159
Views
25
CrossRef citations to date
0
Altmetric
Research Article

THE MECHANISM OF BIOACTIVATION OF N-NITROSODIETHANOLAMINE*

Pages 175-193 | Published online: 02 Aug 1999

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Kadry M. Sadek, Tarek K. Abouzed, Reham Abouelkhair & Sherif Nasr. (2017) The chemo-prophylactic efficacy of an ethanol Moringa oleifera leaf extract against hepatocellular carcinoma in rats. Pharmaceutical Biology 55:1, pages 1458-1466.
Read now
Perumal Subramanian, Kadiyala Babu Dakshayani, Seithikurippu R. Pandi-Perumal, Ilya Trakht & Daniel P. Cardinali. (2008) 24-Hour rhythms in oxidative stress during hepatocarcinogenesis in rats: effect of melatonin or α-ketoglutarate. Redox Report 13:2, pages 78-86.
Read now

Articles from other publishers (23)

Yupeng Li & Stephen S. Hecht. (2022) Metabolic Activation and DNA Interactions of Carcinogenic N-Nitrosamines to Which Humans Are Commonly Exposed. International Journal of Molecular Sciences 23:9, pages 4559.
Crossref
Tetyana Kobets, Michael J Iatropoulos, Jiandong D Duan, Klaus D Brunnemann, Dumitru A Iacobas, Sanda Iacobas, Esther Vock, Ulrich Deschl & Gary M Williams. (2018) Expression of Genes Encoding for Xenobiotic Metabolism After Exposure to Dialkylnitrosamines in the Chicken Egg Genotoxicity Alternative Model. Toxicological Sciences.
Crossref
Y. R. Shahin, N. M. Elguindy, A. Abdel Bary & M. Balbaa. (2018) The protective mechanism of Nigella sativa against diethylnitrosamine-induced hepatocellular carcinoma through its antioxidant effect and EGFR/ERK1/2 signaling . Environmental Toxicology 33:8, pages 885-898.
Crossref
NM Abdel-Hamid, MF Ramadan & SW Amgad. (2013) Glycoregulatory Enzymes as Early Diagnostic Markers during Premalignant Stage in Hepatocellular Carcinoma. American Journal of Cancer Prevention 1:2, pages 14-19.
Crossref
N. M. Abdel-Hamid, M. I. Abdel-Ghany, M. H. Nazmy & S. W. Amgad. (2012) Can methanolic extract of Nigella sativa seed affect glyco-regulatory enzymes in experimental hepatocellular carcinoma?. Environmental Health and Preventive Medicine 18:1, pages 49-56.
Crossref
George G. Chen, Jackie Leung, Nian Ci Liang, Li Li, Kefeng Wu, Ursula P. F. Chan, Billy C. S. Leung, Mingyue Li, Jing Du, Yi Feng Deng, Xianling Gong, Yingnian Lv, Ernest C. W. Chak & Paul B. S. Lai. (2012) Ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid inhibits hepatocellular carcinoma in vitro and in vivo via stabilizing IkBα. Investigational New Drugs 30:6, pages 2210-2218.
Crossref
Anupam Bishayee, Thomas Mbimba, Roslin J. Thoppil, Erzsébet Háznagy-Radnai, Péter Sipos, Altaf S. Darvesh, Hans G. Folkesson & Judit Hohmann. (2011) Anthocyanin-rich black currant (Ribes nigrum L.) extract affords chemoprevention against diethylnitrosamine-induced hepatocellular carcinogenesis in rats. The Journal of Nutritional Biochemistry 22:11, pages 1035-1046.
Crossref
Charles N. Zink, Nicolas Soissons & James C. Fishbein. (2010) Products of the Direct Reaction of the Diazonium Ion of a Metabolite of the Carcinogen N -Nitrosomorpholine with Purines of Nucleosides and DNA . Chemical Research in Toxicology 23:7, pages 1223-1233.
Crossref
Loïc Le Marchand. 2009. Genetics of Colorectal Cancer. Genetics of Colorectal Cancer 261 276 .
