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Research Article

Oral Bioadhesive Drug Delivery Systems

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Pages 293-310 | Published online: 26 Sep 2008

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Read on this site (14)

Fernanda Belincanta Borghi-Pangoni, Mariana Volpato Junqueira & Marcos Luciano Bruschi. (2020) Physicochemical stability of bioadhesive thermoresponsive platforms for methylene blue and hypericin delivery in photodynamic therapy. Pharmaceutical Development and Technology 25:4, pages 482-491.
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A. C. S. Ré, M. P. Ferreira, O. Freitas & C. P. Aires. (2016) Local antibiotic delivery in periodontitis: drug release and its effect on supragingival biofilms. Biofouling 32:9, pages 1061-1066.
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Giovana Calixto, Ana Carolina Yoshii, Hilris Rocha e Silva, Beatriz Stringhetti Ferreira Cury & Marlus Chorilli. (2015) Polyacrylic acid polymers hydrogels intended to topical drug delivery: preparation and characterization. Pharmaceutical Development and Technology 20:4, pages 490-496.
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Ghada Ahmed Abdelbary & Mona Hassan Aburahma. (2015) Oro-dental mucoadhesive proniosomal gel formulation loaded with lornoxicam for management of dental pain. Journal of Liposome Research 25:2, pages 107-121.
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R. Manasadeepa, Paramita Paul & Biswajit Mukherjee. (2013) Pressure-sensitive mucoadhesive polymer-based dental patches to treat periodontal diseases: an in vitro study. Drug Delivery 20:6, pages 258-267.
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Farnoosh Kianfar, Babur Z. Chowdhry, Milan D. Antonijevic & Joshua S. Boateng. (2012) Novel films for drug delivery via the buccal mucosa using model soluble and insoluble drugs. Drug Development and Industrial Pharmacy 38:10, pages 1207-1220.
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Raphaela Regina de Araújo Pereira & Marcos Luciano Bruschi. (2012) Vaginal mucoadhesive drug delivery systems. Drug Development and Industrial Pharmacy 38:6, pages 643-652.
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Subhash S. Vaghani, Sneha G. Patel, Rishad Ramjan Jivani, N. P. Jivani, Madhabhai M. Patel & Rohit Borda. (2012) Design and optimization of a stomach-specific drug delivery system of repaglinide: Application of simplex lattice design. Pharmaceutical Development and Technology 17:1, pages 55-65.
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Franciele Viana Fabri, Rogério Rodrigues Cupertino, Mirian Marubayashi Hidalgo, Rúbia Maria Monteiro Weffort de Oliveira & Marcos Luciano Bruschi. (2011) Preparation and characterization of bioadhesive systems containing propolis or sildenafil for dental pulp protection. Drug Development and Industrial Pharmacy 37:12, pages 1446-1454.
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D.P. Maurya, Yasmin Sultana, M. Aqil, D. Kumar, K. Chuttani, A. Ali & A.K. Mishra. (2011) Formulation and optimization of alkaline extracted ispaghula husk microparticles of isoniazid – in vitro and in vivo assessment. Journal of Microencapsulation 28:6, pages 472-482.
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Jan Gajdziok, Martina Bajerová, Zuzana Chalupová & Miloslava Rabišková. (2010) Oxycellulose as mucoadhesive polymer in buccal tablets. Drug Development and Industrial Pharmacy 36:9, pages 1115-1130.
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Heba A. Gad, Mohamed A. El-Nabarawi & Seham S. Abd El-Hady. (2008) Formulation and Evaluation of Secnidazole or Doxycycline Dento-Oral Gels. Drug Development and Industrial Pharmacy 34:12, pages 1356-1367.
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Marcos Luciano Bruschi, Osvaldo de Freitas, Elza Helena Guimarã es Lara, Heitor Panzeri, Maria Palmira Daflon Gremião & David Simon Jones. (2008) Precursor System of Liquid Crystalline Phase Containing Propolis Microparticles for the Treatment of Periodontal Disease: Development and Characterization. Drug Development and Industrial Pharmacy 34:3, pages 267-278.
