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Drug and Chemical Toxicology Volume 24, 2001 - Issue 4
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Research Article

INHIBITION OF GENOTOXICITY BY SAFFRON (CROCUS SATIVUS L.) IN MICE

K. Premkumar Department of Genetics, Dr. ALM PG Institute of Basic Medical Sciences University of Madras, Taramani, Chennai, 600 113, India
,
Suresh K. Abraham School of Life Sciences, Jawaharlal Nehru University, New Delhi, 110 067, India
,
S. T. Santhiya Department of Genetics, Dr. ALM PG Institute of Basic Medical Sciences University of Madras, Taramani, Chennai, 600 113, India
,
P. M. Gopinath Department of Genetics, Dr. ALM PG Institute of Basic Medical Sciences University of Madras, Taramani, Chennai, 600 113, India
&
A. Ramesh Department of Genetics, Dr. ALM PG Institute of Basic Medical Sciences University of Madras, Taramani, Chennai, 600 113, India
Pages 421-428 | Published online: 30 Nov 2001

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Abbas Ali Vafaei, Hossein Ali Safakhah, Simin Jafari, Azin Tavasoli, Ali Rashidy-Pour, Ali Ghanbari, Seyed Ali Seyedinia & Parnia Tarahomi. (2020) Role of Cannabinoid Receptors in Crocin-Induced Hypoalgesia in Neuropathic Pain in Rats. Journal of Experimental Pharmacology 12, pages 97-106.
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Apurva Koul & Suresh K. Abraham. (2017) Intake of saffron reduces γ-radiation-induced genotoxicity and oxidative stress in mice. Toxicology Mechanisms and Methods 27:6, pages 428-434.
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Zhiyu Zhang, Chong-Zhi Wang, Xiao-Dong Wen, Yukihiro Shoyama & Chun-Su Yuan. (2013) Role of saffron and its constituents on cancer chemoprevention. Pharmaceutical Biology 51:7, pages 920-924.
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Catherine Ulbricht, Julie Conquer, Dawn Costa, Whitney Hollands, Carmen Iannuzzi, Richard Isaac, Joseph K. Jordan, Natalie Ledesma, Cathy Ostroff, Jill M. Grimes Serrano, Michael D. Shaffer & Minney Varghese. (2011) An Evidence-Based Systematic Review of Saffron (Crocus sativus) by the Natural Standard Research Collaboration. Journal of Dietary Supplements 8:1, pages 58-114.
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S. Zahra Bathaie & S. Zeinab Mousavi. (2010) New Applications and Mechanisms of Action of Saffron and its Important Ingredients. Critical Reviews in Food Science and Nutrition 50:8, pages 761-786.
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Articles from other publishers (44)

Zahra Habibi, Mahmood Hoormand, Majid Banimohammad, Marjan Ajami, Gholamreza Amin, Mohsen Amin & Hamidreza Pazoki-Toroudi. (2022) The Novel Role of Crocus sativus L. in Enhancing Skin Flap Survival by Affecting Apoptosis Independent of mTOR: A Data-Virtualized Study. Aesthetic Plastic Surgery 46:6, pages 3047-3062.
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Mohammad Saeedi & Ali Rashidy-Pour. (2021) Association between chronic stress and Alzheimer’s disease: Therapeutic effects of Saffron. Biomedicine & Pharmacotherapy 133, pages 110995.
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Jelena B. Popović-Djordjević, Jelena S. Katanić Stanković, Vladimir Mihailović & Muhammad Akram. 2021. Saffron. Saffron 1 40 .
Deepu Pandita. 2021. Medicinal and Aromatic Plants. Medicinal and Aromatic Plants 325 396 .
Mir Shafat A.Bhat Javeed I.A.Bhat Rouf Ahmad, Beigh Bilal A.Islam Hafiz ul, Ahmad Dar Shakeel, Bashir Ishrat & Rashid Gowhar. 2021. Medicinal and Aromatic Plants. Medicinal and Aromatic Plants 145 167 .
Kyriaki Hatziagapiou & George I. Lambrou. (2020) Anti-toxicant Properties of Saffron and Relevance to Protection from Toxins and Drugs. Current Bioactive Compounds 16:3, pages 265-283.
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Hamid A. Bakshi, Hakkim L. Faruck, Sangilimuthu Alagar Yadav & Murtaza M. Tambuwala. 2020. Saffron. Saffron 245 262 .
Mohammad Hossein Boskabady, Amin Mokhtari-Zaer, Mohammad Reza Khazdair, Arghavan Memarzia & Zahra Gholamnezhad. 2020. Saffron. Saffron 219 231 .
Isabela Machado Barbosa David, Flávia de Souza Fernandes, Juliana Barreto dos Santos Silva Ferreira, Daniela Dero Lüdtke, Daniel Fernandes Martins, Franciane Bobinski, Thiago Bezerra Gaspar Carvalho da Silva, Luiza Daux Buffon, Maria Biatriz Rodrigues Kopper, Gustavo Silveira da Silva, Rodrigo Costa Zeferino, Rozangela Curi Pedrosa & Maicon Roberto Kviecinski. (2019) Dietary supplementation with procyanidin-rich Pinus pinaster extract is associated with attenuated Ehrlich tumor development in mice. Nutrition Research 62, pages 41-50.
