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Research Article

Effect of the Type of Base and Number of Reaction Steps on the Degree of Quaternization and Molecular Weight of N-Trimethyl Chitosan Chloride

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Pages 373-380 | Published online: 30 Apr 2001

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Maliheh Hajiramezanali, Fatemeh Atyabi, Mona Mosayebnia, Mehdi Akhlaghi, Parham Geramifar, Amir Reza Jalilian, Seyed Mohammad Mazidi, Hassan Yousefnia, Soraya Shahhosseini & Davood Beiki. (2019) 68Ga-radiolabeled bombesin-conjugated to trimethyl chitosan-coated superparamagnetic nanoparticles for molecular imaging: preparation, characterization and biological evaluation. International Journal of Nanomedicine 14, pages 2591-2605.
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Ujwala A. Shinde, Prajakta N. Joshi, Divya D. Jain & Kavita Singh. (2019) Preparation and Evaluation of N-Trimethyl Chitosan Nanoparticles of Flurbiprofen for Ocular Delivery. Current Eye Research 44:5, pages 575-582.
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Wei Tao, Hai-Qun Zheng, Ting Fu, Zhuo-Jing He & Yan Hong. (2017) N-(2-hydroxy) propyl-3-trimethylammonium chitosan chloride: An immune-enhancing adjuvant for hepatitis E virus recombinant polypeptide vaccine in mice. Human Vaccines & Immunotherapeutics 13:8, pages 1818-1822.
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Ye Tu, Xinxia Wang, Ying Lu, He Zhang, Yuan Yu, Yan Chen, Junjie Liu, Zhiguo Sun, Lili Cui, Jing Gao & Yanqiang Zhong. (2016) Promotion of the transdermal delivery of protein drugs by N-trimethyl chitosan nanoparticles combined with polypropylene electret. International Journal of Nanomedicine 11, pages 5549-5561.
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Neeraj Mishra, Amit K Goyal, Shailja Tiwari, Rishi Paliwal, Shivani R Paliwal, Bhuvaneshwar Vaidya, Sharad Mangal, Madhu Gupta, Devyani Dube, Abhinav Mehta & Suresh P Vyas. (2010) Recent advances in mucosal delivery of vaccines: role of mucoadhesive/biodegradable polymeric carriers. Expert Opinion on Therapeutic Patents 20:5, pages 661-679.
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Jinna Cao, Jukui Sun, Xiaoyu Wang, Xinran Li & Yingjie Deng. (2009) N-Trimethyl chitosan-coated multivesicular liposomes for oxymatrine oral delivery. Drug Development and Industrial Pharmacy 35:11, pages 1339-1347.
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Elisabete Curti & Sergio Paulo Campana‐Filho. (2006) Viscosity Behavior of Chitosan and N,N,N‐Trimethylchitosan Chloride Salts in Acid‐Free Aqueous Solution. Journal of Macromolecular Science, Part A 43:3, pages 555-572.
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Zhilei Lu, Jan H. Steenekamp & Josias H. Hamman. (2005) Cross-Linked Cationic Polymer Microparticles: Effect of N-Trimethyl Chitosan Chloride on the Release and Permeation of Ibuprofen. Drug Development and Industrial Pharmacy 31:3, pages 311-317.
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J. H. Hamman, C. M. Schultz & A. F. Kotzé. (2003) N-Trimethyl Chitosan Chloride: Optimum Degree of Quaternization for Drug Absorption Enhancement Across Epithelial Cells. Drug Development and Industrial Pharmacy 29:2, pages 161-172.
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Dewald Snyman, Josias H. Hamman & Awie F. Kotze. (2003) Evaluation of the Mucoadhesive Properties of -Trimethyl Chitosan Chloride. Drug Development and Industrial Pharmacy 29:1, pages 61-69.
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Meiyan Wu, Zhu Long, Huining Xiao & Cuihua Dong. (2016) Recent research progress on preparation and application of N, N, N-trimethyl chitosan. Carbohydrate Research 434, pages 27-32.
