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Research Article

Genotoxicity of Aspartame

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Pages 257-268 | Published online: 29 Jul 2004

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Naieli Schiefelbein Souto, Micheli Dassi, Ana Cláudia Monteiro Braga, Érica Vanessa Furlan Rosa, Michele Rechia Fighera, Luiz Fernando Freire Royes, Mauro Schneider Oliveira, Marcel Henrique Marcondes Sari & Ana Flávia Furian. (2022) Hepatic susceptibility to oxidative damage after repeated concomitant exposure to aspartame and aflatoxin B1 in rats. Drug and Chemical Toxicology 45:6, pages 2780-2785.
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Devrim Güzel Bayülken & Berrin Ayaz Tüylü. (2019) In vitro genotoxic and cytotoxic effects of some paraben esters on human peripheral lymphocytes. Drug and Chemical Toxicology 42:4, pages 386-393.
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Devrim Güzel Bayülken, Berrin Ayaz Tüylü, Handan Sinan & Hülya Sivas. (2019) Investigation of genotoxic effects of paraben in cultured human lymphocytes. Drug and Chemical Toxicology 42:4, pages 349-356.
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Armorel Diane van Eyk. (2015) The effect of five artificial sweeteners on Caco-2, HT-29 and HEK-293 cells. Drug and Chemical Toxicology 38:3, pages 318-327.
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Atrayee Bandyopadhyay, Sarbani Ghoshal & Anita Mukherjee. (2008) Genotoxicity Testing of Low-Calorie Sweeteners: Aspartame, Acesulfame-K, and Saccharin. Drug and Chemical Toxicology 31:4, pages 447-457.
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B. A. Magnuson, G. A. Burdock, J. Doull, R. M. Kroes, G. M. Marsh, M. W. Pariza, P. S. Spencer, W. J. Waddell, R. Walker & G. M. Williams. (2007) Aspartame: A Safety Evaluation Based on Current Use Levels, Regulations, and Toxicological and Epidemiological Studies. Critical Reviews in Toxicology 37:8, pages 629-727.
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Semir Canimoğlu & Eyyüp Rencüzoğulları. (2006) The Cytogenetic Effects of Food Sweetener Maltitol in Human Peripheral Lymphocytes. Drug and Chemical Toxicology 29:3, pages 269-278.
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Articles from other publishers (48)

Robinan Gentry, Tracy Greene, Harvey J. ClewellIIIIII & Joseph V. Rodricks. (2023) Critical considerations in the review of the toxicological evidence regarding the potential carcinogenicity of aspartame. Food and Chemical Toxicology 182, pages 114105.
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Lea Victoria Griebsch, Elena Leoni Theiss, Daniel Janitschke, Vincent Konrad Johannes Erhardt, Tobias Erhardt, Elodie Christiane Haas, Konstantin Nicolas Kuppler, Juliane Radermacher, Oliver Walzer, Anna Andrea Lauer, Veronika Matschke, Tobias Hartmann, Marcus Otto Walter Grimm & Heike Sabine Grimm. (2023) Aspartame and Its Metabolites Cause Oxidative Stress and Mitochondrial and Lipid Alterations in SH-SY5Y Cells. Nutrients 15:6, pages 1467.
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Madhu Goud Ediga, Suvarna Annapureddy, Kishore Salikineedy & Mallikarjuna Nimgampalle. (2023) Aspartame consumption causes cognitive impairment in streptozotocin-induced diabetic Wistar rats. Biologia.
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Susan J. Borghoff, Sarah S. Cohen, Xiaohui Jiang, Isabel A. Lea, William D. Klaren, Grace A. Chappell, Janice K. Britt, Brianna N. Rivera, Neepa Y. Choski & Daniele S. Wikoff. (2023) Updated systematic assessment of human, animal and mechanistic evidence demonstrates lack of human carcinogenicity with consumption of aspartame. Food and Chemical Toxicology 172, pages 113549.
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Harold I. Zeliger. 2023. Oxidative Stress. Oxidative Stress 111 135 .
Ece AVULOĞLU YILMAZ, Deniz YÜZBAŞIOĞLU & Fatma ÜNAL. (2022) Investigating In Vitro Genotoxic Effects of Sweetener XylitolTatlandırıcı Olan Xylitol'ün In Vitro Genotoksik Etkilerinin İncelenmesi. Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi 25:6, pages 1315-1325.
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Ziyu Li, Shaoting Yin, Jing Zhang & Gengsi Xi. (2022) Effect of aspartame on survival, morphological and molecular levels of Polyrhachis vicina Roger (Hymenoptera, Formicidae). Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 254, pages 109273.
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Marcos Mateo-Fernández, Miguel Josué González-Jiménez, Mercedes Del Río Celestino, Rafel Font, Ángeles Alonso-Moraga & Tania Merinas-Amo. (2022) Toxicological and Nutraceutical Screening Assays of Some Artificial Sweeteners. Processes 10:2, pages 410.