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Shonaz Ahmadi Khatir, Ayatollah Bayatian, Abolfazl Barzegari, Neda Roshanravan, Abdolrasoul Safaiyan, Graciela Pavon-Djavid & Alireza Ostadrahimi. (2018) Saffron (Crocus sativus L.) Supplements Modulate Circulating MicroRNA (miR-21) in Atherosclerosis Patients; A Randomized, Double-Blind, Placebo-Controlled Trial. Iranian Red Crescent Medical Journal In Press:In Press.
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Azar Hosseini, Bibi Marjan Razavi & Hossein Hosseinzadeh. (2017) Pharmacokinetic Properties of Saffron and its Active Components. European Journal of Drug Metabolism and Pharmacokinetics 43:4, pages 383-390.
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Alireza Timcheh Hariri, Seyed Adel Moallem, Mahmoud Mahmoudi, Bahram Memar, Bibi Marjan Razavi & Hossein Hosseinzadeh. (2018) Effect of Crocus sativus L. stigma (saffron) against subacute effect of diazinon: histopathological, hematological, biochemical and genotoxicity evaluations in rats . Journal of Pharmacopuncture 21:2, pages 61-69.
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Maliheh Moradzadeh, Hamid Reza Sadeghnia, Alijan Tabarraei & Amirhossein Sahebkar. (2018) Anti-tumor effects of crocetin and related molecular targets. Journal of Cellular Physiology 233:3, pages 2170-2182.
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A Koul & SK Abraham. (2017) Efficacy of crocin and safranal as protective agents against genotoxic stress induced by gamma radiation, urethane and procarbazine in mice. Human & Experimental Toxicology 37:1, pages 13-20.
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Yasemin Sunucu Karafakıoğlu, Mehmet Fatih Bozkurt, Ömer Hazman & A. Fatih Fıdan. (2017) Efficacy of safranal to cisplatin-induced nephrotoxicity. Biochemical Journal 474:7, pages 1195-1203.
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A. Yari, A. Sarveazad, E. Asadi, J. Raouf Sarshoori, A. Babahajian, N. Amini, F. Amidi, H. Bahadoran, MT. Joghataei, MH. Asadi & A. Shams. (2016) Efficacy of Crocus sativus L. on reduction of cadmium-induced toxicity on spermatogenesis in adult rats . Andrologia 48:10, pages 1244-1252.
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V. Rodriguez-Ruiz, A. Barzegari, M. Zuluaga, S. Zunooni-Vahed, Y. Rahbar-Saadat, D. Letourneur, V. Gueguen & G. Pavon-Djavid. (2016) Potential of aqueous extract of saffron ( Crocus sativus L.) in blocking the oxidative stress by modulation of signal transduction in human vascular endothelial cells. Journal of Functional Foods 26, pages 123-134.
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Alireza Milajerdi, Kurosh Djafarian & Banafshe Hosseini. (2016) The toxicity of saffron (Crocus sativus L.) and its constituents against normal and cancer cells. Journal of Nutrition & Intermediary Metabolism 3, pages 23-32.
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Elham Mokhber Maleki, Hussein Eimani, Mohammad Reza Bigdeli, Bita Ebrahimi, Abdol Hossein Shahverdi, Afsane Golkar Narenji & Reyhane Abedi. (2014) A comparative study of saffron aqueous extract and its active ingredient, crocin on the in vitro maturation, in vitro fertilization, and in vitro culture of mouse oocytes. Taiwanese Journal of Obstetrics and Gynecology 53:1, pages 21-25.
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Seyedeh Hoda Alavizadeh & Hossein Hosseinzadeh. (2014) Bioactivity assessment and toxicity of crocin: A comprehensive review. Food and Chemical Toxicology 64, pages 65-80.
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T. K. LimT. K. Lim. 2014. Edible Medicinal and Non Medicinal Plants. Edible Medicinal and Non Medicinal Plants 77 136 .
Hossein Hosseinzadeh & Marjan Nassiri-Asl. (2013) Avicenna's (Ibn Sina) the Canon of Medicine and Saffron ( Crocus sativus ): A Review . Phytotherapy Research 27:4, pages 475-483.
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Biplab Bhattacharjee, Sandhya Vijayasarathy, Prashantha Karunakar & Jhinuk Chatterjee. (2012) Comparative Reverse Screening Approach to Identify Potential Anti-neoplastic Targets of Saffron Functional Components and Binding Mode. Asian Pacific Journal of Cancer Prevention 13:11, pages 5605-5611.
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M.H. Boskabady, A. Tabatabaee & G. Byrami. (2012) The effect of the extract of Crocus sativus and its constituent safranal, on lung pathology and lung inflammation of ovalbumin sensitized guinea-pigs. Phytomedicine 19:10, pages 904-911.
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A. Crozet. (2012) Crocus sativus L. (Iridaceae), le safran (II). Phytothérapie 10:3, pages 186-193.