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Prachi S. Bangde, Ratnesh Jain & Prajakta Dandekar. (2016) Alternative Approach to Synthesize Methylated Chitosan Using Deep Eutectic Solvents, Biocatalyst and “Green” Methylating Agents. ACS Sustainable Chemistry & Engineering 4:6, pages 3552-3557.
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Crossref
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Crossref
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Alessandro F. Martins, Suelen P. Facchi, Heveline D.M. Follmann, Adriana P. Gerola, Adley F. Rubira & Edvani C. Muniz. (2015) Shielding effect of ‘surface ion pairs’ on physicochemical and bactericidal properties of N,N,N-trimethyl chitosan salts. Carbohydrate Research 402, pages 252-260.
Crossref
Koen van der Maaden, Jasmine Tomar, Wim Jiskoot & Joke Bouwstra. (2014) Chemical Modifications of Silicon Surfaces for the Generation of a Tunable Surface Isoelectric Point. Langmuir 30:7, pages 1812-1819.
Crossref
Wen He, Xianxi Guo, Min Feng & Nina Mao. (2013) In vitro and in vivo studies on ocular vitamin A palmitate cationic liposomal in situ gels. International Journal of Pharmaceutics 458:2, pages 305-314.
Crossref
Alessandro F. Martins, Pedro V.A. Bueno, Elizângela A.M.S. Almeida, Francisco H.A. Rodrigues, Adley F. Rubira & Edvani C. Muniz. (2013) Characterization of N-trimethyl chitosan/alginate complexes and curcumin release. International Journal of Biological Macromolecules 57, pages 174-184.
Crossref
Xian‐Xi Guo, Wen He, Xiao‐Jie Zhang & Xian‐Ming Hu. (2012) Cytotoxicity of cationic liposomes coated by N ‐trimethyl chitosan and their in vivo tumor angiogenesis targeting containing doxorubicin . Journal of Applied Polymer Science 128:1, pages 21-27.
Crossref
Phruetchika Suvannasara, Kotchakorn Juntapram, Nalena Praphairaksit, Krisana Siralertmukul & Nongnuj Muangsin. (2013) Mucoadhesive 4-carboxybenzenesulfonamide-chitosan with antibacterial properties. Carbohydrate Polymers 94:1, pages 244-252.
Crossref
Heveline D. M. Follmann, Alessandro F. Martins, Adriana P. Gerola, Thiago A. L. Burgo, Celso V. Nakamura, Adley F. Rubira & Edvani C. Muniz. (2012) Antiadhesive and Antibacterial Multilayer Films via Layer-by-Layer Assembly of TMC/Heparin Complexes. Biomacromolecules 13:11, pages 3711-3722.
Crossref
A. Ozhan Aytekin, Shigeru Morimura & Kenji Kida. (2012) Physiological activities of chitosan and N -trimethyl chitosan chloride in U937 and 3T3-L1 cells . Polymers for Advanced Technologies 23:2, pages 228-235.
Crossref
Xian‐Xi Guo, Wen He, Xiao‐Qin Wang & Xian‐Ming Hu. (2011) Preparation and efficacy of tumor vasculature‐targeted doxorubicin cationic liposomes coated by N ‐trimethyl chitosan . Journal of Applied Polymer Science 121:4, pages 2149-2156.
Crossref
Alessandro F. Martins, Antonio G.B. Pereira, André R. Fajardo, Adley F. Rubira & Edvani C. Muniz. (2011) Characterization of polyelectrolytes complexes based on N,N,N-trimethyl chitosan/heparin prepared at different pH conditions. Carbohydrate Polymers 86:3, pages 1266-1272.
Crossref
Douglas de Britto, Rejane Celi Goy, Sergio Paulo Campana Filho & Odilio B. G. Assis. (2011) Quaternary Salts of Chitosan: History, Antimicrobial Features, and Prospects. International Journal of Carbohydrate Chemistry 2011, pages 1-12.
Crossref
Junjie Li, Liandong Deng & Fanglian Yao. 2011. Chitosan-Based Hydrogels. Chitosan-Based Hydrogels 39 107 .
