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Research Article

P450 SUBFAMILY CYP2J AND THEIR ROLE IN THE BIOACTIVATION OF ARACHIDONIC ACID IN EXTRAHEPATIC TISSUES*

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Pages 205-234 | Published online: 02 Aug 1999

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Shotaro Uehara, Yasuhiro Uno, Takashi Inoue, Eriko Okamoto, Erika Sasaki & Hiroshi Yamazaki. (2016) Marmoset cytochrome P450 2J2 mainly expressed in small intestines and livers effectively metabolizes human P450 2J2 probe substrates, astemizole and terfenadine. Xenobiotica 46:11, pages 977-985.
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Ursula Gundert-Remy, Ulrike Bernauer, Brunhilde Blömeke, Barbara Döring, Eric Fabian, Carsten Goebel, Stefanie Hessel, Christine Jäckh, Alfonso Lampen, Franz Oesch, Ernst Petzinger, Wolfgang Völkel & Peter H. Roos. (2014) Extrahepatic metabolism at the body's internal–external interfaces. Drug Metabolism Reviews 46:3, pages 291-324.
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Meijuan Xu, Wenzheng Ju, Haiping Hao, Guangji Wang & Ping Li. (2013) Cytochrome P450 2J2: distribution, function, regulation, genetic polymorphisms and clinical significance. Drug Metabolism Reviews 45:3, pages 311-352.
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Shakil Ahmed Saghir, Sarosh Ahmed Khan & Alene Theresa McCoy. (2012) Ontogeny of mammalian metabolizing enzymes in humans and animals used in toxicological studies. Critical Reviews in Toxicology 42:5, pages 323-357.
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A. Messina, S. Nencioni, P. G. Gervasi, K. H. Gotlinger, M. L. Schwartzman & V. Longo. (2010) Molecular cloning and enzymatic characterization of sheep CYP2J. Xenobiotica 40:2, pages 109-118.
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Ronald N. Hines, Sevasti B. Koukouritaki, Mark T. Poch & Michael C. Stephens. (2008) Regulatory Polymorphisms and their Contribution to Interindividual Differences in the Expression of Enzymes Influencing Drug and Toxicant Disposition. Drug Metabolism Reviews 40:2, pages 263-301.
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H. Yamazaki, A. Okayama, N. Imai, F. P. Guengerich & M. Shimizu. (2006) Inter-individual variation of cytochrome P4502J2 expression and catalytic activities in liver microsomes from Japanese and Caucasian populations. Xenobiotica 36:12, pages 1201-1209.
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H. M. Korashy, R. H. Elbekai & A. O. S. El-Kadi. (2004) Effects of renal diseases on the regulation and expression of renal and hepatic drug-metabolizing enzymes: a review. Xenobiotica 34:1, pages 1-29.
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Saraswathi Viswanathan, Bruce D. Hammock, John W. Newman, Purushothaman Meerarani, Michal Toborek & Bernhard Hennig. (2003) Involvement of CYP 2C9 in Mediating the Proinflammatory Effects of Linoleic Acid in Vascular Endothelial Cells. Journal of the American College of Nutrition 22:6, pages 502-510.
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Slobodan Rendic. (2002) Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metabolism Reviews 34:1-2, pages 83-448.
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Janne Hukkanen, Olavi Pelkonen, Jukka Hakkola & Hannu Raunio. (2002) Expression and Regulation of Xenobiotic-Metabolizing Cytochrome P450 (CYP) Enzymes in Human Lung. Critical Reviews in Toxicology 32:5, pages 391-411.
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