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Research Article

Fast- and Slow-Release Tablets for Oral Administration of Flavonoids: Rutin and Quercetin

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Pages 371-379 | Published online: 16 May 2002

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Hiromasa Uchiyama, Kazunori Kadota & Yuichi Tozuka. (2023) A review of transglycosylated compounds as food additives to enhance the solubility and oral absorption of hydrophobic compounds in nutraceuticals and pharmaceuticals. Critical Reviews in Food Science and Nutrition 63:32, pages 11226-11243.
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Shrestha Sharma, Asgar Ali, Javed Ali, Jasjeet K. Sahni & Sanjula Baboota. (2013) Rutin: therapeutic potential and recent advances in drug delivery. Expert Opinion on Investigational Drugs 22:8, pages 1063-1079.
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Mehdi Sahihi, Zobeideh Heidari-Koholi & Abdol-Khalgh Bordbar. (2012) The Interaction of Polyphenol Flavonoids with β-lactoglobulin: Molecular Docking and Molecular Dynamics Simulation Studies. Journal of Macromolecular Science, Part B 51:12, pages 2311-2323.
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Yoko Shoji & Hideki Nakashima. (2004) Nutraceutics and Delivery Systems. Journal of Drug Targeting 12:6, pages 385-391.
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Articles from other publishers (43)

Abid Naeem, Chengqun Yu, Zhenzhong Zang, Weifeng Zhu, Xuezhen Deng & Yongmei Guan. (2023) Synthesis and Evaluation of Rutin–Hydroxypropyl β-Cyclodextrin Inclusion Complexes Embedded in Xanthan Gum-Based (HPMC-g-AMPS) Hydrogels for Oral Controlled Drug Delivery. Antioxidants 12:3, pages 552.
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Kalyani Pathak, Ratna Jyoti Das, Riya Saikia, Jon Jyoti Sahariah, Hemanta Pathak, Himangshu Sarma & Aparoop Das. (2022) Design and Fabrication of Gallic Acid Loaded Chitosan Nanoformulation. Drug Delivery Letters 12:2, pages 135-148.
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John A. Manthey, Paula S. Ferreira & Thais B. Cesar. (2022) Influences of Solubility and Vehicle Carriers on Eriodictyol Pharmacokinetics in Rats. Journal of Agricultural and Food Chemistry 70:15, pages 4667-4676.
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Ndivhuwo Muvhulawa, Phiwayinkosi V. Dludla, Khanyisani Ziqubu, Sinenhlanhla X.H. Mthembu, Fikile Mthiyane, Bongani B. Nkambule & Sithandiwe E. Mazibuko-Mbeje. (2022) Rutin ameliorates inflammation and improves metabolic function: A comprehensive analysis of scientific literature. Pharmacological Research 178, pages 106163.
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Dina Ashraf Hafez, Doaa A. Abdelmonsif, Rania G. Aly, Wael Mahmoud Samy, Kadria A. Elkhodairy & Noha Khalifa Abo Aasy. (2022) Role of fennel oil/ quercetin dual nano-phytopharmaceuticals in hampering liver fibrosis: Comprehensive optimization and in vivo assessment. Journal of Drug Delivery Science and Technology 69, pages 103177.
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Murad Abualhasan, Mohyeddin Assali, Abeer Mahmoud, Abdel Naser Zaid & Numan Malkieh. (2022) Synthesis of Rutin Derivatives to Enhance Lipid Solubility and Development of Topical Formulation with a Validated Analytical Method. Current Drug Delivery 19:1, pages 117-128.
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Jian-Feng Zhou, Guo-Dong Zheng, Wen-Jun Wang, Zhong-Ping Yin, Ji-Guang Chen, Jing-En Li & Qing-Feng Zhang. (2021) Physicochemical properties and bioavailability comparison of two quercetin loading zein nanoparticles with outer shell of caseinate and chitosan. Food Hydrocolloids 120, pages 106959.
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Maria Assunta Acquavia, Raffaella Pascale, Ilaria Pappalardo, Anna Santarsiero, Giuseppe Martelli & Giuliana Bianco. (2021) Characterization of Quercetin Derivatives in Crossing Combination of Habanero White and Capsicum annuum Peppers and of Anti-Inflammatory and Cytotoxic Activity. Separations 8:7, pages 90.
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Amir Imani, Nasim Maleki, Sepideh Bohlouli, Maryam Kouhsoltani, Simin Sharifi & Solmaz Maleki Dizaj. (2020) Molecular mechanisms of anticancer effect of rutin. Phytotherapy Research 35:5, pages 2500-2513.
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Alejandra Acevedo-Fani, Andrea Ochoa-Grimaldo, Simon M. Loveday & Harjinder Singh. (2021) Digestive dynamics of yoghurt structure impacting the release and bioaccessibility of the flavonoid rutin. Food Hydrocolloids 111, pages 106215.