Sharad Mangal, Dilip Pawar, Neeraj K. Garg, Arvind K. Jain, S.P. Vyas, D.S.V. Raman Rao & K.S. Jaganathan. (2011) Pharmaceutical and immunological evaluation of mucoadhesive nanoparticles based delivery system(s) administered intranasally. Vaccine 29:31, pages 4953-4962.
Crossref
Xiaorong Fu, Yun Shen, Xue Jiang, Dan Huang & Yiqi Yan. (2011) Chitosan derivatives with dual-antibacterial functional groups for antimicrobial finishing of cotton fabrics. Carbohydrate Polymers 85:1, pages 221-227.
Crossref
H. Nazar, D.G. Fatouros, S.M. van der Merwe, N. Bouropoulos, G. Avgouropoulos, J. Tsibouklis & M. Roldo. (2011) Thermosensitive hydrogels for nasal drug delivery: The formulation and characterisation of systems based on N-trimethyl chitosan chloride. European Journal of Pharmaceutics and Biopharmaceutics 77:2, pages 225-232.
Crossref
Aylin Geçer, Nuray Yıldız, Ayla Çalımlı & Belma Turan. (2010) Trimethyl chitosan nanoparticles enhances dissolution of the poorly water soluble drug Candesartan-Cilexetil. Macromolecular Research 18:10, pages 986-991.
Crossref
Jariya Kowapradit, Praneet Opanasopit, Tanasait Ngawhirunpat, Auayporn Apirakaramwong, Theerasak Rojanarata, Uracha Ruktanonchai & Warayuth Sajomsang. (2010) In vitro Permeability Enhancement in Intestinal Epithelial Cells (Caco-2) Monolayer of Water Soluble Quaternary Ammonium Chitosan Derivatives. AAPS PharmSciTech 11:2, pages 497-508.
Crossref
Warayuth Sajomsang. (2010) Synthetic methods and applications of chitosan containing pyridylmethyl moiety and its quaternized derivatives: A review. Carbohydrate Polymers 80:3, pages 631-647.
Crossref
Suzanne M. Bal, Bram Slütter, Elly van Riet, Annelieke C. Kruithof, Zhi Ding, Gideon F.A. Kersten, Wim Jiskoot & Joke A. Bouwstra. (2010) Efficient induction of immune responses through intradermal vaccination with N-trimethyl chitosan containing antigen formulations. Journal of Controlled Release 142:3, pages 374-383.
Crossref
Siling Wang, Tongying Jiang, Mingxin Ma, Yanchen Hu & Jinghai Zhang. (2010) Preparation and evaluation of anti-neuroexcitation peptide (ANEP) loaded N-trimethyl chitosan chloride nanoparticles for brain-targeting. International Journal of Pharmaceutics 386:1-2, pages 249-255.
Crossref
Maryam Amidi, Enrico Mastrobattista, Wim Jiskoot & Wim E. Hennink. (2010) Chitosan-based delivery systems for protein therapeutics and antigens. Advanced Drug Delivery Reviews 62:1, pages 59-82.
Crossref
Wen He, Xianxi Guo, Lihai Xiao & Min Feng. (2009) Study on the mechanisms of chitosan and its derivatives used as transdermal penetration enhancers. International Journal of Pharmaceutics 382:1-2, pages 234-243.
Crossref
Warayuth Sajomsang, Supawan Tantayanon, Varawut Tangpasuthadol & William H. Daly. (2009) Quaternization of N-aryl chitosan derivatives: synthesis, characterization, and antibacterial activity. Carbohydrate Research 344:18, pages 2502-2511.
Crossref
V. K. Mourya & Nazma N. Inamdar. (2008) Trimethyl chitosan and its applications in drug delivery. Journal of Materials Science: Materials in Medicine 20:5, pages 1057-1079.
Crossref
Ögmundur Vidar Rúnarsson, Jukka Holappa, Sigrídur Jónsdóttir, Hákon Steinsson & Már Másson. (2008) N-selective ‘one pot’ synthesis of highly N-substituted trimethyl chitosan (TMC). Carbohydrate Polymers 74:3, pages 740-744.