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Xiang Li, Gaopan Dong, Guangxi Han, Lupei Du & Minyong Li. (2021) Zebrafish Behavioral Phenomics Links Artificial Sweetener Aspartame to Behavioral Toxicity and Neurotransmitter Homeostasis. Journal of Agricultural and Food Chemistry 69:50, pages 15393-15402.
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Sary Kh. Abdel-ghaffar, Mohamed Araf Adly, Mohamed F. El-Sayed & Walaa Magdy Abd-Elsamei. (2021) Protective effects of some antioxidants against long-term intake of aspartame toxicity on liver and kidney: biochemical and histopathological approach in rats. The Journal of Basic and Applied Zoology 82:1.
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Isabel A. Lea, Grace A. Chappell & Daniele S. Wikoff. (2021) Overall lack of genotoxic activity among five common low- and no-calorie sweeteners: A contemporary review of the collective evidence. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 868-869, pages 503389.
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Zhigang Yu, Yue Wang, Ji Lu, Philip L. Bond & Jianhua Guo. (2021) Nonnutritive sweeteners can promote the dissemination of antibiotic resistance through conjugative gene transfer. The ISME Journal 15:7, pages 2117-2130.
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Ariana Saraiva, Conrado Carrascosa, Dele Raheem, Fernando Ramos & António Raposo. (2020) Maltitol: Analytical Determination Methods, Applications in the Food Industry, Metabolism and Health Impacts. International Journal of Environmental Research and Public Health 17:14, pages 5227.
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Kenan ÇADIRCI, Özlem ÖZDEMİR TOZLU, Hasan TÜRKEZ & Adil MARDİNOĞLU. (2020) The in vitro cytotoxic, genotoxic, and oxidative damage potentials of the oral artificial sweetener aspartame on cultured human blood cells. TURKISH JOURNAL OF MEDICAL SCIENCES 44:2, pages 448-454.
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D.S. Wikoff, G.A. Chappell, S. Fitch, C.L. Doepker & S.J. Borghoff. (2020) Lack of potential carcinogenicity for aspartame – Systematic evaluation and integration of mechanistic data into the totality of the evidence. Food and Chemical Toxicology 135, pages 110866.
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Jing-Wen Xu, Zhuo-Miao Cui, Zhan-Qing Liu, Feng Xu, Ya-Shao Chen & Yan-Ling Luo. (2019) Organic–Inorganic Nanohybrid Electrochemical Sensors from Multi-Walled Carbon Nanotubes Decorated with Zinc Oxide Nanoparticles and In-Situ Wrapped with Poly(2-methacryloyloxyethyl ferrocenecarboxylate) for Detection of the Content of Food Additives. Nanomaterials 9:10, pages 1388.
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Akira Otabe, Fumio Ohta, Asuka Takumi & Barry Lynch. (2019) Mutagenicity and genotoxicity studies of aspartame. Regulatory Toxicology and Pharmacology 103, pages 345-351.
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Ab Qayoom Naik & Vinoy Kumar Shrivastav. (2019) Effects of Short-term Consumption of Aspartame on Some Biochemical and Hematological Parameters in Female Swiss Albino Mice. International Journal of Zoological Research 15:1, pages 21-27.
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Ayşe Gül MUTLU & Nesibe KÜRKLÜ. (2018) Aspartame-Induced Mitochondrial DNA Damage in DrosophilaDrosophila’da Aspartam Tarafından Oluşturulan Mitokondrial DNA Hasarı. Mehmet Akif Ersoy Üniversitesi Fen Bilimleri Enstitüsü Dergisi 9:2, pages 129-135.
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Morando Soffritti, Angela Guaragna & Marco Manservigi. 2018. Sweeteners. Sweeteners 311 347 .
Arbind Kumar Choudhary & Etheresia Pretorius. (2017) Revisiting the safety of aspartame. Nutrition Reviews 75:9, pages 718-730.
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Mirley Alves Vasconcelos, Priscila Capelari Orsolin, Rosiane Gomes Silva-Oliveira, Júlio César Nepomuceno & Mário Antônio Spanó. (2017) Assessment of the carcinogenic potential of high intense-sweeteners through the test for detection of epithelial tumor clones (warts) in Drosophila melanogaster. Food and Chemical Toxicology 101, pages 1-7.
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Morando Soffritti, Angela Guaragna & Marco Manservigi. 2017. Sweeteners. Sweeteners 1 37 .
Piya Ghatak & Chandan Sen. 2016. Food Toxicology. Food Toxicology 377 394 .
Takashi Ohtsuki, Ryoichiro Nakamura, Satoru Kubo, Akira Otabe, Yoko Oobayashi, Shoko Suzuki, Mika Yoshida, Mitsuya Yoshida, Chiye Tatebe, Kyoko Sato & Hiroshi Akiyama. (2016) Development of an HPLC Method with an ODS Column to Determine Low Levels of Aspartame Diastereomers in Aspartame. PLOS ONE 11:3, pages e0152174.
