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Drug Development and Industrial Pharmacy Volume 25, 1999 - Issue 10
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Research Article

Investigating the Fundamental Effects of Binders on Pharmaceutical Tablet Performance

S. K. Joneja Hercules Incorporated, 500 Hercules Road, Wilmington, DE, 19808-1599, U.S.A.
,
W. W. Harcum Hercules Incorporated, 500 Hercules Road, Wilmington, DE, 19808-1599, U.S.A.
,
G. W. Skinner Hercules Incorporated, 500 Hercules Road, Wilmington, DE, 19808-1599, U.S.A.
,
P. E. Barnum Hercules Incorporated, 500 Hercules Road, Wilmington, DE, 19808-1599, U.S.A.
&
Jian-Hwa Guo Brecksville Research Center, 9921 Brecksville Road, Cleveland, OH, 44144-3289, U.S.A.
Pages 1129-1135 | Published online: 10 Dec 1999

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Santhni Subramaniam, Srinivas Kamath, Amin Ariaee, Clive Prestidge & Paul Joyce. (2023) The impact of common pharmaceutical excipients on the gut microbiota. Expert Opinion on Drug Delivery 20:10, pages 1297-1314.
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Jason Dawes, Carl Allenspach, John F. Gamble, Richard Greenwood, Phil Robbins & Mike Tobyn. (2013) Application of external lubrication during the roller compaction of adhesive pharmaceutical formulations. Pharmaceutical Development and Technology 18:1, pages 246-256.
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Sameh Abdel-Hamid, Mirko Koziolek & Gabriele Betz. (2012) Study of radial die-wall pressure during high speed tableting: effect of formulation variables. Drug Development and Industrial Pharmacy 38:5, pages 623-634.
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Radha R. Vippagunta, Changkang Pan, Ronak Vakil, Vindhya Meda, Richard Vivilecchia & Michael Motto. (2009) Application of surface area measurement for identifying the source of batch-to-batch variation in processability. Pharmaceutical Development and Technology 14:5, pages 492-498.
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Evren Ataman & Önder Pekcan. (2007) Small Molecule Sorption and Desorption in and Out of Iota‐Carrageenan Gels. Journal of Macromolecular Science, Part B 46:4, pages 705-715.
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Önder Pekcan, Selim Kara & Ertan Arda. (2007) Cation effects on phase transition of kappa-iota-carrageenan hybrids: a photon transmission study. Composite Interfaces 14:1, pages 1-19.
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D. Law & Z. Zhang. (2007) Stabilization and Target Delivery of Nattokinase Using Compression Coating. Drug Development and Industrial Pharmacy 33:5, pages 495-503.
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Önder Pekcan & Selim Kara. (2005) Cation effect on thermal transition of ι-carrageenan: a photon transmission study. Journal of Biomaterials Science, Polymer Edition 16:3, pages 317-333.
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Articles from other publishers (24)

