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Journal of Toxicology: Clinical Toxicology Volume 42, 2004 - Issue 7
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Research Article

Do Adenosine Receptors Play a Role in Amitriptyline‐Induced Cardiovascular Toxicity in Rats?

Sule Kalkan Department of Pharmacology, School of Medicine, Dokuz Eylul University, Balcova, Izmir, 35340, Turkey
, M.D.,
Oguz Aygoren Department of Pharmacology, School of Medicine, Dokuz Eylul University, Balcova, Izmir, 35340, Turkey
, M.D.,
Aylin Akgun Department of Pharmacology, School of Medicine, Dokuz Eylul University, Balcova, Izmir, 35340, Turkey
, Ph.D., Student, M.D.,
Sedef Gidener Department of Pharmacology, School of Medicine, Dokuz Eylul University, Balcova, Izmir, 35340, Turkey
, M.D.,
Hulya Guven Department of Pharmacology, School of Medicine, Dokuz Eylul University, Balcova, Izmir, 35340, Turkey
, M.D. &
Yesim Tuncok Department of Pharmacology, School of Medicine, Dokuz Eylul University, Balcova, Izmir, 35340, Turkey
, M.D.
Pages 945-954 | Published online: 12 Sep 2004

Citations (19)

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Read on this site (6)

Sule Kalkan, Nil Hocaoglu, Kubilay Oransay, Mujgan Buyukdeligoz & Yesim Tuncok. (2012) Adenosine-mediated cardiovascular toxicity in amitriptyline-poisoned rats. Drug and Chemical Toxicology 35:4, pages 423-431.
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Alan Clement, Jeremiah J. Raney, Gary S. Wasserman & Jennifer A. Lowry. (2012) Chronic amitriptyline overdose in a child. Clinical Toxicology 50:5, pages 431-434.
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Kubilay Oransay, Sule Kalkan, Nil Hocaoglu, Aylin Arici & Yesim Tuncok. (2011) An alternative antidote therapy in amitriptyline-induced rat toxicity model: theophylline. Drug and Chemical Toxicology 34:1, pages 53-60.
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Sule Kalkan, Nil Hocaoglu, Aylin (Akgun) Arici, Kubilay Oransay, Gul Ergor & Yesim Tuncok. (2010) Effects of Adenosine Receptor Antagonists on Survival in Amitriptyline-poisoned Mice. Drug and Chemical Toxicology 33:3, pages 233-237.
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Aylin Akgun, Sule Kalkan, Nil Hocaoglu, Sedef Gidener & Yesim Tuncok. (2008) Effects of adenosine receptor antagonists onamitriptyline-induced QRS prolongation in isolated rat hearts. Clinical Toxicology 46:7, pages 677-685.
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Sule Kalkan, Nil Hocaoglu, Aylin Akgun, Sedef Gidener & Yesim Tuncok. (2007) Effects of adenosine receptor antagonists on amitriptyline-induced vasodilation in rat isolated aorta. Clinical Toxicology 45:5, pages 600-604.
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Articles from other publishers (13)

Orhan Sahin, Gozde Akturk, Serap Cilaker Micili, Ozlem Gursoy Doruk, Fazilet Karapinar, Nil Hocaoglu, Bekir Ugur Ergur, Pinar Akan, Yesim Tuncok & Sule Kalkan. (2023) Effect of the selective mitochondrial KATP channel opener nicorandil on the QT prolongation and myocardial damage induced by amitriptyline in rats. Journal of Pharmacy and Pharmacology 75:3, pages 415-426.
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Juliana Maria Navia-Pelaez, Melissa Tainan Silva Dias, Laura Alejandra Ariza Orellano, Gianne Paul Campos, Jacqueline Alvarez-Leite, Paula Peixoto Campos & Luciano Santos Aggum Capettini. (2022) Dual effect of amitriptyline in the control of vascular tone: Direct blockade of calcium channel in smooth muscle cells and reduction of TLR4-dependent NO production in endothelial cells. European Journal of Pharmacology 934, pages 175255.
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Hatice Aygun, Nursah Basol & Serdar Savas Gul. (2020) Cardioprotective Effect of Paricalcitol on Amitriptyline-Induced Cardiotoxicity in Rats: Comparison of [99mTc]PYP Cardiac Scintigraphy with Electrocardiographic and Biochemical Findings. Cardiovascular Toxicology 20:4, pages 427-436.
Crossref
Shogo Tsujikawa, Tadashi Matsuura, Kotaro Hori, Takashi Mori, Miyuki KunoKiyonobu Nishikawa. (2018) Superior Efficacy of Lipid Emulsion Infusion Over Serum Alkalinization in Reversing Amitriptyline-Induced Cardiotoxicity in Guinea Pig. Anesthesia & Analgesia 126:4, pages 1159-1169.
Crossref
Sule Kalkan, Nil Hocaoglu, Mujgan Buyukdelig & Hakan Gurdal. (2017) Binding of Amitriptyline to Adenosine A1 or A2a Receptors Using Radioligand Binding Assay. International Journal of Pharmacology 14:1, pages 116-120.
Crossref
Jan Schmidt & Polonca Ferk. (2017) Safety issues of compounds acting on adenosinergic signalling. Journal of Pharmacy and Pharmacology 69:7, pages 790-806.
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Müge Gülen. (2016) Trisiklik Antidepresanlarla Zehirlenme ve Güncel Tedaviler. Arşiv Kaynak Tarama Dergisi 25:23783, pages 608-617.
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Burc Aydin, Nil Hocaoglu, Serap Cilaker Micili, Bekir Ugur Ergur & Sule Kalkan. (2015) Effects of 2-Hydroxypropyl-Beta-Cyclodextrin on Cardiovascular Signs of Amitriptyline Poisoning in a Rat Model. Cardiovascular Toxicology 16:4, pages 374-380.
Crossref
MAA Arıcı, M Buyukdeligoz, S Kalkan & Y Tuncok. (2012) Effects of BQ-788 on amitriptyline-induced cardiovascular toxicity. Human & Experimental Toxicology 32:3, pages 316-322.
Crossref
S Kalkan, K Oransay, IB Bal, M Ertunc, Y Sara & AB Iskit. (2012) The role of adenosine receptors on amitriptyline-induced electrophysiological changes on rat atrium. Human & Experimental Toxicology 32:1, pages 62-69.
Crossref
Nil Hocaoglu, Sule Kalkan, Mujgan Buyukdeligoz, Kubilay Oransay & Yesim Tuncok. (2011) Is Serum S100B Protein a Biomarker for Amitriptyline-Induced Cardiovascular Toxic Effects?. Cardiovascular Toxicology 12:2, pages 115-122.
Crossref
YC Kaplan, N Hocaoglu, K Oransay, S Kalkan & Y Tuncok. (2008) Effect of glucagon on amitriptyline-induced cardiovascular toxicity in rats. Human & Experimental Toxicology 27:4, pages 321-325.
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. (2006) Invited Lectures. Purinergic Signalling 2:1, pages 1-324.
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