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Iyaswamy Ashok & Rathinasamy Sheeladevi. (2015) Oxidant stress evoked damage in rat hepatocyte leading to triggered nitric oxide synthase (NOS) levels on long term consumption of aspartame. Journal of Food and Drug Analysis 23:4, pages 679-691.
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David Kirkland & David Gatehouse. (2015) “Aspartame: A review of genotoxicity data”. Food and Chemical Toxicology 84, pages 161-168.
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M. Abhilash, Mathews V. Varghese, M. V. Sauganth Paul, Manju Alex & R. Harikumaran Nair. (2014) Effect of long-term intake of aspartame on serum biochemical parameters and erythrocyte oxidative stress biomarkers in rats. Comparative Clinical Pathology 24:4, pages 927-933.
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Serkan Yılmaz & Aslı Uçar. (2014) A review of the genotoxic and carcinogenic effects of aspartame: does it safe or not?. Cytotechnology 66:6, pages 875-881.
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Iyaswamy Ashok, Dapkupar Wankhar, Rathinasamy Sheeladevi & Wankupar Wankhar. (2014) Long-term effect of aspartame on the liver antioxidant status and histopathology in Wistar albino rats. Biomedicine & Preventive Nutrition 4:2, pages 299-305.
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Iyaswamy Ashok, Rathinasamy Sheeladevi & Dapkupar Wankhar. (2014) Long-term effect of aspartame (artificial sweetener) on ATPases, antioxidant status and histopathology in the rat brain. Free Radicals and Antioxidants.
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Rosario Cuomo, Paolo Andreozzi & Francesco Paolo Zito. 2014. Advances in Nutrition and Cancer. Advances in Nutrition and Cancer 97 120 .
Semir Canimoglu & Eyyup Rencuzogullari. (2012) The genotoxic and teratogenic effects of maltitol in rats. Toxicology and Industrial Health 29:10, pages 935-943.
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Katarzyna Regulska, Marek Murias, Beata Stanisz & Miłosz Regulski. (2013) Is there any association between imidapril hydrochloride stability profile under dry air conditions and cancer initiation?. International Journal of Pharmaceutics 456:2, pages 332-339.
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Marina Marinovich, Corrado L. Galli, Cristina Bosetti, Silvano Gallus & Carlo La Vecchia. (2013) Aspartame, low-calorie sweeteners and disease: Regulatory safety and epidemiological issues. Food and Chemical Toxicology 60, pages 109-115.
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Meenakshi Singh, Abhishek Kumar & Nazia Tarannum. (2013) Water-compatible ‘aspartame’-imprinted polymer grafted on silica surface for selective recognition in aqueous solution. Analytical and Bioanalytical Chemistry 405:12, pages 4245-4252.
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Nesreen G. A. El Haliem & Doha S. Mohamed. (2011) The effect of aspartame on the histological structure of the liver and renal cortex of adult male albino rat and the possible protective effect of Pimpinella anisum oil. The Egyptian Journal of Histology 34:4, pages 715-726.
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M. Abhilash, M.V. Sauganth Paul, Mathews V. Varghese & R. Harikumaran Nair. (2011) Effect of long term intake of aspartame on antioxidant defense status in liver. Food and Chemical Toxicology 49:6, pages 1203-1207.
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Renata Alleva, Battista Borghi, Lory Santarelli, Elisabetta Strafella, Damiano Carbonari, Massimo Bracci & Marco Tomasetti. (2011) In vitro effect of aspartame in angiogenesis induction. Toxicology in Vitro 25:1, pages 286-293.
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Harold I Zeliger. 2011. Human Toxicology of Chemical Mixtures. Human Toxicology of Chemical Mixtures 105 128 .
. (2010) Report of the meeting on Aspartame with National Experts. EFSA Supporting Publications 7:5.
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Entissar S. AlSuhaibani. (2010) In Vivo Cytogenetic Studies on Aspartame . Comparative and Functional Genomics 2010, pages 1-4.
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G. Avani & M.V. Rao. (2009) In vitro genotoxicity assays to evaluate the role of vitamin A on arsenic in human lymphocytes. Ecotoxicology and Environmental Safety 72:2, pages 635-638.
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Eşref Demir, Serap Kocaoğlu & Bülent Kaya. (2008) Genotoxicity testing of four benzyl derivatives in the Drosophila wing spot test. Food and Chemical Toxicology 46:3, pages 1034-1041.
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Serkan Yılmaz, Fatma Ünal, Deniz Yüzbaşıoğlu & Hüseyin Aksoy. (2008) Clastogenic effects of food additive citric acid in human peripheral lymphocytes. Cytotechnology 56:2, pages 137-144.
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Deniz Yüzbaşıoğlu, Fatma Ünal, Serkan Yılmaz, Hüseyin Aksoy & Mustafa Çelik. (2008) Genotoxicity testing of fluconazole in vivo and in vitro. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 649:1-2, pages 155-160.
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Harold I. Zeliger. 2008. Human Toxicology of Chemical Mixtures. Human Toxicology of Chemical Mixtures 129 156 .
. (2006) Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to a new long‐term carcinogenicity study on aspartame. EFSA Journal 4:5.
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