Ashagrachew Tewabe Yayehrad, Tesfa Marew, Motlalepula Matsabisa & Gebremariam Birhanu Wondie. (2023) Physicochemical Characterization and Evaluation of Ficus vasta Gum as a Binder in Tablet Formulation. BioMed Research International 2023, pages 1-18.
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Rishi Thakkar, Amit Raviraj Pillai, Vineet R. Kulkarni & Mohammed Maniruzzaman. 2023. A Handbook of Artificial Intelligence in Drug Delivery. A Handbook of Artificial Intelligence in Drug Delivery 259 299 .
Krume Toshev, Ivana Endekovska, Monika Kostovska, Veronika Angelovska & Natasa Anevska Stojanovska. (2022) Impact of qualitative formulation variables on critical quality attributes of tablets with fast disintegration. Macedonian Pharmaceutical Bulletin 68:03, pages 229-230.
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Huda AlFannakh. (2022) Impedance Spectroscopy, AC Conductivity, and Conduction Mechanism of Iron(II) Chloride/Polyvinyl Alcohol/Polyvinylpyrrolidone Polymer Blend. Advances in Materials Science and Engineering 2022, pages 1-16.
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Cedrine de Backere, Thomas De Beer, Chris Vervaet & Valérie Vanhoorne. (2021) Effect of binder type and lubrication method on the binder efficacy for direct compression. International Journal of Pharmaceutics 607, pages 120968.
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Emmanuel Reginald Jacques & Paschalis Alexandridis. (2019) Tablet Scoring: Current Practice, Fundamentals, and Knowledge Gaps. Applied Sciences 9:15, pages 3066.
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Thomas Dürig & Kapish Karan. 2019. Handbook of Pharmaceutical Wet Granulation. Handbook of Pharmaceutical Wet Granulation 317 349 .
Oscar-Rupert Arndt & Peter Kleinebudde. (2018) Towards a better understanding of dry binder functionality. International Journal of Pharmaceutics 552:1-2, pages 258-264.
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Gessyka Rayana S. Pereira, Stephania F. Taveira, Marcilio Cunha-Filho & Ricardo Neves Marreto. (2018) The Effects of Fillers and Binders on the Accuracy of Tablet Subdivision. AAPS PharmSciTech 19:7, pages 2929-2933.
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Rawan A. Fitaihi, Fadilah S. Aleanizy, Samar Elsamaligy, Hanaa A. Mahmoud & Mohsen A. Bayomi. (2018) Role of chitosan on controlling the characteristics and antifungal activity of bioadhesive fluconazole vaginal tablets. Saudi Pharmaceutical Journal 26:2, pages 151-161.
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Dinesh M. Morkhade. (2017) Comparative impact of different binder addition methods, binders and diluents on resulting granule and tablet attributes via high shear wet granulation. Powder Technology 320, pages 114-124.
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Nir Debotton & Arik Dahan. (2017) Applications of Polymers as Pharmaceutical Excipients in Solid Oral Dosage Forms. Medicinal Research Reviews 37:1, pages 52-97.
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Umesh Kestur & Divyakant Desai. 2016. Pharmaceutical Excipients. Pharmaceutical Excipients 51 95 .
Philip F. Builders & Mathew I. Arhewoh. (2016) Pharmaceutical applications of native starch in conventional drug delivery. Starch - Stärke 68:9-10, pages 864-873.
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Haress Mangal, Mehmet Kirsolak & Peter Kleinebudde. (2016) Roll compaction/dry granulation: Suitability of different binders. International Journal of Pharmaceutics 503:1-2, pages 213-219.
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Hiroshi Takasaki, Etsuo Yonemochi, Masanori Ito, Koichi Wada & Katsuhide Terada. (2015) The importance of binder moisture content in Metformin HCL high-dose formulations prepared by moist aqueous granulation (MAG). Results in Pharma Sciences 5, pages 1-7.
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Abayomi Tolulope Ogunjimi & Gbenga Alebiowu. (2014) Neem Gum as a Binder in a Formulated Paracetamol Tablet with Reference to Acacia Gum BP. AAPS PharmSciTech 15:2, pages 500-510.
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Michael Ayodele Odeniyi, Adepeju Oluwadamilare Babalola & John Oluwasogo Ayorinde. (2013) Evaluation of Cedrela gum as a binder and bioadhesive component in ibuprofen tablet formulations. Brazilian Journal of Pharmaceutical Sciences 49:1, pages 95-105.
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Arpit Sand, Dinesh Kumar Mishra, Vijay Shankar Pandey, Madan Mohan Mishra & Kunj Behari. (2012) Synthesis of graft copolymer (CgOH-g-AGA): Physicochemical properties, characterization and application. Carbohydrate Polymers 90:2, pages 901-907.
Crossref
Katharina M Picker‐Freyer. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia 1 46 .
Katharina M. Picker-Freyer & Thomas Dürig. (2007) Physical mechanical and tablet formation properties of hydroxypropylcellulose: In pure form and in mixtures. AAPS PharmSciTech 8:4.
Crossref
Tetsuya Ozeki, Hideyo Katsuyama, Yuriko Yasuzawa, Yuuki Takashima, Takahide Kasai, Takahiro Eguchi, Hisaya Kakiuchi, Hiroshi Yuasa & Hiroaki Okada. (2003) Acid-treated yeast cell wall as a binder displaying function of disintegrant. AAPS PharmSciTech 4:3, pages 94-100.
Crossref
P MacArtain, J.C Jacquier & K.A Dawson. (2003) Physical characteristics of calcium induced ?- carrageenan networks. Carbohydrate Polymers 53:4, pages 395-400.
Crossref
Herbert StickerHerbert Sticker. 2003. Arzneiformen-Entwicklung. Arzneiformen-Entwicklung 39 71 .

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