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Tran Thanh Hoai, Phan Thi Yen, Tran Thi Bich Dao, Luu Hai Long, Duong Xuan Anh, Luu Hai Minh, Bui Quoc Anh & Nghiem Thi Thuong. (2020) Evaluation of the Cytotoxic Effect of Rutin Prenanoemulsion in Lung and Colon Cancer Cell Lines. Journal of Nanomaterials 2020, pages 1-11.
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Camila R. Ferraz, Thacyana T. Carvalho, Marília F. Manchope, Nayara A. Artero, Fernanda S. Rasquel-Oliveira, Victor Fattori, Rubia Casagrande & Waldiceu A. VerriJr.Jr.. (2020) Therapeutic Potential of Flavonoids in Pain and Inflammation: Mechanisms of Action, Pre-Clinical and Clinical Data, and Pharmaceutical Development. Molecules 25:3, pages 762.
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Noelia López, Ignacio Delso, David Matute, Carlos Lafuente & Manuela Artal. (2020) Characterization of xylitol or citric acid:choline chloride:water mixtures: Structure, thermophysical properties, and quercetin solubility. Food Chemistry 306, pages 125610.
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Mozhgan Parsaei & Kamran Akhbari. 2020. Nanomedicine for Bioactives. Nanomedicine for Bioactives 71 126 .
Itzel Rubio-Elizalde, Johanna Bernáldez-Sarabia, Aldo Moreno-Ulloa, Carmel Vilanova, Patricia Juárez, Alexei Licea-Navarro & Ana B. Castro-Ceseña. (2019) Scaffolds based on alginate-PEG methyl ether methacrylate-Moringa oleifera-Aloe vera for wound healing applications. Carbohydrate Polymers 206, pages 455-467.
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Katarzyna Szymczyk & Anna Taraba. (2018) Thermodynamic study of quercetin and rutin mixtures with alcohols. Chemical Physics 505, pages 6-11.
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Hong-liang Song, Xiang Zhang, Wen-zhao Wang, Rong-han Liu, Kai Zhao, Ming-yuan Liu, Wei-ming Gong & Bin Ning. (2018) Neuroprotective mechanisms of rutin for spinal cord injury through anti-oxidation and anti-inflammation and inhibition of p38 mitogen activated protein kinase pathway. Neural Regeneration Research 13:1, pages 128.
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Andrew D. Gilley, Hale Cigdem Arca, Brittany L.B. Nichols, Laura I. Mosquera-Giraldo, Lynne S. Taylor, Kevin J. Edgar & Andrew P. Neilson. (2017) Novel cellulose-based amorphous solid dispersions enhance quercetin solution concentrations in vitro. Carbohydrate Polymers 157, pages 86-93.
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Wei Wang, Qiu-hong Wu, Yong Sui, Yan Wang & Xin Qiu. (2017) Rutin protects endothelial dysfunction by disturbing Nox4 and ROS-sensitive NLRP3 inflammasome. Biomedicine & Pharmacotherapy 86, pages 32-40.
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Beate Petersen, Sarah Egert, Anja Bosy-Westphal, Manfred J. Müller, Siegfried Wolffram, Eva M. Hubbermann, Gerald Rimbach & Karin Schwarz. (2016) Bioavailability of quercetin in humans and the influence of food matrix comparing quercetin capsules and different apple sources. Food Research International 88, pages 159-165.
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Stephen J. Franklin & Paul B. Myrdal. (2015) Solid-State and Solution Characterization of Myricetin. AAPS PharmSciTech 16:6, pages 1400-1408.
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Aliye Aras Perk, Iryna Shatynska-Mytsyk, Yusuf Can Gerçek, Kadir Boztaş, Mevzule Yazgan, Sundas Fayyaz & Ammad Ahmad Farooqi. (2014) Rutin mediated targeting of signaling machinery in cancer cells. Cancer Cell International 14:1.
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Linghui Dian, Enjiang Yu, Xiaona Chen, Xinguo Wen, Zhengzan Zhang, Lingzhen Qin, Qingqing Wang, Ge Li & Chuanbin Wu. (2014) Enhancing oral bioavailability of quercetin using novel soluplus polymeric micelles. Nanoscale Research Letters 9:1.
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Michael H. Abraham & William E. AcreeJr.Jr.. (2014) On the solubility of quercetin. Journal of Molecular Liquids 197, pages 157-159.
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Daniel Althans, Philipp Schrader & Sabine Enders. (2014) Solubilisation of quercetin: Comparison of hyperbranched polymer and hydrogel. Journal of Molecular Liquids 196, pages 86-93.
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YuJun Wang, LiJuan Chen, LiWei Tan, Qian Zhao, Feng Luo, YuQuan Wei & ZhiYong Qian. (2014) PEG–PCL based micelle hydrogels as oral docetaxel delivery systems for breast cancer therapy. Biomaterials 35:25, pages 6972-6985.