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Abeer M. Al-Ghananeem, Ahmad H. Malkawi & Peter A. Crooks. (2007) Scopolamine Sublingual Spray: An Alternative Route of Delivery for the Treatment of Motion Sickness. Drug Development and Industrial Pharmacy 33:5, pages 577-582.
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Ariane Stephanie Fernandes, Sabrina Barbosa de Souza Ferreira, Mariana Carla de Oliveira, Wilker Caetano & Marcos Luciano Bruschi. (2022) The influence of different bioadhesive polymers on physicochemical properties of thermoresponsive emulgels containing Amazonian andiroba oil. Journal of Molecular Liquids 365, pages 120102.
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Bruno Vincenzo Fiod Riccio, Amanda Letícia Polli Silvestre, Andreia Bagliotti Meneguin, Tais de Cassia Ribeiro, Ana Beatriz Klosowski, Priscileila Colerato Ferrari & Marlus Chorilli. (2022) Exploiting Polymeric Films as a Multipurpose Drug Delivery System: a Review. AAPS PharmSciTech 23:7.
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Jinghang Li, Xin Yu, Eduardo Enciso Martinez, Jiaqing Zhu, Ting Wang, Shengwei Shi, Su Ryon Shin, Shabir Hassan & Chengchen Guo. (2021) Emerging Biopolymer‐Based Bioadhesives. Macromolecular Bioscience 22:2, pages 2100340.
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Khalid M. El-Say & Tarek A. Ahmed. 2022. The ADME Encyclopedia. The ADME Encyclopedia 222 231 .
Daniela A. Rodrigues, Sónia P. Miguel, Jorge Loureiro, Maximiano Ribeiro, Fátima Roque & Paula Coutinho. (2021) Oromucosal Alginate Films with Zein Nanoparticles as a Novel Delivery System for Digoxin. Pharmaceutics 13:12, pages 2030.
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Sevda Şenel, Ayben Işılay Özdoğan & Gülçin Akca. (2021) Current status and future of delivery systems for prevention and treatment of infections in the oral cavity. Drug Delivery and Translational Research 11:4, pages 1703-1734.
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Ana Carolina S. Ré, Jayanaraian F. Martins, Marcílio Cunha‐Filho, Guilherme M. Gelfuso, Carolina P. Aires & Taís Gratieri. (2021) New perspectives on the topical management of recurrent candidiasis. Drug Delivery and Translational Research 11:4, pages 1568-1585.
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Nayla Francine Garcia Pastório, Camila Felix Vecchi, Rafaela Said dos Santos & Marcos Luciano Bruschi. (2021) Design of Mucoadhesive Strips for Buccal Fast Release of Tramadol. Pharmaceutics 13:8, pages 1187.
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Dorota Kida, Aneta Zakrzewska, Jacek Zborowski, Małgorzata Szulc & Bożena Karolewicz. (2021) Polymer-Based Carriers in Dental Local Healing—Review and Future Challenges. Materials 14:14, pages 3948.
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Xiuqing Gao, Lei Wu, Robert Y. L. Tsai, Jing Ma, Xiaohua Liu, Diana S.-L. Chow, Dong Liang & Huan Xie. (2021) Pharmacokinetic Model Analysis of Supralingual, Oral and Intravenous Deliveries of Mycophenolic Acid. Pharmaceutics 13:4, pages 574.
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Sabrina Barbosa de Souza Ferreira, Giovana Okuda Fukase, Raquel Guttierres Gomes & Marcos Luciano Bruschi. (2021) Mucoadhesive wafers for buccal delivery of probiotic bacteria: Mechanical properties and enumeration. Journal of Drug Delivery Science and Technology 61, pages 102201.
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Lorena Garcia-del Rio, Patricia Diaz-Rodriguez & Mariana Landin. (2021) Design of novel orotransmucosal vaccine-delivery platforms using artificial intelligence. European Journal of Pharmaceutics and Biopharmaceutics 159, pages 36-43.
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Khalid M. El-Say & Tarek A. Ahmed. 2021. The ADME Encyclopedia. The ADME Encyclopedia 1 10 .
