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Drug and Chemical Toxicology Volume 25, 2002 - Issue 1
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Research Article

LACK OF DNA BINDING IN THE RAT NASAL MUCOSA AND OTHER TISSUES OF THE NASAL TOXICANTS ROFLUMILAST, A PHOSPHODIESTERASE 4 INHIBITOR, AND A METABOLITE, 4-AMINO-3,5-DICHLOROPYRIDINE, IN CONTRAST TO THE NASAL CARCINOGEN 2,6-DIMETHYLANILINE*

Alan M. Jeffrey Department of Pathology, New York Medical College, Valhalla, NY, 10595, U.S.A.
,
Feng-Qi Luo American Health Foundation, Valhalla, NY, 10595, U.S.A.
,
Shantilal Amin American Health Foundation, Valhalla, NY, 10595, U.S.A.
,
Jacek Krzeminski American Health Foundation, Valhalla, NY, 10595, U.S.A.
,
Karl Zech Byk Gulden Lomberg Chemische Fabrik GmbH, Postfach 1003 10, Konstanz, 76403, Germany
&
Gary M. Williams Department of Pathology, New York Medical College, Valhalla, NY, 10595, U.S.A.
Pages 93-107 | Published online: 30 Jan 2002

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Nicholas J. Gross, Mark A. Giembycz & Stephen I. Rennard. (2010) Treatment of Chronic Obstructive Pulmonary Disease with Roflumilast, a New Phosphodiesterase 4 Inhibitor. COPD: Journal of Chronic Obstructive Pulmonary Disease 7:2, pages 141-153.
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Matthew W. Himmelstein, Peter J. Boogaard, Jean Cadet, Peter B. Farmer, James H. Kim, Elizabeth A. Martin, Rudranath Persaud & David E.G. Shuker. (2009) Creating context for the use of DNA adduct data in cancer risk assessment: II. Overview of methods of identification and quantitation of DNA damage. Critical Reviews in Toxicology 39:8, pages 679-694.
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Articles from other publishers (23)