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Dan Liu, Haiyang Hu, Zhixiu Lin, Dawei Chen, Yongyuan Zhu, Shengtao Hou & Xiaojun Shi. (2013) Quercetin deformable liposome: Preparation and efficacy against ultraviolet B induced skin damages in vitro and in vivo. Journal of Photochemistry and Photobiology B: Biology 127, pages 8-17.
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Lipeng Bi, Daniel Wehrung & Moses O. Oyewumi. (2013) Contributory roles of innate properties of cetyl alcohol/gelucire nanoparticles to antioxidant and anti-inflammation activities of quercetin. Drug Delivery and Translational Research 3:4, pages 318-329.
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Bin Li, Stephanie Konecke, Kim Harich, Lindsay Wegiel, Lynne S. Taylor & Kevin J. Edgar. (2013) Solid dispersion of quercetin in cellulose derivative matrices influences both solubility and stability. Carbohydrate Polymers 92:2, pages 2033-2040.
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Guangyue Bai, Marieta Nichifor & Margarida Bastos. (2010) Cationic Polyelectrolytes as Drug Delivery Vectors: Calorimetric and Fluorescence Study of Rutin Partitioning. The Journal of Physical Chemistry B 114:49, pages 16236-16243.
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M Goniotaki, S Hatziantoniou, K Dimas, M Wagner & C Demetzos. (2004) Encapsulation of naturally occurring flavonoids into liposomes: physicochemical properties and biological activity against human cancer cell lines. Journal of Pharmacy and Pharmacology 56:10, pages 1217-1224.
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Associate Professor Eli Chan, Akhil Hegde & Xin Chen. (2009) Effect of rutin on warfarin anticoagulation and pharmacokinetics of warfarin enantiomers in rats. Journal of Pharmacy and Pharmacology 61:4, pages 451-458.
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Maria Elenir N.P. Ribeiro, Ícaro G.P. Vieira, Igor Marques Cavalcante, Nágila M.P.S. Ricardo, David Attwood, Stephen G. Yeates & Colin Booth. (2009) Solubilisation of griseofulvin, quercetin and rutin in micellar formulations of triblock copolymers E62P39E62 and E137S18E137. International Journal of Pharmaceutics 378:1-2, pages 211-214.
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Yan Gao, Yuqiang Wang, Yukun Ma, Aihua Yu, Fengqun Cai, Wei Shao & Guangxi Zhai. (2009) Formulation optimization and in situ absorption in rat intestinal tract of quercetin-loaded microemulsion. Colloids and Surfaces B: Biointerfaces 71:2, pages 306-314.
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F. Sansone, R.P. Aquino, P. Del Gaudio, P. Colombo & P. Russo. (2009) Physical characteristics and aerosol performance of naringin dry powders for pulmonary delivery prepared by spray-drying. European Journal of Pharmaceutics and Biopharmaceutics 72:1, pages 206-213.
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Greice S. Borghetti, Ivana S. Lula, Ruben D. Sinisterra & Valquiria L. Bassani. (2009) Quercetin/β-Cyclodextrin Solid Complexes Prepared in Aqueous Solution Followed by Spray-drying or by Physical Mixture. AAPS PharmSciTech 10:1, pages 235-242.
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HouLi Li, XiaoBin Zhao, YuKun Ma, GuangXi Zhai, LingBing Li & HongXiang Lou. (2009) Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles. Journal of Controlled Release 133:3, pages 238-244.
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V.M. Barvinchenko, N. O. Lipkovska, T.V. Fedyanina & V.K. Pogorelyi. 2010. Nanomaterials and Supramolecular Structures. Nanomaterials and Supramolecular Structures 281 291 .
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Rebecca L. Carrier, Lee A. Miller & Imran Ahmed. (2007) The utility of cyclodextrins for enhancing oral bioavailability. Journal of Controlled Release 123:2, pages 78-99.
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V.A. Alexandrova, N.G. Balabushevich, G.N. Bondarenko, N.S. Domnina & N.I. Larionova. (2006) Water soluble chitosan conjugates with plant antioxidants and polyelectrolyte complexes on their basis. Journal of Drug Delivery Science and Technology 16:4, pages 279-283.
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Kota M Krishna, Akula Annapurna, Gopisetty S Gopal, Chitrapu R.V Chalam, Kalagara Madan, Veeravalli K Kumar & Gomedhikam J Prakash. (2005) Partial reversal by rutin and quercetin of impaired cardiac function in streptozotocin-induced diabetic rats. Canadian Journal of Physiology and Pharmacology 83:4, pages 343-355.
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M.R. Lauro, L. Maggi, U. Conte, F. De Simone & R.P. Aquino. (2005) Rutin and quercetin gastro-resistant microparticles obtained by spray-drying technique. Journal of Drug Delivery Science and Technology 15:5, pages 363-369.
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