Yungang Liu & Hansruedi Glatt. (2008) Mutagenicity of N-nitrosodiethanolamine in a V79-derived cell line expressing two human biotransformation enzymes. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 643:1-2, pages 64-69.
Crossref
Perumal Subramanian, Shankaran Mirunalini, Kadiyala Babu Dakshayani, Seithikurippu R. Pandi-Perumal, Ilya Trakht & Daniel P. Cardinali. (2007) Prevention by melatonin of hepatocarcinogenesis in rats injected with N-nitrosodiethylamine. Journal of Pineal Research 43:3, pages 305-312.
Crossref
Charles N. Zink, Hyun-Joong Kim & James C. Fishbein. (2005) Synthesis and Aqueous Chemistry of α-Acetoxy- N -nitrosomorpholine:  Reactive Intermediates and Products . The Journal of Organic Chemistry 71:1, pages 202-209.
Crossref
Richard N. Loeppky, Sunil Sukhtankar, Feng Gu & Misun Park. (2005) The Carcinogenic Significance of Reactive Intermediates Derived from 3-Acetoxy- and 5-Acetoxy-2-hydroxy- N- nitrosomorpholine . Chemical Research in Toxicology 18:12, pages 1955-1966.
Crossref
Margaretha Jägerstad & Kerstin Skog. (2005) Genotoxicity of heat-processed foods. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 574:1-2, pages 156-172.
Crossref
Michelle K. Dennehy & Richard N. Loeppky. (2005) Mass Spectrometric Methodology for the Determination of Glyoxaldeoxyguanosine and O 6 -Hydroxyethyldeoxyguanosine DNA Adducts Produced by Nitrosamine Bident Carcinogens . Chemical Research in Toxicology 18:3, pages 556-565.
Crossref
Hyun-Joong Kim & James C. Fishbein. (2003) Reexamination of the Aqueous Chemistry of N-Nitroso-3-hydroxymorpholine, a Metabolite of the Carcinogen N-Nitrosomorpholine. Chemical Research in Toxicology 16:6, pages 715-720.
Crossref
Radoslav Goldman & Peter G. Shields. (2003) Food Mutagens. The Journal of Nutrition 133:3, pages 965S-973S.
Crossref
Richard N. Loeppky, Qiuping Ye, Petra Goelzer & Yuen Chen. (2002) DNA Adducts from N- Nitrosodiethanolamine and Related β-Oxidized Nitrosamines in Vivo:  32 P-Postlabeling Methods for Glyoxal- and O 6 -Hydroxyethyldeoxyguanosine Adducts . Chemical Research in Toxicology 15:4, pages 470-482.
Crossref
Richard N. Loeppky & Petra Goelzer. (2002) Microsome-Mediated Oxidation of N -Nitrosodiethanolamine (NDELA), a Bident Carcinogen . Chemical Research in Toxicology 15:4, pages 457-469.
Crossref
Jonghyuk Lee, Li Chen, Ann H. West & George B. Richter-Addo. (2002) Interactions of Organic Nitroso Compounds with Metals. Chemical Reviews 102:4, pages 1019-1066.
Crossref
Ahmed H Al-Mustafa, Helmut Sies & Wilhelm Stahl. (2001) Sulfur-to-nitrogen transnitrosation: transfer of nitric oxide from S-nitroso compounds to diethanolamine and the role of intermediate sulfur-to-sulfur transnitrosation. Toxicology 163:2-3, pages 127-136.
Crossref
Mingyao Wang, Edward J. McIntee, Guang Cheng, Yongli Shi, Peter W. Villalta & Stephen S. Hecht. (2000) Identification of Paraldol-Deoxyguanosine Adducts in DNA Reacted with Crotonaldehyde. Chemical Research in Toxicology 13:10, pages 1065-1074.
Crossref
Misun Park & Richard N. Loeppky. (1999) In Vitro DNA Deamination by α-Nitrosaminoaldehydes Determined by GC/MS-SIM Quantitation. Chemical Research in Toxicology 13:2, pages 72-81.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.