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Mohammad Hossein BoskabadySeyedh Masoumeh Seyedhosseini TamijaniHoushang RafatpanahAbadolrahim RezaeiAzam Alavinejad. (2011) The Effect of Crocus sativus Extract on Human Lymphocytes' Cytokines and T Helper 2/T Helper 1 Balance . Journal of Medicinal Food 14:12, pages 1538-1545.
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Saeed Samarghandian, Jalil Tavakkol Afshari & Saeideh Davoodi. (2010) Suppression of Pulmonary Tumor Promotion and Induction of Apoptosis by Crocus sativus L. Extraction. Applied Biochemistry and Biotechnology 164:2, pages 238-247.
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Alireza Timcheh Hariri, Seyed Adel Moallem, Mahmoud Mahmoudi & Hossein Hosseinzadeh. (2011) The effect of crocin and safranal, constituents of saffron, against subacute effect of diazinon on hematological and genotoxicity indices in rats. Phytomedicine 18:6, pages 499-504.
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Juliana Mara Serpeloni, Denise Grotto, Adriana Zerlotti Mercadante, Maria de Lourdes Pires Bianchi & Lusânia Maria Greggi Antunes. (2010) Lutein improves antioxidant defense in vivo and protects against DNA damage and chromosome instability induced by cisplatin. Archives of Toxicology 84:10, pages 811-822.
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M H Boskabady & M R Aslani. (2006) Relaxant effect of Crocus sativus (saffron) on guinea-pig tracheal chains and its possible mechanisms . Journal of Pharmacy and Pharmacology 58:10, pages 1385-1390.
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Hossein HosseinzadehAkram AbootorabiHamid R. Sadeghnia. (2008) Protective Effect of Crocus sativus Stigma Extract and Crocin ( trans -crocin 4) on Methyl Methanesulfonate–Induced DNA Damage in Mice Organs . DNA and Cell Biology 27:12, pages 657-664.
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H. Nemati, M.H. Boskabady & H. Ahmadzadef Vostakolaei. (2008) Stimulatory effect of Crocus sativus (saffron) on β2-adrenoceptors of guinea pig tracheal chains. Phytomedicine 15:12, pages 1038-1045.
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M. H. Boskabady, M. N. Shafei, A. Shakiba & H. Sang Sefidi. (2007) Effect of aqueous‐ethanol extract from Crocus sativus (saffron) on guinea‐pig isolated heart . Phytotherapy Research 22:3, pages 330-334.
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Hossein HosseinzadehHamid R. Sadeghnia. (2007) Effect of Safranal, a Constituent of Crocus sativus (Saffron), on Methyl Methanesulfonate (MMS)–Induced DNA Damage in Mouse Organs: An Alkaline Single-Cell Gel Electrophoresis (Comet) Assay . DNA and Cell Biology 26:12, pages 841-846.
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Thomas Paul Devasagayam, Jai Tilak & Rekha Singhal. 2007. Anti-Angiogenic Functional and Medicinal Foods. Anti-Angiogenic Functional and Medicinal Foods 69 96 .
H. Hosseinzadeh & H.R. Sadeghnia. (2007) Protective effect of safranal on pentylenetetrazol-induced seizures in the rat: Involvement of GABAergic and opioids systems. Phytomedicine 14:4, pages 256-262.
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M. Mastan, U. V. Prasad & P. R. Parthasarathy. (2007) Protective effect ofBacopa monniera L. on cytarabine induced biochemical changes in chick embryo. Indian Journal of Clinical Biochemistry 22:1, pages 122-127.
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K Premkumar, C Thirunavukkarasu, S K Abraham, S T Santhiya & A Ramesh. (2016) Protective effect of saffron (Crocus sativus L.) aqueous extract against genetic damage induced by anti-tumor agents in mice. Human & Experimental Toxicology 25:2, pages 79-84.
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José-Antonio Fernández. 2006. Lead Molecules from Natural Products - Discovery and New Trends. Lead Molecules from Natural Products - Discovery and New Trends 313 330 .
K. Premkumar, S.K. Abraham, S.T. Santhiya & A. Ramesh. (2004) Protective effect of Spirulina fusiformis on chemical-induced genotoxicity in mice. Fitoterapia 75:1, pages 24-31.
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F.I. Abdullaev & J.J. Espinosa-Aguirre. (2004) Biomedical properties of saffron and its potential use in cancer therapy and chemoprevention trials. Cancer Detection and Prevention 28:6, pages 426-432.
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F.I. Abdullaev, L. Riverón-Negrete, H. Caballero-Ortega, J. Manuel Hernández, I. Pérez-López, R. Pereda-Miranda & J.J. Espinosa-Aguirre. (2003) Use of in vitro assays to assess the potential antigenotoxic and cytotoxic effects of saffron (Crocus sativus L.). Toxicology in Vitro 17:5-6, pages 731-736.
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K. Premkumar, Suresh K. Abraham, S. T. Santhiya & A. Ramesh. (2003) Protective effects of saffron ( Crocus sativus Linn.) on genotoxins‐induced oxidative stress in Swiss albino mice . Phytotherapy Research 17:6, pages 614-617.
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