Camila Felix Vecchi, Rafaela Said dos Santos, Jéssica Bassi da Silva, Hélen Cassia Rosseto, Karina Mayumi Sakita, Terezinha Inez Estivalet Svidzinski, Patrícia de Souza Bonfim-Mendonça & Marcos Luciano Bruschi. (2020) Development and in vitro evaluation of buccal mucoadhesive films for photodynamic inactivation of Candida albicans. Photodiagnosis and Photodynamic Therapy 32, pages 101957.
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Oksana Zaitseva, Andrey Khudyakov, Marta Sergushkina, Olga Solomina & Tatyana Polezhaeva. (2020) Pectins as a universal medicine. Fitoterapia 146, pages 104676.
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Sabrina Barbosa de Souza Ferreira, Klaudia M. Slowik, Lidiane Vizioli de Castro Hoshino, Mauro Luciano Baesso, Craig Murdoch, Helen Elizabeth Colley & Marcos Luciano Bruschi. (2020) Mucoadhesive emulgel systems containing curcumin for oral squamous cell carcinoma treatment: From pre-formulation to cytotoxicity in tissue-engineering oral mucosa. European Journal of Pharmaceutical Sciences 151, pages 105372.
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Camila Felix Vecchi, Rafaela Said dos Santos & Marcos Luciano Bruschi. (2020) Technological development of mucoadhesive film containing poloxamer 407, polyvinyl alcohol and polyvinylpyrrolidone for buccal metronidazole delivery. Therapeutic Delivery 11:7, pages 431-446.
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Jenny K.W. Lam, Chucky C.K. Cheung, Michael Y.T. Chow, Emily Harrop, Susie Lapwood, Stephen I.G. Barclay & Ian C.K. Wong. (2020) Transmucosal drug administration as an alternative route in palliative and end-of-life care during the COVID-19 pandemic. Advanced Drug Delivery Reviews 160, pages 234-243.
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Marcos Luciano Bruschi, Sabrina Barbosa de Souza Ferreira & Jéssica Bassi da Silva. 2020. Nanotechnology for Oral Drug Delivery. Nanotechnology for Oral Drug Delivery 77 141 .
Manu Sharma, Aishwarya Rathore, Sheelu Sharma, Veera Sadhu, Kakarla Raghava Reddy & Raghavendra V. Kulkarni. 2020. Nanomaterials in Diagnostic Tools and Devices. Nanomaterials in Diagnostic Tools and Devices 213 240 .
Grzegorz Krasowski, Ruth Wicher-Dudek, Justyna Paleczny, Iwona Bil-Lula, Karol Fijałkowski, Parish Paymon Sedghizadeh, Patrycja Szymczyk, Bartłomiej Dudek, Marzenna Bartoszewicz & Adam Junka. (2019) Potential of Novel Bacterial Cellulose Dressings Chemisorbed with Antiseptics for the Treatment of Oral Biofilm Infections. Applied Sciences 9:24, pages 5321.
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Sabrina Barbosa de Souza Ferreira, Gustavo Braga, Évelin Lemos Oliveira, Jéssica Bassi da Silva, Hélen Cássia Rosseto, Lidiane Vizioli de Castro Hoshino, Mauro Luciano Baesso, Wilker Caetano, Craig Murdoch, Helen Elizabeth Colley & Marcos Luciano Bruschi. (2019) Design of a nanostructured mucoadhesive system containing curcumin for buccal application: from physicochemical to biological aspects. Beilstein Journal of Nanotechnology 10, pages 2304-2328.
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Phuong H.L. Tran, Wei Duan & Thao T.D. Tran. (2019) Recent developments of nanoparticle-delivered dosage forms for buccal delivery. International Journal of Pharmaceutics 571, pages 118697.
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Someshwar Komati, Suryakanta SwainMuddana Eswara Bhanoji RaoBikash Ranjan JenaVishali Dasi. (2019) Mucoadhesive Multiparticulate Drug Delivery Systems: An ExtensiveReview of Patents. Advanced Pharmaceutical Bulletin 9:4, pages 521-538.
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Anahita Rohani Shirvan, Azadeh Bashari & Nahid Hemmatinejad. (2019) New insight into the fabrication of smart mucoadhesive buccal patches as a novel controlled-drug delivery system. European Polymer Journal 119, pages 541-550.