Crossref
Timo Korjamo, Jukka Holappa, Sanna Taimisto, Jouko Savolainen, Tomi Järvinen & Jukka Mönkkönen. (2008) Effect of N-betainate and N-piperazine derivatives of chitosan on the paracellular transport of mannitol in Caco-2 cells. European Journal of Pharmaceutical Sciences 35:3, pages 226-234.
Crossref
Anchalee Jintapattanakit, Shirui Mao, Thomas Kissel & Varaporn Buraphacheep Junyaprasert. (2008) Physicochemical properties and biocompatibility of N-trimethyl chitosan: Effect of quaternization and dimethylation. European Journal of Pharmaceutics and Biopharmaceutics 70:2, pages 563-571.
Crossref
Warayuth Sajomsang, Supawan Tantayanon, Varawut Tangpasuthadol & William H. Daly. (2008) Synthesis of methylated chitosan containing aromatic moieties: Chemoselectivity and effect on molecular weight. Carbohydrate Polymers 72:4, pages 740-750.
Crossref
Wen He, Xianxi Guo & Mian Zhang. (2008) Transdermal permeation enhancement of N-trimethyl chitosan for testosterone. International Journal of Pharmaceutics 356:1-2, pages 82-87.
Crossref
Ögmundur Vidar Rúnarsson, Jukka Holappa, Tapio Nevalainen, Martha Hjálmarsdóttir, Tomi Järvinen, Thorsteinn Loftsson, Jón M. Einarsson, Sigrídur Jónsdóttir, Margrét Valdimarsdóttir & Már Másson. (2007) Antibacterial activity of methylated chitosan and chitooligomer derivatives: Synthesis and structure activity relationships. European Polymer Journal 43:6, pages 2660-2671.
Crossref
Evgeniya A. Stepnova, Vladimir E. Tikhonov, Tatiana A. Babushkina, Tamara P. Klimova, Evgeniy V. Vorontsov, Valery G. Babak, Sergey A. Lopatin & Igor A. Yamskov. (2007) New approach to the quaternization of chitosan and its amphiphilic derivatives. European Polymer Journal 43:6, pages 2414-2421.
Crossref
Wen He, Yumin Du, Wenbing Dai, Yan Wu & Mian Zhang. (2005) Effects of N ‐trimethyl chitosan chloride as an absorption enhancer on properties of insulin liquid suppository in vitro and in vivo . Journal of Applied Polymer Science 99:3, pages 1140-1146.
Crossref
Giacomo Di Colo, Susi Burgalassi, Ylenia Zambito, Daniela Monti & Patrizia Chetoni. (2004) Effects of Different N-Trimethyl Chitosans on In Vitro/In Vivo Ofloxacin Transcorneal Permeation. Journal of Pharmaceutical Sciences 93:11, pages 2851-2862.
Crossref
Elisabete Curti, Douglas de Britto & Sérgio Paulo Campana-Filho. (2003) Methylation of Chitosan with Iodomethane: Effect of Reaction Conditions on Chemoselectivity and Degree of Substitution. Macromolecular Bioscience 3:10, pages 571-576.
Crossref
D Snyman, J.H Hamman, J.S Kotze, J.E Rollings & A.F Kotzé. (2002) The relationship between the absolute molecular weight and the degree of quaternisation of N-trimethyl chitosan chloride. Carbohydrate Polymers 50:2, pages 145-150.
Crossref
C Jonker, J.H Hamman & A.F Kotzé. (2002) Intestinal paracellular permeation enhancement with quaternised chitosan: in situ and in vitro evaluation. International Journal of Pharmaceutics 238:1-2, pages 205-213.
Crossref
J.H Hamman, M Stander & A.F Kotzé. (2002) Effect of the degree of quaternisation of N-trimethyl chitosan chloride on absorption enhancement: in vivo evaluation in rat nasal epithelia. International Journal of Pharmaceutics 232:1-2, pages 235-242.
Crossref

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