pages 772-776.
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Rachel E. Tuuri, Leticia M. Ryan, Jianping He, Robert J. McCarter & Joseph L. Wright. (2009) Does Emergency Medical Services Transport for Pediatric Ingestion Decrease Time to Activated Charcoal?. Prehospital Emergency Care 13:3, pages 295-303.
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Richard C. Dart, Andrew R. Erdman, Kent R. Olson, Gwenn Christianson, Anthony S. Manoguerra, Peter A. Chyka, E. Martin Caravati, Paul M. Wax, Daniel C. Keyes, Alan D. Woolf, Elizabeth J. Scharman, Lisa L. Booze & William G. Troutman. (2006) Acetaminophen Poisoning: an Evidence-Based Consensus Guideline for Out-of-Hospital Management. Clinical Toxicology 44:1, pages 1-18.
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American Academy of Clinical Toxicology & European Association of Poisons Centres and Clinical Toxicologists. (2005) Position Paper: Single-Dose Activated Charcoal. Clinical Toxicology 43:2, pages 61-87.
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Randall D. Hofbauer & Joel S. Holger. (2004) The Use of Cholecystokinin as an Adjunctive Treatment for Toxin Ingestion . Journal of Toxicology: Clinical Toxicology 42:1, pages 61-66.
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Ian M. Whyte, Nicholas A. Buckley & Andrew H. Dawson. (2002) Data Collection in Clinical Toxicology: Are There Too Many Variables?*. Journal of Toxicology: Clinical Toxicology 40:3, pages 223-230.
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Chengyin Wang, Xiaoya Hu, Zongzhou Leng, Gongjun Yang & Gendi Jin. (2001) DIFFERENTIAL PULSE VOLTAMMETRY FOR DETERMINATION OF PARACETAMOL AT A PUMICE MIXED CARBON PASTE ELECTRODE. Analytical Letters 34:15, pages 2747-2759.
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Geoff Isbister, Ian Whyte & Andrew Dawson. (2001) Pediatric Acetaminophen Overdose. Journal of Toxicology: Clinical Toxicology 39:2, pages 169-170.
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Ewurabena Y. Afful, Samuel Frimpong-Manso, Samuel O. Bekoe, Chris O. Barfi, Kwabena F.M. Opuni & Mahmood B. Oppong. (2022) The Unethical Use of Paracetamol As a Food Tenderizer in Four Selected African Countries: A Major Public Health Concern?. Drug Metabolism and Bioanalysis Letters 15:3, pages 159-165.
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Okuyama JHH, Galvao TF & Silva MT. (2022) Estimates of Paracetamol Poisoning in Brazil: Analysis of Official Records From 1990s to 2020. Frontiers in Pharmacology 13.
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Apu Chowdhury, Jahan Nabila, Isaac Adelusi Temitope & Sicen Wang. (2020) Current etiological comprehension and therapeutic targets of acetaminophen-induced hepatotoxicity. Pharmacological Research 161, pages 105102.
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Tobias Zellner, Dagmar Prasa, Elke Färber, Petra Hoffmann-Walbeck, Dieter Genser & Florian Eyer. (2019) The Use of Activated Charcoal to Treat Intoxications. Deutsches Ärzteblatt international.
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Sohyun Park, Hui Jai Lee, Jonghwan Shin, Kyoung Min You, Se Jong Lee & Euigi Jung. (2018) Clinical Effects of Activated Charcoal Unavailability on Treatment Outcomes for Oral Drug Poisoned Patients. Emergency Medicine International 2018, pages 1-9.
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