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Ana Ré, Maria Bonjovanni, Maíra Ferreira, Osvaldo Freitas & Carolina Aires. (2019) Effect of an Experimental Formulation Containing Chlorhexidine on Pathogenic Biofilms and Drug Release Behavior in the Presence or Absence of Bacteria. Pharmaceutics 11:2, pages 88.
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Marcos Luciano Bruschi. (2019) Lectins and Nanostructured Drug Delivery Systems. Current Drug Delivery 16:3, pages 268-269.
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Bojan Petrović. (2019) Salivary theranostics in pediatric and special care dentistry. Balkan Journal of Dental Medicine 23:3, pages 113-120.
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Mahendra Singh, Jovita Kanoujia, Poonam Parashar, Malti Arya, Chandra B. Tripathi, V. R. Sinha, Shailendra K. Saraf & Shubhini A. Saraf. (2018) Assessment of improved buccal permeation and bioavailability of felodipine microemulsion-based cross-linked polycarbophil gel. Drug Delivery and Translational Research 8:3, pages 591-601.
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Bruno Fonseca-Santos & Marlus Chorilli. (2018) An overview of polymeric dosage forms in buccal drug delivery: State of art, design of formulations and their in vivo performance evaluation. Materials Science and Engineering: C 86, pages 129-143.
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Bruno Fonseca-Santos, Maria Palmira Daflon Gremião & Marlus Chorilli. (2017) A simple reversed phase high-performance liquid chromatography (HPLC) method for determination of in situ gelling curcumin-loaded liquid crystals in in vitro performance tests. Arabian Journal of Chemistry 10:7, pages 1029-1037.
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Fernanda Belincanta Borghi-Pangoni, Mariana Volpato Junqueira, Sabrina Barbosa de Souza Ferreira, Larissa Lachi Silva, Bruno Ribeiro Rabello, Lidiane Vizioli de Castro, Mauro Luciano Baesso, Andréa Diniz, Wilker Caetano & Marcos Luciano Bruschi. (2017) Preparation and characterization of bioadhesive system containing hypericin for local photodynamic therapy. Photodiagnosis and Photodynamic Therapy 19, pages 284-297.
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Guiyun Song, Daniel Banov, August S. Bassani & Benigno C. Valdez. (2016) Evaluation of the Safety, Cell Migration, and Mucoadhesive Properties of a Mucoadhesive Polymer Blend in Human Oral Mucosa. AAPS PharmSciTech 18:5, pages 1617-1623.
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Hadel A. Abo Enin, Nagla Ahmed El Nabarawy & Rehab A. Abd Elmonem. (2016) Treatment of Radiation-Induced Oral Mucositis Using a Novel Accepted Taste of Prolonged Release Mucoadhesive Bi-medicated Double-Layer Buccal Films. AAPS PharmSciTech 18:2, pages 563-575.
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Sona Dave, Deepa Shriyan & Pinakin Gujjar. (2017) Newer drug delivery systems in anesthesia. Journal of Anaesthesiology Clinical Pharmacology 33:2, pages 157.
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Marcos L. Bruschi, Hélen C. Rosseto, Lizziane M.B. de Francisco, Lucas de A.S. de Toledo & Raphaela R. de A. Pereira. 2017. Nano- and Microscale Drug Delivery Systems. Nano- and Microscale Drug Delivery Systems 377 391 .
Fernanda Belincanta Borghi-Pangoni, Mariana Volpato Junqueira, Sabrina Barbosa de Souza Ferreira, Larissa Lachi Silva, Bruno Ribeiro Rabello, Wilker Caetano, Andrea Diniz & Marcos Luciano Bruschi. (2015) Screening and In Vitro Evaluation of Mucoadhesive Thermoresponsive System Containing Methylene Blue for Local Photodynamic Therapy of Colorectal Cancer. Pharmaceutical Research 33:3, pages 776-791.
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Jéssica Bernegossi, Giovana Calixto, Paulo Sanches, Carla Fontana, Eduardo Cilli, Saulo Garrido & Marlus Chorilli. (2015) Peptide KSL-W-Loaded Mucoadhesive Liquid Crystalline Vehicle as an Alternative Treatment for Multispecies Oral Biofilm. Molecules 21:1, pages 37.