David J. Kirkland, Meredith L. Sheil, Michael A. Streicker & George E. Johnson. (2021) A weight of evidence assessment of the genotoxicity of 2,6-xylidine based on existing and new data, with relevance to safety of lidocaine exposure. Regulatory Toxicology and Pharmacology 119, pages 104838.
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Tetyana Kobets, Alexander T. Cartus, Julia A. Fuhlbrueck, Alexander Brengel, Simone Stegmüller, Jian-Dong Duan, Klaus D. Brunnemann & Gary M. Williams. (2019) Assessment and characterization of DNA adducts produced by alkenylbenzenes in fetal turkey and chicken livers. Food and Chemical Toxicology 129, pages 424-433.
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Arihiro Kohara, Mariko Matsumoto, Akihiko Hirose, Makoto Hayashi, Masamitsu Honma & Takayoshi Suzuki. (2018) Mutagenic properties of dimethylaniline isomers in mice as evaluated by comet, micronucleus and transgenic mutation assays. Genes and Environment 40:1.
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Gary M. Williams, Tetyana Kobets, Jian-Dong Duan & Michael J. Iatropoulos. (2017) Assessment of DNA Binding and Oxidative DNA Damage by Acrylonitrile in Two Rat Target Tissues of Carcinogenicity: Implications for the Mechanism of Action. Chemical Research in Toxicology 30:7, pages 1470-1480.
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Mariana S. Pinheiro, Gil M. Viana, B?rbara de A. Abrahim Vieira, Alessandra Mendon?a Teles de Souza, Carlos Rangel Rodrigues, Rita de C?ssia E.E. Marins, L?cio M. Cabral & Val?ria P. de Sousa. (2017) Identification, characterization and in silico ADMET prediction of Roflumilast degradation products. Journal of Pharmaceutical and Biomedical Analysis 138, pages 126-133.
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Gary M. Williams, Jian-Dong Duan, Michael J. Iatropoulos & Carmen E. Perrone. (2014) Sex differences in DNA damage produced by the carcinogen 2-acetylaminofluorene in cultured human hepatocytes compared to rat liver and cultured rat hepatocytes. Archives of Toxicology 90:2, pages 427-432.
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M.J. Iatropoulos, J.-D. Duan, G. Schmuck & G.M. Williams. (2015) The urinary bladder carcinogen propoxur does not produce genotoxic effects in the urinary bladder of Wistar male rats. Experimental and Toxicologic Pathology 67:9, pages 453-458.
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Wei Ding, Dan D. Levy, Michelle E. Bishop, Mason G. Pearce, Kelly J. Davis, Alan M. Jeffrey, Jian-Dong Duan, Gary M. Williams, Gene A. White, Lascelles E. Lyn-Cook & Mugimane G. Manjanatha. (2015) In vivo genotoxicity of estragole in male F344 rats. Environmental and Molecular Mutagenesis 56:4, pages 356-365.
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Gary M. Williams, Jian-Dong Duan, Michael J. Iatropoulos & Tetyana Kobets. (2015) A no observed adverse effect level for DNA adduct formation in rat liver with prolonged dosing of the hepatocarcinogen 2-acetylaminofluorene. Toxicology Research 4:2, pages 233-240.
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Gary M. Williams, Jian-Dong Duan, Klaus D. Brunnemann, Michael J. Iatropoulos, Esther Vock & Ulrich Deschl. (2014) Chicken Fetal Liver DNA Damage and Adduct Formation by Activation-Dependent DNA-Reactive Carcinogens and Related Compounds of Several Structural Classes. Toxicological Sciences 141:1, pages 18-28.
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M.J. Iatropoulos, J.-D. Duan, A.M. Jeffrey, M.W. Leach, A.N. Hayes, N.L. Stedman & G.M. Williams. (2013) Hepatocellular proliferation and hepatocarcinogen bioactivation in mice with diet-induced fatty liver and obesity. Experimental and Toxicologic Pathology 65:4, pages 451-456.
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Gary M. Williams, Michael J. Iatropoulos, Alan M. Jeffrey & Jian-Dong Duan. (2013) Methyleugenol hepatocellular cancer initiating effects in rat liver. Food and Chemical Toxicology 53, pages 187-196.
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. 2002. The MAK-Collection for Occupational Health and Safety. The MAK-Collection for Occupational Health and Safety 1 318 .
. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 4 45 .
. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 41 .
. 2002. The MAK-Collection for Occupational Health and Safety. The MAK-Collection for Occupational Health and Safety 4 10 .
P. L. Skipper, M. Y. Kim, H.-L. P. Sun, G. N. Wogan & S. R. Tannenbaum. (2009) Monocyclic aromatic amines as potential human carcinogens: old is new again. Carcinogenesis 31:1, pages 50-58.
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Jian-Dong Duan, Alan M. Jeffrey & Gary M. Williams. (2008) Assessment of the Medicines Lidocaine, Prilocaine, and Their Metabolites, 2,6-Dimethylaniline and 2-Methylaniline, for DNA Adduct Formation in Rat Tissues. Drug Metabolism and Disposition 36:8, pages 1470-1475.
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Gary M. Williams, Michael J. Iatropoulos, Alan M. Jeffrey, Jian-Dong Duan & Carmen E. Perrone. (2007) Inhibition by acetaminophen of neoplastic initiation elicited in rat liver by the DNA-reactive hepatocarcinogen N-acetyl-2-aminofluorene. European Journal of Cancer Prevention 16:6, pages 528-534.
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Gary M. Williams, Michael J. Iatropoulos, Alan M. Jeffrey & Jian-Dong Duan. (2007) Inhibition by dietary hydroquinone of acetylaminofluorene induction of initiation of rat liver carcinogenesis. Food and Chemical Toxicology 45:9, pages 1620-1625.
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Alan M. Jeffrey, Michael J. Iatropoulos & Gary M. Williams. (2016) Nasal Cytotoxic and Carcinogenic Activities of Systemically Distributed Organic Chemicals. Toxicologic Pathology 34:7, pages 827-852.
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Miriam Sander, Jean Cadet, Daniel A. Casciano, Sheila M. Galloway, Lawrence J. Marnett, Raymond F. Novak, Syril D. Pettit, R. Julian Preston, Julie A. Skare, Gary M. Williams, Bennett Van Houten & B. Bhaskar Gollapudi. (2005) Proceedings of a workshop on DNA adducts: Biological significance and applications to risk assessment Washington, DC, April 13?14, 2004. Toxicology and Applied Pharmacology 208:1, pages 1-20.
Crossref
Gary M. Williams, Michael J. Iatropoulos & Alan M. Jeffrey. (2005) Thresholds for DNA-Reactive (Genotoxic) Organic Carcinogens. Journal of Toxicologic Pathology 18:2, pages 69-77.
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