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Jae Bem You, Ah Young Choi, Jieung Baek, Myung Seok Oh, Sung Gap Im, Kyung Eun Lee & Hye Sun Gwak. (2015) Application of Monodirectional Janus Patch to Oromucosal Delivery System. Advanced Healthcare Materials 4:15, pages 2229-2236.
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Heba A. Hazzah, Ragwa M. Farid, Maha M.A. Nasra, Magda A. EL-Massik & Ossama Y. Abdallah. (2015) Lyophilized sponges loaded with curcumin solid lipid nanoparticles for buccal delivery: Development and characterization. International Journal of Pharmaceutics 492:1-2, pages 248-257.
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Chuan Tang, Yi-Xin Guan, Shan-Jing Yao & Zi-Qiang Zhu. (2014) Preparation of ibuprofen-loaded chitosan films for oral mucosal drug delivery using supercritical solution impregnation. International Journal of Pharmaceutics 473:1-2, pages 434-441.
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Galal M. El-Mahrouk, Omaima N. El-Gazayerly, Ahmed A. Aboelwafa & Maie S. Taha. (2014) Chitosan lactate wafer as a platform for the buccal delivery of tizanidine HCl: In vitro and in vivo performance. International Journal of Pharmaceutics 467:1-2, pages 100-112.
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Rewathi R. Shiledar, Amol A. Tagalpallewar & Chandrakant R. Kokare. (2014) Formulation and in vitro evaluation of xanthan gum-based bilayered mucoadhesive buccal patches of zolmitriptan. Carbohydrate Polymers 101, pages 1234-1242.
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C. Kyada, K. Ranch & D. Shah. (2014) Optimization of Mucoadhesive Microspheres of Acyclovir by Applying 32 Full Factorial Design. Journal of Drug Delivery Science and Technology 24:1, pages 61-68.
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Zhaolu Zhu, Yinglei Zhai, Ning Zhang, Donglei Leng & Pingtian Ding. (2013) The development of polycarbophil as a bioadhesive material in pharmacy. Asian Journal of Pharmaceutical Sciences 8:4, pages 218-227.
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M. Nappinnai & S. Sivaneswari. (2013) Formulation optimization and characterization of gastroretentive cefpodoxime proxetil mucoadhesive microspheres using 32 factorial design. Journal of Pharmacy Research 7:4, pages 304-309.
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Jaya Lakkakula, Rui Werner Maçedo Krause, Derek Tantoh Ndinteh, S. P. Vijaylakshmi & Ashok M. Raichur. (2012) Detailed investigation of a γ-cyclodextrin inclusion complex with l-thyroxine for improved pharmaceutical formulations. Journal of Inclusion Phenomena and Macrocyclic Chemistry 74:1-4, pages 397-405.
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Mario Jug, Ivan Kosalec, Francesca Maestrelli & Paola Mura. (2012) Development of low methoxy amidated pectin-based mucoadhesive patches for buccal delivery of triclosan: Effect of cyclodextrin complexation. Carbohydrate Polymers 90:4, pages 1794-1803.
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Carlo Paderni, Domenico Compilato, Libero Italo Giannola & Giuseppina Campisi. (2012) Oral local drug delivery and new perspectives in oral drug formulation. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 114:3, pages e25-e34.
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Viralkumar F. Patel, Fang Liu & Marc B. Brown. (2012) Modeling the oral cavity: In vitro and in vivo evaluations of buccal drug delivery systems. Journal of Controlled Release 161:3, pages 746-756.
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Viralkumar F. Patel, Fang Liu & Marc B. Brown. (2011) Advances in oral transmucosal drug delivery. Journal of Controlled Release 153:2, pages 106-116.
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Lars Joergensen, Beate Klösgen, Adam Cohen Simonsen, Jonas Borch & Ellen Hagesaether. (2011) New insights into the mucoadhesion of pectins by AFM roughness parameters in combination with SPR. International Journal of Pharmaceutics 411:1-2, pages 162-168.
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Yunying Tao, Yifan Lu, Yinjing Sun, Bing Gu, Weiyue Lu & Jun Pan. (2009) Development of mucoadhesive microspheres of acyclovir with enhanced bioavailability. International Journal of Pharmaceutics 378:1-2, pages 30-36.
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